4.7 Article

Polymeric micelles assisted combinatorial therapy: Is it new hope for pancreatic cancer?

Journal

EUROPEAN POLYMER JOURNAL
Volume 184, Issue -, Pages -

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2022.111784

Keywords

Chemotherapeutics; Combination-approach; Drug resistance; Micelle; Nanoparticles; Pancreatic cancer

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Pancreatic cancer (PC) is a deadly disease with a low 5-year survival rate and is expected to become the second leading cause of cancer-related deaths in the United States by 2030. Treatment options are limited and the tumor microenvironment hinders therapeutic agents. Combining chemotherapeutics using nanoparticle-mediated delivery, such as micelles, shows promise in improving treatment outcomes and reducing side effects.
Pancreatic cancer (PC) is a fatal disease that has a 5-year survival rate of less than 9%. It is expected to rank second in cancer-related deaths across the United States by 2030. Out of all the patients only about one-fifth patients are potentially treatable, and treatment options are often palliative. PC's poor prognosis is credited to its difficult early detection and also the tumour microenvironment that restrict therapeutic agents' mobility. Numerous experimental and clinical research studies have demonstrated excellent therapeutic outcomes when a combination or simultaneous administration of chemotherapeutics is achieved. But even so, these 'combination' therapies frequently result in significant systemic toxicity. Nanoparticle-mediated delivery, particularly micelles, has the loading potential for multiple combinations of chemotherapeutics, thereby improving stability and accessibility, tumour-targeted delivery, and reducing chemotherapy-related adverse effects. As a result, a combinatorial approach can modify survival rates in patients promoting quality of life, and potentially providing a solution to hurdles in therapy. This review outlines the key challenges in treating PC, as well as recent advances in micelle-mediated combination treatments that combine chemotherapeutics and other gene-targeting agents such as siRNA and miRNA.

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