Article
Nutrition & Dietetics
Justyna Kubacka, Paulina Cembrowska, Grazyna Sypniewska, Anna Stefanska
Summary: The study examined the relationships between total serum branched-chain amino acid (BCAA) concentrations and cardiometabolic risk factors in middle-aged Caucasian women stratified by glycemic status. The findings suggest that dysglycemia predisposes women to a significant relationship between total BCAAs and circulating calcium, HbA1c, independent of BMI, indicating possible pathophysiological mechanisms linking BCAAs with metabolic disturbances.
Article
Medicine, General & Internal
Marwah Doestzada, Daria V. Zhernakova, Inge C. L. van den Munckhof, Daoming Wang, Alexander Kurilshikov, Lianmin Chen, Vincent W. Bloks, Martijn van Faassen, Joost H. W. Rutten, Leo A. B. Joosten, Mihai G. Netea, Cisca Wijmenga, Niels P. Riksen, Alexandra Zhernakova, Folkert Kuipers, Jingyuan Fu
Summary: This study systematically investigated the associations between branched-chain amino acids (BCAAs) and cardiometabolic diseases (CMD), and found significant correlations but no causal relationships between BCAAs and CMD parameters. Specific associations were identified for isoleucine, and the association of valine was influenced by obesity status. These findings highlight the clinical importance of individual BCAAs in the diagnosis, prevention, and treatment of CMD.
Article
Psychology, Clinical
Tahani Alshehri, Dennis O. Mook-Kanamori, Ko Willems van Dijk, Richard Dinga, Brenda W. J. H. Penninx, Frits R. Rosendaal, Saskia le Cessie, Yuri Milaneschi
Summary: Combining data on metabolomics and depressive symptoms, researchers identified a replicable depression dimension associated with adverse metabolic alterations, supporting the hypothesis of immune-metabolic depression. Patients with this type of depression may have a higher cardiometabolic risk.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Yuyan Liu, Chengwen Zhang, Yuan Zhang, Xuheng Jiang, Yuanhong Liang, Huan Wang, Yongfang Li, Guifan Sun
Summary: This study aimed to investigate the relationship between dietary intake of branched-chain amino acids (BCAAs) and hypertension risk in the Chinese population. The findings showed that dietary BCAAs intake was positively associated with both systolic and diastolic blood pressure values, as well as an increased risk of hypertension.
Review
Cell Biology
Michaela E. Trautman, Nicole E. Richardson, Dudley W. Lamming
Summary: The proportion of people suffering from age-related diseases is increasing worldwide. Recent research has shown that low protein diets, particularly those low in branched-chain amino acids (BCAAs), can reduce mortality and promote metabolic health and extended lifespan in both humans and rodents. This article discusses the emerging evidence that BCAAs play a crucial role in healthy metabolism and longevity, and explores the physiological and molecular mechanisms behind the benefits of restricting dietary BCAAs. The findings suggest that the quality of protein, specifically the composition of dietary protein, may be a previously overlooked factor in metabolic dysfunction and reducing dietary BCAAs could be a promising new approach to delaying and preventing age-related diseases.
Article
Nutrition & Dietetics
Lianlong Yu, Qianrang Zhu, Yuqian Li, Pengkun Song, Jian Zhang
Summary: This study aimed to explore the association between dietary BCAAs, blood lipid levels and risk of dyslipidemia. The results showed that dietary BCAAs were positively correlated with total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), and the relationship between dietary BCAAs and the risk of hypercholesteremia and hyper-LDL-cholesterolemia were both nonlinear.
Article
Endocrinology & Metabolism
Ximena Orozco-Ruiz, Andrea Anesi, Fulvio Mattivi, Monique M. B. Breteler
Summary: Visceral and subcutaneous adipose tissue function as endocrine organs and affect metabolic health through metabolite concentrations. This study found that certain metabolite concentrations associated with cardiometabolic risk markers are altered with increased visceral adipose tissue volume.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Pharmacology & Pharmacy
Tiangang Wu, Mengling Wang, Fengling Ning, Shilin Zhou, Xuetao Hu, Hong Xin, Svetlana Reilly, Xuemei Zhang
Summary: Fibrosis, characterized by excessive production of extracellular matrix, is a common pathological feature of organ diseases. Metabolic alterations, especially in the regulation of branched-chain amino acids (BCAAs), have been found to play significant roles in fibrogenesis. Dysregulation of BCAAs metabolism has been implicated in various diseases. This review summarizes the metabolic regulation of fibrosis, changes in BCAAs metabolism associated with fibrosis, and the effects and mechanisms of BCAAs intervention in hepatic, renal, and cardiac fibrosis, with a focus on liver fibrosis and associated hepatocellular carcinoma.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Damoon Ashtary-Larky, Sara Niknam, Meysam Alipour, Reza Bagheri, Omid Asbaghi, Mehrnaz Mohammadian, Salvador J. Jaime, Julien S. Baker, Alexei Wong, Katsuhiko Suzuki, Reza Afrisham
Summary: This study aimed to evaluate the cardiometabolic abnormalities in women with normal-weight obesity (NWO) in comparison with lean, overweight, and obese women. Significant differences were observed in HDL concentrations between NWO, lean, and obese participants. Individuals with NWO had a significantly higher incidence of cardiometabolic abnormalities when compared to lean participants.
Article
Rheumatology
Naoki Kimura, Takuya Kawahara, Yukari Uemura, Tatsuya Atsumi, Takayuki Sumida, Toshihide Mimura, Yasushi Kawaguchi, Hirofumi Amano, Yukiko Iwasaki, Yuko Kaneko, Toshihiro Matsui, Yoshinao Muro, Yoshitaka Imura, Takashi Kanda, Yoshiya Tanaka, Atsushi Kawakami, Masatoshi Jinnin, Tomonori Ishii, Keiju Hiromura, Yusuke Miwa, Hiroshi Nakajima, Masataka Kuwana, Yasuhiko Nishioka, Akio Morinobu, Hideto Kameda, Hitoshi Kohsaka
Summary: BCAAs showed no significant effect on improving MMT scores and clinical response, but were partially effective in improving dynamic repetitive muscle functions.
Article
Clinical Neurology
Min Kyu Park, Sook Joung Lee, Eunseok Choi, Sangjee Lee, JungSoo Lee
Summary: Stroke-related sarcopenia is influenced by factors such as brain damage and malnutrition. The study found that BCAA supplementation combined with intensive rehabilitation therapy can significantly improve skeletal muscle index and functional status in stroke patients. Nutritional support also plays a role in improving functional outcomes during neurological recovery.
FRONTIERS IN NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Chaofan Zeng, Peicong Ge, Chenglong Liu, Xiaofan Yu, Yuanren Zhai, Wei Liu, Qiheng He, Junsheng Li, Xingju Liu, Jia Wang, Xun Ye, Qian Zhang, Rong Wang, Yan Zhang, Jizong Zhao, Dong Zhang
Summary: This study found that an increased level of circulating BCAAs was associated with an increased risk of moyamoya disease and clinical subtypes. This provides support for further elucidating the pathogenesis of moyamoya disease and guiding treatment and prevention strategies.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Pei Xiao, Hong Cheng, Yinkun Yan, Junting Liu, Xiaoyuan Zhao, Haibo Li, Jie Mi
Summary: Unlike BMI and FMI, lean mass was found to have an inverse association with insulin resistance, fasting plasma glucose, non-HDL cholesterol, LDL cholesterol, and total cholesterol. Greater lean mass may have a protective impact on high TC, high LDL cholesterol, hyperglycemia, and insulin resistance in children and adolescents. This finding suggests that the obesity paradox may be partly explained by high lean mass.
JOURNAL OF NUTRITION
(2021)
Article
Clinical Neurology
Masakazu Minetama, Mamoru Kawakami, Masatoshi Teraguchi, Yoshio Enyo, Masafumi Nakagawa, Yoshio Yamamoto, Nana Sakon, Sachika Matsuo, Tomohiro Nakatani, Ryota Nakagawa, Wakana Nagata, Yukihiro Nakagawa
Summary: A randomized controlled trial found that supplementation with branched-chain amino acids (BCAA) and vitamin D did not improve postoperative recovery in patients with lumbar spinal stenosis (LSS).
Article
Endocrinology & Metabolism
Si Fang, Kaitlin H. Wade, David A. Hughes, Sophie Fitzgibbon, Vikki Yip, Nicholas J. Timpson, Laura J. Corbin
Summary: This study estimated the effect of BMI on circulating metabolites in young adults using a recall-by-genotype study design. After analyzing samples from 756 participants, it was found that there were associations between BMI genetic risk score groups and the levels of certain metabolites. The results suggest that a genetic predisposition to higher BMI captures differences in metabolism leading to adiposity gain.
Review
Food Science & Technology
Wolfgang J. Schnedl, Dietmar Enko
Summary: In western countries, a significant portion of the population may experience adverse reactions to certain food components, leading to various gastrointestinal issues. Thus, a thorough diagnostic workup is necessary for managing patients with functional gastrointestinal complaints, including consideration of individual tolerance to different food components.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Medical Laboratory Technology
Dietmar Enko, Ingeborg Stelzer, Michael Boeckl, Wolfgang J. Schnedl, Andreas Meinitzer, Markus Herrmann, Martin Toetsch, Michael Gehrer
Summary: The study found that the UF-5000 urine sediment analyzer is a reliable tool for diagnosing urinary tract infections, with its BACT-Info flags assisting clinicians in rapid diagnosis. However, it is advisable to verify the automated Gram categories with urine culture results.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Medicine, Research & Experimental
Wolfgang J. Schnedl, Harald Mangge, Michael Schenk, Dietmar Enko
Summary: This study investigated 20 non-responsive, celiac disease patients with refractory symptoms for more than 6 months, and found that the majority of them had additional food intolerances/malabsorption and/or H.p. infection. Histamine intolerance was prevalent in over 50% of the patients, suggesting its importance in non-responsive celiac disease.
MEDICAL HYPOTHESES
(2021)
Article
Medicine, General & Internal
Wolfgang J. Schnedl, Sandra J. Holasek, Michael Schenk, Dietmar Enko, Harald Mangge
Summary: HNF1A-MODY, caused by monogenic mutations of hepatocyte nuclear factor 1, presents as early onset diabetes which requires different antihyperglycemic treatment compared to type 1 or type 2 diabetes. Proper genetic diagnosis and identification of HNF1A-MODY patients is crucial for discontinuing insulin therapy and initiating adjusted diabetes management.
WIENER KLINISCHE WOCHENSCHRIFT
(2021)
Article
Clinical Neurology
Markus Kneihsl, Egbert Bisping, Daniel Scherr, Harald Mangge, Simon Fandler-Hoefler, Isabella Colonna, Melanie Haidegger, Sebastian Eppinger, Edith Hofer, Franz Fazekas, Christian Enzinger, Thomas Gattringer
Summary: A clinical risk score was developed for predicting atrial fibrillation (AF) occurrence in cryptogenic stroke (CS) patients, demonstrating high sensitivity, reasonable specificity, and excellent negative predictive value over a 1-year follow-up period. Further validation in external cohorts with continuous cardiac rhythm monitoring is needed to assess the generalizability of the score.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Wolfgang J. Schnedl, Nathalie Meier-Allard, Simon Michaelis, Sonja Lackner, Dietmar Enko, Harald Mangge, Sandra J. Holasek
Summary: Lactose intolerance is one of the major causes of irritable bowel syndrome, but its pathophysiology is still unclear. This study retrospectively assessed the impact of histamine intolerance on exhaled hydrogen levels in lactose intolerance patients. The results showed that lactose intolerance patients with histamine intolerance had significantly higher levels of exhaled hydrogen and a higher number of patients with gastrointestinal symptoms during breath tests.
Article
Biochemistry & Molecular Biology
Harald Mangge, Florian Prueller, Christine Dawczynski, Pero Curcic, Zdenka Sloup, Magdalena Holter, Markus Herrmann, Andreas Meinitzer
Summary: This study reveals significantly decreased levels of vitamin K, especially vitamin K2 (MK7), in patients with COVID-19. This depletion of vitamin K may be attributed to the immanent effects of COVID-19, such as inflammation and oxidative stress.
Article
Biochemistry & Molecular Biology
Julia T. Stadler, Harald Mangge, Alankrita Rani, Pero Curcic, Markus Herrmann, Florian Prueller, Gunther Marsche
Summary: This study evaluates the impact of COVID-19 infection on HDL function and metabolism, and finds that low HDL cholesterol efflux capacity is associated with increased mortality risk in COVID-19 patients, independent of HDL-cholesterol levels.
Article
Medical Laboratory Technology
Simon Michaelis, Sieglinde Zelzer, Christopher Schneider, Wolfgang J. Schnedl, Andreas Baranyi, Andreas Meinitzer, Markus Herrmann, Dietmar Enko
Summary: The study found that patients with higher activation levels of the kynurenine pathway tended to develop lower anti-SARS-CoV-2 antibody titers.
CLINICA CHIMICA ACTA
(2022)
Article
Chemistry, Physical
Jonas Dinter, Ralf. P. P. Friedrich, Hai Yang, Christian Pilarsky, Harald Mangge, Marina Poettler, Christina Janko, Christoph Alexiou, Stefan Lyer
Summary: Pancreatic ductal adenocarcinoma is a difficult-to-treat cancer with poor long-term survival rates. In this study, a 3D cell culture model of human pancreatic ductal adenocarcinoma was used to investigate the potential use of superparamagnetic iron oxide nanoparticles (SPIONs) as a drug delivery system for the chemotherapeutic agent mitoxantrone (MTO). The results showed that MTO-loaded SPIONs induced cell death in tumor spheroids, with increased uptake in spheroids with a SMAD4 mutation. This suggests that MTO-loaded SPIONs could be a promising approach for treating pancreatic ductal adenocarcinomas.
Article
Nutrition & Dietetics
Wolfgang J. Schnedl, Simon Michaelis, Dietmar Enko, Harald Mangge
Summary: Inflammatory bowel disease (IBD) can be distinguished from functional bowel diseases using fecal calprotectin (FCAL) as a marker. This retrospective study investigated the levels of FCAL in patients with irritable bowel syndrome (IBS) caused by food intolerances/malabsorption. The study found elevated FCAL levels in 17.1% of the IBS patients with food intolerance/malabsorption and H. pylori infection. After individualized diet and eradication therapy, FCAL values were significantly lowered or reduced to normal range.
Review
Nutrition & Dietetics
Wolfgang J. Schnedl, Simon Michaelis, Harald Mangge, Dietmar Enko
Summary: Symptoms of irritable bowel syndrome (IBS) spectrum disorders include postprandial abdominal complaints. However, dietary treatments for IBS have not been personalized or supported with sufficient scientific evidence, relying on 'one-size-fits-all' approaches such as exclusion diets and specific nutrient-free diets. The pathophysiology of IBS remains unclear, but similar symptoms to food intolerance/malabsorption syndromes suggest a connection, and the presence of Helicobacter pylori infection may contribute to the development of IBS-like symptoms. This review highlights the limitations of the 'one-size-fits-all' approach and recommends a noninvasive diagnostic workup for food intolerance/malabsorption and individualized dietary intervention.
CLINICAL NUTRITION ESPEN
(2023)
Article
Neurosciences
Sabrina Moerkl, Andreas Oberascher, Josef M. Tatschl, Sonja Lackner, Thomaz F. S. Bastiaanssen, Mary Butler, Maximilian Moser, Matthias Fruehwirth, Harald Mangge, John F. Cryan, Timothy G. Dinan, Sandra J. Holasek
Summary: This study investigates the association between cardiac vagal activity (CVA) and gut microbiota diversity. The results show a significant correlation between daytime CVA and gut microbiota diversity, as well as inflammatory parameters. Furthermore, different abundances of specific microbial taxa are observed in the high CVA group. The study also identifies two enterotypes that differ in CVA, age, BMI, inflammatory parameters, and diversity.
DIALOGUES IN CLINICAL NEUROSCIENCE
(2022)
Article
Biology
Wolfgang J. Schnedl, Nathalie Meier-Allard, Michael Schenk, Sonja Lackner, Dietmar Enko, Harald Mangge, Sandra J. Holasek
Summary: In patients infected with Helicobacter pylori and experiencing symptoms of the irritable bowel syndrome, there may be additional food intolerance/malabsorption. Higher levels of exhaled hydrogen in lactose breath tests among lactose intolerance patients may indicate the presence of H. pylori infection and other food intolerance/malabsorption. In addition to H. pylori eradication, an individually tailored reduction or exclusion diet of symptom-triggering food components is necessary for these patients.
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)