Selectively bred rodent models for studying the etiology of type 2 diabetes: Goto-Kakizaki rats and Oikawa-Nagao mice

Secretory granule exocytosis and its amplification by cAMP in pancreatic β-cells

(2022) Mototsugu Nagao et al.   Diabetology International

Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells

(2020) Mototsugu Nagao et al.   DIABETES

Leptin production capacity determines food intake and susceptibility to obesity-induced diabetes in Oikawa–Nagao Diabetes-Prone and Diabetes-Resistant mice

(2020) Akira Asai et al.   DIABETOLOGIA

GK-rats respond to gastric bypass surgery with improved glycemia despite unaffected insulin secretion and beta cell mass

(2020) Michael G. Miskelly et al.   PEPTIDES

Metformin Attenuates Early-Stage Atherosclerosis in Mildly Hyperglycemic Oikawa-Nagao Mice

(2019) Akira Asai et al.   Journal of Atherosclerosis and Thrombosis

Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men

(2018) Patrik Rorsman et al.   PHYSIOLOGICAL REVIEWS

MicroRNAs in islet hormone secretion

(2018) Jonathan L. S. Esguerra et al.   DIABETES OBESITY & METABOLISM

Munc18b Increases Insulin Granule Fusion, Restoring Deficient Insulin Secretion in Type-2 Diabetes Human and Goto-Kakizaki Rat Islets with Improvement in Glucose Homeostasis

(2017) Tairan Qin et al.   EBioMedicine

Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell

(2017) Jones K. Ofori et al.   Scientific Reports

Left ventricular pressure-volume measurements and myocardial gene expression profile in type 2 diabetic Goto-Kakizaki rats

(2016) Sevil Korkmaz-Icöz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Fat intake and the development of type 2 diabetes [Review]

(2015) Mototsugu Nagao et al.   ENDOCRINE JOURNAL

β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment

(2014) Philippe A. Halban et al.   DIABETES CARE

Characterization of Pancreatic Islets in Two Selectively Bred Mouse Lines with Different Susceptibilities to High-Fat Diet-Induced Glucose Intolerance

(2014) Mototsugu Nagao et al.   PLoS One

Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin Secretion

(2014) Tasnim Dayeh et al.   PLoS Genetics

Effect of impaired glucose tolerance on atherosclerotic lesion formation: An evaluation in selectively bred mice with different susceptibilities to glucose intolerance

(2013) Akira Asai et al.   ATHEROSCLEROSIS

Genetics of diabetes – Are we missing the genes or the disease?

(2013) Leif Groop et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Genomic and Metabolic Disposition of Non-Obese Type 2 Diabetic Rats to Increased Myocardial Fatty Acid Metabolism

(2013) Sriram Devanathan et al.   PLoS One

The use of animal models in diabetes research

(2012) Aileen JF King   BRITISH JOURNAL OF PHARMACOLOGY

Reduced Insulin Exocytosis in Human Pancreatic  -Cells With Gene Variants Linked to Type 2 Diabetes

(2012) A. H. Rosengren et al.   DIABETES

Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes

(2012) Sofia A. Andersson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Cyclic AMP dynamics in the pancreatic β-cell

(2012) Anders Tengholm   UPSALA JOURNAL OF MEDICAL SCIENCES

CD36 as a lipid sensor

(2011) Céline Martin et al.   PHYSIOLOGY & BEHAVIOR

Differential Glucose-Regulation of MicroRNAs in Pancreatic Islets of Non-Obese Type 2 Diabetes Model Goto-Kakizaki Rat

(2011) Jonathan Lou S. Esguerra et al.   PLoS One

Selective breeding of mice for different susceptibilities to high fat diet-induced glucose intolerance: Development of two novel mouse lines, Selectively bred Diet-induced Glucose intolerance-Prone and -Resistant

(2011) Mototsugu Nagao et al.   Journal of Diabetes Investigation

Genetic loci for bone architecture determined by three-dimensional CT in crosses with the diabetic GK rat

(2010) Sofia Lagerholm et al.   BONE

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat

(2009) J. A. Ehses et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes

(2009) A. H. Rosengren et al.   SCIENCE

10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes

(2008) Rury R. Holman et al.   NEW ENGLAND JOURNAL OF MEDICINE