Review
Immunology
Arsheena Yassin, Mariya Huralska, Jason M. Pogue, Deepali Dixit, Robert G. Sawyer, Keith S. Kaye
Summary: The prevalence of multidrug-resistant gram-negative bacterial infections has significantly increased in the past decade, leading to higher rates of morbidity and mortality. Treating these infections presents challenges, particularly for critically ill patients with limited margin for error. The availability of new therapies has improved treatment options, but optimal clinical and therapeutic approaches for managing these infections still need to be established.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Hak-Jae Kim, Sae Won Na, Hissah Abdulrahman Alodaini, Munirah Abdullah Al-Dosary, P. Nandhakumari, L. Dyona
Summary: The study revealed a high prevalence of antibiotic resistance among bacterial strains isolated from wound infections, with some showing sensitivity to vancomycin. Specifically, Enterococcus faecalis and Proteus species exhibited resistance to various antibiotics.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Infectious Diseases
Monirul I. Sajib, Melinda Monteforte, Roderick Go
Summary: Cefiderocol is shown to be possibly associated with lower all-cause mortality than previously thought. The use of dual antibiotics in conjunction with cefiderocol may be advantageous in reducing mortality compared to using cefiderocol alone.
Article
Biochemistry & Molecular Biology
Susumu Shinya, Kentaro Kawai, Naoki Kobayashi, Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Masato Otsuka, Masaaki Omote
Summary: Drug efflux pump inhibitors were investigated to increase drug susceptibility of multidrug-resistant bacteria and restore the antimicrobial effect of fluoroquinolones. The lead inhibitor, derived from a known hMATE1 inhibitor, showed significant reduction in resistance and could act synergistically with antimicrobial drugs against infections caused by multidrug-resistant bacteria.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Infectious Diseases
Veronica Folliero, Federica Dell'Annunziata, Emanuela Roscetto, Marcella Cammarota, Anna De Filippis, Chiara Schiraldi, Maria Rosaria Catania, Vincenzo Casolaro, Alessandro Perrella, Massimiliano Galdiero, Gianluigi Franci
Summary: This study demonstrates the antimicrobial activity of the anthelmintic drug niclosamide against multidrug-resistant Corynebacterium striatum, showing bactericidal action and biofilm biomass degradation. These findings suggest the potential repurposing of niclosamide as a therapeutic agent for C. striatum infections.
Review
Infectious Diseases
Benoit Pilmis, Emmanuel Weiss, Anne Scemla, Alban Le Monnier, Paolo Antonio Grossi, Monica A. Slavin, Christian Van Delden, Olivier Lortholary, Catherine Paugam-Burtz, Jean-Ralph Zahar
Summary: Transplant recipients are highly susceptible to multidrug-resistant (MDR) related infections, especially those caused by metallo-β-lactamases. It is important to develop control strategies to manage MDR Gram-negative bacilli infections in transplant recipients. Understanding the clinical microbiology and infectious diseases is crucial for reducing the risk of infection in transplant recipients and the appropriate use of antibiotics.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Review
Infectious Diseases
Dana Holger, Razieh Kebriaei, Taylor Morrisette, Katherine Lev, Jose Alexander, Michael Rybak
Summary: Pseudomonas aeruginosa is a common pathogen causing healthcare-associated diseases and is highly resistant to many antibiotics, posing challenges in treatment. Bacteriophages, as viruses targeting and infecting bacterial cells, offer promise as an alternative therapy for multidrug-resistant P. aeruginosa infections. Further studies on phage pharmacokinetics and pharmacodynamics are needed to guide successful phage therapy for these infections.
Article
Chemistry, Multidisciplinary
Yiwen Zhu, Minzheng Gao, Mengrui Su, Yanzhe Shen, Kai Zhang, Bingran Yu, Fu-Jian Xu
Summary: Traditional photodynamic therapy (PDT) is limited in treating deep infections due to insufficient penetration of light and oxygen. A targeting singlet oxygen delivery system, CARG-Py, was designed for irradiation-free and oxygen-free PDT. The system converted to CARG-O-1(2) released singlet oxygen without external irradiation or oxygen and showed potential in efficient treatment of deep infections. This work provides a new strategy to improve traditional PDT for irradiation- and oxygen-free treatment of deep infections while improving convenience.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Microbiology
Mohd W. Azam, Raffaele Zarrilli, Asad U. Khan
Summary: The Enterobacterales order is a large group of Gram-negative bacteria that includes both pathogenic and nonpathogenic members, including beneficial gut microbiota. Pathogenic members produce virulence factors and display antimicrobial resistance. This review focuses on the virulence factors, pathogenicity, and infections caused by multidrug-resistant Enterobacterales, particularly E. coli and similar bacterial species. The review also discusses different approaches for combating these infections. Understanding the virulence factors of pathogenic bacteria can aid in the development of novel strategies to treat infections caused by them.
Article
Chemistry, Multidisciplinary
Jessa Marie V. Makabenta, Ahmed Nabawy, Aritra Nath Chattopadhyay, Taewon Jeon, Jungmi Park, Pui Chi Lo, Stas Nosovitski, Rui Huang, Cheng-Hsuan Li, Mingdi Jiang, Vincent M. Rotello
Summary: Integration of antimicrobial polymeric nanoparticles into hydrogel materials provides a promising strategy for treating multidrug-resistant biofilm infections. This study demonstrates the efficacy and selectivity of an injectable hydrogel loaded with engineered cationic antimicrobial polymeric nanoparticles (PNPs) for the treatment of severe wound biofilm infections.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Infectious Diseases
Sisi Zhen, Hui Wang, Sizhou Feng
Summary: CAZ-AVI is a valuable therapeutic option for MDR-GNB infections, particularly for KPC or OXA-48 CRE infections. It shows significant benefits and improved clinical outcomes, even in immunocompromised patients. Early use of CAZ-AVI is associated with better efficacy. However, resistance development in CRE and MDR-PA against CAZ-AVI is a concern, and further investigations are needed.
Review
Medicine, General & Internal
Guido Granata, Fabrizio Taglietti, Francesco Schiavone, Nicola Petrosillo
Summary: This study assessed the efficacy and safety of a novel antibiotic, durlobactam, in the treatment of multidrug-resistant A. baumannii infections. Sixteen studies met the inclusion criteria, and it was found that durlobactam is effective when used in combination with sulbactam against A. baumannii. Further clinical trials are needed to confirm the potential of this combination therapy for treating infections caused by multidrug-resistant A. baumannii.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Infectious Diseases
Victoria Gavaghan, Jessica L. Miller, Jennifer Dela-Pena
Summary: This case series examines the real-world usage of cefiderocol in treating carbapenem-resistant Gram-negative bacterial infections and its associated clinical outcomes. The study found that cefiderocol remains a viable option for treating these types of infections.
Review
Infectious Diseases
Jaideep Vazirani, Thomas Crowhurst, C. Orla Morrissey, Gregory Snell
Summary: Cystic fibrosis is a genetic multisystem disease, and lung transplantation is an effective treatment option. However, managing recurrent infections and balancing immune suppression in this setting can be difficult. Infections are a major contributor to post-transplant mortality, with multidrug-resistant organisms posing a significant threat to survival.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Chemistry, Multidisciplinary
Biying Huang, Long Wang, Kui Tang, Sijie Chen, Yan Xu, Haiqin Liao, Chengcheng Niu
Summary: In this study, we have developed IR780-based PLGA nanoparticles as sonosensitizers for the treatment of MDR bacterial infections. By combining high-frequency ultrasound and therapeutic low-frequency US, the sonodynamic therapy showed high efficacy in monitoring and combating MDR bacterial infections.
FRONTIERS IN CHEMISTRY
(2022)
