Article
Infectious Diseases
Harald Seifert, Carina Mueller, Danuta Stefanik, Paul G. G. Higgins, Esther Wohlfarth, Michael Kresken
Summary: Cefiderocol has potent activity against multi-drug-resistant Gram-negative pathogens, including carbapenem-resistant Acinetobacter baumannii. However, some carbapenem-resistant Acinetobacter baumannii isolates have elevated minimum inhibitory concentrations, especially those carrying metallo-β-lactamase.
Review
Infectious Diseases
Marin Kollef, Herve Dupont, David E. Greenberg, Pierluigi Viale, Roger Echols, Yoshinori Yamano, David P. Nicolau
Summary: Carbapenem-resistant Acinetobacter baumannii (CRAB) has been classified as a critical pathogen requiring urgent new antibiotic treatment options. Cefiderocol, the first approved siderophore cephalosporin, shows stable activity against carbapenem-resistant pathogens and has demonstrated clinical efficacy in treating CRAB infections. Combination therapy with other active antibiotics and monitoring for resistance development are recommended.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Microbiology
Jacinda C. Abdul-Mutakabbir, Logan Nguyen, Philip T. Maassen, Kyle C. Stamper, Razieh Kebriaei, Keith S. Kaye, Mariana Castanheira, Michael J. Rybak
Summary: Cefiderocol, a novel siderophore cephalosporin, shows potent activity against multidrug-resistant Acinetobacter baumannii, with lower MIC values compared to other Gram-negative agents. Studies indicate synergistic effects when combined with other antibiotics, and beta-lactamase inhibitors increase susceptibility to CFDC in MDR A. baumannii isolates.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Marco Falcone, Giusy Tiseo, Alessandro Leonildi, Leonardo Della Sala, Alessandra Vecchione, Simona Barnini, Alessio Farcomeni, Francesco Menichetti
Summary: Cefiderocol appears to be a promising therapeutic option for carbapenem-resistant Acinetobacter baumannii (CRAB) infections, with a potential protective effect on 30-day mortality. However, further studies are needed to address the issue of microbiological failure.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Wesley D. Kufel, Yasmeen Abouelhassan, Jeffrey M. Steele, Ramiro L. Gutierrez, Talha Perwez, George Bourdages, David P. Nicolau
Summary: The study investigated the pharmacokinetics of cefiderocol in cerebrospinal fluid (CSF) and plasma during the treatment of carbapenem-resistant Acinetobacter baumannii (CRAB) meningitis using two different dosing regimens. Results showed that cefiderocol achieved CSF concentrations surpassing the organism-specific MIC and the CLSI susceptible breakpoint for 100% of the dosing interval, leading to microbiological and clinical cure without any adverse effects.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Microbiology
Carina Mueller, Sandra Reuter, Julia Wille, Kyriaki Xanthopoulou, Danuta Stefanik, Hajo Grundmann, Paul G. Higgins, Harald Seifert
Summary: This study conducted molecular epidemiology and global distribution research on 313 carbapenem-resistant Acinetobacter baumannii isolated from 114 study centers in 47 countries. The results revealed a wide variation in the distribution of carbapenemase encoding genes among different geographical regions.
Review
Medicine, General & Internal
Flora Cruz-Lopez, Adrian Martinez-Melendez, Licet Villarreal-Trevino, Rayo Morfin-Otero, Hector Maldonado-Garza, Elvira Garza-Gonzalez
Summary: This review examines the contamination of CRAB on corporal surfaces of patients and healthcare workers, as well as environmental sites in healthcare-related settings. It summarizes the published data on potential reservoirs, contamination frequency, resistance mechanisms, and measures for eliminating CRAB from hospital surfaces.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Article
Infectious Diseases
Jia-Ling Yang, Chia-Jui Yang, Yu-Chung Chuang, Wang-Huei Sheng, Yee-Chun Chen, Shan-Chwen Chang
Summary: This study evaluated the susceptibility of carbapenem-resistant Acinetobacter baumannii (CRAB) clinical strains to minocycline, and found a significant correlation between tetB carriage and minocycline susceptibility in CRAB.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Public, Environmental & Occupational Health
Federica Calo, Lorenzo Onorato, Ilaria De Luca, Margherita Macera, Caterina Monari, Emanuele Durante-Mangoni, Alessia Massa, Ivan Gentile, Giovanni Di Caprio, Pasquale Pagliano, Fabio Giuliano Numis, Pasquale Iuliano, Antonio Riccardo Buonomo, Sebastiano Leone, Paolo Maggi, Nicola Coppola
Summary: In an observational retrospective/prospective multicenter study, the effectiveness of cefiderocol in carbapenem-resistant A. baumannii (CRAB) infections was demonstrated, and it was found to be effective as monotherapy. However, larger prospective multicenter studies with a control group using standard of care are needed to determine the optimal treatment for CRAB infections.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Infectious Diseases
Nalumon Thadtapong, Soraya Chaturongakul, Sunhapas Soodvilai, Padungsri Dubbs
Summary: This study focused on analyzing the whole genome data of Aci46, and found that it belongs to the Pasture ST2 cluster and is phylogenetically clustered with the international clone (IC) II, a predominant strain in Thailand. Interestingly, Aci46 is identical to Oxford ST1962, which has never been isolated in Thailand before. The presence of potential virulence-associated factors and antibiotic resistance phenotypes were explored in the study.
Article
Immunology
Marco Falcone, Giusy Tiseo, Manuela Nicastro, Alessandro Leonildi, Alessandra Vecchione, Costanza Casella, Francesco Forfori, Paolo Malacarne, Fabio Guarracino, Simona Barnini, Francesco Menichetti
Summary: In this study, cefiderocol was used to treat patients with bacteremia or ventilator-associated pneumonia caused by drug-resistant strains, showing a 70% clinical success rate and 90% survival rate. However, two patients experienced microbiological failure, highlighting the need for future prospective studies to further evaluate the effectiveness of the treatment.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Shuk-Ching Wong, Jonathan Hon-Kwan Chen, Pui-Hing Chau, Simon Yung-Chun So, Christine Ho-Yan Auyeung, Lithia Lai-Ha Yuen, Veronica Wing-Man Chan, Germaine Kit-Ming Lam, Kelvin Hei-Yeung Chiu, Pak-Leung Ho, Janice Yee-Chi Lo, Kwok-Yung Yuen, Vincent Chi-Chung Cheng
Summary: The study aims to analyze the incidence, risk factors, and clinical outcomes of newly identified gastrointestinal colonization of carbapenem-resistant Acinetobacter baumannii (CRAB) in a healthcare region in Hong Kong. The results showed that patients referred from residential care homes for the elderly, use of indwelling devices, and previous use of certain medications were significantly associated with gastrointestinal colonization of CRAB. Gastrointestinal colonization of CRAB poses a challenge for infection prevention and control.
Review
Infectious Diseases
Neetu Gupta, Kalpana Angadi, Savita Jadhav
Summary: This review aims to understand the mechanisms of carbapenem resistance, categorize and discuss carbapenemases encoding genes and various mobile genetic elements, as well as the prevalence of carbapenemase genes in recent years in A. baumannii from various geographical regions.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Jacinda C. Abdul-Mutakabbir, Juwon Yim, Logan Nguyen, Philip T. Maassen, Kyle Stamper, Zain Shiekh, Razieh Kebriaei, Ryan K. Shields, Mariana Castanheira, Keith S. Kaye, Michael J. Rybak
Summary: The study explored the potential utility of antibiotic combinations for carbapenem-resistant Acinetobacter baumannii isolates, identifying synergistic and bactericidal effects in certain combination therapies. Results suggest that certain antibiotic combinations can restore efficacy against resistant strains, offering new treatment options for difficult-to-treat infections caused by Acinetobacter baumannii.
Article
Infectious Diseases
Sirijan Santajit, Phuangthip Bhoopong, Thida Kong-Ngoen, Witawat Tunyong, Dararat Horpet, Wanfudhla Paehoh-ele, Tasneem Zahedeng, Pornpan Pumirat, Nitat Sookrung, Woranich Hinthong, Nitaya Indrawattana
Summary: This study characterized the genetic traits of biofilm-forming carbapenem-resistant A. baumannii clinical isolates in a tertiary care hospital. The prevalence of biofilm-producing A. baumannii isolates was determined and their association with biofilm-related and antibiotic resistance-associated genotypes was investigated. The predominance of biofilm-producing CRAB isolates identified in this study is concerning, and understanding the risk factors could help control the selection and spread of A. baumannii in hospitals, thereby improving patient care quality.