Take a break: Transcription regulation and RNA processing by the Integrator complex

Integrator is a genome-wide attenuator of non-productive transcription

(2021) Søren Lykke-Andersen et al.   MOLECULAR CELL

The RNA polymerase II subunit RPB‐9 recruits the integrator complex to terminate Caenorhabditis elegans piRNA transcription

(2021) Ahmet C Berkyurek et al.   EMBO JOURNAL

Structure of the catalytic core of the Integrator complex

(2021) Moritz M. Pfleiderer et al.   MOLECULAR CELL

Disruption of pathways regulated by Integrator complex in Galloway–Mowat syndrome due to WDR73 mutations

(2021) F. C. Tilley et al.   Scientific Reports

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

(2021) Stephin J. Vervoort et al.   CELL

U7 deciphered: the mechanism that forms the unusual 3′ end of metazoan replication-dependent histone mRNAs

(2021) Zbigniew Dominski et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Protein phosphatase 2A – structure, function and role in neurodevelopmental disorders

(2021) Priyanka Sandal et al.   JOURNAL OF CELL SCIENCE

Crystal structure of the INTS3/INTS6 complex reveals the functional importance of INTS3 dimerization in DSB repair

(2021) Yu Jia et al.   Cell Discovery

Structural basis of Integrator-mediated transcription regulation

(2021) Isaac Fianu et al.   SCIENCE

Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals

(2020) Seulgi Lee et al.   MOLECULES

INTS10–INTS13–INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module

(2020) Kevin Sabath et al.   Nature Communications

Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1

(2020) Jasmine Barra et al.   Science Advances

Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination

(2020) Kai-Lieh Huang et al.   MOLECULAR CELL

Integrator is recruited to promoter‐proximally paused RNA Pol II to generate Caenorhabditis elegans piRNA precursors

(2020) Toni Beltran et al.   EMBO JOURNAL

Structural basis for multifunctional roles of human Ints3 C-terminal domain

(2020) Jian Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biallelic sequence variants in INTS1 in patients with developmental delays, cataracts, and craniofacial anomalies

(2019) Max Krall et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Disruption of the Caenorhabditis elegans Integrator complex triggers a non-conventional transcriptional mechanism beyond snRNA genes

(2019) Eva Gómez-Orte et al.   PLoS Genetics

Integrator is a key component of human telomerase RNA biogenesis

(2019) M. P. Rubtsova et al.   Scientific Reports

The Integrator complex cleaves nascent mRNAs to attenuate transcription

(2019) Deirdre C. Tatomer et al.   GENES & DEVELOPMENT

Biallelic INTS1 Mutations Cause a Rare Neurodevelopmental Disorder in Two Chinese Siblings

(2019) Xuemin Zhang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Organization and regulation of gene transcription

(2019) Patrick Cramer   NATURE

Transcriptional Control by Premature Termination: A Forgotten Mechanism

(2019) Kinga Kamieniarz-Gdula et al.   TRENDS IN GENETICS

Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis

(2019) Akihide Yoshimi et al.   NATURE

The Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes

(2019) Nathan D. Elrod et al.   MOLECULAR CELL

Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals

(2018) Nilay Shah et al.   MOLECULAR CELL

Targeted Enhancer Activation by a Subunit of the Integrator Complex

(2018) Elisa Barbieri et al.   MOLECULAR CELL

Integrator subunit 4 is a ‘Symplekin-like’ scaffold that associates with INTS9/11 to form the Integrator cleavage module

(2018) Todd R Albrecht et al.   NUCLEIC ACIDS RESEARCH

Structure of paused transcription complex Pol II–DSIF–NELF

(2018) Seychelle M. Vos et al.   NATURE

Pan-Cancer Mutational and Transcriptional Analysis of the Integrator Complex

(2017) Antonio Federico et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Distinctive Patterns of Transcription and RNA Processing for Human lincRNAs

(2017) Margarita Schlackow et al.   MOLECULAR CELL

Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance

(2017) Yixuan Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrator complex and transcription regulation: Recent findings and pathophysiology

(2016) Monica Rienzo et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The host Integrator complex acts in transcription-independent maturation of herpesvirus microRNA 3′ ends

(2015) Mingyi Xie et al.   GENES & DEVELOPMENT

Integrator mediates the biogenesis of enhancer RNAs

(2015) Fan Lai et al.   NATURE

Integrator Regulates Transcriptional Initiation and Pause Release following Activation

(2014) Alessandro Gardini et al.   MOLECULAR CELL

DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes

(2014) Junichi Yamamoto et al.   Nature Communications

Structural Basis of SOSS1 Complex Assembly and Recognition of ssDNA

(2014) Wendan Ren et al.   Cell Reports

Functional Analysis of the Integrator Subunit 12 Identifies a Microdomain That Mediates Activation of theDrosophilaIntegrator Complex

(2013) Jiandong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An RNAi screen identifies additional members of the Drosophila Integrator complex and a requirement for cyclin C/Cdk8 in snRNA 3'-end formation

(2012) J. Chen et al.   RNA

Analysis of the Human Endogenous Coregulator Complexome

(2011) Anna Malovannaya et al.   CELL

A Primate Herpesvirus Uses the Integrator Complex to Generate Viral MicroRNAs

(2011) Demián Cazalla et al.   MOLECULAR CELL

The Integrator Complex Recognizes a New Double Mark on the RNA Polymerase II Carboxyl-terminal Domain

(2010) Sylvain Egloff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Subset of Drosophila Integrator Proteins Is Essential for Efficient U7 snRNA and Spliceosomal snRNA 3'-End Formation

(2010) N. Ezzeddine et al.   MOLECULAR AND CELLULAR BIOLOGY