Article
Medicine, Research & Experimental
Huanhuan Ma, Aiqin Dong
Summary: Carotid angioplasty and stenting are effective treatments for carotid stenosis, but postoperative restenosis is a common issue. The study found that abnormal expression levels of lncRNA SNHG1 and microRNA145 may serve as risk factors for restenosis. Investigating the SNHG1/miR-145 axis could provide insights for potential prevention and treatment strategies for restenosis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Gabriel Hoi-Huen Chan, Enoch Chan, Carsten Tsun-Ka Kwok, George Pak-Heng Leung, Simon Ming-Yuen Lee, Sai-Wang Seto
Summary: Ageing is a risk factor for degenerative diseases, including cardiovascular diseases. The tumor suppressor gene p53 may play a regulatory role in vascular remodeling, atherosclerosis, and pulmonary hypertension. Further studies are needed to fully understand the effects of p53 in cardiovascular function and its therapeutic potential.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ying-ying Liu, Xiu Liu, Jia-guo Zhou, Si-jia Liang
Summary: MiR-302a exacerbates smooth muscle cell proliferation and restenosis by increasing Akt signaling through targeting PHLPP2.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Cardiac & Cardiovascular Systems
Yuxia Yin, Zhen Cheng, Xiaoling Fu, Shishun Ji
Summary: The expression level of miR-375-3p in asymptomatic CAS patients was significantly higher than healthy controls, with high diagnostic value. In vitro experiments showed that up-regulation of miR-375-3p promoted VSMCs proliferation and migration, along with inflammatory factor generation and phenotypic transformation. Additionally, XIAP was confirmed as a target gene of miR-375-3p, negatively regulated by miR-375-3p.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Medicine, General & Internal
Alison Halliday, Richard Bulbulia, Leo H. Bonati, Johanna Chester, Andrea Cradduck-Bamford, Richard Peto, Hongchao Pan
Summary: The international multicentre randomised trial ACST-2 compared the effects of CAS and CEA for asymptomatic patients with severe stenosis, showing that the long-term effects of these two procedures on fatal or disabling stroke are comparable.
Review
Cardiac & Cardiovascular Systems
Magnus Back, Jean-Baptiste Michel
Summary: This review discusses the role of phosphates in arterial and valvular calcification, as well as potential novel therapeutic approaches for calcification prevention.
CARDIOVASCULAR RESEARCH
(2021)
Article
Medicine, Research & Experimental
Yishu Luo, Chen Huang
Summary: The study showed that circSFMBT2 is upregulated in neointimal tissue and PDGF-BB-treated VSMCs, and its knockdown inhibits VSMC proliferation and migration while enhancing the expression of contractile markers. CircSFMBT2 was found to regulate VSMC proliferation and migration through the miR-331/HDAC5/Aggf1 axis, suggesting a potential novel target for treating proliferative vascular diseases.
Article
Biochemistry & Molecular Biology
Karim J. Brandt, Fabienne Burger, Daniela Baptista, Aline Roth, Rafaela Fernandes da Silva, Fabrizio Montecucco, Francois Mach, Kapka Miteva
Summary: The study revealed the crucial role of GDF10 in the phenotypic switch of VSMCs, which may have a detrimental impact on the stability of atherosclerotic plaques and increase the risk of carotid artery disease (CAD) events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Peripheral Vascular Disease
Dai Sik Ko, Seung Eun Baek, Mihyang Ha, Jeong Jun Park, Changjin Lee, Hye Young Kim, YunJae Jung, Jin Mo Kang, Yun Hak Kim
Summary: This study identified OPN as a key factor associated with outflow vein stenosis in arteriovenous fistulas (AVFs) and demonstrated its increased expression in stenotic outflow veins of AVFs in patients. In vitro experiments showed that inhibiting OPN can reduce vascular smooth muscle cell proliferation, suggesting it as a potential therapeutic target to improve AVF patency.
MICROVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Charles U. Solomon, David G. McVey, Catherine Andreadi, Peng Gong, Lenka Turner, Paulina J. Stanczyk, Sonja Khemiri, Julie C. Chamberlain, Wei Yang, Tom R. Webb, Christopher P. Nelson, Nilesh J. Samani, Shu Ye
Summary: This comprehensive analysis shows that a large percentage of CAD loci can modulate gene expression in VSMCs and influence VSMC behavior. Several candidate causal genes identified are likely to be druggable and thus represent potential therapeutic targets.
Article
Cell Biology
Till Seime, Max van Wanrooij, Eva Karlof, Malin Kronqvist, Staffan Johansson, Ljubica Matic, T. Christian Gasser, Ulf Hedin
Summary: This study investigated the influence of macro-calcification on smooth muscle cell (SMC) phenotype and survival, and its contribution to atherosclerotic plaque stabilization. The findings showed that macro-calcification played a role in SMC differentiation and survival, and influenced the biomechanical forces within the plaque.
Article
Biotechnology & Applied Microbiology
Dayong Shen, Qiang Chen, Jianchao Li, Shuang Wang, He Song, Feng Wang
Summary: This study investigated the clinical role of HOTAIR in patients with carotid artery stenosis (CAS) and its mechanism in vascular smooth muscle cells (VSMCs). The results showed that HOTAIR was significantly upregulated in CAS patients and could discriminate between patients and healthy individuals. Overexpression of HOTAIR increased the viability and migration of VSMCs, while silencing HOTAIR restricted abnormal activities of VSMCs. Furthermore, a targeted relationship between HOTAIR and miR-148b-3p was confirmed, and the levels of miR-148b-3p in VSMCs were regulated by HOTAIR. Therefore, HOTAIR may serve as a diagnostic biomarker for CAS patients and play a role in regulating the activity of VSMCs.
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION
(2023)
Article
Biochemistry & Molecular Biology
Min Xun, Jie Zhang, Meichun Wu, Yuping Chen
Summary: The understanding of the proliferation disorders of vascular smooth muscle cells and the related mechanism is crucial for effective intervention and control of cardiovascular diseases. Long non-coding RNAs have been identified as upstream regulators in multiple proliferative signaling pathways, contributing to dysregulated proliferation and apoptosis of vascular smooth muscle cells. This article discusses the role of long noncoding RNAs in atherosclerosis, pulmonary hypertension, and aneurysms, and their modulation of vascular smooth muscle cell population affecting these deadly cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jie Huang, Yongpeng Xie, Bing Chen, Yu Xia, Yanjiao Jiang, Yun Liu
Summary: This study investigated the role of GPR146 in pulmonary arterial hypertension (PAH) and found that GPR146 is highly expressed in the pulmonary vessels. It was discovered that GPR146 promotes pulmonary vascular remodeling by promoting the proliferation of pulmonary artery smooth muscle cells (PASMCs) through the upregulation of 5-lipoxygenase (5-LO) expression. This finding suggests that GPR146 may serve as a possible target for the prevention and treatment of PAH.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Chao Ye, Ying Tong, Nan Wu, Guo-wei Wan, Fen Zheng, Jing-yu Chen, Jian-zhen Lei, Hong Zhou, Ai-dong Chen, Jue-jin Wang, Qi Chen, Yue-hua Li, Yu-ming Kang, Guo-qing Zhu
Summary: The study demonstrated that miR-135a-5p promotes vascular smooth muscle cell (VSMC) proliferation in spontaneously hypertensive rats (SHRs), while FNDC5 inhibits it. Silencing miR-135a-5p or upregulating FNDC5 could attenuate VSMC proliferation and vascular remodeling in SHRs. These findings suggest that manipulating miR-135a-5p or FNDC5 levels may be a therapeutic strategy for reducing vascular remodeling and hypertension.
ACTA PHARMACOLOGICA SINICA
(2021)
