Review
Medicine, General & Internal
Dan L. Li, Marvin W. Kronenberg
Summary: Coronary artery disease is a major global health concern with noninvasive imaging tests playing a crucial role in its diagnosis and management. Myocardial perfusion imaging, along with other noninvasive tests such as stress echocardiography, coronary computed tomography angiography, and cardiac magnetic resonance imaging, have been widely used for evaluating ischemia and myocardial viability. The accuracy and clinical significance of these tests are essential in guiding risk stratification and revascularization decisions.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Andrew E. Arai, Jeanette Schulz-Menger, Dipan J. Shah, Yuchi Han, W. Patricia Bandettini, Arun Abraham, Pamela K. Woodard, Joseph B. Selvanayagam, Christian Hamilton-Craig, Ru-San Tan, James Carr, Lynette Teo, Christopher M. Kramer, Bernd J. Wintersperger, Mukesh G. Harisinghani, Scott D. Flamm, Matthias G. Friedrich, Igor Klem, Subha Raman, Daniel Haverstock, Zheyu Liu, Guenther Brueggenwerth, Marta Santiuste, Daniel S. Berman, Dudley J. Pennell
Summary: The study demonstrates that vasodilator stress perfusion cardiovascular magnetic resonance (CMR) performed with gadobutrol has superior diagnostic accuracy for the diagnosis and exclusion of significant coronary artery disease (CAD) compared to gated single-photon emission computed tomography (SPECT).
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Abdurrahim Rahimian, Mahanaz Etehadtavakol, Masoud Moslehi, Eddie Y. K. Ng
Summary: The study evaluated the effectiveness of different filters in improving the quality of myocardial perfusion single-photon emission computed tomography (SPECT) images. Data from 30 patients, consisting of over 900 images, were collected using the Siemens Symbia T2 dual-head SPECT/CT scanner. The results showed that the Wiener filter with a kernel size of 5 x 5 outperformed other filters in denoising the SPECT images.
Article
Radiology, Nuclear Medicine & Medical Imaging
Georgios Benetos, Dominik C. Benz, Georgios P. Rampidis, Andreas A. Giannopoulos, Elia von Felten, Adam Bakula, Aleksandra Sustar, Tobias A. Fuchs, Aju P. Pazhenkottil, Catherine Gebhard, Philipp A. Kaufmann, Christoph Grani, Ronny R. Buechel
Summary: CAVi, derived from CCTA, is proposed as an indicator of diffuse atherosclerosis. This study found that CAVi is moderately correlated with stress MBF and MFR, and has incremental value in predicting abnormal stress MBF and ischemia compared to CCTA alone.
EUROPEAN RADIOLOGY
(2021)
Article
Medicine, General & Internal
Takanori Kouchi, Yuki Tanabe, Takumasa Takemoto, Kazuki Yoshida, Yuta Yamamoto, Shigehiro Miyazaki, Naoki Fukuyama, Hikaru Nishiyama, Shinji Inaba, Naoto Kawaguchi, Tomoyuki Kido, Osamu Yamaguchi, Teruhito Kido
Summary: The study evaluated the feasibility of myocardial perfusion ratio (MPR) in static computed tomography perfusion (CTP) for detecting myocardial perfusion abnormalities. The results showed that MPR had higher diagnostic accuracy for detecting myocardial perfusion abnormalities compared to other quantitative parameters.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ting-Heng Chou, Jessica L. Alvelo, Sarah Janse, Xenophon Papademetris, Bauer E. Sumpio, Carlos Mena-Hurtado, Albert J. Sinusas, Mitchel R. Stacy
Summary: This study evaluated the prognostic value of SPECT/CT imaging of foot perfusion in predicting amputation outcomes in patients with critical limb ischemia and diabetes mellitus. The results showed that patients with lower microvascular perfusion response were more likely to undergo amputation, with high-perfusion responders having lower risk of amputation after revascularization.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haytham Derbel, Mahdi Krichen, Julia Chalaye, Laetitia Saccenti, William van der Sterren, Anne-Hilde Muris, Lionel Lerman, Athena Galletto, Youssef Zaarour, Alain Luciani, Hicham Kobeiter, Vania Tacher
Summary: This study evaluated the anatomical and volumetric predictability of CBCT-based VPP software for SPECT/CT imaging results in HCC patients undergoing TARE. The results showed that the CBCT-based VPP software accurately and reliably predicted the anatomical and volumetric results of Tc-99m-MAA SPECT/CT in HCC patients during TARE.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Olga Sliwicka, Andrea Baggiano, Ioannis Sechopoulos, Gianluca Pontone
Summary: The purpose of this study was to investigate the diagnostic performance of stress-only dynamic myocardial computed tomography perfusion (CTP) without computed tomography coronary angiography (CCTA) in diagnosing ischemia. The results showed that dynamic CTP alone has good sensitivity but low specificity in diagnosing ischemia. These findings highlight the importance of combining functional tests with knowledge of coronary artery anatomy in interpretation.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Anna Oleksiak, Cezary Kepka, Koen Nieman, Mariusz Debski, Marcin Demkow, Mariusz Kruk
Summary: This study aimed to compare a novel ischemic volume quantification method based on dynamic computed tomography perfusion (VOL CTP) with other CT-based imaging modalities for revascularization prediction. The results showed that VOL CTP performed better in predicting total revascularization compared to other methods.
KARDIOLOGIA POLSKA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yarong Yu, Wenli Yang, Xu Dai, Lihua Yu, Ziting Lan, Xiaoying Ding, Jiayin Zhang
Summary: This study investigated the incidence of microvascular myocardial ischemia in diabetic patients without obstructive coronary artery disease (CAD) and its relationship with angina. Dynamic computed tomography-myocardial perfusion imaging and coronary computed tomography angiography were used to assess coronary stenosis, myocardial blood flow, and extracellular volume. The results showed a high incidence of microvascular myocardial ischemia in diabetic patients without obstructive CAD, which was strongly associated with angina.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Review
Medicine, General & Internal
Agata Zdanowicz, Maciej Guzinski, Michal Pula, Agnieszka Witkowska, Krzysztof Reczuch
Summary: Coronary computed tomography angiography (CTA) is a widely used non-invasive diagnostic method for suspected coronary artery disease. However, it lacks information on the hemodynamic significance of the coronary lesion. The combination of stress dynamic CT perfusion with CTA provides both anatomical and functional information and has been validated in clinical studies. CT perfusion has comparable accuracy to PET and MRI, and superior performance to SPECT in diagnosing hemodynamically significant coronary stenosis. CTP-derived perfusion has a strong correlation with FFR and can reduce unnecessary catheterizations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Jei-Yie Huang, Chun-Kai Huang, Ruoh-Fang Yen, Kuo-Liong Chien, Yen-Wen Wu
Summary: The study found that attenuation correction (AC) can improve the diagnostic accuracy of myocardial perfusion imaging (MPI) in diagnosing coronary artery disease (CAD), regardless of the type of radiotracer used. Specifically, AC was shown to improve the specificity of detecting right coronary artery (RCA) stenosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Ana Carolina do A. H. de Souza, Hendrik J. Harms, Laurel Martell, Courtney Bibbo, Meagan Harrington, Kyle Sullivan, Jon Hainer, Sharmila Dorbala, Ron Blankstein, Viviany R. Taqueti, Marie Foley Kijewski, Mi-Ae Park, Alejandro Meretta, Christopher Breault, Nathaniel Roth, Alexis Poitrasson-Riviere, Prem Soman, Grant T. Gullberg, Marcelo F. Di Carli
Summary: This study aimed to validate the accuracy of Tc-99m-sestamibi SPECT in quantifying MBF and MFR, as well as evaluate its reproducibility. The results showed that using splines in SPECT imaging improved the correlation with N-13-ammonia positron emission tomography and demonstrated good test/retest reproducibility.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Review
Medicine, General & Internal
Andrea Baggiano, Gianpiero Italiano, Marco Guglielmo, Laura Fusini, Andrea Igoren Guaricci, Riccardo Maragna, Carlo Maria Giacari, Saima Mushtaq, Edoardo Conte, Andrea Daniele Annoni, Alberto Formenti, Maria Elisabetta Mancini, Daniele Andreini, Mark Rabbat, Mauro Pepi, Gianluca Pontone
Summary: Coronary artery disease is a common cardiovascular disease that can be assessed using various functional tests. These tests provide detailed imaging information to better evaluate the condition of patients. Cardiovascular imaging techniques have greatly contributed to our understanding of the physiological and clinical implications of CAD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Takao Kato, Mitsuru Momose, Yukari Uemura, Masanao Naya, Naoya Matsumoto, Satoshi Hida, Takao Yamauchi, Takatomo Nakajima, Eriko Suzuki, Moriaki Inoko, Nagara Tamaki
Summary: This study aimed to evaluate the association between the extent of myocardial ischemia and outcomes in Japanese patients with suspected coronary artery disease. The results showed a significant association between myocardial ischemia ≥10% and the risk of major adverse cardiac events within 1 year, which became insignificant after adjusting for treatments.
JOURNAL OF CARDIOLOGY
(2022)
Article
Biophysics
Arnab Pal, Kuldeep Kaswan, Snigdha Roy Barman, Yu-Zih Lin, Jun-Hsuan Chung, Manish Kumar Sharma, Kuei-Lin Liu, Bo-Huan Chen, Chih-Cheng Wu, Sangmin Lee, Dongwhi Choi, Zong-Hong Lin
Summary: This review provides a comprehensive overview of the latest research on microfluidics-based drug sensing and screening strategies, highlighting their advantages and challenges. Microfluidics technology shows promise in high-throughput drug screening and biomimetics of the human body, contributing significantly to drug development.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Endocrinology & Metabolism
Hung-Ju Lin, Jui Wang, Po-Yuan Tseng, Li-Chen Fu, Yi-Chia Lee, Ming-Shiang Wu, Wei-Shiung Yang, Han-Mo Chiu
Summary: Lower glycemic levels than currently accepted could lead to optimal risk reduction of incident diabetes among individuals with prediabetes, highlighting the importance of stringent glycemic management for diabetes prevention.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Medicine, General & Internal
Kei-Ip Cheong, Hsin-Bang Leu, Chau-Chung Wu, Wei-Hsian Yin, Ji-Hung Wang, Tsung-Hsien Lin, Wei-Kung Tseng, Kuan-Cheng Chang, Shu-Hsun Chu, Hung- Yeh, Jaw-Wen Chen, Yen-Wen Wu
Summary: This study aimed to evaluate the association between osteopontin (OPN) levels and the prognosis of Taiwanese patients with chronic coronary syndrome (CCS). The results showed that higher OPN levels were associated with an increased risk of hospitalization for acute myocardial infarction (AMI). However, combining OPN with hs-CRP did not improve the prediction of cardiovascular outcomes.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Ching-Chi Chi, Yen-Wen Wu, Ting-Hsing Chao, Chih-Chiang Chen, Yi-Ju Chen, Hao-Min Cheng, Hsien-Yi Chiu, Yu-Wei Chiu, Wen-Hung Chung, Tsu-Yi Hsieh, Po-Hsun Huang, Yu-Huei Huang, Shang-Hung Lin, Tsung-Hsien Lin, Kwo-Chang Ueng, Chun-Chieh Wang, Yu-Chen Wang, Nan-Lin Wu, Charles Jia-Yin Hou, Tsen-Fang Tsai
Summary: Psoriatic disease, a chronic inflammatory disorder with skin and joint manifestations, is associated with an increased risk of cardiovascular diseases due to the shared pathogenic mechanisms between psoriatic and CV diseases. Therefore, attention to cardiovascular comorbidities is crucial in the management of psoriasis, particularly in screening, primary prevention, and treatment selection. The collaboration between dermatology, cardiology, and rheumatology experts has led to consensus expert recommendations for the management of patients with psoriatic disease with a focus on CV comorbidities.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Chia-Wen Lu, Kuen-Cheh Yang, Yu-Chiao Chi, Tsan-Yu Wu, Chien-Hsieh Chiang, Hao-Hsiang Chang, Kuo-Chin Huang, Wei-Shiung Yang
Summary: Lean non-alcoholic fatty liver disease (NAFLD) is similar to overweight NAFLD and should be detected early. The adiponectin-leptin ratio (AL ratio) may serve as a reliable marker for early detection of lean NAFLD independent of insulin resistance.
ANNALS OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Kuan-Yin Ko, Chi-Lun Ko, Chii-Ming Lee, Ju-Shin Cheng, Yen-Wen Wu, Ron-Bin Hsu, Yih-Sharng Chen, Shoei-Shen Wang, Ruoh-Fang Yen, Mei-Fang Cheng
Summary: This study investigated the diagnostic performance of Tc-99m and Tl-201 tracers in assessing cardiac allograft vasculopathy (CAV) in heart transplant patients using cadmium-zinc-telluride (CZT) single-photon emission computed tomography (SPECT) for myocardial blood flow (MBF) and myocardial flow reserve (MFR) quantification. The results showed that CZT SPECT using Tl-201 and Tc-99m tracers had comparable MBF and MFR, and correlated well with (13) N-NH3 PET.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Multidisciplinary Sciences
Shan-Ying Wang, Kuan-Heng Lin, Yen-Wen Wu, Chih-Wei Yu, Shu-Ya Yang, Pei-Wei Shueng, Chen-Xiong Hsu, Tung-Hsin Wu
Summary: Adjuvant breast radiotherapy reduces local recurrence risk but increases the risk of cardiotoxicity. This study aimed to evaluate cardiac subvolume doses and corresponding perfusion defects after breast cancer radiotherapy. Results showed that radiation doses were higher in segments with new perfusion defects compared to those without, suggesting that even low radiation doses may cause cardiac perfusion decline.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Shan-Ying Wang, Wei-Ta Tsai, Kuan-Heng Lin, Chih-Wei Yu, Shu-Ya Yang, Pei-Wei Shueng, Yen-Wen Wu, Chen-Xiong Hsu, Tung-Hsin Wu
Summary: This study aimed to integrate the 20 subvolume dose of left ventricle and Tl-201 single photon emission computed tomography (SPECT) with myocardial perfusion imaging (MPI) parameters to evaluate the cardiac condition of breast cancer patients after radiation therapy. The results showed that left-sided breast cancer patients received higher radiation doses to the heart, left ventricular, and its territories and subvolumes compared to right-sided breast cancer patients. The study also found a significant decline in wall motion and wall thickening in the coronary artery territories of both sides.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mei-Fang Cheng, Yue Leon Guo, Ruoh-Fang Yen, Yen-Wen Wu, Hsiu-Po Wang
Summary: This study aimed to determine whether inflammation levels detected by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) could predict disease relapse in immunoglobulin G4-related disease (IgG4-RD) patients receiving standard induction steroid therapy. The results showed that whole-body total lesion glycolysis (WTLG) > 600 on FDG-PET was an independent risk factor for disease relapse, and could be used for guiding the treatment and management of IgG-RD patients.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Chun-Chieh Wang, Wei-Ting Chang, Yen-Hung Lin, Bing-Hsiean Tzeng, Ting-Hsing Chao, Chung-Lieh Hung, Yen-Wen Wu, Cheng-Hsuan Tsai, Wei-Wen Lin, Kuan-Cheng Chang, Hung-Yu Chang, Wen-Chung Yu, Wen-Hwa Wang, Cheng- Cheng, Tzung-Dau Wang, Charles Jia-Yin Hou, Wen-Jone Chen
Summary: Cardiac amyloidosis is a form of systemic amyloidosis characterized by abnormal amyloid fibril deposits in the myocardium, leading to heart failure and conduction disturbances. The incidence and prevalence of cardiac amyloidosis are higher than previously thought, especially in special populations. The diagnosis of cardiac amyloidosis is often delayed, highlighting gaps in knowledge and lack of multidisciplinary teamwork in clinical practice.
ACTA CARDIOLOGICA SINICA
(2023)
Article
Cardiac & Cardiovascular Systems
Chern-En Chiang, Chung-Lieh Hung, Yen-Wen Wu, Tsung-Hsien Lin, Kwo-Chang Ueng, Shih-Hsien Sung, Cho-Kai Wu, Ting-Hsing Chao, Hung-Ju Lin, Yen-Hung Lin, Jin-Long Huang, Michael Yu Chih Chen, Po-Lin Lin, Tze-Fan Chao, Hao-Min Cheng, Ming-En Liu, Tzung-Dau Wang, Hung- Yeh, Yi-Heng Li, Ping-Yen Liu, Wei-Hsian Yin, I-Chang Hsieh, Chun-Chieh Wang, Chen-Huan Chen, Pao-Hsien Chu, Shing-Jong Lin, San-Jou Yeh, Jiunn-Lee Lin, Juey-Jen Hwang, Huei-Fong Hung, Wen-Jone Chen, Charles Jia-Yin Hou
Summary: The prevalence of heart failure is increasing and has become a significant burden on healthcare systems worldwide. Despite the availability of effective treatments, mortality rates remain high. In order to prioritize and integrate these therapies for Asian patients, the Taiwan Society of Cardiology has formed a working group to create a consensus on pharmacological treatment for chronic heart failure.
ACTA CARDIOLOGICA SINICA
(2023)
Letter
Cardiac & Cardiovascular Systems
Pei-Lin Lee, Yen-Wen Wu
ACTA CARDIOLOGICA SINICA
(2023)
Article
Cardiac & Cardiovascular Systems
Kwo-Chang Ueng, Chern-En Chiang, Ting-Hsing Chao, Yen-Wen Wu, Wen-Lieng Lee, Yi-Heng Li, Ke-Hsin Ting, Chun-Hung Su, Hung-Ju Lin, Ta-Chen Su, Tsun-Jui Liu, Tsung-Hsien Lin, Po-Chao Hsu, Yu-Chen Wang, Zhih-Cherng Chen, Hsu-Lung Jen, Po-Lin Lin, Feng-You Ko, Hsueh-Wei Yen, Wen-Jone Chen, Charles Jia-Yin Hou
Summary: Coronary artery disease (CAD) ranges from asymptomatic to acute coronary syndromes (ACS) and sudden cardiac death. The 2023 guidelines of the Taiwan Society of Cardiology categorize CAD into acute or chronic coronary syndromes (ACS and CCS). Treatment focus has shifted from functional evaluation to anatomic burden of disease.
ACTA CARDIOLOGICA SINICA
(2023)
Article
Cardiac & Cardiovascular Systems
Wei-Chun Huang, Song-Chou Hsieh, Yen-Wen Wu, Tsu-Yi Hsieh, Yih-Jer Wu, Ko-Jen Li, Min-Ji Charng, Wei-Sheng Chen, Shih-Hsien Sung, Yen-Po Tsao, Wan-Jin Ho, Chien-Chih Lai, Chin-Chang Cheng, Hung-Cheng Tsai, Chih-Hsin Hsu, Cheng-Hsun Lu, Yu-Wei Chiu, Chieh-Yu Shen, Chun-Hsien Wu, Feng-Cheng Liu, Yen-Hung Lin, Fu-Chiang Yeh, Wei-Shin Liu, Hui-Ting Lee, Shu-Hao Wu, Chi-Ching Chang, Chun-Yuan Chu, Charles Jia-Yin Hou, Chang-Youh Tsai
Summary: This study aimed to obtain a comprehensive understanding and provide recommendations for the management of connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH) in Taiwan, focusing on its clinical importance, prognosis, risk stratification, diagnostic and screening algorithm, and pharmacological treatment. Early detection by regularly screening at-risk patients with incorporations of relevant autoantibodies and biomarkers may lead to better outcomes of CTD-PAH.
ACTA CARDIOLOGICA SINICA
(2023)
Article
Multidisciplinary Sciences
Hung-Chih Chen, Yen-Wen Liu, Kuan-Cheng Chang, Yen-Wen Wu, Yi-Ming Chen, Yu-Kai Chao, Min-Yi You, David J. Lundy, Chen-Ju Lin, Marvin L. Hsieh, Yu-Che Cheng, Ray P. Prajnamitra, Po-Ju Lin, Shu-Chian Ruan, David Hsin-Kuang Chen, Edward S. C. Shih, Ke-Wei Chen, Shih-Sheng Chang, Cindy M. C. Chang, Riley Puntney, Amy Wu Moy, Yuan-Yuan Cheng, Hsin-Yuan Chien, Jia-Jung Lee, Deng-Chyang Wu, Ming-Jing Hwang, Jennifer Coonen, Timothy A. Hacker, C-L. Eric Yen, Federico E. Rey, Timothy J. Kamp, Patrick C. H. Hsieh
Summary: The study reveals the role of butyrate-producing bacteria in the post-response to myocardial infarction (MI). Through analysis using animal models and machine learning, the researchers found that these bacteria can produce beta-hydroxybutyrate, which improves cardiac function. Further experiments confirmed this finding and highlighted the significance of butyrate-producing bacteria and beta-hydroxybutyrate in improving post-MI outcomes.
NATURE COMMUNICATIONS
(2023)
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)