Article
Engineering, Environmental
Kang Mao, Zhugen Yang, Hua Zhang, Xiqing Li, Jonathan M. Cooper
Summary: Wastewater-based epidemiology is a powerful technique for monitoring illicit drugs, and a surface-enhanced Raman spectroscopy sensor assembled with noble metal core-shell nanoparticles on a custom-made glassy nanofibrous electrospun paper matrix enables sensitive and selective detection of methamphetamine. The study shows that higher drug mass loads are generally found in sewage influent from urban areas, suggesting more local methamphetamine usage compared to less populated areas.
Review
Chemistry, Analytical
S. Irem Kaya, Ahmet Cetinkaya, Sibel A. Ozkan
Summary: Nanotechnology and nanomaterials play a critical role in drug analysis. Carbon-based nanomaterials and electrochemical techniques are widely used for sensor development, aiming for rapid development, ease of use, and high sensitivity in drug analysis.
CURRENT ANALYTICAL CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Yao-Te Yen, Yu-Syuan Lin, Yin-Jue Chang, Ming-Ta Li, San-Chong Chyueh, Huan-Tsung Chang
Summary: This study demonstrates a rapid and accurate screening method for illicit drugs using different probes and optical techniques. By establishing a deep learning-drug screening platform and system, the testing results are consistent with GC-MS, indicating the potential of this technology for multi-drug screening at crime scenes.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Review
Environmental Sciences
Thanh Tam Toan Tran, Mai Nguyen Do, Thi Ngoc Hoa Dang, Quang Huy Tran, Van Thuan Le, Anh Quang Dao, Yasser Vasseghian
Summary: This paper presents recent advances in the use of graphene nanomaterials for biosensors to detect antibiotics, and discusses the emerging issues and potential opportunities in this field. Various electrochemical techniques were employed to determine antibiotic residues in different systems, and it was demonstrated how graphene nanomaterials can be utilized for antibiotic detection.
ENVIRONMENTAL RESEARCH
(2022)
Review
Materials Science, Multidisciplinary
Ozgecan Erdem, Esma Derin, Saeedreza Zeibi Shirejini, Kutay Sagdic, Eylul Gulsen Yilmaz, Selvin Yildiz, Garbis Atam Akceoglu, Fatih Inci
Summary: The healthcare system has shifted towards home-based and self-monitoring strategies, utilizing wearable technologies to track physiological parameters and monitor biochemical markers without disrupting daily routines. Carbon nanomaterials offer unique features for integration with smart materials and sensors, showcasing their potential in wearable technologies. Further integration with various devices and technologies is presented in this manuscript.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Review
Engineering, Electrical & Electronic
Ren Shufang, Zeng Junling, Zheng Zhixiang, Shi Hongqiang
Summary: The analysis of illicit drugs is an important branch of modern forensic science, with electrochemical sensing technique emerging as a rapidly developing technology due to its advantages. Material technology of modified electrodes plays a crucial role in enhancing sensing performance, and there is a need for more research in this area for the detection of illicit drugs.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Review
Electrochemistry
Lijuan Su
Summary: The abuse of illicit drugs in sports undermines fair competition and harms athletes' health. Therefore, the development of rapid, sensitive, portable and easy-to-use methods for detecting these drugs is highly desired. Electrochemical techniques, with the discovery of novel electrode materials, have shown great potential as substitutes for chromatographic and spectral analysis.
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Yong Xiang Leong, Emily Xi Tan, Shi Xuan Leong, Charlynn Sher Lin Koh, Lam Bang Thanh Nguyen, Jaslyn Ru Ting Chen, Kelin Xia, Xing Yi Ling
Summary: This article discusses the potential of nanosensors in detecting the unknown disease X and highlights the important role of machine learning algorithms in nanosensor research, as well as the potential applications in other aspects.
Article
Chemistry, Analytical
Wenyu Huang, Chao Guo, Jingying Zhai, Xiaojiang Xie
Summary: This study demonstrates the development of fluorescence anisotropic ion-selective optodes based on homoFRET, which can be effectively used for ion concentration detection and bioimaging.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Tahir Rasheed, Sameera Shafi, Farooq Sher
Summary: This review discusses the recent progress on chemical sensors based on different nanomaterials for sensing heavy metal ions, as well as various types of optical sensors.
TRENDS IN ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2022)
Review
Medicine, Research & Experimental
Xiaofang Tang, Yaping Zhu, Weijiang Guan, Wenjuan Zhou, Peifa Wei
Summary: Cardiovascular diseases are a major global health issue, and nanosensors have shown great potential in the rapid and accurate diagnosis and prediction of these diseases.
Review
Chemistry, Analytical
Tshimangadzo S. Munonde, Philiswa N. Nomngongo
Summary: This article discusses the development of electrochemical nanosensors for detecting trace metals in water bodies with elevated concentrations exceeding existing guidelines. Advanced functional nanocomposites have been synthesized to improve sensitivity, specificity, and stability. Recent progress on nanocomposites structured as carbon, metallic, and metal oxide/hydroxide is summarized, along with their application as electrochemical nanosensors for trace metals detection in water matrices.
Article
Engineering, Electrical & Electronic
Lucjan Grzegorzewski, Robert Zierold, Robert H. Blick
Summary: In this study, a novel coupling-based sensor operating at 20 GHz was designed to increase the sensitivity for detecting nanoscale objects. The sensor's geometry was fine-tuned for an optimal coupling coefficient, and its performance was compared with that of conventional sensors. The exceptional sensitivity of the sensor was demonstrated through the in-flow detection of 200 nm-sized polystyrene beads, achieving a high signal-to-noise ratio.
IEEE SENSORS JOURNAL
(2023)
Review
Chemistry, Analytical
My-Van Tieu, Hien T. Ngoc Le, Sungbo Cho
Summary: Advancing low-cost and user-friendly innovations in scientific and engineering research is crucial for public health. Electrochemical sensors are being developed for low-cost SARS-CoV-2 diagnosis, particularly in resource-limited settings, providing an excellent alternative to existing techniques. Nanostructures, such as metal, 1D, and 2D materials, have successfully been applied in detecting a wide range of infectious diseases, including SARS-CoV-2, offering rapid, sensitive, and selective detection capabilities.
Review
Chemistry, Analytical
Shihchun Wei, Yijia Li, Hsinhua Liang, Yaote Yen, Yihui Lin, Huantsung Chang
Summary: Carbon dots (C-dots) based photoluminescent (PL) assays have the potential to screen illicit drugs, and their advantages include stability and biocompatibility.
ANALYTICAL SCIENCES
(2022)
Article
Chemistry, Analytical
Naveen Tiwari, Subhodeep Chatterjee, Kuldeep Kaswan, Jun-Hsuan Chung, Kai-Po Fan, Zong-Hong Lin
Summary: Wearable electrochemical sensors are a rapidly developing technology in digital health, with the ability to non-invasively detect chemical analytes. These sensors have excellent performance and low cost, making them ideal for continuous monitoring of real-time health status. This review article discusses the advancements in wearable biosensors, focusing on their electrochemical analysis capabilities. It also explores the challenges and opportunities in this field.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Analytical
Santoshi U. Singh, Subhodeep Chatterjee, Shahbaz Ahmad Lone, Hsin-Hsuan Ho, Kuldeep Kaswan, Kiran Peringeth, Arshad Khan, Yun-Wei Chiang, Sangmin Lee, Zong-Hong Lin
Summary: Graphene is a trending material for developing wearable biosensors due to its outstanding physical, chemical, and structural properties. Wearable biosensors can non-invasively identify diseases by detecting relevant biomarkers in biofluids such as tears, sweat, interstitial fluid, saliva, and exhaled breath.
Review
Chemistry, Physical
Shahbaz Ahmad Lone, Kee Chin Lim, Kuldeep Kaswan, Subhodeep Chatterjee, Kai-Po Fan, Dongwhi Choi, Sangmin Lee, Hulin Zhang, Jia Cheng, Zong-Hong Lin
Summary: Triboelectric nanogenerators (TENGs) are highly efficient in converting mechanical energy to electrical energy. This review discusses recent progress in improving the output performance of TENGs and proposes a holistic approach for enhancing their charging and power conversion efficiency. The review also explores the applications of TENGs in wearable electronic devices and implantable medical devices, and highlights the challenges and future prospects of TENG research.
Article
Cardiac & Cardiovascular Systems
Mu-Yang Hsieh, Chi-Hung Cheng, Chiu-Hui Chen, Min-Tsun Liao, Chih-Ching Lin, Ten-Fang Yang, Shao-Yuan Chuang, Chih-Cheng Wu
Summary: Blood pressure variability is associated with an increased risk of vascular access thrombosis in hemodialysis patients, independent of average blood pressure, intradialytic hypotension, and comorbidities.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medical Laboratory Technology
Jiun-Yang Chiang, Lin Lin, Chih-Cheng Wu, Juey-Jen Hwang, Wei-Shiung Yang, Yen-Wen Wu
Summary: This study found that serum levels of myostatin were positively correlated with myocardial scar burden, suggesting it may be a predictor of myocardial scarring.
CLINICA CHIMICA ACTA
(2022)
Article
Chemistry, Physical
Cheng Yeh, Fu-Cheng Kao, Po-Han Wei, Arnab Pal, Kuldeep Kaswan, Yan-Tsz Huang, Parag Parashar, Hsuan-Yu Yeh, Ting-Wei Wang, Naveen Tiwari, Tsung-Ting Tsai, Yu-Fen Hua, Zong-Hong Lin
Summary: A next-generation self-powered solid-liquid triboelectric nanogenerator-based flexible wearable sensor has been developed for real-time gait monitoring. The sensor possesses high sensitivity and long-term stability, thanks to its unique surface morphology. It is a low-cost, highly scalable sensor compatible with diverse detection strategies, making it applicable in personalized health care and sports science.
Review
Chemistry, Multidisciplinary
Manish Kumar Sharma, Imran Khan, Kuldeep Kaswan, Snigdha Roy Barman, Subhajit Saha, Wu-Chiao Hsieh, Yu-Lun Chueh, Yu-Lin Wang, Sangmin Lee, Dukhyun Choi, Zong-Hong Lin
Summary: Catalysis is crucial in addressing energy and environmental challenges. However, traditional photocatalysts and electrocatalysts have limitations, such as low efficiency and charge recombination. Therefore, it is important to explore non-photoresponsive catalysts as alternative solutions.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Review
Chemistry, Physical
Sanjay Sahare, Prachi Ghoderao, Manish Kumar Sharma, Mykhailo Solovan, Radhamanohar Aepuru, Manjeet Kumar, Yue Chan, Marcin Ziolek, Shern-Long Lee, Zong-Hong Lin
Summary: The Photodetector (PD) is a device that directly converts light energy into electric current and finds applications in various fields. Self-powered PDs have gained attention due to their significance in science, daily life, and commercial value. The pyro-phototronic effect (PPE) in self-powered PDs enhances device performance by modulating charge carrier separations, transportation, and extraction. This review assesses the mechanism of PPE and discusses its progress and challenges in nanostructured materials, offering a path for future developments.
Article
Cardiac & Cardiovascular Systems
Chiu-Hui Chen, Yu-Ling Hsieh, Shao-Yuan Chuang, Fan-Yin Su, Kuan-Ting Wang, Chien-Ming Luo, Shih-Wei Meng, Chih-Cheng Wu
Summary: Frail phenotype is common in Taiwanese patients who undergo maintenance HD and is associated with adverse outcomes of dialysis vascular access.
ACTA CARDIOLOGICA SINICA
(2022)
Article
Urology & Nephrology
Heng-Cheng Tsai, Shuo-Ming Ou, Chih-Cheng Wu, Chin-Chou Huang, Jyh-Tong Hsieh, Po-Yu Tseng, Chiu-Yang Lee, Chih-Yu Yang, Der-Cherng Tarng
Summary: Plasma levels of pentraxin 3 (PTX3) are associated with the risk of arteriovenous fistula (AVF) functional patency loss and mortality in chronic hemodialysis patients.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Tzu-Shan Yeh, Shih-Wei Meng, Lin Linz, Chih-Cheng Wu
ACTA CARDIOLOGICA SINICA
(2022)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)