A microbial transporter of the dietary antioxidant ergothioneine

Cellular adaptation of Clostridioides difficile to high salinity encompasses a compatible solute‐responsive change in cell morphology

(2022) Annika‐Marisa Michel et al.   ENVIRONMENTAL MICROBIOLOGY

In Vitro Reconstitution of a Five-Step Pathway for Bacterial Ergothioneine Catabolism

(2021) Mariia A. Beliaeva et al.   ACS Chemical Biology

Whole-blood metabolomics of dementia patients reveal classes of disease-linked metabolites

(2021) Takayuki Teruya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low plasma ergothioneine levels are associated with neurodegeneration and cerebrovascular disease in dementia

(2021) Liu-Yun Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Potential TMA-Producing Bacteria Are Ubiquitously Found in Mammalia

(2020) Silke Rath et al.   Frontiers in Microbiology

Oral administration of the food derived hydrophilic antioxidant ergothioneine enhances object recognition memory in mice.

(2020) Noritaka Nakamichi et al.   Current Molecular Pharmacology

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Frailty markers comprise blood metabolites involved in antioxidation, cognition, and mobility

(2020) Masahiro Kameda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effects of neutrophil-generated hypochlorous acid and other hypohalous acids on host and pathogens

(2020) Agnes Ulfig et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

H2S and reactive sulfur signaling at the host bacterial pathogen interface

(2020) Brenna J.C. Walsh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum Metabolomics Identifies Altered Bioenergetics, Signaling Cascades in Parallel with Exposome Markers in Crohn’s Disease

(2019) Yunjia Lai et al.   MOLECULES

A genome-wide Helicobacter pylori morphology screen uncovers a membrane spanning helical cell shape complex

(2019) Desirée C. Yang et al.   JOURNAL OF BACTERIOLOGY

High-resolution mapping reveals that microniches in the gastric glands control Helicobacter pylori colonization of the stomach

(2019) Connie Fung et al.   PLOS BIOLOGY

Structure and Mechanism of Ergothionase from Treponema denticola

(2019) Alice Maurer et al.   CHEMISTRY-A EUROPEAN JOURNAL

The role of thiols in antioxidant systems

(2019) Kathrin Ulrich et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mapping human microbiome drug metabolism by gut bacteria and their genes

(2019) Michael Zimmermann et al.   NATURE

Helicobacter pylori senses bleach (HOCl) as a chemoattractant using a cytosolic chemoreceptor

(2019) Arden Perkins et al.   PLOS BIOLOGY

Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease

(2019) Einar Smith et al.   HEART

L-(+)-Ergothioneine Significantly Improves the Clinical Characteristics of Preeclampsia in the Reduced Uterine Perfusion Pressure Rat Model

(2019) Rachel D. Williamson et al.   HYPERTENSION

Role of Ergothioneine in Microbial Physiology and Pathogenesis

(2018) Bridgette M. Cumming et al.   ANTIOXIDANTS & REDOX SIGNALING

Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance

(2018) Wen Zhou et al.   CELL

The Stringent Response Determines the Ability of a Commensal Bacterium to Survive Starvation and to Persist in the Gut

(2018) Whitman B. Schofield et al.   Cell Host & Microbe

Ergothioneine - a diet-derived antioxidant with therapeutic potential

(2018) Barry Halliwell et al.   FEBS LETTERS

Chemotaxis Allows Bacteria To Overcome Host-Generated Reactive Oxygen Species That Constrain Gland Colonization

(2018) Kieran D. Collins et al.   INFECTION AND IMMUNITY

Distribution and accumulation of dietary ergothioneine and its metabolites in mouse tissues

(2018) Richard Ming Yi Tang et al.   Scientific Reports

A Clostridium difficile -Specific, Gel-Forming Protein Required for Optimal Spore Germination

(2017) M. Lauren Donnelly et al.   mBio

Multiple Acid Sensors Control Helicobacter pylori Colonization of the Stomach

(2017) Julie Y. Huang et al.   PLoS Pathogens

Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration?

(2016) Irwin K. Cheah et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pathobiology of Helicobacter pylori–Induced Gastric Cancer

(2016) Manuel Amieva et al.   GASTROENTEROLOGY

Conserved ABC Transport System Regulated by the General Stress Response Pathways of Alpha- and Gammaproteobacteria

(2016) Julien Herrou et al.   JOURNAL OF BACTERIOLOGY

Cyclic di-AMP targets the cystathionine beta-synthase domain of the osmolyte transporter OpuC

(2016) TuAnh Ngoc Huynh et al.   MOLECULAR MICROBIOLOGY

The second messenger c-di-AMP inhibits the osmolyte uptake system OpuC inStaphylococcus aureus

(2016) Christopher F. Schuster et al.   Science Signaling

Spatial and Temporal Shifts in Bacterial Biogeography and Gland Occupation during the Development of a Chronic Infection

(2016) Daniela Keilberg et al.   mBio

Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis

(2016) Vikram Saini et al.   Cell Reports

Trimethylamine N-Oxide: The Good, the Bad and the Unknown

(2016) Manuel Velasquez et al.   Toxins

The second messenger c-di-AMP inhibits the osmolyte uptake system OpuC inStaphylococcus aureus

(2016) Christopher F. Schuster et al.   Science Signaling

YehZYXW of Escherichia coli Is a Low-Affinity, Non-Osmoregulatory Betaine-Specific ABC Transporter

(2015) Shenhui Lang et al.   BIOCHEMISTRY

Identification of novel biomarkers for Parkinson's disease by metabolomic technologies

(2015) Taku Hatano et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Glutathione activates virulence gene expression of an intracellular pathogen

(2015) Michelle L. Reniere et al.   NATURE

Analysis of gene–environment interactions in postnatal development of the mammalian intestine

(2015) Seth Rakoff-Nahoum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Defined Single-Gene and Multi-Gene Deletion Mutant Collections in Salmonella enterica sv Typhimurium

(2014) Steffen Porwollik et al.   PLoS One

Importance of Bacillithiol in the Oxidative Stress Response of Staphylococcus aureus

(2013) Ana C. Posada et al.   INFECTION AND IMMUNITY

Roles of YehZ, a Putative Osmoprotectant Transporter, in Tempering Growth of Salmonella enterica serovar Typhimurium

(2013) Seul I Kim   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori

(2013) Nina R. Salama et al.   NATURE REVIEWS MICROBIOLOGY

Expanding the Repertoire of Gene Tools for Precise Manipulation of the Clostridium difficile Genome: Allelic Exchange Using pyrE Alleles

(2013) Yen Kuan Ng et al.   PLoS One

Low-Molecular-Weight Thiols in Thiol–Disulfide Exchange

(2012) Koen Van Laer et al.   ANTIOXIDANTS & REDOX SIGNALING

Characterization of ergothionase from Burkholderia sp. HME13 and its application to enzymatic quantification of ergothioneine

(2012) Hisashi Muramatsu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Glutathione analogs in prokaryotes

(2012) Robert C. Fahey   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Glutathione transporters

(2012) Anand K. Bachhawat et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Identification of a Third Osmoprotectant Transport System, the OsmU System, in Salmonella enterica

(2012) S. M. Frossard et al.   JOURNAL OF BACTERIOLOGY

Linking Crystallographic Model and Data Quality

(2012) P. A. Karplus et al.   SCIENCE

Structures of the substrate-binding protein provide insights into the multiple compatible solute binding specificities of theBacillus subtilisABC transporter OpuC

(2011) Yang Du et al.   BIOCHEMICAL JOURNAL

Ergothioneine; antioxidant potential, physiological function and role in disease

(2011) Irwin K. Cheah et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

RNA-Seq-Based Monitoring of Infection-Linked Changes in Vibrio cholerae Gene Expression

(2011) Anjali Mandlik et al.   Cell Host & Microbe

The Neurospora crassa mutant NcΔEgt-1 identifies an ergothioneine biosynthetic gene and demonstrates that ergothioneine enhances conidial survival and protects against peroxide toxicity during conidial germination

(2011) Marco H. Bello et al.   FUNGAL GENETICS AND BIOLOGY

Association of the OCTN1/1672T variant with increased risk for colorectal cancer in young individuals and ulcerative colitis patients

(2011) Maurizio Martini et al.   INFLAMMATORY BOWEL DISEASES

The Crystal Structure of the Substrate-Binding Protein OpuBC from Bacillus subtilis in Complex with Choline

(2011) Marco Pittelkow et al.   JOURNAL OF MOLECULAR BIOLOGY

Crohn's Disease and Genetic Hitchhiking at IBD5

(2011) C. D. Huff et al.   MOLECULAR BIOLOGY AND EVOLUTION

Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice

(2011) A. L. Goodman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ChePep Controls Helicobacter pylori Infection of the Gastric Glands and Chemotaxis in the Epsilonproteobacteria

(2011) M. R. Howitt et al.   mBio

Integration, scaling, space-group assignment and post-refinement

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Tolerance Rather Than Immunity Protects From Helicobacter pylori–Induced Gastric Preneoplasia

(2010) Isabelle C. Arnold et al.   GASTROENTEROLOGY

In Vitro Reconstitution of Mycobacterial Ergothioneine Biosynthesis

(2010) Florian P. Seebeck   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gut inflammation provides a respiratory electron acceptor for Salmonella

(2010) Sebastian E. Winter et al.   NATURE

Gene Knockout and Metabolome Analysis of Carnitine/Organic Cation Transporter OCTN1

(2010) Yukio Kato et al.   PHARMACEUTICAL RESEARCH

Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli

(2010) A. Gaballa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Glutathione dysregulation and the etiology and progression of human diseases

(2009) Nazzareno Ballatori et al.   BIOLOGICAL CHEMISTRY

Increased ergothioneine tissue concentrations in carriers of the Crohn's disease risk-associated 503F variant of the organic cation transporter OCTN1

(2009) D Taubert et al.   GUT

Short-Term Signatures of Evolutionary Change in the Salmonella enterica Serovar Typhimurium 14028 Genome

(2009) T. Jarvik et al.   JOURNAL OF BACTERIOLOGY

A protective function for interleukin 17A in T cell–mediated intestinal inflammation

(2009) William O'Connor Jr et al.   NATURE IMMUNOLOGY

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

The Complete Genome Sequence of Helicobacter pylori Strain G27

(2008) D. A. Baltrus et al.   JOURNAL OF BACTERIOLOGY

Biosynthesis and Functions of Mycothiol, the Unique Protective Thiol of Actinobacteria

(2008) G. L. Newton et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Structure, Function, and Evolution of Bacterial ATP-Binding Cassette Systems

(2008) A. L. Davidson et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

PROMALS3D: a tool for multiple protein sequence and structure alignments

(2008) Jimin Pei et al.   NUCLEIC ACIDS RESEARCH

Ergothioneine Modulates Proinflammatory Cytokines and Heat Shock Protein 70 in Mesenteric Ischemia and Reperfusion Injury

(2007) Omer Sakrak et al.   JOURNAL OF SURGICAL RESEARCH