Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics

Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias

(2022) Kouki Kawakami et al.   Nature Communications

GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision

(2022) Wesley B. Asher et al.   CELL

Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism

(2021) Zhenmei Xu et al.   Nature Chemical Biology

Structure of the neurotensin receptor 1 in complex with β-arrestin 1

(2020) Weijiao Huang et al.   NATURE

Key phosphorylation sites in GPCR s orchestrate the contribution of β‐Arrestin 1 in ERK 1/2 activation

(2020) Mithu Baidya et al.   EMBO REPORTS

Molecular basis of β-arrestin coupling to formoterol-bound β1-adrenoceptor

(2020) Yang Lee et al.   NATURE

How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling

(2020) Naomi R. Latorraca et al.   CELL

An Eight Amino Acid Segment Controls Oligomerization and Preferred Conformation of the two Non-visual Arrestins

(2020) Qiuyan Chen et al.   JOURNAL OF MOLECULAR BIOLOGY

Lysolipid receptor cross-talk regulates lymphatic endothelial junctions in lymph nodes

(2019) Yu Hisano et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Conformational transitions of a neurotensin receptor 1–Gi1 complex

(2019) Hideaki E. Kato et al.   NATURE

Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe

(2019) Tyler S. Beyett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex

(2019) Anthony H. Nguyen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

G protein-coupled receptor kinases: Past, present and future

(2018) Konstantin E. Komolov et al.   CELLULAR SIGNALLING

GPCR desensitization: Acute and prolonged phases

(2018) Sudarshan Rajagopal et al.   CELLULAR SIGNALLING

Catalytic activation of β-arrestin by GPCRs

(2018) Kelsie Eichel et al.   NATURE

Molecular mechanism of GPCR-mediated arrestin activation

(2018) Naomi R. Latorraca et al.   NATURE

Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation

(2018) Andrija Sente et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling

(2018) Dean P. Staus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lack of beta-arrestin signaling in the absence of active G proteins

(2018) Manuel Grundmann et al.   Nature Communications

Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation

(2018) Andrija Sente et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

(2018) Hsin-Yung Yen et al.   NATURE

Development of an antibody fragment that stabilizes GPCR/G-protein complexes

(2018) Shoji Maeda et al.   Nature Communications

S1P1 receptor phosphorylation, internalization, and interaction with Rab proteins: effects of sphingosine 1-phosphate, FTY720-P, phorbol esters, and paroxetine

(2018) Juan Carlos Martínez-Morales et al.   BIOSCIENCE REPORTS

State-dependent Lipid Interactions with the A2a Receptor Revealed by MD Simulations Using In Vivo-Mimetic Membranes

(2018) Wanling Song et al.   STRUCTURE

When trafficking and signaling mix: how subcellular location shapes GPCR activation of heterotrimeric G proteins

(2018) Braden T. Lobingier et al.   TRAFFIC

Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation

(2018) Wataru Shihoya et al.   Nature Communications

Core engagement with β-arrestin is dispensable for agonist-induced vasopressin receptor endocytosis and ERK activation

(2017) Punita Kumari et al.   MOLECULAR BIOLOGY OF THE CELL

Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

(2017) Thomas J. Cahill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK

(2017) Morgan O’Hayre et al.   Science Signaling

V1b vasopressin receptor trafficking and signaling: Role of arrestins, G proteins and Src kinase

(2017) Sanja Perkovska et al.   TRAFFIC

C-edge loops of arrestin function as a membrane anchor

(2017) Ciara C M. Lally et al.   Nature Communications

Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK

(2017) Morgan O’Hayre et al.   Science Signaling

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

(2016) Alex R.B. Thomsen et al.   CELL

Regulation of clathrin-mediated endocytosis by hierarchical allosteric activation of AP2

(2016) Zuzana Kadlecova et al.   JOURNAL OF CELL BIOLOGY

The conformational signature of β-arrestin2 predicts its trafficking and signalling functions

(2016) Mi-Hye Lee et al.   NATURE

β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle

(2016) Susanne Nuber et al.   NATURE

β-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation

(2016) K. Eichel et al.   NATURE CELL BIOLOGY

Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRET

(2016) Yoon Namkung et al.   Nature Communications

NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells

(2015) Andrew S. Dixon et al.   ACS Chemical Biology

Effects of endocytosis on receptor-mediated signaling

(2015) Roshanak Irannejad et al.   CURRENT OPINION IN CELL BIOLOGY

Dose-Response Analysis Using R

(2015) Christian Ritz et al.   PLoS One

Differential Regulation of Endosomal GPCR/β-Arrestin Complexes and Trafficking by MAPK

(2014) Etienne Khoury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visualization of arrestin recruitment by a G-protein-coupled receptor

(2014) Arun K. Shukla et al.   NATURE

β1-Adrenergic Receptor Recycles Via a Membranous Organelle, Recycling Endosome, by Binding with Sorting Nexin27

(2013) Takatoshi Nakagawa et al.   JOURNAL OF MEMBRANE BIOLOGY

Crystal structure of pre-activated arrestin p44

(2013) Yong Ju Kim et al.   NATURE

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

(2013) Arun K. Shukla et al.   NATURE

Conformational biosensors reveal GPCR signalling from endosomes

(2013) Roshanak Irannejad et al.   NATURE

Acute depletion of plasma membrane phosphatidylinositol 4,5-bisphosphate impairs specific steps in endocytosis of the G-protein-coupled receptor

(2012) Dániel J. Tóth et al.   JOURNAL OF CELL SCIENCE

TGFα shedding assay: an accurate and versatile method for detecting GPCR activation

(2012) Asuka Inoue et al.   NATURE METHODS

Molecular Mechanism of β-Arrestin-Biased Agonism at Seven-Transmembrane Receptors

(2011) Eric Reiter et al.   Annual Review of Pharmacology and Toxicology

Retromer terminates the generation of cAMP by internalized PTH receptors

(2011) Timothy N Feinstein et al.   Nature Chemical Biology

How Does Arrestin Assemble MAPKs into a Signaling Complex?

(2008) Xiufeng Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improving the photostability of bright monomeric orange and red fluorescent proteins

(2008) Nathan C Shaner et al.   NATURE METHODS

Regulation of GPCRs by Endocytic Membrane Trafficking and Its Potential Implications

(2007) Aylin C. Hanyaloglu et al.   Annual Review of Pharmacology and Toxicology