Therapeutic inhibition of PPARα-HIF1α-PGK1 signaling targets leukemia stem and progenitor cells in acute myeloid leukemia

Hematopoietic versus leukemic stem cell quiescence: Challenges and therapeutic opportunities

(2021) Eimear O'Reilly et al.   BLOOD REVIEWS

MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling

(2020) Divya Venkatesh et al.   GENES & DEVELOPMENT

Treatment of Relapsed Acute Myeloid Leukemia

(2020) Felicitas Thol et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

The role of Peroxisome Proliferator-Activated Receptors (PPAR) in immune responses

(2020) Anthos Christofides et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Leukemia Stem Cell Release From the Stem Cell Niche to Treat Acute Myeloid Leukemia

(2020) Alicia Villatoro et al.   Frontiers in Cell and Developmental Biology

Enasidenib: First Mutant IDH2 Inhibitor for the Treatment of Refractory and Relapsed Acute Myeloid Leukemia

(2019) Raghav Dogra et al.   Anti-Cancer Agents in Medicinal Chemistry

Venetoclax-based Therapies for Acute Myeloid Leukemia

(2019) Veronica A. Guerra et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Synthetic lethality of combined AT-101 with idarubicin in acute myeloid leukemia via blockade of DNA repair and activation of intrinsic apoptotic pathway

(2019) Qianying Yang et al.   CANCER LETTERS

HIF‐1α forms regulatory loop with YAP to coordinate hypoxia‐induced adriamycin resistance in acute myeloid leukemia cells

(2019) Bin Zhu et al.   CELL BIOLOGY INTERNATIONAL

The Involvement of PPARs in the Peculiar Energetic Metabolism of Tumor Cells

(2018) Andrea Antonosante et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long-term health outcomes in survivors of childhood AML treated with allogeneic HSCT: a NOPHO–AML Study

(2018) Mari Wilhelmsson et al.   BONE MARROW TRANSPLANTATION

Chiglitazar Preferentially Regulates Gene Expression via Configuration-Restricted Binding and Phosphorylation Inhibition of PPARγ

(2017) De-Si Pan et al.   PPAR Research

Oxidative stress and hypoxia in normal and leukemic stem cells

(2016) Ugo Testa et al.   EXPERIMENTAL HEMATOLOGY

Effect of hypoxia-inducible factors in normal and leukemic stem cell regulation and their potential therapeutic impact

(2016) Kevin Rouault-Pierre et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Identifying high-risk adult AML patients: epigenetic and genetic risk factors and their implications for therapy

(2016) Caroline Bret et al.   Expert Review of Hematology

Hypoxia-Activated Prodrug TH-302 Targets Hypoxic Bone Marrow Niches in Preclinical Leukemia Models

(2015) J. Benito et al.   CLINICAL CANCER RESEARCH

Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance

(2015) Milica Vukovic et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PPARα Regulates Endothelial Progenitor Cell Maturation and Myeloid Lineage Differentiation Through a NADPH Oxidase-Dependent Mechanism in Mice

(2015) Luisa Vergori et al.   STEM CELLS

HIF-1α and GLUT1 Gene Expression is Associated with Chemoresistance of Acute Myeloid Leukemia

(2014) Kui Song et al.   Asian Pacific Journal of Cancer Prevention

Role of the ubiquitin–proteasome system in cardiac dysfunction of adipose triglyceride lipase-deficient mice

(2014) Marion Mussbacher et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Fenofibrate-induced nuclear translocation of FoxO3A triggers Bim-mediated apoptosis in glioblastoma cells in vitro

(2012) Anna Wilk et al.   CELL CYCLE

Peroxisome proliferator–activated receptor activation increases imatinib uptake and killing of chronic myeloid leukemia cells

(2012) Lihui Wang et al.   EXPERIMENTAL HEMATOLOGY

Activation of Peroxisome Proliferator-activated Receptor α (PPARα) Suppresses Hypoxia-inducible Factor-1α (HIF-1α) Signaling in Cancer Cells

(2012) Jundong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPAR-alpha is a therapeutic target for chronic lymphocytic leukemia

(2012) D E Spaner et al.   LEUKEMIA

Resistance of leukemic stem-like cells in AML cell line KG1a to natural killer cell-mediated cytotoxicity

(2011) Miaorong She et al.   CANCER LETTERS

Targeting HIF1α Eliminates Cancer Stem Cells in Hematological Malignancies

(2011) Yin Wang et al.   Cell Stem Cell

Role of Peroxisome Proliferator-Activated Receptor-γ and Its Coactivator DRIP205 in Cellular Responses to CDDO (RTA-401) in Acute Myelogenous Leukemia

(2010) Twee Tsao et al.   CANCER RESEARCH

Involvement of PPARα and PPARγ in apoptosis and proliferation of human hepatocarcinoma HepG2 cells

(2010) Marina Maggiora et al.   CELL BIOCHEMISTRY AND FUNCTION

Fenofibrate induces effective apoptosis in mantle cell lymphoma by inhibiting the TNFα/NF-κB signaling axis

(2010) Z Zak et al.   LEUKEMIA

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL