Article
Engineering, Electrical & Electronic
Alessandra Galli, Nicolo Lago, Sarah Tonello, Mario Bortolozzi, Marco Buonomo, Morten Gram Pedersen, Andrea Cester, Giada Giorgi
Summary: This paper proposes a processing technique to accurately and reliably extract single-cell action potentials from signals acquired by extracellular recording devices. The proposed method utilizes denoising and threshold-based classification techniques to improve the performance of peak detection. The results of tests on simulated and experimental data demonstrate the effectiveness of the proposed approach.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2022)
Article
Multidisciplinary Sciences
Christine Grienberger, Jeffrey C. Magee
Summary: This study reveals that learning-related changes in the hippocampus are produced by synaptic plasticity directed by an instructive signal from the entorhinal cortex layer 3 that seems to be specifically adapted to the behaviorally relevant features of the environment.
Article
Biology
Lingjun Ding, Giuseppe Balsamo, Hongbiao Chen, Eduardo Blanco-Hernandez, Ioannis S. Zouridis, Robert Naumann, Patricia Preston-Ferrer, Andrea Burgalossi
Summary: Neural circuits are composed of diverse neuronal cell types, and this diversity plays a crucial role in brain function during natural behavior. In this study, the combination of juxtacellular recording, labeling, and optogenetics enabled the investigation of molecularly defined cell classes in freely moving mice, revealing the weaker spatial modulation and information transmission of Calbindin-positive CA1 pyramidal cells.
Article
Neurosciences
Hadas E. Sloin, Amir Levi, Shirly Someck, Lidor Spivak, Eran Stark
Summary: Single hippocampal cells can encode the spatial position of an animal through phase rolling, a faster and distinct form of phase change compared to phase precession. Place fields exhibiting phase rolling are larger in size than nonrolling fields.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Hiroki Kawashima, Yuri Aono, Yuriko Watanabe, John L. Waddington, Tadashi Saigusa
Summary: This study demonstrates that accumbal OX2 receptors, not OX1 receptors, inhibit basal dopamine efflux, while blocking OX2 receptors increases dopamine efflux. OX1 receptors have no effect on dopamine efflux.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Anatomy & Morphology
Denise Riquelme, Oscar Cerda, Elias Leiva-Salcedo
Summary: In this study, the localization and expression of TRPM4 in CA1 pyramidal neurons during postnatal development were examined using immunofluorescence and patch-clamp techniques in C57BL/6J mice. The results show that TRPM4 is expressed in the soma and apical dendrites of CA1 pyramidal neurons, associated with a TRPM4-like current that depolarizes the neurons. These findings suggest that TRPM4 may play a role in controlling membrane potential and action potential firing during critical periods of neuronal development, particularly in circuit establishment.
FRONTIERS IN NEUROANATOMY
(2021)
Article
Biochemical Research Methods
Loic Duffet, Seher Kosar, Mariangela Panniello, Bianca Viberti, Edward Bracey, Anna D. Zych, Arthur Radoux-Mergault, Xuehan Zhou, Jan Dernic, Luca Ravotto, Yuan-Chen Tsai, Marta Figueiredo, Shiva K. Tyagarajan, Bruno Weber, Miriam Stoeber, Nadine Gogolla, Markus H. Schmidt, Antoine R. Adamantidis, Tommaso Fellin, Denis Burdakov, Tommaso Patriarchi
Summary: This study developed a genetically encoded orexin sensor called OxLight1, which enables sensitive and direct optical detection of orexin neuropeptides in living animals with high spatiotemporal resolution. The sensor was used in mouse experiments to show that orexin release is associated with behaviors such as running, stress, and sleep-to-wake transitions.
Article
Pharmacology & Pharmacy
Ying Zhang, Hai-Yan Yin, Patrizia Rubini, Peter Illes, Yong Tang
Summary: There is a dispute about whether CNS neurons possess ATP-sensitive P2X7 receptors. By genetically deleting P2X7 receptors in astrocytes and oligodendrocytes, it was found that these receptors indirectly modulate the neuronal input to neighboring neurons.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Seyedehdelaram Ghalebandi, Fatemeh Zareie, Kobra Askari, Jale Yuzugulen, Abbas Haghparast
Summary: Orexins or hypocretins, produced in the lateral hypothalamus, play a role in pain modulation and responsiveness to stressful stimuli. The study found that orexin receptors in the hippocampal CA1 region are involved in stress-induced analgesia, and blocking these receptors attenuates the analgesic effect of forced swim stress.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ali Veisi, Hossein Khaleghzadeh-Ahangar, Mojdeh Fattahi, Abbas Haghparast
Summary: This study investigated the role of orexin-1 receptors (OX1R) in the hippocampal CA1 subregion in the extinction and reinstatement of methamphetamine-induced conditioned place preference. The findings showed that blocking OX1R in the CA1 area during the extinction period reduced the extinction latency and maintenance of rewarding aspects of methamphetamine. Additionally, blocking OX1R on the reinstatement phase prevented methamphetamine-induced reinstatement of drug-seeking behaviors. These results provide further evidence for the involvement of hippocampal OX1R in the maintenance and relapse of methamphetamine addiction.
NEUROCHEMICAL RESEARCH
(2023)
Article
Neurosciences
Catherine S. Thomas, Aida Mohammadkhani, Madiha Rana, Min Qiao, Corey Baimel, Stephanie L. Borgland
Summary: Reward and reinforcement processes are critical for survival and propagation of genes, with mesolimbic dopamine playing a central role. Optogenetic stimulation of orexin/dynorphin inputs in the VTA potentiates dopamine release in the NAc core, resulting in real time and conditioned place preference as well as increased food cue-directed orientation. While dynorphin contributes to aversive conditioning, the rewarding effects of LH orexin/dynorphin stimulation in the VTA are primarily driven by orexin rather than dynorphin.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Sachin S. Deshmukh
Summary: The study shows that the inputs from different regions in the proximal and distal CA1 areas cause differential representation responses. While pCA1 representation splits when faced with conflicting inputs, dCA1 is more influenced by global cues. Overall spatial selectivity is not significantly different, possibly due to the richer sensory information available in the behavioral environment.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Na Jin, Su-Yue Zhu, Xin-Yu Yang, Cheng Zhen, Yan Li, Huan-Huan Zhang, Ai-Ping Xu, Meng-Ya Wang, Chao Zheng
Summary: Orexin-A potentiates glycine currents in spinal cord ventral horn neurons by activating OX1R, likely through an IP3/Ca2+-dependent PKC signaling pathway.
BRAIN RESEARCH BULLETIN
(2021)
Article
Medicine, Research & Experimental
Vajihe Imanpour, Parham Reisi
Summary: This study aimed to evaluate the modulatory effects of orexin-2 (OX2R) and endocannabinoid-1 (CB1R) receptors on neuronal activity in CA1, in response to tramadol. The findings suggest that neural activity in CA1 is rapidly affected by acute use of tramadol, and some of these effects may be induced through the endocannabinoid and orexin systems. Therefore, the function of endocannabinoid and orexin systems in CA1 may play a role in tramadol addiction.
ADVANCED BIOMEDICAL RESEARCH
(2022)
Article
Neurosciences
Paola Vitale, Fabio Librizzi, Andrea C. Vaiana, Elisa Capuana, Maurizio Pezzoli, Ying Shi, Armando Romani, Michele Migliore, Rosanna Migliore
Summary: The fundamental role of neurons in a network is to transform complex input patterns into output spikes, and understanding species-specific differences in this process is important. This study compared the morphological and electrophysiological properties of mouse and rat neurons to determine the parameters underlying their differences and created computational models to further investigate these distinctions.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Yan Xue, Yu-Ting Yang, Hong-Yun Liu, Wen-Fang Chen, An-Qi Chen, Qing Sheng, Xin-Yi Chen, Ying Wang, Hua Chen, Hong-Xia Liu, Ya-Yan Pang, Lei Chen
EUROPEAN JOURNAL OF NEUROSCIENCE
(2016)
Review
Neurosciences
Xin-Yi Chen, Yi-Feng Du, Lei Chen
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2019)
Review
Biochemistry & Molecular Biology
Xin-Yi Chen, Yan Xue, Hua Chen, Lei Chen
Article
Multidisciplinary Sciences
Lei Zhao, Zhongqi Li, Joaquim S. L. Vong, Xinyi Chen, Hei-Ming Lai, Leo Y. C. Yan, Junzhe Huang, Samuel K. H. Sy, Xiaoyu Tian, Yu Huang, Ho Yin Edwin Chan, Hon-Cheong So, Wai-Lung Ng, Yamei Tang, Wei-Jye Lin, Vincent C. T. Mok, Ho Ko
NATURE COMMUNICATIONS
(2020)
Article
Biology
Zhongqi Li, Xinyi Chen, Joaquim S. L. Vong, Lei Zhao, Junzhe Huang, Leo Y. C. Yan, Bonaventure Ip, Yun Kwok Wing, Hei-Ming Lai, Vincent C. T. Mok, Ho Ko
Summary: Research shows that pharmacological reversal of brain aging is possible through the use of GLP-1R agonists, which can reverse transcriptomic aging signatures in various brain cell types and reduce AD-related transcriptomic signatures in microglia. This suggests that GLP-1R agonists may be a promising therapeutic option for preventing age-related neurodegeneration.
COMMUNICATIONS BIOLOGY
(2021)
Review
Neurosciences
Xin-Yi Chen, Lei Chen, Wu Yang, An-Mu Xie
Summary: GLP-1 plays important roles in regulating food intake and body weight by modulating neuronal activity in various brain regions, which can induce feeding inhibition through postsynaptic depolarization and/or presynaptic modulation of neurotransmission.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Oncology
Junfan Chen, Lei Sun, Hao Lyu, Zhiyuan Zheng, Huasheng Lai, Yang Wang, Yujie Luo, Gang Lu, Wai Yee Chan, Sheng Guan, Yisen Zhang, Xinyi Chen, Zhongqi Li, Ho Ko, Kwok Chu George Wong
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)