Editorial Material
Biochemistry & Molecular Biology
Mark D. Bevan
Summary: The basal ganglia play a crucial role in regulating behavior, with a new study revealing a feedback circuit that can strongly inhibit locomotion in mice.
Article
Biochemistry & Molecular Biology
Asier Aristieta, Massimo Barresi, Shiva Azizpour Lindi, Gregory Barriere, Gilles Courtand, Brice de la Cromp, Lise Guilhemsang, Sophie Gauthier, Stephanie Fioramonti, Jerome Baufreton, Nicolas P. Mallet
Summary: The basal ganglia inhibit movements through two independent pathways, and affect external globus pallidus neurons differently. Recent research suggests that arkypallidal neurons play a role in a novel disynaptic feedback loop, inhibiting locomotion only when their activity increases.
Article
Radiology, Nuclear Medicine & Medical Imaging
Henning Richter, Patrick Buecker, Louise Francoise Martin, Calvin Dunker, Stefanie Fingerhut, Anna Xia, Agnieszka Karol, Michael Sperling, Uwe Karst, Alexander Radbruch, Astrid Jeibmann
Summary: The study compared gadolinium tissue concentrations in various organs 10 weeks after injection of linear and macrocyclic GBCAs in a large-animal model. Linear GBCAs resulted in higher concentrations in the kidney and liver compared to macrocyclic GBCAs, but no tissue injury was detected despite the presence of gadolinium in the organs.
Article
Biology
Alexander Kaplan, Aviv D. Mizrahi-Kliger, Pnina Rappel, Liliya Iskhakova, Gennadiy Fonar, Zvi Israel, Hagai Bergman
Summary: Integrated analysis of non-human primate data reveals that pauses in GPe firing are associated with pupil dilation, suggesting that GPe pauses may influence basal ganglia downstream structures and play a role in exploratory behavior.
COMMUNICATIONS BIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Wei Li, Ling Yue, Shifu Xiao
Summary: This study found that internet use may be a protective factor for mild cognitive impairment among older Chinese adults, and it may prevent cognitive decline by affecting the volume of the globus pallidus.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Neurosciences
Maya Ketzef, Gilad Silberberg
Summary: The rodent external globus pallidus (GPe) contains two main neuronal subpopulations, prototypic and arkypallidal cells, with distinct functional synaptic connectivity patterns. Both subpopulations receive excitatory and inhibitory inputs during slow wave activity and respond to sensory stimulation with multiphasic patterns. The connectivity patterns of GPe subtypes underlie their respective functional roles.
Article
Multidisciplinary Sciences
Alireza Shariati, Tahereh Ebrahimi, Parva Babadinia, Fatemeh Sadat Shariati, Reza Ahangari Cohan
Summary: A new class of dual contrast agents based on polydopamine nanoparticles (PDA-NPs) targeted with hyaluronic acid (HA) has been developed and tested for better contrast in magnetic resonance imaging (MRI) and computed tomography (CT). The synthesized PDA-NPs showed a spherical morphology and good stability, with low toxicity and similar contrast performance compared to commercial agents.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Joshua W. Callahan, David L. Wokosin, Mark D. Bevan
Summary: This study used optogenetics and electrophysiology to reveal some characteristics of early Huntington's disease, including abnormal activity of the indirect pathway neurons and changes in inhibitory mechanisms.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Engineering, Electrical & Electronic
Alessandra Galli, Nicolo Lago, Sarah Tonello, Mario Bortolozzi, Marco Buonomo, Morten Gram Pedersen, Andrea Cester, Giada Giorgi
Summary: This paper proposes a processing technique to accurately and reliably extract single-cell action potentials from signals acquired by extracellular recording devices. The proposed method utilizes denoising and threshold-based classification techniques to improve the performance of peak detection. The results of tests on simulated and experimental data demonstrate the effectiveness of the proposed approach.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2022)
Article
Clinical Neurology
Joshua M. Diamond, M. Beatriz Lopes, W. Jeff Elias, Laura A. Jansen
Summary: The study aimed to characterize GABA(A) receptor subunit expression in the normal and parkinsonian human globus pallidus using fluorescence microscopy. The results showed no significant differences in GABA(A) receptor subunit expression between PD specimens and control specimens in the globus pallidus. Compensatory changes in GABA(A) receptor alpha 1 and alpha 3 subunit expression in response to PD-related signaling abnormalities in the globus pallidus were not observed in the PD cohort studied.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Joshua M. Diamond, M. Beatriz Lopes, W. Jeff Elias, Laura A. Jansen
Summary: This study suggests that compensatory changes in the expression of GABA(A) receptor alpha 1 and alpha 3 subunits do not occur in the globus pallidus of Parkinson's disease patients.
WORLD NEUROSURGERY
(2022)
Article
Neurosciences
Michael S. Patton, Samuel H. Sheats, Allison N. Siclair, Brian N. Mathur
Summary: Fast-spiking interneurons in the dorsal striatum can be modulated by ethanol, which may result in excessive activation of dopamine neurons and further promote compulsive ethanol consumption behavior.
Article
Cell & Tissue Engineering
Fu-Chen Yang, Jay L. Vivian, Catherine Traxler, Steven M. Shapiro, John A. Stanford
Summary: This study investigates the potential of using stem cell transplantation to treat dystonia in kernicterus. Human embryonic stem cells were differentiated into MGE-like neural precursor cells and transplanted into the GP of jaundiced rats. The transplanted cells survived in the brain and expressed characteristics of the normal GP, but with low survival rate and varying maturity.
CELL TRANSPLANTATION
(2022)
Article
Clinical Neurology
Shiro Horisawa, Atsushi Fukui, Kotaro Kohara, Takakazu Kawamata, Takaomi Taira
Summary: The study suggests that unilateral pallidotomy is an acceptable treatment option for patients with asymmetrical cervical dystonia, with over half of the patients showing significant improvement in TWSTRS scores at 6 months postoperatively. Preoperative severity of the condition was identified as a prognostic factor for treatment outcomes. Further research with larger sample sizes and longer follow-up periods are needed to confirm these findings.
JOURNAL OF NEUROSURGERY
(2021)
Article
Medicine, General & Internal
Yasuyuki Tamai, Motoh Iwasa, Yuichi Yoshida, Jun Nomoto, Takahiro Kato, Hiroe Asuke, Akiko Eguchi, Yoshiyuki Takei, Hayato Nakagawa
Summary: This study aimed to develop a new diagnostic index to distinguish hepatic encephalopathy from dementia. The findings showed that hepatic encephalopathy patients with liver cirrhosis had significantly increased signal intensity in the globus pallidus, compared to those without hepatic encephalopathy, healthy subjects, and dementia patients. The automatic assessment of signal intensity in the globus pallidus was found to be useful in identifying liver cirrhosis patients with hepatic encephalopathy.
Article
Neurosciences
Xin-Yi Chen, Lei Chen, Yi-Feng Du
JOURNAL OF NEUROSCIENCE RESEARCH
(2017)
Review
Neurosciences
Xin-Yi Chen, Yi-Feng Du, Lei Chen
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2019)
Review
Biochemistry & Molecular Biology
Xin-Yi Chen, Yan Xue, Hua Chen, Lei Chen
Article
Multidisciplinary Sciences
Lei Zhao, Zhongqi Li, Joaquim S. L. Vong, Xinyi Chen, Hei-Ming Lai, Leo Y. C. Yan, Junzhe Huang, Samuel K. H. Sy, Xiaoyu Tian, Yu Huang, Ho Yin Edwin Chan, Hon-Cheong So, Wai-Lung Ng, Yamei Tang, Wei-Jye Lin, Vincent C. T. Mok, Ho Ko
NATURE COMMUNICATIONS
(2020)
Article
Biology
Zhongqi Li, Xinyi Chen, Joaquim S. L. Vong, Lei Zhao, Junzhe Huang, Leo Y. C. Yan, Bonaventure Ip, Yun Kwok Wing, Hei-Ming Lai, Vincent C. T. Mok, Ho Ko
Summary: Research shows that pharmacological reversal of brain aging is possible through the use of GLP-1R agonists, which can reverse transcriptomic aging signatures in various brain cell types and reduce AD-related transcriptomic signatures in microglia. This suggests that GLP-1R agonists may be a promising therapeutic option for preventing age-related neurodegeneration.
COMMUNICATIONS BIOLOGY
(2021)
Review
Neurosciences
Xin-Yi Chen, Lei Chen, Wu Yang, An-Mu Xie
Summary: GLP-1 plays important roles in regulating food intake and body weight by modulating neuronal activity in various brain regions, which can induce feeding inhibition through postsynaptic depolarization and/or presynaptic modulation of neurotransmission.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Oncology
Junfan Chen, Lei Sun, Hao Lyu, Zhiyuan Zheng, Huasheng Lai, Yang Wang, Yujie Luo, Gang Lu, Wai Yee Chan, Sheng Guan, Yisen Zhang, Xinyi Chen, Zhongqi Li, Ho Ko, Kwok Chu George Wong
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)