In vivo monitoring of brain pharmacokinetics and pharmacodynamics with cerebral open flow microperfusion

Current Approaches to Monitor Macromolecules Directly from the Cerebral Interstitial Fluid

(2022) Marie-Laure Custers et al.   Pharmaceutics

Applicability of cerebral open flow microperfusion and microdialysis to quantify a brain-penetrating nanobody in mice

(2021) Marie-Laure Custers et al.   ANALYTICA CHIMICA ACTA

The development of biological therapies for neurological diseases: moving on from previous failures

(2018) Hisham Qosa et al.   Expert Opinion on Drug Discovery

Antibody pharmacokinetics in rat brain determined using microdialysis

(2018) Hsueh-Yuan Chang et al.   mAbs

Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood–brain barrier in leptin resistant mice

(2018) Maximilian Kleinert et al.   Molecular Metabolism

Comparison of cerebral Open Flow Microperfusion and Microdialysis when sampling small lipophilic and small hydrophilic substances

(2018) Thomas Altendorfer-Kroath et al.   JOURNAL OF NEUROSCIENCE METHODS

Brain Tissue Responses to Neural Implants Impact Signal Sensitivity and Intervention Strategies

(2015) Takashi D. Y. Kozai et al.   ACS Chemical Neuroscience

Secukinumab distributes into dermal interstitial fluid of psoriasis patients as demonstrated by open flow microperfusion

(2015) Christian Dragatin et al.   EXPERIMENTAL DERMATOLOGY

Probing the extracellular diffusion of antibodies in brain using in vivo integrative optical imaging and ex vivo fluorescence imaging

(2015) Daniel J. Wolak et al.   JOURNAL OF CONTROLLED RELEASE

Enhanced Doxorubicin Delivery to the Brain Administered Through Glutathione PEGylated Liposomal Doxorubicin (2B3-101) as Compared with Generic Caelyx,®/Doxil®—A Cerebral Open Flow Microperfusion Pilot Study

(2014) Thomas Birngruber et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Long-Term Implanted cOFM Probe Causes Minimal Tissue Reaction in the Brain

(2014) Thomas Birngruber et al.   PLoS One

Assessment of Blood-Brain Barrier Function and the Neuroinflammatory Response in the Rat Brain by Using Cerebral Open Flow Microperfusion (cOFM)

(2014) Arijit Ghosh et al.   PLoS One

Albumin activates astrocytes and microglia through mitogen-activated protein kinase pathways

(2009) Hantamalala Ralay Ranaivo et al.   BRAIN RESEARCH

Diffusion in Brain Extracellular Space

(2008) Eva Syková et al.   PHYSIOLOGICAL REVIEWS