Novel spirooxindole based benzimidazole scaffold: In vitro, nanoformulation and in vivo studies on anticancer and antimetastatic activity of breast adenocarcinoma

Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next generation p53 activators

(2021) Gehad Lotfy et al.   BIOORGANIC CHEMISTRY

Recent Small-Molecule Inhibitors of the p53–MDM2 Protein–Protein Interaction

(2020) Anastasia Beloglazkina et al.   MOLECULES

Synthesis, Anticancer Activity, and Molecular Modeling of New Halogenated Spiro[pyrrolidine-thiazolo-oxindoles] Derivatives

(2020) Mohammad Shahidul Islam et al.   Applied Sciences-Basel

Fabrication of Transgelosomes for Enhancing the Ocular Delivery of Acetazolamide: Statistical Optimization, In Vitro Characterization, and In Vivo Study

(2020) Eman A. Mazyed et al.   Pharmaceutics

Formulation of Sodium Valproate Nanospanlastics as a Promising Approach for Drug Repurposing in the Treatment of Androgenic Alopecia

(2020) Farid. A. Badria et al.   Pharmaceutics

Design and synthesis of new substituted spirooxindoles as potential inhibitors of the MDM2–p53 interaction

(2019) Assem Barakat et al.   BIOORGANIC CHEMISTRY

Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells

(2019) Zuzana Mrkvová et al.   MOLECULES

Evaluation of Carum-loaded Niosomes on Breast Cancer Cells:Physicochemical Properties, In Vitro Cytotoxicity, Flow Cytometric, DNA Fragmentation and Cell Migration Assay

(2019) Mahmood Barani et al.   Scientific Reports

Antiproliferative Aspect of Benzimidazole Derivatives’ Activity and Their Impact on NF-κB Expression

(2019) Błaszczak-Świątkiewicz   MOLECULES

Synthesis of new thiazolo-pyrrolidine–(spirooxindole) tethered to 3-acylindole as anticancer agents

(2018) Mohammad Shahidul Islam et al.   BIOORGANIC CHEMISTRY

Enhanced non invasive trans -tympanic delivery of ciprofloxacin through encapsulation into nano-spanlastic vesicles: Fabrication, in-vitro characterization, and comparative ex-vivo permeation studies

(2017) Abdulaziz Mohsen Al-mahallawi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Changes in physical and chemical properties of niosome membrane induced by cholesterol: a promising approach for niosome bilayer intervention

(2017) Mohammad Hadi Nematollahi et al.   RSC Advances

DOE Optimization of Nano-based Carrier of Pregabalin as Hydrogel: New Therapeutic & Chemometric Approaches for Controlled Drug Delivery Systems

(2017) Mona G. Arafa et al.   Scientific Reports

Ultradeformable Liposomes: a Novel Vesicular Carrier For Enhanced Transdermal Delivery of Procyanidins: Effect of Surfactants on the Formation, Stability, and Transdermal Delivery

(2016) Rencai Chen et al.   AAPS PHARMSCITECH

Systematic Development of Transethosomal Gel System of Piroxicam: Formulation Optimization, In Vitro Evaluation, and Ex Vivo Assessment

(2016) Varun Garg et al.   AAPS PHARMSCITECH

Exploration of 2-benzylbenzimidazole scaffold as novel inhibitor of NF-κB

(2016) PullaReddy Boggu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A novel mathematical model of ATM/p53/NF- κB pathways points to the importance of the DDR switch-off mechanisms

(2016) Katarzyna Jonak et al.   BMC Systems Biology

Design, synthesis and biological evaluation of novel benzimidazole-2-substituted phenyl or pyridine propyl ketene derivatives as antitumour agents

(2016) Lin-tao Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Novel Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2–p53 Interaction

(2016) Andreas Gollner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development, characterization, and skin delivery studies of related ultradeformable vesicles: transfersomes, ethosomes, and transethosomes

(2015) Andreia Ascenso et al.   International Journal of Nanomedicine

Searching for Dual Inhibitors of the MDM2-p53 and MDMX-p53 Protein-Protein Interaction by a Scaffold-Hopping Approach

(2014) Andrey Zaytsev et al.   Chemical Biology & Drug Design

Nano-transfersomal ciprofloxacin loaded vesicles for non-invasive trans-tympanic ototopical delivery: In-vitro optimization, ex-vivo permeation studies, and in-vivo assessment

(2014) Abdulaziz Mohsen Al-mahallawi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Preparation, characterization and evaluation of novel elastic nano-sized niosomes (ethoniosomes) for ocular delivery of prednisolone

(2014) Passent M. E. Gaafar et al.   JOURNAL OF LIPOSOME RESEARCH

MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models

(2013) C. Tovar et al.   CANCER RESEARCH

The p53 family and VEGF regulation: “It’s complicated”

(2013) Morvarid Farhang Ghahremani et al.   CELL CYCLE

Diastereomeric Spirooxindoles as Highly Potent and Efficacious MDM2 Inhibitors

(2013) Yujun Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development

(2013) Zhuming Zhang et al.   ACS Medicinal Chemistry Letters

Benzimidazole-2-one: A novel anchoring principle for antagonizing p53-Mdm2

(2012) Wei Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Dynamics of p53 and NF-κB regulation in response to DNA damage and identification of target proteins suitable for therapeutic intervention

(2012) Rainer Poltz et al.   BMC Systems Biology

The Structure-Based Design of Mdm2/Mdmx-p53 Inhibitors Gets Serious

(2011) Grzegorz M. Popowicz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Signaling mechanism of cell adhesion molecules in breast cancer metastasis: potential therapeutic targets

(2011) Dong-Mei Li et al.   BREAST CANCER RESEARCH AND TREATMENT

Small-Molecule Inhibitors of p53-MDM2 Interaction: the 2006-2010 Update

(2011) Melissa Millard et al.   CURRENT PHARMACEUTICAL DESIGN

In Vitro and In Vivo Evaluation of Proniosomes Containing Celecoxib for Oral Administration

(2010) Mohamed Nasr   AAPS PHARMSCITECH

Formulation and Optimization of Zidovudine Niosomes

(2010) Kandasamy Ruckmani et al.   AAPS PHARMSCITECH

Selective benzimidazole inhibitors of the antigen receptor-mediated NF-κB activation pathway

(2010) Karl J. Okolotowicz et al.   BIOORGANIC & MEDICINAL CHEMISTRY

p53 and NF-κB: different strategies for responding to stress lead to a functional antagonism

(2010) Prashanth Ak et al.   FASEB JOURNAL

Optimization and physicochemical characterization of a triamcinolone acetonide-loaded NLC for ocular antiangiogenic applications

(2010) J. Araújo et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Inhibitors of MDM2 and MDMX: a structural perspective

(2009) Christiane Riedinger et al.   Future Medicinal Chemistry

Effect of Charged and Non-ionic Membrane Additives on Physicochemical Properties and Stability of Niosomes

(2008) Varaporn Buraphacheep Junyaprasert et al.   AAPS PHARMSCITECH

Effect of hydration on the structure of solid-supported Niosomal membranes investigated by in situ energy dispersive X-ray diffraction

(2008) Giulio Caracciolo et al.   CHEMICAL PHYSICS LETTERS

Regulation of MMP-9 by p53 in first trimester cytotrophoblastic cells

(2008) M. Cohen et al.   HUMAN REPRODUCTION

Double-edged swords as cancer therapeutics: simultaneously targeting p53 and NF-κB pathways

(2008) Anwesha Dey et al.   NATURE REVIEWS DRUG DISCOVERY