Synthesis and pharmacological validation of a novel radioligand for the orphan GPR88 receptor

Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex

(2022) Geng Chen et al.   Nature Communications

The GPR88 agonist RTI‐13951‐33 reduces alcohol drinking and seeking in mice

(2022) Sami Ben Hamida et al.   ADDICTION BIOLOGY

The orphan receptor GPR88 controls impulsivity and is a risk factor for Attention-Deficit/Hyperactivity Disorder

(2022) Sami Ben Hamida et al.   MOLECULAR PSYCHIATRY

Evaluation of Amide Bioisosteres Leading to 1,2,3-Triazole Containing Compounds as GPR88 Agonists: Design, Synthesis, and Structure–Activity Relationship Studies

(2021) Md Toufiqur Rahman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Impaired working memory, cognitive flexibility and reward processing in mice genetically lacking Gpr88: evidence for a key role for Gpr88 in multiple cortico‐striatal‐thalamic circuits

(2020) David M. Thomson et al.   GENES BRAIN AND BEHAVIOR

Design, Synthesis, and Structure–Activity Relationship Studies of (4-Alkoxyphenyl)glycinamides and Bioisosteric 1,3,4-Oxadiazoles as GPR88 Agonists

(2020) Md Toufiqur Rahman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genetic deletion of GPR88 enhances the locomotor response to L-DOPA in experimental parkinsonism while counteracting the induction of dyskinesia

(2019) Ioannis Mantas et al.   NEUROPHARMACOLOGY

Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks

(2018) Sami Ben Hamida et al.   BIOLOGICAL PSYCHIATRY

Discovery of a Potent, Selective, and Brain-Penetrant Small-Molecule that Activates the Orphan Receptor GPR88 and Reduces Alcohol Intake

(2018) Chunyang Jin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA: Synthesis, Structure–Activity Relationships, and Molecular Modeling Studies

(2016) Chunyang Jin et al.   ACS Chemical Neuroscience

Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist

(2016) Aura C. Meirsman et al.   BIOLOGICAL PSYCHIATRY

Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88

(2015) Carolyn D. Dzierba et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The discovery of potent agonists for GPR88, an orphan GPCR, for the potential treatment of CNS disorders

(2015) Yingzhi Bi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, Pharmacological Characterization, and Structure–Activity Relationship Studies of Small Molecular Agonists for the Orphan GPR88 Receptor

(2014) Chunyang Jin et al.   ACS Chemical Neuroscience

Development of [3H]2-Carboxy-4,6-dichloro-1H-indole-3-propionic Acid ([3H]PSB-12150): A Useful Tool for Studying GPR17

(2014) Meryem Köse et al.   ACS Medicinal Chemistry Letters

Association study in three different populations between the GPR88 gene and major psychoses

(2013) Maria Del Zompo et al.   Molecular Genetics & Genomic Medicine

Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors

(2012) Albert Quintana et al.   NATURE NEUROSCIENCE

Ligand binding assays at equilibrium: validation and interpretation

(2010) Edward C. Hulme et al.   BRITISH JOURNAL OF PHARMACOLOGY

Striatal GPR88 expression is confined to the whole projection neuron population and is regulated by dopaminergic and glutamatergic afferents

(2009) Renaud Massart et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The orphan GPCR, GPR88, modulates function of the striatal dopamine system: A possible therapeutic target for psychiatric disorders?

(2009) Sheree F. Logue et al.   MOLECULAR AND CELLULAR NEUROSCIENCE