Elucidating the Kinetic Mechanism of Human METTL16

METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis

(2022) Rui Su et al.   NATURE CELL BIOLOGY

Enzymatic characterization of three human RNA adenosine methyltransferases reveals diverse substrate affinities and reaction optima

(2021) Dan Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A

(2021) Anna M Scarborough et al.   eLife

Novel METTL3 Modulators for Treating Acute Myeloid Leukemia (AML)

(2021) Ram W. Sabnis   ACS Medicinal Chemistry Letters

A single m6A modification in U6 snRNA diversifies exon sequence at the 5’ splice site

(2021) Yuma Ishigami et al.   Nature Communications

Mechanistic insights into m6A modification of U6 snRNA by human METTL16

(2020) Tomohiko Aoyama et al.   NUCLEIC ACIDS RESEARCH

Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site

(2019) Simona Selberg et al.   Cell Reports

Dynamic m6A mRNA methylation reveals the role of METTL3-m6A-CDCP1 signaling axis in chemical carcinogenesis

(2019) Fan Yang et al.   ONCOGENE

Messenger RNA Modifications in Plants

(2019) Lisha Shen et al.   TRENDS IN PLANT SCIENCE

m6A enhances the phase separation potential of mRNA

(2019) Ryan J. Ries et al.   NATURE

The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112

(2019) Nhan van Tran et al.   NUCLEIC ACIDS RESEARCH

Interplay Between N6-Methyladenosine (m6A) and Non-coding RNAs in Cell Development and Cancer

(2019) Francesco Fazi et al.   Frontiers in Cell and Developmental Biology

Atlas of quantitative single-base-resolution N6-methyl-adenine methylomes

(2019) Casslynn W. Q. Koh et al.   Nature Communications

Sink into the Epigenome: Histones as Repositories That Influence Cellular Metabolism

(2018) Cunqi Ye et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Chemical Modifications in the Life of an mRNA Transcript

(2018) Sigrid Nachtergaele et al.   Annual Review of Genetics

Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor

(2018) Katelyn A. Doxtader et al.   MOLECULAR CELL

Structural insights into the RNA methyltransferase domain of METTL16

(2018) Agnieszka Ruszkowska et al.   Scientific Reports

N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation

(2018) Honghui Ma et al.   Nature Chemical Biology

S -Adenosylmethionine Synthesis Is Regulated by Selective N 6 -Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1

(2017) Hiroki Shima et al.   Cell Reports

Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex

(2016) Xiang Wang et al.   NATURE

Methyltransferase-like protein 16 binds the 3′-terminal triple helix of MALAT1 long noncoding RNA

(2016) Jessica A. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

5′ UTR m6A Promotes Cap-Independent Translation

(2015) Kate D. Meyer et al.   CELL

Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome

(2015) Bastian Linder et al.   NATURE METHODS

MicroScale Thermophoresis: Interaction analysis and beyond

(2014) Moran Jerabek-Willemsen et al.   JOURNAL OF MOLECULAR STRUCTURE

Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix

(2014) Jessica A Brown et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

Transcriptome-wide mapping of N6-methyladenosine by m6A-seq based on immunocapturing and massively parallel sequencing

(2013) Dan Dominissini et al.   Nature Protocols

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

Formation of triple-helical structures by the 3'-end sequences of MALAT1 and MEN  noncoding RNAs

(2012) J. A. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-throughput protein purification and quality assessment for crystallization

(2011) Youngchang Kim et al.   METHODS

The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation

(2010) Vidisha Tripathi et al.   MOLECULAR CELL

3′ End Processing of a Long Nuclear-Retained Noncoding RNA Yields a tRNA-like Cytoplasmic RNA

(2008) Jeremy E. Wilusz et al.   CELL

The ybiN Gene of Escherichia coli Encodes Adenine-N6 Methyltransferase Specific for Modification of A1618 of 23 S Ribosomal RNA, a Methylated Residue Located Close to the Ribosomal Exit Tunnel

(2007) Petr V. Sergiev et al.   JOURNAL OF MOLECULAR BIOLOGY