Article
Clinical Neurology
Mengyi Guo, Jing Wang, Zhonghua Xiong, Xiongfei Wang, Yujiao Yang, Yifan Zhang, Chongyang Tang, Jing Zhang, Yuguang Guan, Fan Chen, Kun Yao, Pengfei Teng, Jian Zhou, Feng Zhai, Detlev Boison, Guoming Luan, Tianfu Li
Summary: Mesial temporal lobe epilepsy without hippocampal sclerosis (no-HS MTLE) patients have resistance to antiepileptic drugs, difficulties in precise seizure location, and poor surgical outcomes. This study found maladaptive changes in adenosine metabolism and neuronal pathology in no-HS MTLE patients, suggesting potential new therapeutic targets.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2023)
Article
Behavioral Sciences
Bulent Guven, Asli Ece Cilliler
Summary: Approximately half of patients with HS-MTLE had headaches, with about one third reporting migraine type headaches. This highlights the potential pathogenetic role of HS in the development of headaches, especially migraines, in patients with epilepsy. Further studies are necessary to determine if accompanying headaches, particularly migraine attacks, could be determining factors for HS-MTLE, and if they have a lateralizing value for HS.
EPILEPSY & BEHAVIOR
(2021)
Article
Pharmacology & Pharmacy
Soumil Dey, Aparna Banerjee Dixit, Manjari Tripathi, Ramesh Sharanappa Doddamani, Mehar Chand Sharma, Sanjeev Lalwani, Poodipedi Sarat Chandra, Jyotirmoy Banerjee
Summary: The study identified that levels of kynurenic acid were reduced and quinolinic acid levels were raised in the hippocampus of patients with MTLE-HS, along with abnormal glutamatergic activities. Altered metabolism of tryptophan-kynurenine pathway metabolites in the hippocampus could contribute to hyperglutamatergic tone in patients with MTLE-HS.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoyu Wang, Xiaoting Luo, Haitao Pan, Xiaoyang Wang, Shangwen Xu, Hui Li, Zhiping Lin
Summary: Hippocampal radiomics models based on T2-FLAIR images can aid in the diagnosis of MTLE with HS, serving as biological markers for MTLE diagnosis.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Clinical Neurology
Margaux Cheval, Marion Houot, Nathalie Chastan, William Szurhaj, Cecile Marchal, Helene Catenoix, Luc Valton, Martine Gavaret, Bastien Herlin, Arnaud Biraben, Stanislas Lagarde, Laure Mazzola, Lorella Minotti, Louis Maillard, Sophie Dupont
Summary: This study investigated the clinical factors associated with seizure freedom in medically treated MTLE-HS patients and developed a machine-learning classifier to identify these patients earlier. The results showed that these seizure-free patients had different clinical characteristics compared to drug-resistant MTLE-HS patients. The classifier built with clinical data accurately identified these patients, which could individualize the management of MTLE-HS patients according to their expected pharmacosensitivity.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Shengkun Yu, Yifei Gu, Tianyu Wang, Long Mu, Haiyang Wang, Shi Yan, Aoweng Wang, Jiabin Wang, Li Liu, Hong Shen, Meng Na, Zhiguo Lin
Summary: This study revealed the molecular mechanisms of neuronal apoptosis in hippocampal sclerosis of intractable temporal lobe epilepsy patients through RNA sequencing and ceRNA network analysis, establishing a ceRNA network of lncRNA-mediated neuronal apoptosis in HS-TLE.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Izumi Itabashi, Kazutaka Jin, Shiho Sato, Hiroyoshi Suzuki, Masaki Iwasaki, Yu Kitazawa, Yosuke Kakisaka, Nobukazu Nakasato
Summary: The study aimed to investigate whether scalp EEG findings during seizures can indicate purely hippocampal epileptogenicity in mTLE patients with hippocampal sclerosis. It was found that the ID-DT pattern on ictal EEG suggests a higher likelihood of becoming seizure-free after surgery, particularly selective amygdalohippocampectomy (SelAH). The results are significant in guiding treatment decisions for mTLE patients with hippocampal sclerosis.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Laura Fischbach, Tobias Bauer, Kersten Diers, Juri-Alexander Witt, Mar Brugues, Valeri Borger, Martin Schidlowski, Attila Racz, Tobias Baumgartner, Randi von Wrede, Daniel Paech, Bernd Weber, Alexander Radbruch, Hartmut Vatter, Albert J. Becker, Hans-Juergen Huppertz, Christoph Helmstaedter, Rainer Surges, Martin Reuter, Theodor Rueber
Summary: Hippocampal volumetry is limited in detecting subtle alterations in hippocampal morphometry. A geometry-based tool that enables point-wise morphometric analysis based on the hippocampus' intrinsic coordinate system is established and applied. Point-wise analysis reveals structural alterations associated with histological underpinnings and the neuropsychological profile of mesial temporal lobe epilepsy (mTLE) that are not measurable by volumetry. This highlights the clinical potential of point-wise measures of hippocampal morphometry.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Anaclara Prada Jardim, Jeana Torres Corso Duarte, Carmen Lucia Penteado Lancellotti, Henrique Carrete Jr, Ricardo Silva Centeno, Carla Alessandra Scorza, Esper Abrao Cavalheiro, Mirian Salvadori Bittar Guaranha, Elza Marcia Targas Yacubian
Summary: This study characterized a 10-year series of MTLE patients with unilateral hippocampal sclerosis, identifying an association between GCD and hippocampal neuronal loss. Patients with HS Type 1 had better surgical outcomes.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2021)
Article
Health Care Sciences & Services
Sung Chul Lim, Juhee Oh, Bo Young Hong, Seong Hoon Lim
Summary: Temporal lobe epilepsy (TLE) is a network disorder of the brain, characterized by hippocampal dysfunction. This study found significant changes in the volumes of the amygdala, hippocampus, and thalamus in patients with left TLE and hippocampal sclerosis (HS), while no abnormal diffusion properties associated with volume reduction were found in specific brain regions of patients with right TLE and HS.
Article
Clinical Neurology
Giorgi Kuchukhidze, Iris Unterberger, Elisabeth Schmid, Laura Zamarian, Christian Michael Siedentopf, Florian Koppelstaetter, Elke Gizewski, Martin Kronbichler, Gerhard Luef, Hennric Jokeit, Eugen Trinka
Summary: In this study, we found that unilateral mesial TLE and ipsilateral AE could lead to dysfunction in emotion recognition. Patients with right-side mTLE had more impaired perception and recognition of emotions compared to those with left-side mTLE. Patients also showed deficits in emotion recognition compared to healthy controls.
FRONTIERS IN NEUROLOGY
(2022)
Editorial Material
Clinical Neurology
Cleiton Formentin, Dayvid Leonardo de Castro Oliveira, Leo Gordiano Matias, Andrei Fernandes Joaquim, Helder Tedeschi, Enrico Ghizoni
Summary: Mesial temporal lobe epilepsy is the most common type of focal epilepsy in young adults and has high success rates with surgical resection. Although postoperative MRI scans showed temporal pole atrophy and potential gliosis, temporopolar amygdalohippocampectomy demonstrated good outcomes in terms of temporal stem preservation, visual outcomes, and memory results.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Hossein Sanjari Moghaddam, Mohammad Hadi Aarabi, Jafar Mehvari-Habibabadi, Roya Sharifpour, Bahram Mohajer, Neda Mohammadi-Mobarakeh, Seyed Sohrab Hashemi-Fesharaki, Kost Elisevich, Mohammad-Reza Nazem-Zadeh
Summary: The study demonstrates distinct patterns of hippocampal subfield atrophy in patients with left and right mesial temporal lobe epilepsy (mTLE), suggesting that the pathophysiology of epileptogenesis in left and right mTLE may be different.
NEUROLOGICAL SCIENCES
(2021)
Article
Cell Biology
Arpna Srivastava, Jyotirmoy Banerjee, Vivek Dubey, Manjari Tripathi, P. Sarat Chandra, M. C. Sharma, Sanjeev Lalwani, Fouzia Siraj, Ramesh Doddamani, Aparna Banerjee Dixit
Summary: HDACs play important roles in epilepsy, and their expression and activity levels are altered in MTLE-HS patients. Understanding HDACs can aid in the development of specific HDAC inhibitors for epilepsy treatment.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Behavioral Sciences
Niyatee Samudra, Eric Armour, Hernan Gonzalez, Danielle Mattingly, Kevin Haas, Pradumna Singh, Hasan Sonmezturk, Martin Gallagher, Angela Crudele, William Nobis, Shilpa Reddy, Monica Jacobs, Joseph M. Aulino, Sarah Bick, Victoria Morgan, Dario Englot, Bassel Abou-Khalil
Summary: By comparing the clinical and neuropsychological characteristics of patients with ATE and MTS, this study identified ATE as a potential etiology of refractory TLE in adults. Female gender, delayed onset of epilepsy, and absence of febrile seizures were frequently observed in ATE patients. Initial imaging often failed to detect ATE, but targeted encephalocele resections resulted in good treatment outcomes.
EPILEPSY & BEHAVIOR
(2023)
Article
Neurosciences
Gunseli Orhun, Figen Esen, Vuslat Yilmaz, Canan Ulusoy, Elif Sanli, Elif Yildirim, Hakan Gurvit, Perihan Ergin Ozcan, Serra Sencer, Nerses Bebek, Erdem Tuzun
Summary: The study investigates whether neurofilament light chain (NFL) and soluble triggering receptor expressed on myeloid cells 2 (sTREM2) could serve as prognostic biomarkers in sepsis-associated encephalopathy (SAE). The results show that serum and cerebrospinal fluid (CSF) levels of sTREM2 and NFL are associated with the severity of cognitive decline in SAE patients.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Ayse Nur Ozdag Acarli, Ayse Deniz Elmali, Nermin Gorkem Sirin, Betul Baykan, Nerses Bebek
Summary: Ictal blinking is a useful lateralizing sign in focal seizures, especially when it is unilateral or asymmetrical. It often appears early in the seizures and is associated with fronto-temporal seizure onset. However, symmetrical blinking does not seem to be valuable in lateralization and localization of focal seizures. Further studies using invasive recordings and periocular electrodes are needed to evaluate the value of blinking in lateralization and localization.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Article
Clinical Neurology
Cem Ismail Kucukali, Busra Sengul, Duygu Gezen-Ak, Erdinc Dursun, Ece Erdag, Gurler Akpinar, Murat Kasap, Zerrin Karaaslan, Nermin Gorkem Sirin, Pinar Tekturk, Betul Baykan, Erdem Tuzun
Summary: A novel neuronal surface antibody to Kv5.1 was identified in patients with treatment-resistant epilepsy of unknown cause, suggesting a potential autoimmune etiology that requires further investigation.
Article
Clinical Neurology
Ebru Nur Vanli Yavuz, Ebru Altindag, Erdem Tuzun, Betul Baykan
Summary: This survey study on the attitudes of neurologists towards autoimmune epilepsy (AE) suggests that there is a relatively high level of awareness and understanding of AE, but there are still some deficiencies. Participants reported a lack of satisfactory guidelines for diagnosis and treatment, as well as widespread laboratory support. In addition, neurologists with less experience and those working outside of training hospitals tend to seek more consultation from experienced clinicians and conduct more detailed investigations.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Emanuele Cerulli Irelli, Enrico Cocchi, Georgia Ramantani, Roberto H. Caraballo, Loretta Giuliano, Tulay Yilmaz, Alessandra Morano, Eleni Panagiotakaki, Francesca F. Operto, Beatriz Gonzalez Giraldez, Katri Silvennoinen, Sara Casciato, Marion Comajuan, Simona Balestrini, Francesco Fortunato, Antonietta Coppola, Giancarlo Di Gennaro, Angelo Labate, Vito Sofia, Gerhard J. Kluger, Dorothee G. A. Kasteleijn-Nolst Trenite, Antonio Gambardella, Betul Baykan, Sanjay M. Sisodiya, Alexis Arzimanoglou, Pasquale Striano, Carlo Di Bonaventura
Summary: This study investigated electrodinical endophenotypes and long-term seizure outcome in patients with eyelid myoclonia with absences (EMA). The results showed that early epilepsy onset was the most relevant prognostic factor for poor treatment response. Additionally, two distinct endophenotypes were identified, EMA-plus and EMA-only, which differed in terms of remission rates and cognitive outcomes.
Article
Clinical Neurology
Kubra Yeni, Zeliha Tulek, Arif Ozer, Aysel Cavusoglu, Gorkem Sirin Inan, Betul Baykan, Nerses Bebek
Summary: This study examined the impact of COVID-19 fear on the quality of life in epilepsy patients, and found that fear increased anxiety and depression, ultimately leading to a decrease in quality of life.
Article
Medicine, Research & Experimental
Serkan Aksu, Tuba Cerrahoglu Sirin, Buse Rahime Hasirci Bayir, Cagri Ulukan, Ahmet Zihni Soyata, Adnan Kurt, Sacit Karamursel, Betul Baykan
Summary: This study found that long-term extended transcranial direct current stimulation (tDCS) can effectively alleviate allodynia symptoms in migraine patients and meet the goals of prophylactic treatment.
Article
Clinical Neurology
Emel Oguz-Akarsu, Baris Salman, Sibel Ugur-Iseri, Betul Baykan
Summary: This article reports a case of a 20-year-old woman with long-lasting bilateral paroxysmal high-voltage slow waves on EEG, which were interrupted by sudden verbal stimuli. Whole exome sequencing revealed potential genetic etiology. This rare manifestation of subclinical periodic discharges terminated by verbal stimuli deserves particular attention.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Article
Clinical Neurology
Emanuele Cerulli Irelli, Enrico Cocchi, Georgia Ramantani, Antonella Riva, Roberto Horacio Caraballo, Alessandra Morano, Loretta Giuliano, Tulay Yilmaz, Eleni Panagiotakaki, Francesca F. Operto, Beatriz Gonzalez Giraldez, Simona Balestrini, Katri Silvennoinen, Sara Casciato, Marion Comajuan, Francesco Fortunato, Anna Teresa Giallonardo, Rimma Gamirova, Antonietta Coppola, Giancarlo Di Gennaro, Angelo Labate, Vito Sofia, Gerhard Josef Kluger, Antonio Gambardella, Dorothee G. A. Kasteleijn-NolstTrenite, Betul Baykan, Sanjay M. Sisodiya, Alexis Arzimanoglou, Pasquale Striano, Carlo Di Bonaventura
Summary: Based on age at epilepsy onset (AEO), this study identified three subtypes of objective epilepsy with eyelid myoclonia (EEM) and analyzed their distinct clinical features. Early onset EEM was associated with higher rates of intellectual disability, antiseizure medication refractoriness, and psychiatric comorbidities, while late onset EEM had the highest proportion of myoclonia involving body regions other than eyelids and generalized tonic-clonic seizures. Intermediate onset EEM had the lowest observed rate of additional findings. Family history of EEM was more frequent in the subtypes with intermediate and late onset. Patients with body-MYO showed higher rates of migraine and generalized tonic-clonic seizures.
Article
Clinical Neurology
Betul Baykan, Silvana Franceschetti, Laura Canafoglia, Gianpiero L. Cavalleri, Roberto Michelucci, Ingrid E. Scheffer
Summary: Familial adult myoclonic epilepsy (FAME) is a under-recognized disorder characterized by cortical myoclonus, generalized tonic-clonic seizures, and additional clinical symptoms, which vary depending on the FAME subtype. FAME is caused by pentanucleotide repeat expansions of intronic TTTCA/TTTTA in different genes.
Article
Immunology
Selen Soylu, Minara Cherkezzade, Ece Akbayir, Hande Yuceer Korkmaz, Gizem Koral, Elif Sanli, Pinar Topaloglu, Vuslat Yilmaz, Erdem Tuzun, Cem Ismail Kucukali
Summary: This study provides additional evidence for the involvement of inflammation in West Syndrome through immunophenotype analysis of peripheral blood. The results show that there are alterations in the proportions of certain immune cells in the peripheral blood of patients, but treatment with synthetic adrenocorticotropic hormone does not have a significant beneficial effect on most immune cells.
IMMUNOLOGY LETTERS
(2023)
Article
Clinical Neurology
Birgul Bastan, Ece Erdag Turgeon, Elif Sanli, Muhammet Duran Bayar, Aysel Busra Sisman, Miray Atacan Yasguclukal, Cem Ismail Kucukali, Erdem Tuzun, Sefer Gunaydin
Summary: This study investigated the presence and clinical impact of neuronal cell surface antibodies in patients with COVID-19 associated AIS. The results showed the existence of neuropil antibodies in COVID-19 patients, which may be associated with AIS and COVID-19. The antigenic targets and potential pathogenic action of these antibodies need further exploration.
NEUROLOGICAL RESEARCH
(2023)
Article
Clinical Neurology
Irem Ilgezdi Kaya, Betuel Baykan
Summary: The ILAE Task Force on Classification released a report in 2015 to clarify the classification of status epilepticus. Non-convulsive status epilepticus (NCSE) was defined as SE without prominent motor symptoms, with or without coma. The increasing evidence in patients, who do not meet the Salzburg Consensus Criteria for NCSE diagnosis of 'NCSE' or 'possible NCSE', but whose clinical and electrophysiological features are still suspicious for NCSE, may pave the way for developing more comprehensive criteria. Therefore, we present here the 'generalized non-reactive alpha activity' in the electroencephalogram (EEG) of an elderly patient with no known epilepsy before, who presented with acute confusional state of unexplained cause, which we suspected as NCSE and managed accordingly with success. Considering that 'time is brain', early and correct NCSE diagnosis is critical and the NCSE EEG criteria should be more inclusive for the patients in the 'grey zone like the one presented here with 'generalized non-reactive alpha activity'.
ARCHIVES OF EPILEPSY
(2023)
Letter
Clinical Neurology
Zerrin Karaaslan, Murat Kurtuncu, Halil Ibrahim Akcay, Tuncay Gunduz, Burcu Altunrende, Recai Turkoglu, Mefkure Eraksoy, Canan Ulusoy, Vuslat Yilmaz, Erdem Tuzun
EUROPEAN NEUROLOGY
(2022)
