Whither digitalis? What we can still learn from cardiotonic steroids about heart failure and hypertension

Fluorescence lifetime imaging microscopy reveals sodium pump dimers in live cells

(2022) Jaroslava Seflova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FXYD proteins and sodium pump regulatory mechanisms

(2021) John Q. Yap et al.   JOURNAL OF GENERAL PHYSIOLOGY

Antihypertensive treatment guided by genetics: PEARL-HT, the randomized proof-of-concept trial comparing rostafuroxin with losartan

(2021) Lorena Citterio et al.   PHARMACOGENOMICS JOURNAL

Quo vadis Cardiac Glycoside Research?

(2021) Jiří Bejček et al.   Toxins

The α2-isoform of the Na+/K+-ATPase protects against pathological remodeling and β-adrenergic desensitization after myocardial infarction

(2021) Antonella Cellini et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Ouabain, endogenous ouabain and ouabain-like factors: The Na+ pump/ouabain receptor, its linkage to NCX, and its myriad functions

(2020) Mordecai P. Blaustein et al.   CELL CALCIUM

Digoxin: Pharmacology and toxicology—A review

(2020) Jiri Patocka et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

SGLT2 inhibitors in patients with heart failure with reduced ejection fraction: a meta-analysis of the EMPEROR-Reduced and DAPA-HF trials

(2020) Faiez Zannad et al.   LANCET

NO-induced vasodilation correlates directly with BP in smooth muscle-Na/Ca exchanger-1-engineered mice: elevated BP does not attenuate endothelial function

(2020) Youhua Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Phospholemman Phosphorylation Regulates Vascular Tone, Blood Pressure and Hypertension in Mice and Man

(2020) Andrii Boguslavskyi et al.   CIRCULATION

Binding of cardiotonic steroids to Na+,K+-ATPase in the E2P state

(2020) Ryuta Kanai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome editing retraces the evolution of toxin resistance in the monarch butterfly

(2019) Marianthi Karageorgi et al.   NATURE

Sodium pumps, ouabain and aldosterone in the brain: A neuromodulatory pathway underlying salt-sensitive hypertension and heart failure

(2019) Frans H.H. Leenen et al.   CELL CALCIUM

Endogenous cardiotonic steroids and cardiovascular disease, where to next?

(2019) Davor Pavlovic   CELL CALCIUM

Prevalent digoxin use and subsequent risk of death or hospitalization in ambulatory heart failure patients with a reduced ejection fraction—Findings from the Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) randomized controlled trial

(2018) Andrew P. Ambrosy et al.   AMERICAN HEART JOURNAL

The pump, the exchanger, and the holy spirit: origins and 40-year evolution of ideas about the ouabain-Na+ pump endocrine system

(2018) Mordecai P. Blaustein   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Integrative Physiological Aspects of Brain RAS in Hypertension

(2018) Sharon D. B. de Morais et al.   CURRENT HYPERTENSION REPORTS

Effect of digoxin in patients with heart failure and mid-range (borderline) left ventricular ejection fraction

(2018) Azmil H. Abdul-Rahim et al.   EUROPEAN JOURNAL OF HEART FAILURE

A Transgenic Mouse Model to Selectively Identify α 3 Na,K-ATPase Expressing Cells in the Nervous System

(2018) Maxim Dobretsov et al.   NEUROSCIENCE

Clinical Use of Digitalis: A State of the Art Review

(2018) Thomas F. Whayne   American Journal of Cardiovascular Drugs

The Transition From Hypertension to Heart Failure

(2017) Franz H. Messerli et al.   JACC-Heart Failure

Update on angiotensin II: new endocrine connections between the brain, adrenal glands and the cardiovascular system

(2017) Frans H H Leenen et al.   Endocrine Connections

Safety of Long-term Treatment With Certolizumab Pegol in Patients With Crohn's Disease, Based on a Pooled Analysis of Data From Clinical Trials

(2016) Edward V. Loftus et al.   Clinical Gastroenterology and Hepatology

In Liddle Syndrome, Epithelial Sodium Channel Is Hyperactive Mainly in the Early Part of the Aldosterone-Sensitive Distal NephronNovelty and Significance

(2016) Viatcheslav Nesterov et al.   HYPERTENSION

Endogenous Ouabain

(2016) John M. Hamlyn et al.   HYPERTENSION

Pivotal role of α2 Na+pumps and their high affinity ouabain binding site in cardiovascular health and disease

(2016) Mordecai P. Blaustein et al.   JOURNAL OF PHYSIOLOGY-LONDON

Letter to the Editor concerning Baecher et al. (Clin Chim Acta 2014;431:87–92)

(2015) Mordecai P. Blaustein   CLINICA CHIMICA ACTA

Digoxin Withdrawal Worsens Clinical Status in Stable Patients With Heart Failure Receiving Optimal Contemporaneous Therapy—A Randomized Controlled Trial

(2015) Ingrid Hopper et al.   JOURNAL OF CARDIAC FAILURE

Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex

(2015) Mette Laursen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous Ouabain: An Old Cardiotonic Steroid as a New Biomarker of Heart Failure and a Predictor of Mortality after Cardiac Surgery

(2015) Marco Simonini et al.   Biomed Research International

No endogenous ouabain is detectable in human plasma by ultra-sensitive UPLC-MS/MS

(2014) Silvia Baecher et al.   CLINICA CHIMICA ACTA

Digoxin-specific antibody fragments in the treatment of digoxin toxicity

(2014) B. S. H. Chan et al.   CLINICAL TOXICOLOGY

A perspective on re-evaluating digoxin's role in the current management of patients with chronic systolic heart failure: targeting serum concentration to reduce hospitalization and improve safety profile

(2014) Kirkwood F. Adams et al.   EUROPEAN JOURNAL OF HEART FAILURE

Neuroendocrine Humoral and Vascular Components in the Pressor Pathway for Brain Angiotensin II: A New Axis in Long Term Blood Pressure Control

(2014) John M. Hamlyn et al.   PLoS One

Digoxin antibody fragment, antigen binding (Fab), treatment of preeclampsia in women with endogenous digitalis-like factor: a secondary analysis of the DEEP Trial

(2013) Garrett K. Lam et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Knockout of the Na,K-ATPase α2-isoform in cardiac myocytes delays pressure overload-induced cardiac dysfunction

(2013) Tara N. Rindler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Quantification of Cardiomyocyte Hypertrophy by Cardiac Magnetic Resonance

(2013) Otavio R. Coelho-Filho et al.   CIRCULATION

Overexpression of the Na + /K + ATPase α2 But Not α1 Isoform Attenuates Pathological Cardiac Hypertrophy and Remodeling

(2013) Robert N. Correll et al.   CIRCULATION RESEARCH

Preoperative Endogenous Ouabain Predicts Acute Kidney Injury in Cardiac Surgery Patients*

(2013) Elena Bignami et al.   CRITICAL CARE MEDICINE

Calcium oscillations triggered by cardiotonic steroids

(2013) Jacopo M. Fontana et al.   FEBS Journal

Rostafuroxin ameliorates endothelial dysfunction and oxidative stress in resistance arteries from deoxycorticosterone acetate-salt hypertensive rats

(2013) Camilla F. Wenceslau et al.   JOURNAL OF HYPERTENSION

Novel regulation of cardiac Na pump via phospholemman

(2013) Davor Pavlovic et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ouabain-digoxin antagonism in rat arteries and neurones

(2013) Hong Song et al.   JOURNAL OF PHYSIOLOGY-LONDON

Activation of c-SRC underlies the differential effects of ouabain and digoxin on Ca2+ signaling in arterial smooth muscle cells

(2012) Alessandra Zulian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Nanomolar ouabain increases NCX1 expression and enhances Ca2+ signaling in human arterial myocytes: a mechanism that links salt to increased vascular resistance?

(2012) Cristina I. Linde et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Serendipitous discovery of a novel protein signaling mechanism in heart failure

(2012) Andrea M. Vitello et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Salt-Induced Hypertension in a Mouse Model of Liddle Syndrome Is Mediated by Epithelial Sodium Channels in the Brain

(2012) James W. Van Huysse et al.   HYPERTENSION

Endogenous ouabain regulates cell viability

(2011) Moran Dvela et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Knockout of the Na,K-ATPase α2-isoform in the cardiovascular system does not alter basal blood pressure but prevents ACTH-induced hypertension

(2011) Tara N. Rindler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Hypertension from chronic central sodium chloride in mice is mediated by the ouabain-binding site on the Na,K-ATPase α2-isoform

(2011) James W. Van Huysse et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Ouabain increases iNOS-dependent nitric oxide generation which contributes to the hypertrophic effect of the glycoside: possible role of peroxynitrite formation

(2011) Xiaohong Tracey Gan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Central regulation of blood pressure by the mineralocorticoid receptor

(2011) Elise P. Gomez-Sanchez et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A poisonous surprise under the coat of the African crested rat

(2011) J. Kingdon et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Role of phospholemman phosphorylation sites in mediating kinase-dependent regulation of the Na+-K+-ATPase

(2010) Fei Han et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mice expressing ouabain-sensitive α1-Na,K-ATPase have increased susceptibility to pressure overload-induced cardiac hypertrophy

(2010) Arshani N. Wansapura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The central role of the brain aldosterone–“ouabain” pathway in salt-sensitive hypertension

(2010) Frans H.H. Leenen   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ouabain attenuates cardiotoxicity induced by other cardiac steroids

(2010) M Nesher et al.   BRITISH JOURNAL OF PHARMACOLOGY

Physiological roles of endogenous ouabain in normal rats

(2009) Maoz Nesher et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Brain renin–angiotensin–aldosterone system and ventricular remodeling after myocardial infarct: a reviewThis article is one of a selection of papers published in a special issue on Advances in Cardiovascular Research.

(2009) Katherine V. Westcott et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Aldosterone synthesis in the brain contributes to Dahl salt-sensitive rat hypertension

(2009) Elise P. Gomez-Sanchez et al.   EXPERIMENTAL PHYSIOLOGY

Isoform Specificity of the Na/K-ATPase Association and Regulation by Phospholemman

(2009) Julie Bossuyt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The hemodynamic effects of intravenous digoxin-binding fab immunoglobulin in severe preeclampsia: a double-blind, randomized, clinical trial

(2009) C D Adair et al.   Journal of Perinatology

Effectiveness of Digoxin in Reducing One-Year Mortality in Chronic Heart Failure in the Digitalis Investigation Group Trial

(2008) Ali Ahmed et al.   AMERICAN JOURNAL OF CARDIOLOGY