Article
Psychiatry
Kristina M. Deligiannidis, Samantha Meltzer-Brody, Bassem Maximos, E. Quinn Peeper, Marlene Freeman, Robert Lasser, Amy Bullock, Mona Kotecha, Sigui Li, Fiona Forrestal, Nilanjana Rana, Manny Garcia, Bridgette Leclair, James Doherty
Summary: This study investigated the efficacy and safety of Zuranolone, a positive allosteric modulator of GABAA receptors, as an oral treatment for severe postpartum depression. The results demonstrated significant improvements in depressive symptoms and a good tolerability profile for Zuranolone.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychology, Clinical
Kristina M. Deligiannidis, Leslie Citrome, Ming-Yi Huang, Sarah Acaster, Moshe Fridman, Vijayveer Bonthapally, Robert Lasser, Stephen J. Kanes
Summary: Concurrent anxiety and insomnia symptoms in women with postpartum depression (PPD) are common and associated with more severe PPD. The ROBIN study explored the effects of Zuranolone on these symptoms and patient-perceived functional health in women with PPD. The results showed that Zuranolone can improve anxiety and depressive symptoms, as well as insomnia symptoms and patient-perceived functional health.
JOURNAL OF CLINICAL PSYCHIATRY
(2023)
Article
Psychiatry
Kristina M. Deligiannidis, Samantha Meltzer-Brody, Handan Gunduz-Bruce, James Doherty, Jeffrey Jonas, Sigui Li, Abdul J. Sankoh, Christopher Silber, Andrew D. Campbell, Brian Werneburg, Stephen J. Kanes, Robert Lasser
Summary: Zuranolone demonstrated significant improvements in core symptoms of depression in women with postpartum depression (PPD) and was generally well tolerated, supporting further development of zuranolone as a treatment for PPD.
Article
Psychology, Clinical
Kewei Wang, Jun Qiu, Liping Meng, Xin Lai, Zhenzhen Yao, Songxu Peng
Summary: This study explores the relationship between postpartum hemorrhage (PPH) and postpartum depressive symptoms and finds that PPH increases the risk of postpartum depressive symptoms. Therefore, it is recommended to actively screen women with PPH for postpartum depressive symptoms.
DEPRESSION AND ANXIETY
(2022)
Article
Psychiatry
Michele L. Okun, Andrew Lac
Summary: Insomnia and poor sleep quality during the perinatal period are common and are associated with increased risk of postpartum depression and anxiety. Evaluating and addressing sleep disturbances during the perinatal period may help reduce the risk of postpartum mood disorders and improve overall health outcomes.
PSYCHOSOMATIC MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Kylie N. Barnes, Claire M. Vogl, Leigh Anne Nelson
Summary: This study reviewed the characteristics, efficacy, and safety of zuranolone in the management of postpartum depression (PPD). Two phase III trials showed statistically significant improvement in depressive symptoms with zuranolone treatment for moderate to severe PPD. Common side effects included somnolence, dizziness, headache, and sedation. Zuranolone, approved by the FDA as the second medication for PPD, offers the advantage of oral administration in the outpatient setting. However, limited information is available on its safety during lactation.
ANNALS OF PHARMACOTHERAPY
(2023)
Article
Clinical Neurology
Yun Ho Choi, Kwang Ik Yang, Chang-Ho Yun, Won-Joo Kim, Kyoung Heo, Min Kyung Chu
Summary: This study found that participants with insomnia symptoms had a higher prevalence of depressive symptoms, while participants with depressive symptoms also had a higher prevalence of insomnia symptoms. Additionally, participants with both depressive and insomnia symptoms showed higher severity in both conditions.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Jennifer N. Felder, Elissa S. Epel, John Neuhaus, Andrew D. Krystal, Aric A. Prather
Summary: The study examines the effects of digital cognitive behavior therapy for insomnia (dCBT-I) during pregnancy on subjective sleep outcomes, depressive symptoms, and anxiety symptoms. The findings suggest that dCBT-I can improve postpartum insomnia remission rates and reduce the incidence of insomnia. Additionally, dCBT-I shows significant improvements in depressive and anxiety symptom severity, particularly among patients with minimal depressive symptoms at baseline.
Article
Medicine, General & Internal
Sumin Hong, Seolmin Kim, Doo Heum Park, Seung Ho Ryu, Jee Hyun Ha, Hong Jun Jeon
Summary: Depressive symptoms and insomnia are common in patients with panic disorder. Insomnia partially mediates the development of depression in these patients. Intervention for insomnia in patients with panic disorder may help prevent depression.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Clinical Neurology
Helen Bradshaw, Julia N. Riddle, Rodion Salimgaraev, Liudmila Zhaunova, Jennifer L. Payne
Summary: This study aimed to evaluate the association between maternal age, parity, gestational number, newborn gender and postpartum depressive symptoms. The results showed that postpartum depressive symptoms decreased with advancing age. First-time mothers reported higher rates of depressive symptoms. Twin births were associated with a higher symptom burden than singleton births, and mothers of twins in the oldest age group reported the greatest burden. There was no clinically significant difference in rates of depressive symptoms between mothers of singleton girls and boys.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Yifan Zhang, Yunge Fan, Zijuan Ma, Dongfang Wang, Fang Fan
Summary: This study aimed to evaluate the associations of social jetlag and insomnia symptoms with depressive symptoms among adolescents. The prevalence of depressive symptoms was 13.1%, and they were more common in adolescents with social jetlag >= 2 h and insomnia symptoms. The study also found a positive additive interaction of social jetlag >= 2 h and insomnia symptoms on depressive symptoms in female adolescents.
Article
Clinical Neurology
Yanyun Yang, Xianchen Liu, Zhen-Zhen Liu, Jenn-Yun Tein, Cun-Xian Jia
Summary: This longitudinal study explored the associations between life stress, insomnia, and anxiety/depressive symptoms (ADS) in a large sample of adolescents. The results showed that the prevalence and persistence rates of insomnia and ADS significantly increased with elevated life stress score. Cross-lagged panel analysis revealed bidirectional relationships between life stress, insomnia, and ADS over time, with insomnia partially mediating the relationship between life stress and ADS, and vice versa. These findings highlight the importance of assessing and intervening in sleep and mental health among adolescents following life stress.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Medicine, General & Internal
Marcin Sochal, Alicja Witkowska, Agata Binienda, Agata Gabryelska, Piotr Bialasiewicz, Jakub Fichna, Renata Talar-Wojnarowska, Ewa Malecka-Wojciesko
Summary: The study investigates the impact of the serotonergic pathway on the pathogenesis and course of inflammatory bowel diseases (IBDs), and its relationship with sleep and mood disorders. The results show that patients with active IBD have higher levels of 5-HT and SERT protein expression, which are positively correlated with insomnia severity. After treatment, only 5-HT levels are decreased.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Psychiatry
Ewa Drozdowicz-Jastrzebska, Anna Mach, Michal Skalski, Piotr Januszko, Zoulikha Jabiry-Zieniewicz, Marcin Siwek, Zbigniew Maciej Wawrzyniak, Maria Radziwon-Zaleska
Summary: This study found a relationship between anxiety, insomnia, and postpartum depression. Assessing anxiety symptoms and sleep quality is important in screening women at risk of postpartum depression. Additionally, divorced and single women were shown to be at higher risk of postpartum depression.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Hailey Meaklim, William J. Saunders, Michelle L. Byrne, Moira F. Junge, Prerna Varma, Wendy A. Finck, Melinda L. Jackson
Summary: This study aimed to examine whether individuals with insomnia symptoms early in the pandemic were more vulnerable to anxiety and depressive symptoms over time compared to those with normal sleep. The results showed that both pre-existing and new-onset insomnia predicted persistent anxiety and depressive symptoms, surpassing other known risk factors. Pre-sleep arousal increased the risk of clinically significant anxiety, while dysfunctional sleep-related beliefs and attitudes predicted clinically significant depression.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
