Retinal glial responses to optic nerve crush are attenuated in Bax-deficient mice and modulated by purinergic signaling pathways

Toll-like receptor-4 knockout mice are more resistant to optic nerve crush damage than wild-type mice

(2015) Dana Morzaev et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system

(2015) Elly M Hol et al.   CURRENT OPINION IN CELL BIOLOGY

Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma

(2015) A. Bosco et al.   Disease Models & Mechanisms

Tools and resources for analyzing gene expression changes in glaucomatous neurodegeneration

(2015) Robert W. Nickells et al.   EXPERIMENTAL EYE RESEARCH

Transient activation of microglia following acute alcohol exposure in developing mouse neocortex is primarily driven by BAX-dependent neurodegeneration

(2015) Katelin E. Ahlers et al.   GLIA

Understanding the role of P2X7 in affective disorders—are glial cells the major players?

(2015) Leanne Stokes et al.   Frontiers in Cellular Neuroscience

Ionotropic purinergic receptors P2X in frog and turtle retina: Glial and neuronal localization

(2014) Lily Alexandrova Vitanova et al.   ACTA HISTOCHEMICA

Nestin, A New Marker, Expressed in Müller Cells Following Retinal Injury

(2014) Liping Xue et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Mechanosensitive release of adenosine 5′-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: A mechanism for purinergic involvement in chronic strain

(2014) Jonathan M. Beckel et al.   GLIA

Tumor necrosis factor alpha has an early protective effect on retinal ganglion cells after optic nerve crush

(2014) Caitlin E Mac Nair et al.   Journal of Neuroinflammation

Müller glial cell reprogramming and retina regeneration

(2014) Daniel Goldman   NATURE REVIEWS NEUROSCIENCE

Brilliant blue G treatment facilitates regeneration after optic nerve injury in the adult rat

(2014) Mikael Ridderström et al.   NEUROREPORT

Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits

(2014) Milos Pekny et al.   PHYSIOLOGICAL REVIEWS

The Complex Role of Neuroinflammation in Glaucoma

(2014) I. Soto et al.   Cold Spring Harbor Perspectives in Medicine

DAMP-Mediated Activation of NLRP3-Inflammasome in Brain Sterile Inflammation: The Fine Line between Healing and Neurodegeneration

(2014) Anna Rubartelli   Frontiers in Immunology

Muller Glia in Retinal Innate Immunity: A Perspective on Their Roles in Endophthalmitis

(2013) Ashok Kumar et al.   CRITICAL REVIEWS IN IMMUNOLOGY

From Mechanosensitivity to Inflammatory Responses: New Players in the Pathology of Glaucoma

(2013) David Križaj et al.   CURRENT EYE RESEARCH

The eye: A window to the soul of the immune system

(2013) V.L. Perez et al.   JOURNAL OF AUTOIMMUNITY

The Time Course of Gene Expression during Reactive Gliosis in the Optic Nerve

(2013) Juan Qu et al.   PLoS One

Functional diversity of microglia – how heterogeneous are they to begin with?

(2013) Uwe-Karsten Hanisch   Frontiers in Cellular Neuroscience

Under Pressure: Cellular and Molecular Responses During Glaucoma, a Common Neurodegeneration with Axonopathy

(2012) Robert W. Nickells et al.   Annual Review of Neuroscience

Toll-like receptor 9 activation: a novel mechanism linking placenta-derived mitochondrial DNA and vascular dysfunction in pre-eclampsia

(2012) Styliani Goulopoulou et al.   CLINICAL SCIENCE

ATP-P2X7 receptor signaling controls basal and TNFα-stimulated glial cell proliferation

(2012) Jian Zou et al.   GLIA

Pannexin 1, an ATP Release Channel, Is Activated by Caspase Cleavage of Its Pore-associated C-terminal Autoinhibitory Region

(2012) Joanna K. Sandilos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurons respond directly to mechanical deformation with pannexin-mediated ATP release and autostimulation of P2X7receptors

(2012) Jingsheng Xia et al.   JOURNAL OF PHYSIOLOGY-LONDON

Genetic Ablation of Pannexin1 Protects Retinal Neurons from Ischemic Injury

(2012) Galina Dvoriantchikova et al.   PLoS One

Etanercept, a Widely Used Inhibitor of Tumor Necrosis Factor-α (TNF- α), Prevents Retinal Ganglion Cell Loss in a Rat Model of Glaucoma

(2012) Miin Roh et al.   PLoS One

Pathophysiology of astroglial purinergic signalling

(2012) Heike Franke et al.   Purinergic Signalling

TLR9 Ligand CpG-ODN Applied to the Injured Mouse Cornea Elicits Retinal Inflammation

(2011) Holly R. Chinnery et al.   AMERICAN JOURNAL OF PATHOLOGY

Purinergic regulation of high-glucose-induced caspase-1 activation in the rat retinal Müller cell line rMC-1

(2011) Katherine E. Trueblood et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Sustained elevation of extracellular ATP in aqueous humor from humans with primary chronic angle-closure glaucoma

(2011) Ang Li et al.   EXPERIMENTAL EYE RESEARCH

Chronic Swelling and Abnormal Myelination during Secondary Degeneration after Partial Injury to a Central Nervous System Tract

(2011) Sophie C. Payne et al.   JOURNAL OF NEUROTRAUMA

Glaucoma

(2011) Harry A Quigley   LANCET

A Single Nucleotide Polymorphism in the Bax Gene Promoter Affects Transcription and Influences Retinal Ganglion Cell Death

(2010) Sheila J Semaan et al.   ASN Neuro

Histone H4 deacetylation plays a critical role in early gene silencing during neuronal apoptosis

(2010) Heather R. Pelzel et al.   BMC NEUROSCIENCE

Stimulation of the P2X7 receptor kills rat retinal ganglion cells in vivo

(2010) Huiling Hu et al.   EXPERIMENTAL EYE RESEARCH

What has gene expression profiling taught us about glaucoma?

(2010) Zhiyong Yang et al.   EXPERIMENTAL EYE RESEARCH

Early microglia activation in a mouse model of chronic glaucoma

(2010) Alejandra Bosco et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The role of nucleotides in apoptotic cell clearance: implications for disease pathogenesis

(2010) Faraaz B. Chekeni et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

(2010) Faraaz B. Chekeni et al.   NATURE

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Detection of early neuron degeneration and accompanying glial responses in the visual pathway in a rat model of acute intraocular hypertension

(2009) ShaoDan Zhang et al.   BRAIN RESEARCH

Maintenance of the relative proportion of oligodendrocytes to axons even in the absence of BAX and BAK

(2009) Kumi Kawai et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Mechanism of retinal ganglion cells death in secondary degeneration of the optic nerve

(2009) Hani Levkovitch-Verbin et al.   EXPERIMENTAL EYE RESEARCH

Excitotoxic Death of Retinal Neurons In Vivo Occurs via a Non-Cell-Autonomous Mechanism

(2009) F. Lebrun-Julien et al.   JOURNAL OF NEUROSCIENCE

The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore

(2009) M. Monif et al.   JOURNAL OF NEUROSCIENCE

Early Events of Secondary Degeneration after Partial Optic Nerve Transection: An Immunohistochemical Study

(2009) Melinda Fitzgerald et al.   JOURNAL OF NEUROTRAUMA

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Secondary degeneration of the optic nerve following partial transection: The benefits of lomerizine

(2008) Melinda Fitzgerald et al.   EXPERIMENTAL NEUROLOGY

Cellular tropism and transduction properties of seven adeno-associated viral vector serotypes in adult retina after intravitreal injection

(2008) M Hellström et al.   GENE THERAPY

Elevated pressure triggers a physiological release of ATP from the retina: Possible role for pannexin hemichannels

(2008) D. Reigada et al.   NEUROSCIENCE