A novel antagonist of p75NTR reduces peripheral expansion and CNS trafficking of pro-inflammatory monocytes and spares function after traumatic brain injury

A novel inhibitor of p75-neurotrophin receptor improves functional outcomes in two models of traumatic brain injury

(2016) Sandrine Delbary-Gossart et al.   BRAIN

Granzymes Regulate Proinflammatory Cytokine Responses

(2015) Annette C. Wensink et al.   JOURNAL OF IMMUNOLOGY

DAMP Signaling is a Key Pathway Inducing Immune Modulation after Brain Injury

(2015) A. Liesz et al.   JOURNAL OF NEUROSCIENCE

CCR2 Antagonism Alters Brain Macrophage Polarization and Ameliorates Cognitive Dysfunction Induced by Traumatic Brain Injury

(2015) J. M. Morganti et al.   JOURNAL OF NEUROSCIENCE

Long-Term Consequences of Traumatic Brain Injury: Current Status of Potential Mechanisms of Injury and Neurological Outcomes

(2015) Helen M. Bramlett et al.   JOURNAL OF NEUROTRAUMA

Proneurotrophin Binding to P75 Neurotrophin Receptor (P75ntr) Is Essential for Brain Lesion Formation and Functional Impairment after Experimental Traumatic Brain Injury

(2015) Anne Sebastiani et al.   JOURNAL OF NEUROTRAUMA

Nuclear pore complex remodeling by p75NTR cleavage controls TGF-β signaling and astrocyte functions

(2015) Christian Schachtrup et al.   NATURE NEUROSCIENCE

The paradox of chronic neuroinflammation, systemic immune suppression, autoimmunity after traumatic chronic spinal cord injury

(2014) Jan M. Schwab et al.   EXPERIMENTAL NEUROLOGY

Dynamic Nature of the p75 Neurotrophin Receptor in Response to Injury and Disease

(2014) Rick Meeker et al.   Journal of Neuroimmune Pharmacology

CCR2 Deficiency Impairs Macrophage Infiltration and Improves Cognitive Function after Traumatic Brain Injury

(2014) Christine L. Hsieh et al.   JOURNAL OF NEUROTRAUMA

Diffusion Tensor Imaging for Outcome Prediction in Mild Traumatic Brain Injury: A TRACK-TBI Study

(2014) Esther L. Yuh et al.   JOURNAL OF NEUROTRAUMA

CCR2 Gene Deletion and Pharmacologic Blockade Ameliorate a Severe Murine Experimental Autoimmune Neuritis Model of Guillain-Barré Syndrome

(2014) Furong Yuan et al.   PLoS One

Genkwanin Inhibits Proinflammatory Mediators Mainly through the Regulation of miR-101/MKP-1/MAPK Pathway in LPS-Activated Macrophages

(2014) Yuan Gao et al.   PLoS One

The Irvine, Beatties, and Bresnahan (IBB) Forelimb Recovery Scale: An Assessment of Reliability and Validity

(2014) Karen-Amanda Irvine et al.   Frontiers in Neurology

Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells

(2013) Hannah Gola et al.   BMC Psychiatry

Inflammation and white matter degeneration persist for years after a single traumatic brain injury

(2013) Victoria E. Johnson et al.   BRAIN

Traumatic Injury to the Immature Frontal Lobe: A New Murine Model of Long-Term Motor Impairment in the Absence of Psychosocial or Cognitive Deficits

(2013) Chien-Yi Chen et al.   DEVELOPMENTAL NEUROSCIENCE

Traumatic brain injury induces macrophage subsets in the brain

(2013) Christine L. Hsieh et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Combined SCI and TBI: Recovery of forelimb function after unilateral cervical spinal cord injury (SCI) is retarded by contralateral traumatic brain injury (TBI), and ipsilateral TBI balances the effects of SCI on paw placement

(2013) Tomoo Inoue et al.   EXPERIMENTAL NEUROLOGY

Extracellular cleavage of the p75 neurotrophin receptor is implicated in its pro-survival effect in breast cancer cells

(2013) Stéphanie Verbeke et al.   FEBS LETTERS

Inhibition of Endogenous Activated Protein C Attenuates Experimental Autoimmune Encephalomyelitis by Inducing Myeloid-Derived Suppressor Cells

(2013) L. M. Alabanza et al.   JOURNAL OF IMMUNOLOGY

Involvement of NT3 and P75NTR in photoreceptor degeneration following selective Müller cell ablation

(2013) Weiyong Shen et al.   Journal of Neuroinflammation

Oral Administration of a Small Molecule Targeted to Block proNGF Binding to p75 Promotes Myelin Sparing and Functional Recovery after Spinal Cord Injury

(2013) C. Tep et al.   JOURNAL OF NEUROSCIENCE

Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot: Multicenter Implementation of the Common Data Elements for Traumatic Brain Injury

(2013) John K. Yue et al.   JOURNAL OF NEUROTRAUMA

Traumatic brain injury–induced alterations in peripheral immunity

(2013) Steven J. Schwulst et al.   Journal of Trauma and Acute Care Surgery

Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease

(2013) Frank M. Longo et al.   NATURE REVIEWS DRUG DISCOVERY

Clinical targeting of the TNF and TNFR superfamilies

(2013) Michael Croft et al.   NATURE REVIEWS DRUG DISCOVERY

Interleukin-1β enhances neuronal vulnerability to proNGF-mediated apoptosis by increasing surface expression of p75NTR and sortillin

(2013) S. Choi et al.   NEUROSCIENCE

A small molecule p75NTRligand protects neurogenesis after traumatic brain injury

(2013) Jian Shi et al.   STEM CELLS

Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease

(2013) Sheila M. Fleming et al.   Jove-Journal of Visualized Experiments

Magnetic resonance imaging improves 3-month outcome prediction in mild traumatic brain injury

(2012) Esther L. Yuh et al.   ANNALS OF NEUROLOGY

Inflammatory Monocytes Are Critical for Induction of a Polysaccharide-Specific Antibody Response to an Intact Bacterium

(2012) Q. Chen et al.   JOURNAL OF IMMUNOLOGY

Ly6C+Ly6G−Myeloid-derived suppressor cells play a critical role in the resolution of acute inflammation and the subsequent tissue repair process after spinal cord injury

(2012) Hirokazu Saiwai et al.   JOURNAL OF NEUROCHEMISTRY

Inflammatory monocytes and the pathogenesis of viral encephalitis

(2012) Rachael L Terry et al.   Journal of Neuroinflammation

The Neuropathology and Neurobiology of Traumatic Brain Injury

(2012) Kaj Blennow et al.   NEURON

p75 neurotrophin receptor signaling in nervous system injury and degeneration: paradox and opportunity

(2012) Carlos F. Ibáñez et al.   TRENDS IN NEUROSCIENCES

Inflammation after trauma: Microglial activation and traumatic brain injury

(2011) Anil F. Ramlackhansingh et al.   ANNALS OF NEUROLOGY

Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?

(2011) Sune Skeldal et al.   BIOESSAYS

Long-lasting protection in brain trauma by endotoxin preconditioning

(2011) Luca Longhi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tissue inhibitor of metalloproteinases-3 mediates the death of immature oligodendrocytes via TNF-α/TACE in focal cerebral ischemia in mice

(2011) Yi Yang et al.   Journal of Neuroinflammation

Matrix Metalloproteinase-9 and Stromal Cell-Derived Factor-1 Act Synergistically to Support Migration of Blood-Borne Monocytes into the Injured Spinal Cord

(2011) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

Prevention of Both Neutrophil and Monocyte Recruitment Promotes Recovery after Spinal Cord Injury

(2011) Sang Mi Lee et al.   JOURNAL OF NEUROTRAUMA

Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells

(2011) E Gardiner et al.   MOLECULAR PSYCHIATRY

A Novel Method for Assessing Proximal and Distal Forelimb Function in the Rat: the Irvine, Beatties and Bresnahan (IBB) Forelimb Scale

(2011) Karen-Amanda Irvine et al.   Jove-Journal of Visualized Experiments

Contribution of systemic inflammation to chronic neurodegeneration

(2010) V. Hugh Perry   ACTA NEUROPATHOLOGICA

Posttraumatic epilepsy

(2010) Irina Kharatishvili et al.   CURRENT OPINION IN NEUROLOGY

AMPA-receptor trafficking and injury-induced cell death

(2010) Michael S. Beattie et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

CD271 antigen defines a subset of multipotent stromal cells with immunosuppressive and lymphohematopoietic engraftment-promoting properties

(2010) S. Kuci et al.   HAEMATOLOGICA

Role of CCL2 (MCP-1) in Traumatic Brain Injury (TBI): Evidence from Severe TBI Patients and CCL2−/− Mice

(2010) Bridgette D Semple et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

ProNGF mediates death of Natural Killer cells through activation of the p75NTR–sortilin complex

(2010) Mary-Louise Rogers et al.   JOURNAL OF NEUROIMMUNOLOGY

Deficiency of the chemokine receptor CXCR2 attenuates neutrophil infiltration and cortical damage following closed head injury

(2010) Bridgette D. Semple et al.   NEUROBIOLOGY OF DISEASE

Selective Chemokine Receptor Usage by Central Nervous System Myeloid Cells in CCR2-Red Fluorescent Protein Knock-In Mice

(2010) Noah Saederup et al.   PLoS One

Inflammatory Cytokines IL-1β and TNF-α Regulate p75NTR Expression in CNS Neurons and Astrocytes by Distinct Cell-Type-Specific Signalling Mechanisms

(2009) Soyoung Choi et al.   ASN Neuro

Maternal separation decreases the stability of mushroom spines in adult mice somatosensory cortex

(2009) Yusuke Takatsuru et al.   BRAIN RESEARCH

The adhesive removal test: a sensitive method to assess sensorimotor deficits in mice

(2009) Valentine Bouet et al.   Nature Protocols

Integrin α9β1 is a receptor for nerve growth factor and other neurotrophins

(2008) Izabela Staniszewska et al.   JOURNAL OF CELL SCIENCE

Induction of Proneurotrophins and Activation of p75NTR-Mediated Apoptosis via Neurotrophin Receptor-Interacting Factor in Hippocampal Neurons after Seizures

(2008) M. Volosin et al.   JOURNAL OF NEUROSCIENCE

The p75 neurotrophin receptor

(2007) Clare K. Underwood et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

TLR4 signaling induces functional nerve growth factor receptor p75NTR on mouse dendritic cells via p38MAPK and NF-κB pathways

(2007) Yingming Jiang et al.   MOLECULAR IMMUNOLOGY