Article
Radiology, Nuclear Medicine & Medical Imaging
Mika Naganawa, Songye Li, Nabeel Nabulsi, Shannan Henry, Ming-Qiang Zheng, Richard Pracitto, Zhengxin Cai, Hong Gao, Michael Kapinos, David Labaree, David Matuskey, Yiyun Huang, Richard E. Carson
Summary: The novel synaptic vesicle glycoprotein 2A tracer, F-18-SynVesT-1, displays excellent kinetic and in vivo binding properties in humans, showing great potential for imaging and quantification of synaptic density in neuropsychiatric disorders.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Ming-Kai Chen, Adam P. Mecca, Mika Naganawa, Jean-Dominique Gallezot, Takuya Toyonaga, Jayanta Mondal, Sjoerd J. Finnema, Shu-fei Lin, Ryan S. O'Dell, Julia W. McDonald, Hannah R. Michalak, Brent Vander Wyk, Nabeel B. Nabulsi, Yiyun Huang, Amy F. T. Arnsten, Christopher H. van Dyck, Richard E. Carson
Summary: We conducted a comparison study on the synaptic density and metabolism in AD and CN participants using [C-11]UCB-J PET and [F-18]FDG PET, finding a similar reduction in the medial temporal lobe but a discordant reduction in neocortical regions, with higher correlations between synaptic density and metabolism in the former.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Samantha Rossano, Takuya Toyonaga, Jason Bini, Nabeel Nabulsi, Jim Ropchan, Zhengxin Cai, Yiyun Huang, Richard E. Carson
Summary: This study investigates the feasibility of using PET imaging with [C-11]UCB-J to visualize synaptic density and integrity in the human spinal cord, and finds that the synaptic structure and integrity in the spinal cord is lower than in the brain.
Article
Radiology, Nuclear Medicine & Medical Imaging
Richard E. Carson, Mika Naganawa, Takuya Toyonaga, Sheida Koohsari, Yanghong Yang, Ming-Kai Chen, David Matuskey, Sjoerd J. Finnema
Summary: PET technology has developed radiopharmaceuticals targeting specific brain proteins. A new approach of imaging synaptic density by targeting SV2A protein has emerged. SV2A PET imaging shows potential clinical value and has been applied in various neurodegenerative diseases.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Takuya Toyonaga, Nikkita Khattar, Yanjun Wu, Yihuan Lu, Mika Naganawa, Jean-Dominique Gallezot, David Matuskey, Adam P. Mecca, Brian Pittman, Mark Dias, Nabeel B. Nabulsi, Sjoerd J. Finnema, Ming-Kai Chen, Amy Arnsten, Rajiv Radhakrishnan, Patrick D. Skosnik, Deepak Cyril D'Souza, Irina Esterlis, Yiyun Huang, Christopher H. van Dyck, Richard E. Carson
Summary: Age-related decreases in gray matter volume, synaptic density, and blood flow were observed using MRI and [C-11]UCB-J PET. Regional patterns of the reductions in volume and SV2A binding were different, suggesting that MR-based measures of GM volume may not be directly representative of synaptic density.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mika Naganawa, Jean-Dominique Gallezot, Sjoerd J. Finnema, David Matuskey, Adam Mecca, Nabeel B. Nabulsi, David Labaree, Jim Ropchan, Robert T. Malison, Deepak Cyril D'Souza, Irina Esterlis, Kamil Detyniecki, Christopher H. van Dyck, Yiyun Huang, Richard E. Carson
Summary: This study compared SUVR-1 with BPND to select the optimal time window in healthy and neuropsychiatric subjects, finding that SUVR-1 showed greater correlation and less bias at later time windows. The 60-90 min period provided the best match between SUVR-1 and BPND.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Neuroimaging
Letizia Vogler, Anna Ballweg, Bernd Bohr, Nils Briel, Karin Wind, Melissa Antons, Lea H. Kunze, Johannes Gnoerich, Simon Lindner, Franz-Josef Gildehaus, Karlheinz Baumann, Peter Bartenstein, Guido Boening, Sibylle I. Ziegler, Johannes Levin, Andreas Zwergal, Guenter U. Hoeglinger, Jochen Herms, Matthias Brendel
Summary: This study aimed to investigate the feasibility of using [F-18]UCB-H PET with synaptic vesicle glycoprotein 2A (SV2A) as an alternative preclinical biomarker for neurodegenerative processes. The results showed that [F-18]UCB-H reliably depicts progressive synaptic loss in PS2APP and P301S transgenic mice, potentially qualifying as a more reliable alternative to [F-18]FDG as a biomarker for assessment of neurodegeneration in preclinical research.
NEUROIMAGE-CLINICAL
(2023)
Article
Behavioral Sciences
Els F. Halff, Marie-Caroline Cotel, Sridhar Natesan, Richard McQuade, Chris J. Ottley, Deepak P. Srivastava, Oliver D. Howes, Anthony C. Vernon
Summary: PET studies using SV2A radioligand provide evidence for synaptic dysfunction in the cingulate and frontal cortex of schizophrenia patients. Chronic exposure to antipsychotics did not affect SV2A levels, while chronic lithium exposure increased NLGN density. Further research is needed to understand the functional consequences of these changes.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neuroimaging
Ryan S. O'Dell, Albert Higgins-Chen, Dhruva Gupta, Ming -Kai Chen, Mika Naganawa, Takuya Toyonaga, Yihuan Lu, Gessica Ni, Anna Chupak, Wenzhen Zhao, Elaheh Salardini, Nabeel B. Nabulsi, Yiyun Huang, Amy F. T. Arnsten, Richard E. Carson, Christopher H. van Dyck, Adam P. Mecca
Summary: PCA analysis revealed regional patterns of synaptic density in AD patients, with PC1 associated with cognitive performance, PC2 associated with age, and PC3 associated with disease severity. These findings reinforce the significance of synaptic density as a robust biomarker of early-stage AD.
NEUROIMAGE-CLINICAL
(2023)
Article
Clinical Neurology
Ryan S. O'Dell, Adam P. Mecca, Ming-Kai Chen, Mika Naganawa, Takuya Toyonaga, Yihuan Lu, Tyler A. Godek, Joanna E. Harris, Hugh H. Bartlett, Emmie R. Banks, Victoria L. Kominek, Wenzhen Zhao, Nabeel B. Nabulsi, Jim Ropchan, Yunpeng Ye, Brent C. Vander Wyk, Yiyun Huang, Amy F. T. Arnsten, Richard E. Carson, Christopher H. van Dyck
Summary: This study found a significant inverse association between global Aβ deposition and synaptic binding in early AD patients with aMCI, but not in those with mild dementia. Exploratory analyses did not reveal broad or consistent associations between global Aβ deposition and regional synaptic binding across various brain regions.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Neurosciences
Jonas L. Olesen, Leif Ostergaard, Noam Shemesh, Sune N. Jespersen
Summary: This article discusses the characterization of neural tissue microstructure and the issue of specificity of dMRI signals, as well as experimental validation of biophysical models for white and gray matter cells.
Article
Clinical Neurology
Aline Delva, Koen Van Laere, Wim Vandenberghe
Summary: This study used PET imaging to longitudinally assess presynaptic terminal loss in early Parkinson's disease (PD). The results showed that F-18-FE-PE2I PET was able to detect a significant decline over 2 years in early PD, while C-11-UCB-J PET did not show any changes. However, the changes in F-18-FE-PE2I binding did not correlate with clinical motor progression.
MOVEMENT DISORDERS
(2022)
Article
Neurosciences
Marissa DiPiero, Hassan Cordash, Molly B. Prigge, Carolyn K. King, Jubel Morgan, Jose Guerrero-Gonzalez, Nagesh Adluru, Jace B. King, Nicholas Lange, Erin D. Bigler, Brandon A. Zielinski, Andrew L. Alexander, Janet E. Lainhart, Douglas C. Dean
Summary: All diffusion MRI measures showed significant associations with age across white matter and gray matter. Significant group differences were observed in both white matter and gray matter. There were no significant age-by-group interactions detected. Within the ASD group, positive relationships were found between white matter microstructure and ADOS-2 Calibrated Severity Scores. The findings provide new insights into group differences of white matter and gray matter microstructure in autistic males from adolescence into adulthood, contributing to a better understanding of brain-behavior relationships of ASD.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Neurosciences
Rachele Rossi, Shokouh Arjmand, Simone Larsen Baerentzen, Albert Gjedde, Anne M. Landau
Summary: SV2A, a transmembrane protein of synaptic vesicles, serves as a potential marker of synaptic density with stronger associations to GABAergic synapses. Despite being ubiquitously expressed, the biological function and interaction between SV2A and its tracers remain unclear. Further research is required for a better understanding of the protein's involvement in neurotransmission and its implications in neuroimaging studies.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Kelly Smart, Heather Liu, David Matuskey, Ming-Kai Chen, Kristen Torres, Nabeel Nabulsi, David Labaree, Jim Ropchan, Ansel T. Hillmer, Yiyun Huang, Richard E. Carson
Summary: The study suggests that the tissue influx and binding potential of the positron emission tomography radioligand [C-11]UCB-J are influenced by neural activation, while the volume of distribution remains stable. K(1) significantly increased during stimulation in the primary visual cortex, correlating with fMRI BOLD response.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
