Review
Cell Biology
Xuehan Li, Chunyu Liang, Yi Yan
Summary: The Kiss1/GPR54 system plays a crucial role in regulating energy balance and metabolic homeostasis by controlling energy intake and expenditure balance, affecting insulin secretion, and influencing skeletal muscle function.
Article
Cell Biology
Georgia S. Kavanagh, Jason Tadi, Sydney M. Balkenhol, Alexander S. Kauffman, Shane K. Maloney, Jeremy T. Smith
Summary: Kisspeptin signaling depletion leads to increased adiposity and reduced energy expenditure in mice, as well as alterations in the regulation of core body temperature as well as circadian and ultradian rhythms.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Mageswary Sivalingam, Ishwar S. Parhar
Summary: Kisspeptin, encoded by the KISS1 gene, is a potential metastasis suppressor gene. Multiple types of Kiss and KissR genes have been discovered in mammalian and non-mammalian vertebrate species, but are notably absent in birds. Kiss neuronal populations are mainly found in the hypothalamus, while KissRs are widely distributed in the brain and play a role in puberty, gonadal maturation, and the reproductive axis. Recent gene deletion studies in zebrafish and medaka have raised controversy regarding the reproductive role of kiss.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Noelia P. Di Giorgio, Marianne Bizzozzero-Hiriart, Pablo N. Surkin, Esteban Repetto, Maria M. Bonaventura, Florencia N. Tabares, Nadia S. Bourguignon, Ayelen Converti, Juan M. Riano Gomez, Bernhard Bettler, Victoria Lux-Lantos
Summary: GABA and Kisspeptin play critical roles in reproduction and metabolic control. A unique mouse lacking GABAB receptors in Kiss1 cells showed severe impairment in glucose homeostasis, which worsened with aging. These results reinforce the involvement of Kisspeptin in metabolic regulation and highlight the importance of GABA through GABAB receptors in the regulation of the peripheral pancreas Kisspeptin system.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Review
Pharmacology & Pharmacy
Alexandra D. Hudson, Alexander S. Kauffman
Summary: Kisspeptin signaling plays a significant role in metabolism and energy balance, and may regulate multiple physiological parameters. The findings highlight the importance of further research on the non-reproductive actions of Kisspeptin signaling.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Oncology
Marek Gowkielewicz, Aleksandra Lipka, Aleksandra Piotrowska, Marta Szadurska-Noga, Jacek J. Nowakowski, Ewa Lepiarczyk, Marta Wiszpolska, Tomasz Wasniewski, Piotr Dziegiel, Jerzy Kaleczyc, Mariusz Krzysztof Majewski, Marta Majewska
Summary: The study aims to analyze the expression of KISS and its receptor GPR54 in cells of various histological types of endometrial cancer (EC) and correlate it with concomitant diseases and biometric characteristics. The study found that the expression of KISS and GPR54 is correlated with concomitant diseases and demographic characteristics, but not with histological type of cancer or hormonal contraception. The results suggest that the expression levels of KISS and GPR54 are associated with the development and prognosis of endometrial cancer.
Article
Endocrinology & Metabolism
Eulalia A. Coutinho, Lourdes A. Esparza, Alexandra D. Hudson, Nathanael Rizo, Paige Steffen, Alexander S. Kauffman
Summary: Classic pharmacological studies have shown the importance of endogenous dynorphin-KOR signaling in reproductive neuroendocrine regulation. However, the necessity of KOR signaling in kisspeptin neurons for LH secretion has not been directly tested until now. This study knocked out KOR selectively from kisspeptin neurons and found no significant effect on puberty, LH pulse parameters, LH surges, FSH levels, estrous cycles, or fertility. These findings suggest that besides KNDy neurons, other mechanisms may regulate GnRH and LH pulses, necessitating the expansion of current models.
Article
Medicine, Research & Experimental
Cho-Won Kim, Hong Kyu Lee, Min-Woo Nam, Gabsang Lee, Kyung-Chul Choi
Summary: This study found that KiSS1 overexpression increases the growth and migration of metastatic prostate cancer cells, as well as promoting tumor metastasis and angiogenesis. These findings highlight the critical role of KiSS1 in prostate cancer progression.
Article
Biochemistry & Molecular Biology
Mahdi Golshan, Azadeh Hatef, Negar Kazori, Magdalena Socha, Miroslawa Sokolowska-Mikolajczyk, Hamid R. Habibi, Otomar Linhart, Sayyed Mohammad Hadi Alavi
Summary: This study reveals that exposure to bisphenol A (BPA) reduces sperm quality in goldfish and increases the levels of circulating LH and mRNA transcripts of upstream neuroendocrine regulators of reproduction.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Obstetrics & Gynecology
Fanting Meng, Aiqin Zhao, Haiying Lu, Dan Zou, Bei Dong, Xiaoqing Wang, Li Liu, Sufang Zhou
Summary: The study examines the association between three missense SNPs (rs12998, rs35431622, and rs4889) in the KISS1 gene and idiopathic recurrent pregnancy loss (iRPL). The results suggest that rs12998 and rs4889 variants are associated with unexplained recurrent pregnancy loss.
REPRODUCTIVE SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Su Zhang, Fangfei Yu, Anran Che, Binghe Tan, Chenshen Huang, Yuxue Chen, Xiaohong Liu, Qi Huang, Wenying Zhang, Chengbin Ma, Min Qian, Mingyao Liu, Juliang Qin, Bing Du
Summary: Emerging evidence suggests that physiological distress is closely correlated with cancer incidence and mortality. This study demonstrates that acute restraint increases the levels of kisspeptin and the expression of its receptor, Gpr54, in the hypothalamus and T cells within the spleen and tumor microenvironment. The administration of kisspeptin-10 impairs T cell function, while knockout of Gpr54 inhibits lung tumor progression. These findings indicate that kisspeptin/GPR54 signaling plays a nonredundant role in stress-induced tumor immune evasion.
Review
Neurosciences
Alexander S. Kauffman
Summary: Sex steroid feedback is a fundamental principle in reproductive neuroendocrinology, which regulates the neural circuits governing the reproductive neuroendocrine axis through the feedback loops. In females, the rise of estradiol during the menstrual cycle switches the effect on GnRH secretion from negative to positive, resulting in ovulation. However, the underlying mechanisms and the interaction between the circadian clock and endocrine signals are still poorly understood.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Md. Mahiuddin Zahangir, Md. Shahjahan, Hironori Ando
Summary: Kisspeptin plays an important role in reproductive regulation in animals. In grass puffer, kisspeptin has different effects depending on the reproductive stage, and it mainly acts by regulating the expression of genes in the hypothalamic-pituitary-gonadal axis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Lanlan Fang, Yang Yan, Yibo Gao, Ze Wu, Zhen Wang, Sizhu Yang, Jung-Chien Cheng, Ying-Pu Sun
Summary: This study found that TGF-beta 1 can upregulate the expression of kisspeptin in human EVT cells through the ALK5 receptor. TGF-beta 1 activates both the SMAD2/3 and the ERK1/2 and PI3K/AKT signaling pathways, with inhibition of ERK1/2 attenuating the stimulatory effect of TGF-beta 1 on kisspeptin expression. Knockdown of kisspeptin attenuates the inhibitory effect of TGF-beta 1 on EVT cell invasion. Serum levels of TGF-beta 1 and kisspeptin are also significantly elevated in patients with PE.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
D. Franssen, A. Barroso, F. Ruiz-Pino, M. J. Vazquez, D. Garcia-Galiano, J. M. Castellano, R. Onieva, M. Ruiz-Cruz, M. Poutanen, F. Gaytan, C. Dieguez, L. Pinilla, M. Lopez, J. Roa, M. Tena-Sempere
Summary: Reproduction is closely linked to energy and metabolic status, with AMPK signaling in GnRH neurons playing a crucial role in metabolic control of the female reproductive axis, particularly during puberty and negative energy balance.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Behavioral Sciences
Jazmin E. Hawes, Dijana Tesic, Andrew J. Whitehouse, Graeme R. Zosky, Jeremy T. Smith, Caitlin S. Wyrwoll
BEHAVIOURAL BRAIN RESEARCH
(2015)
Article
Reproductive Biology
Alexander S. Kauffman, Varykina G. Thackray, Genevieve E. Ryan, Kristen P. Tolson, Christine A. Glidewell-Kenney, Sheila J. Semaan, Matthew C. Poling, Nahoko Iwata, Kellie M. Breen, Antoni J. Duleba, Elisabet Stener-Victorin, Shunichi Shimasaki, Nicholas J. Webster, Pamela L. Mellon
BIOLOGY OF REPRODUCTION
(2015)
Article
Endocrinology & Metabolism
A. S. L. Caldwell, S. Eid, C. R. Kay, M. Jimenez, A. C. McMahon, R. Desai, C. M. Allan, J. T. Smith, D. J. Handelsman, Kirsty A. Walters
Article
Endocrinology & Metabolism
Shannon B. Z. Stephens, Kristen P. Tolson, Melvin L. Rouse, Matthew C. Poling, Minako K. Hashimoto-Partyka, Pamela L. Mellon, Alexander S. Kauffman
Article
Endocrinology & Metabolism
Qun Li, Robert P. Millar, Iain J. Clarke, Jeremy T. Smith
NEUROENDOCRINOLOGY
(2015)
Article
Endocrinology & Metabolism
Kristen P. Tolson, Christian Garcia, Iris Delgado, Nuha Marooki, Alexander S. Kauffman
Article
Endocrinology & Metabolism
Michaela D. Wharfe, Peter J. Mark, Caitlin S. Wyrwoll, Jeremy T. Smith, Cassandra Yap, Michael W. Clarke, Brendan J. Waddell
JOURNAL OF ENDOCRINOLOGY
(2016)
Article
Endocrinology & Metabolism
Cassandra C. Yap, Michaela D. Wharfe, Peter J. Mark, Brendan J. Waddell, Jeremy T. Smith
JOURNAL OF ENDOCRINOLOGY
(2016)
Article
Cell Biology
Luba Sominsky, Ilvana Ziko, Alita Soch, Jeremy T. Smith, Sarah J. Spencer
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2016)
Article
Endocrinology & Metabolism
Chad D. Foradori, Brian K. Whitlock, Jay A. Daniel, Arthur D. Zimmerman, Melaney A. Jones, Casey C. Read, Barbara P. Steele, Jeremy T. Smith, Iain J. Clarke, Theodore H. Elsasser, Duane H. Keisler, James L. Sartin
Article
Endocrinology & Metabolism
Peyton Weems, Jeremy Smith, Iain J. Clarke, Lique M. Coolen, Robert L. Goodman, Michael N. Lehman
Article
Developmental Biology
Cassandra C. Yap, Peter J. Mark, Brendan J. Waddell, Jeremy T. Smith
REPRODUCTION FERTILITY AND DEVELOPMENT
(2017)
Article
Neurosciences
Shannon B. Z. Stephens, Melvin L. Rouse, Kristen P. Tolson, Reanna B. Liaw, Ruby A. Parra, Navi Chahal, Alexander S. Kauffman