High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects

New development of the yolk sac theory in diabetic embryopathy: molecular mechanism and link to structural birth defects

(2016) Daoyin Dong et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Oxidative stress is responsible for maternal diabetes-impaired transforming growth factor beta signaling in the developing mouse heart

(2015) Fang Wang et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Curcumin ameliorates high glucose-induced neural tube defects by suppressing cellular stress and apoptosis

(2015) Yanqing Wu et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Decoding the oxidative stress hypothesis in diabetic embryopathy through proapoptotic kinase signaling

(2015) Peixin Yang et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Advances in revealing the molecular targets downstream of oxidative stress–induced proapoptotic kinase signaling in diabetic embryopathy

(2015) Fang Wang et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Maternal diabetes triggers DNA damage and DNA damage response in neurulation stage embryos through oxidative stress

(2015) Daoyin Dong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Punicalagin exerts protective effect against high glucose-induced cellular stress and neural tube defects

(2015) Jianxiang Zhong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Superoxide Dismutase 1 In Vivo Ameliorates Maternal Diabetes Mellitus–Induced Apoptosis and Heart Defects Through Restoration of Impaired Wnt SignalingCLINICAL PERSPECTIVE

(2015) Fang Wang et al.   Circulation-Cardiovascular Genetics

Cellular Stress, Excessive Apoptosis, and the Effect of Metformin in a Mouse Model of Type 2 Diabetic Embryopathy

(2015) Yanqing Wu et al.   DIABETES

MiR-17 Downregulation by High Glucose Stabilizes Thioredoxin-Interacting Protein and Removes Thioredoxin Inhibition on ASK1 Leading to Apoptosis

(2015) Daoyin Dong et al.   TOXICOLOGICAL SCIENCES

Superoxide Dismutase 1 In Vivo Ameliorates Maternal Diabetes Mellitus–Induced Apoptosis and Heart Defects Through Restoration of Impaired Wnt SignalingCLINICAL PERSPECTIVE

(2015) Fang Wang et al.   Circulation-Cardiovascular Genetics

Sirtuin inhibitor Ex-527 causes neural tube defects, ventral edema formations, and gastrointestinal malformations inXenopus laevisembryos

(2014) Yoshihisa Ohata et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Ask1Gene Deletion Blocks Maternal Diabetes–Induced Endoplasmic Reticulum Stress in the Developing Embryo by Disrupting the Unfolded Protein Response Signalosome

(2014) Fang Wang et al.   DIABETES

Discovery of Novel and Selective SIRT6 Inhibitors

(2014) Marco Daniele Parenti et al.   JOURNAL OF MEDICINAL CHEMISTRY

The miR-322-TRAF3 Circuit Mediates the Pro-apoptotic Effect of High Glucose on Neural Stem Cells

(2014) Hui Gu et al.   TOXICOLOGICAL SCIENCES

Cell differentiation versus cell death: extracellular glucose is a key determinant of cell fate following oxidative stress exposure

(2014) R C Poulsen et al.   Cell Death & Disease

Superoxide dismutase 1 overexpression in mice abolishes maternal diabetes–induced endoplasmic reticulum stress in diabetic embryopathy

(2013) Fang Wang et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Trehalose prevents neural tube defects by correcting maternal diabetes-suppressed autophagy and neurogenesis

(2013) Cheng Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sirtuin deacetylases in neurodegenerative diseases of aging

(2013) Adrianna Z Herskovits et al.   CELL RESEARCH

Maternal Hyperglycemia Activates an ASK1-FoxO3a-Caspase 8 Pathway That Leads to Embryonic Neural Tube Defects

(2013) P. Yang et al.   Science Signaling

Nitrosative stress and redox-cycling agents synergize to cause mitochondrial dysfunction and cell death in endothelial cells

(2013) Anne R. Diers et al.   Redox Biology

SOD1 suppresses maternal hyperglycemia-increased iNOS expression and consequent nitrosative stress in diabetic embryopathy

(2012) Hongbo Weng et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Oxidative Stress-Induced JNK1/2 Activation Triggers Proapoptotic Signaling and Apoptosis That Leads to Diabetic Embryopathy

(2012) X. Li et al.   DIABETES

c-Jun NH2-Terminal Kinase 1/2 and Endoplasmic Reticulum Stress as Interdependent and Reciprocal Causation in Diabetic Embryopathy

(2012) X. Li et al.   DIABETES

A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol

(2012) Melanie Gertz et al.   PLoS One

SOD1 overexpression in vivo blocks hyperglycemia-induced specific PKC isoforms: substrate activation and consequent lipid peroxidation in diabetic embryopathy

(2011) Xuezheng Li et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Lack of periconceptional vitamins or supplements that contain folic acid and diabetes mellitus–associated birth defects

(2011) Adolfo Correa et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Diabetic embryopathy: A role for the epigenome?

(2011) J. Michael Salbaum et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability

(2011) Bo Yang et al.   CELL CYCLE

Sirtuin 1-Mediated Cellular Metabolic Memory of High Glucose Via the LKB1/AMPK/ROS Pathway and Therapeutic Effects of Metformin

(2011) Z. Zheng et al.   DIABETES

Sirtuins at a glance

(2011) T. Nakagawa et al.   JOURNAL OF CELL SCIENCE

Resveratrol prevents embryonic oxidative stress and apoptosis associated with diabetic embryopathy and improves glucose and lipid profile of diabetic dam

(2011) Chandra K. Singh et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

(2011) E. Jing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigallocatechin-3-gallate ameliorates hyperglycemia-induced embryonic vasculopathy and malformation by inhibition of Foxo3a activation

(2010) Peixin Yang et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

SRT1720 Induces Mitochondrial Biogenesis and Rescues Mitochondrial Function after Oxidant Injury in Renal Proximal Tubule Cells

(2010) J. A. Funk et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

NAD+-dependent histone deacetylases (sirtuins) as novel therapeutic targets

(2009) Jörg Schemies et al.   MEDICINAL RESEARCH REVIEWS

HIS-24 Linker Histone and SIR-2.1 Deacetylase Induce H3K27me3 in the Caenorhabditis elegans Germ Line

(2009) M. Wirth et al.   MOLECULAR AND CELLULAR BIOLOGY

Blockade of c-Jun N-terminal kinase activation abrogates hyperglycemia-induced yolk sac vasculopathy in vitro

(2008) Peixin Yang et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Activation of oxidative stress signaling that is implicated in apoptosis with a mouse model of diabetic embryopathy

(2008) Peixin Yang et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Diabetes mellitus and birth defects

(2008) Adolfo Correa et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Biological and Potential Therapeutic Roles of Sirtuin Deacetylases

(2008) D. M. Taylor et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Trends in the Prevalence of Preexisting Diabetes and Gestational Diabetes Mellitus Among a Racially/Ethnically Diverse Population of Pregnant Women, 1999-2005

(2008) J. M. Lawrence et al.   DIABETES CARE

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE