Pharmacokinetic investigation of sildenafil using positron emission tomography and determination of its effect on cerebrospinal fluid cGMP levels

Decreased levels of guanosine 3′, 5′-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease

(2015) Ana Ugarte et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Sildenafil Mediates Blood-Flow Redistribution and Neuroprotection After Neonatal Hypoxia-Ischemia

(2014) Christiane Charriaut-Marlangue et al.   STROKE

Evaluation of PET radioligands for in vivo visualization of phosphodiesterase 5 (PDE5)

(2013) Rufael Chekol et al.   NUCLEAR MEDICINE AND BIOLOGY

Biodistribution and metabolism of 11C-labeled Kendine 91 in mice and rats

(2012) Vanessa Gómez-Vallejo et al.   APPLIED RADIATION AND ISOTOPES

Modulation of the ASK1-MKK3/6-p38/MAPK signalling pathway mediates sildenafil protection against chemical hypoxia caused by malonate

(2012) L Barros-Miñones et al.   BRITISH JOURNAL OF PHARMACOLOGY

Tadalafil crosses the blood–brain barrier and reverses cognitive dysfunction in a mouse model of AD

(2012) Carolina García-Barroso et al.   NEUROPHARMACOLOGY

Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease

(2011) M Cuadrado-Tejedor et al.   BRITISH JOURNAL OF PHARMACOLOGY

Long-lasting neuroprotective effect of sildenafil against 3,4-methylenedioxymethamphetamine- induced 5-hydroxytryptamine deficits in the rat brain

(2011) Elena Puerta et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Sildenafil ameliorates cognitive deficits and tau pathology in a senescence-accelerated mouse model

(2011) Lourdes Orejana et al.   NEUROBIOLOGY OF AGING

Longitudinal Magnetic Resonance Imaging of Sildenafil Treatment of Embolic Stroke in Aged Rats

(2011) Guangliang Ding et al.   STROKE

Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB, and BDNF

(2010) Elena Puerta et al.   NEUROBIOLOGY OF DISEASE

Phosphodiesterase 5 Inhibition Improves Synaptic Function, Memory, and Amyloid-  Load in an Alzheimer's Disease Mouse Model

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

In vivo, in vitro and in silico methods for small molecule transfer across the BBB

(2009) Jurgen Mensch et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Subtype Selectivity in Phosphodiesterase 4 (PDE4): A Bottleneck in Rational Drug Design

(2008) P. Srivani et al.   CURRENT PHARMACEUTICAL DESIGN

Magnetic Resonance Imaging Investigation of Axonal Remodeling and Angiogenesis after Embolic Stroke in Sildenafil-Treated Rats

(2008) Guangliang Ding et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Phosphodiesterase 5 inhibitors prevent 3,4-methylenedioxymethamphetamine-induced 5-HT deficits in the rat

(2008) Elena Puerta et al.   JOURNAL OF NEUROCHEMISTRY