Overcoming translational barriers impeding development of Alzheimer's disease modifying therapies

TREM2 R47H Variant as a Risk Factor for Early-Onset Alzheimer's Disease

(2018) Cyril Pottier et al.   JOURNAL OF ALZHEIMERS DISEASE

Phase 3 solanezumab trials: Secondary outcomes in mild Alzheimer's disease patients

(2016) Eric R. Siemers et al.   Alzheimers & Dementia

PART, a distinct tauopathy, different from classical sporadic Alzheimer disease

(2015) Kurt A. Jellinger et al.   ACTA NEUROPATHOLOGICA

Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014

(2015) Michael W. Weiner et al.   Alzheimers & Dementia

The Worldwide Alzheimer's Disease Neuroimaging Initiative: An update

(2015) James A. Hendrix et al.   Alzheimers & Dementia

Crf receptor 1 antagonism as a disease-modifying therapy for Alzheimer's disease: Preclincal data on pathology and cognitive and synaptic deficits

(2015) Cheng Zhang et al.   Alzheimers & Dementia

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

(2015) Heather M. Snyder et al.   Alzheimers & Dementia

2015 Alzheimer's disease facts and figures

(2015)   Alzheimers & Dementia

TAR DNA-binding protein 43 and pathological subtype of Alzheimer's disease impact clinical features

(2015) Keith A. Josephs et al.   ANNALS OF NEUROLOGY

Age and amyloid effects on human central nervous system amyloid-beta kinetics

(2015) Bruce W. Patterson et al.   ANNALS OF NEUROLOGY

Learning by Failing: Ideas and Concepts to Tackle γ-Secretases in Alzheimer's Disease and Beyond

(2015) Bart De Strooper et al.   Annual Review of Pharmacology and Toxicology

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

The stress response neuropeptide CRF increases amyloid-  production by regulating  -secretase activity

(2015) H.-J. Park et al.   EMBO JOURNAL

TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

(2015) Taylor R. Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antibody drugs for Alzheimer’s show glimmers of promise

(2015) Sara Reardon   NATURE

Amyloid-β11C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials

(2015) Enchi Liu et al.   NEUROLOGY

Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease

(2015) Edward J. Goetzl et al.   NEUROLOGY

Immunotherapeutic Approaches for Alzheimer’s Disease

(2015) Thomas Wisniewski et al.   NEURON

TREM2 and Risk of Alzheimer’s Disease — Friend or Foe?

(2015) Rudolph E. Tanzi   NEW ENGLAND JOURNAL OF MEDICINE

Alzheimer's amyloid theory gets modest boost

(2015) E. Underwood   SCIENCE

Long-term treatment with active Aβ immunotherapy with CAD106 in mild Alzheimer’s disease

(2015) Martin R Farlow et al.   Alzheimers Research & Therapy

What lessons can be learned from failed Alzheimer’s disease trials?

(2015) Jeremy Toyn   Expert Review of Clinical Pharmacology

Differential clinicopathologic and genetic features of late-onset amnestic dementias

(2014) Melissa E. Murray et al.   ACTA NEUROPATHOLOGICA

Stress, PTSD, and dementia

(2014) Mark S. Greenberg et al.   Alzheimers & Dementia

Amyloid-based immunotherapy for Alzheimer's disease in the time of prevention trials: the way forward

(2014) Francesco Panza et al.   Expert Review of Clinical Immunology

Charting a path toward combination therapy for Alzheimer’s disease

(2014) Diane Stephenson et al.   Expert Review of Neurotherapeutics

Human-induced pluripotent stem cells: potential for neurodegenerative diseases

(2014) C. A. Ross et al.   HUMAN MOLECULAR GENETICS

Human stem cell models of dementia

(2014) F. J. Livesey   HUMAN MOLECULAR GENETICS

Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014

(2014) L. S. Schneider et al.   JOURNAL OF INTERNAL MEDICINE

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

(2014) Robert Vassar et al.   JOURNAL OF NEUROCHEMISTRY

Targeting the β secretase BACE1 for Alzheimer's disease therapy

(2014) Riqiang Yan et al.   LANCET NEUROLOGY

Single App knock-in mouse models of Alzheimer's disease

(2014) Takashi Saito et al.   NATURE NEUROSCIENCE

Resting microglia react to Aβ42 fibrils but do not detect oligomers or oligomer-induced neuronal damage

(2014) Denise Ferrera et al.   NEUROBIOLOGY OF AGING

Recommendations of the Alzheimer's Disease-Related Dementias Conference

(2014) T. J. Montine et al.   NEUROLOGY

CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival

(2014) T. Skillback et al.   NEUROLOGY

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

The A4 Study: Stopping AD Before Symptoms Begin?

(2014) R. A. Sperling et al.   Science Translational Medicine

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Modeling neurodegenerative diseases in Caenorhabditis elegans

(2013) Jia Li et al.   EXPERIMENTAL NEUROLOGY

Thinking laterally about neurodegenerative proteinopathies

(2013) Todd E. Golde et al.   JOURNAL OF CLINICAL INVESTIGATION

A Transgenic Alzheimer Rat with Plaques, Tau Pathology, Behavioral Impairment, Oligomeric A , and Frank Neuronal Loss

(2013) R. M. Cohen et al.   JOURNAL OF NEUROSCIENCE

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Drosophila melanogaster as a model organism for Alzheimer’s disease

(2013) Katja Prüßing et al.   Molecular Neurodegeneration

Dominantly Inherited Alzheimer Network: facilitating research and clinical trials

(2013) Krista L Moulder et al.   Alzheimers Research & Therapy

Biomarkers for Alzheimer's disease in plasma, serum and blood - conceptual and practical problems

(2013) Douglas Galasko et al.   Alzheimers Research & Therapy

Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome

(2013) Benjamin Lam et al.   Alzheimers Research & Therapy

Fluid Biomarkers in Alzheimer Disease

(2013) K. Blennow et al.   Cold Spring Harbor Perspectives in Medicine

Animal Models of Alzheimer Disease

(2013) F. M. LaFerla et al.   Cold Spring Harbor Perspectives in Medicine

β-Amyloid oligomers in aging and Alzheimer’s disease

(2013) Kathleen R. Zahs et al.   Frontiers in Aging Neuroscience

iPSCs to the Rescue in Alzheimer's Research

(2012) Se Hoon Choi et al.   Cell Stem Cell

Nonhuman Primate Models of Alzheimer-Like Cerebral Proteopathy

(2012) Eric Heuer et al.   CURRENT PHARMACEUTICAL DESIGN

Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study

(2012) Bengt Winblad et al.   LANCET NEUROLOGY

Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology

(2012) Pritam Das et al.   Molecular Neurodegeneration

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Genentech's Alzheimer's antibody trial to study disease prevention

(2012) Ken Garber   NATURE BIOTECHNOLOGY

A Plaque-Specific Antibody Clears Existing β-amyloid Plaques in Alzheimer's Disease Mice

(2012) Ronald B. DeMattos et al.   NEURON

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evidence for Ordering of Alzheimer Disease Biomarkers

(2011) Clifford R. Jack   ARCHIVES OF NEUROLOGY

Efficacy of statin therapy in chronic systolic cardiac insufficiency: A meta-analysis

(2011) Shuning Zhang et al.   European Journal of Internal Medicine

Robust Amyloid Clearance in a Mouse Model of Alzheimer's Disease Provides Novel Insights into the Mechanism of Amyloid-  Immunotherapy

(2011) A. Wang et al.   JOURNAL OF NEUROSCIENCE

Chronic Stress Exacerbates Tau Pathology, Neurodegeneration, and Cognitive Performance through a Corticotropin-Releasing Factor Receptor-Dependent Mechanism in a Transgenic Mouse Model of Tauopathy

(2011) J. C. Carroll et al.   JOURNAL OF NEUROSCIENCE

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Epidemiology of Alzheimer disease

(2011) Christiane Reitz et al.   Nature Reviews Neurology

Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift

(2011) Todd E. Golde et al.   NEURON

Right sizing funding for Alzheimer's disease

(2011) Todd E Golde et al.   Alzheimers Research & Therapy

Vascular risk factors and Alzheimer's disease: are these risk factors for plaques and tangles or for concomitant vascular pathology that increases the likelihood of dementia? An evidence-based review

(2011) Helena C Chui et al.   Alzheimers Research & Therapy

The worldwide societal costs of dementia: Estimates for 2009

(2010) Anders Wimo et al.   Alzheimers & Dementia

Safety and Changes in Plasma and Cerebrospinal Fluid Amyloid β After a Single Administration of an Amyloid β Monoclonal Antibody in Subjects With Alzheimer Disease

(2010) Eric R. Siemers et al.   CLINICAL NEUROPHARMACOLOGY

TAU Aggregation is a Therapeutic Target for Alzheimers Disease

(2010) A. Takashima   Current Alzheimer Research

Neural mechanisms of ageing and cognitive decline

(2010) Nicholas A. Bishop et al.   NATURE

Protein aggregation diseases: pathogenicity and therapeutic perspectives

(2010) Adriano Aguzzi et al.   NATURE REVIEWS DRUG DISCOVERY

RTN/Nogo in forming Alzheimer's neuritic plaques

(2010) Marguerite Prior et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Synthetic Peptide-Based Cancer Vaccines: Lessons Learned and Hurdles to Overcome

(2009) Caroline Voskens et al.   CURRENT MOLECULAR MEDICINE

The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal

(2009) John Hardy   JOURNAL OF NEUROCHEMISTRY

Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases

(2009) Todd E Golde et al.   Alzheimers Research & Therapy

The Aging Brain

(2008) Bruce A. Yankner et al.   Annual Review of Pathology-Mechanisms of Disease

Protein folding diseases and neurodegeneration: Lessons learned from yeast

(2008) Joris Winderickx et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE