Repeated Topical Administration of 3 nm Cerium Oxide Nanoparticles Reverts Disease Atrophic Phenotype and Arrests Neovascular Degeneration in AMD Mouse Models

How Does Immunomodulatory Nanoceria Work? ROS and Immunometabolism

(2022) Lena M. Ernst et al.   Frontiers in Immunology

Novel Eye Drop Delivery Systems: Advance on Formulation Design Strategies Targeting Anterior and Posterior Segments of the Eye

(2022) Yaru Wang et al.   Pharmaceutics

Antioxidant Properties of Cerium Oxide Nanoparticles Prevent Retinal Neovascular Alterations In Vitro and In Vivo

(2022) Annamaria Tisi et al.   Antioxidants

Cell therapy with hiPSC-derived RPE cells and RPCs prevents visual function loss in a rat model of retinal degeneration

(2021) Anna Salas et al.   Molecular Therapy-Methods & Clinical Development

Topical treatment of diabetic retinopathy: a systematic review

(2021) Mikkel S. Thagaard et al.   ACTA OPHTHALMOLOGICA

Vascular Endothelial Growth Factor Antagonists: Promising Players in the Treatment of Neovascular Age-Related Macular Degeneration

(2021) Rehan M Hussain et al.   Drug Design Development and Therapy

Up-regulation of pro-angiogenic pathways and induction of neovascularization by an acute retinal light damage

(2020) A. Tisi et al.   Scientific Reports

The characterization of purified citrate-coated cerium oxide nanoparticles prepared via hydrothermal synthesis

(2020) Matthew L. Hancock et al.   APPLIED SURFACE SCIENCE

Transcriptomics analysis of Ccl2/Cx3cr1/Crb1rd8 deficient mice provides new insights into the pathophysiology of progressive retinal degeneration

(2020) Anna Badia et al.   EXPERIMENTAL EYE RESEARCH

Posterior segment drug delivery for the treatment of exudative age-related macular degeneration and diabetic macular oedema

(2019) Chee Wai Wong et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Evolution Shapes the Gene Expression Response to Oxidative Stress

(2019) Rima Siauciunaite et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Traffic-related air pollutants increase the risk for age-related macular degeneration

(2019) Kuang-Hsi Chang et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Ceria Nanoparticle Systems for Selective Scavenging of Mitochondrial, Intracellular, and Extracellular Reactive Oxygen Species in Parkinson's Disease

(2018) Hyek Jin Kwon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Changes in Retinal Glial Cells with Age and during Development of Age-Related Macular Degeneration

(2018) D. V. Telegina et al.   BIOCHEMISTRY-MOSCOW

Nanoceria suppresses multiple low doses of streptozotocin-induced Type 1 diabetes by inhibition of Nrf2/NF-κB pathway and reduction of apoptosis

(2018) Amit Khurana et al.   Nanomedicine

Topical Administration of Bosentan Prevents Retinal Neurodegeneration in Experimental Diabetes

(2018) Patricia Bogdanov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biomedical applications of nanoceria: new roles for an old player

(2018) Saeid Kargozar et al.   Nanomedicine

Animal models of ocular angiogenesis: from development to pathologies

(2017) Chi-Hsiu Liu et al.   FASEB JOURNAL

Activated microglia induce the production of reactive oxygen species and promote apoptosis of co-cultured retinal microvascular pericytes

(2017) Xinyi Ding et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Cyclodextrins and topical drug delivery to the anterior and posterior segments of the eye

(2017) Thorsteinn Loftsson et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The role of autophagy in pro-inflammatory responses of microglia activation via mitochondrial reactive oxygen species in vitro

(2017) Junli Ye et al.   JOURNAL OF NEUROCHEMISTRY

Pharmacokinetic aspects of retinal drug delivery

(2017) Eva M. del Amo et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Intrinsic and Extrinsic Properties Affecting Innate Immune Responses to Nanoparticles: The Case of Cerium Oxide

(2017) Eudald Casals et al.   Frontiers in Immunology

Nanotechnology-based strategies for treatment of ocular disease

(2017) Yuhua Weng et al.   Acta Pharmaceutica Sinica B

A novel synthetic approach of cerium oxide nanoparticles with improved biomedical activity

(2017) Fanny Caputo et al.   Scientific Reports

Distribution of topical ocular nepafenac and its active metabolite amfenac to the posterior segment of the eye

(2016) James E. Chastain et al.   EXPERIMENTAL EYE RESEARCH

Cerium oxide nanoparticles reduce steatosis, portal hypertension and display anti-inflammatory properties in rats with liver fibrosis

(2016) Denise Oró et al.   JOURNAL OF HEPATOLOGY

Age-related myelin degradation burdens the clearance function of microglia during aging

(2016) Shima Safaiyan et al.   NATURE NEUROSCIENCE

Nrf2 Is an Attractive Therapeutic Target for Retinal Diseases

(2016) Yasuhiro Nakagami   Oxidative Medicine and Cellular Longevity

Histopathological Insights Into Choroidal Vascular Loss in Clinically Documented Cases of Age-Related Macular Degeneration

(2016) Johanna M. Seddon et al.   JAMA Ophthalmology

Topical administration of GLP-1 receptor agonists prevents retinal neurodegeneration in experimental diabetes

(2015) Cristina Hernández et al.   DIABETES

Light pollution: the possible consequences of excessive illumination on retina

(2015) M A Contín et al.   EYE

Müller glia as an important source of cytokines and inflammatory factors present in the gliotic retina during proliferative vitreoretinopathy

(2015) K. Eastlake et al.   GLIA

Defining the Catalytic Activity of Nanoceria in the P23H-1 Rat, a Photoreceptor Degeneration Model

(2015) Lily L. Wong et al.   PLoS One

Cerium Oxide Nanoparticles Reduce Microglial Activation and Neurodegenerative Events in Light Damaged Retina

(2015) Lavinia Fiorani et al.   PLoS One

Nanosafety Research-Are We on the Right Track?

(2014) Harald F. Krug   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cerium oxide nanoparticles protect against Aβ-induced mitochondrial fragmentation and neuronal cell death

(2014) J M Dowding et al.   CELL DEATH AND DIFFERENTIATION

Platelet-derived growth factor (PDGF)-C inhibits neuroretinal apoptosis in a murine model of focal retinal degeneration

(2014) Yujuan Wang et al.   LABORATORY INVESTIGATION

On the Barrier Properties of the Cornea: A Microscopy Study of the Penetration of Fluorescently Labeled Nanoparticles, Polymers, and Sodium Fluorescein

(2014) Ellina A. Mun et al.   MOLECULAR PHARMACEUTICS

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Oxidative Stress, Hypoxia, and Autophagy in the Neovascular Processes of Age-Related Macular Degeneration

(2014) Janusz Blasiak et al.   Biomed Research International

Pigment Epithelium-Derived Factor Reduces Apoptosis and Pro-Inflammatory Cytokine Gene Expression in a Murine Model of Focal Retinal Degeneration

(2013) Yujuan Wang et al.   ASN Neuro

Sustained inhibition of neovascularization in vldlr−/− mice following intravitreal injection of cerium oxide nanoparticles and the role of the ASK1-P38/JNK-NF-κB pathway

(2013) Xue Cai et al.   BIOMATERIALS

Topical Administration of Somatostatin Prevents Retinal Neurodegeneration in Experimental Diabetes

(2013) C. Hernandez et al.   DIABETES

Synthesis and Characterization of Polyvinylpyrrolidone Coated Cerium Oxide Nanoparticles

(2013) Ruth C. Merrifield et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Nanoceria inhibit expression of genes associated with inflammation and angiogenesis in the retina of Vldlr null mice

(2013) Svetlana V. Kyosseva et al.   EXPERIMENTAL EYE RESEARCH

Adverse events and complications associated with intravitreal injection of anti-VEGF agents: a review of literature

(2013) K Ghasemi Falavarjani et al.   EYE

Nutrient Supplementation with n3 Polyunsaturated Fatty Acids, Lutein, and Zeaxanthin Decrease A2E Accumulation and VEGF Expression in the Retinas of Ccl2/Cx3cr1-Deficient Mice on Crb1rd8 Background

(2013) Hema L. Ramkumar et al.   JOURNAL OF NUTRITION

Catalytic Nanoceria Are Preferentially Retained in the Rat Retina and Are Not Cytotoxic after Intravitreal Injection

(2013) Lily L. Wong et al.   PLoS One

Nanoceria: A Rare-Earth Nanoparticle as a Novel Anti-Angiogenic Therapeutic Agent in Ovarian Cancer

(2013) Shailendra Giri et al.   PLoS One

Early degeneration of photoreceptor synapse inCcl2/Cx3cr1-deficient mice onCrb1rd8background

(2013) Jun Zhang et al.   SYNAPSE

Sustained protection against photoreceptor degeneration in tubby mice by intravitreal injection of nanoceria

(2012) Xue Cai et al.   BIOMATERIALS

Antioxidant Therapy: Current Status and Future Prospects

(2012) O. Firuzi et al.   CURRENT MEDICINAL CHEMISTRY

Anti-inflammatory recombinant TSG-6 stabilizes the progression of focal retinal degeneration in a murine model

(2012) Jingsheng Tuo et al.   Journal of Neuroinflammation

Age-related macular degeneration

(2012) Laurence S Lim et al.   LANCET

Antioxidant therapy: Still in search of the ‘magic bullet’

(2012) Sofia Benfeito et al.   MITOCHONDRION

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Biomolecular coronas provide the biological identity of nanosized materials

(2012) Marco P. Monopoli et al.   Nature Nanotechnology

Ce3+ Ions Determine Redox-Dependent Anti-apoptotic Effect of Cerium Oxide Nanoparticles

(2011) Ivana Celardo et al.   ACS Nano

Global estimates of visual impairment: 2010

(2011) Donatella Pascolini et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Cellular and 3D optical coherence tomography assessment during the initiation and progression of retinal degeneration in the Ccl2/Cx3cr1-deficient mouse

(2011) Yongdong Zhou et al.   EXPERIMENTAL EYE RESEARCH

Cerium Oxide Nanoparticles Inhibits Oxidative Stress and Nuclear Factor- B Activation in H9c2 Cardiomyocytes Exposed to Cigarette Smoke Extract

(2011) J. Niu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Nanoceria Inhibit the Development and Promote the Regression of Pathologic Retinal Neovascularization in the Vldlr Knockout Mouse

(2011) Xiaohong Zhou et al.   PLoS One

Hardening of the Nanoparticle-Protein Corona in Metal (Au, Ag) and Oxide (Fe3O4, CoO, and CeO2) Nanoparticles

(2011) Eudald Casals et al.   Small

Time Evolution of the Nanoparticle Protein Corona

(2010) Eudald Casals et al.   ACS Nano

Redox-active radical scavenging nanomaterials

(2010) Ajay Karakoti et al.   CHEMICAL SOCIETY REVIEWS

A High Omega-3 Fatty Acid Diet Reduces Retinal Lesions in a Murine Model of Macular Degeneration

(2009) Jingsheng Tuo et al.   AMERICAN JOURNAL OF PATHOLOGY

Nanoceria have no genotoxic effect on human lens epithelial cells

(2009) Barbara K Pierscionek et al.   NANOTECHNOLOGY

The dynamic nature of Bruch's membrane

(2009) J.C. Booij et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Anti-inflammatory Properties of Cerium Oxide Nanoparticles

(2009) Suzanne M. Hirst et al.   Small

Why Have Antioxidants Failed in Clinical Trials?

(2008) Steven R. Steinhubl   AMERICAN JOURNAL OF CARDIOLOGY

The role of cerium redox state in the SOD mimetic activity of nanoceria

(2008) Eric G. Heckert et al.   BIOMATERIALS

Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy

(2008) Masuko Ushio-Fukai et al.   CANCER LETTERS

Ccl2/Cx3cr1-Deficient Mice: An Animal Model for Age-Related Macular Degeneration

(2008) Chi-Chao Chan et al.   OPHTHALMIC RESEARCH