Cellular and molecular modifier pathways in tauopathies: the big picture from screening invertebrate models

Complex Splicing and Neural Expression of Duplicated Tau Genes in Zebrafish Embryos

(2017) Mengqi Chen et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau neurotoxicity and rescue in animal models of human Tauopathies

(2016) Lars Krüger et al.   CURRENT OPINION IN NEUROBIOLOGY

Rare coding mutations identified by sequencing of Alzheimer disease genome-wide association studies loci

(2015) Badri N. Vardarajan et al.   ANNALS OF NEUROLOGY

Essential role of POLDIP2 in Tau aggregation and neurotoxicity via autophagy/proteasome inhibition

(2015) YoungDoo Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification

(2015) Caroline Mauvezin et al.   Nature Communications

Tau co-organizes dynamic microtubule and actin networks

(2015) Auréliane Elie et al.   Scientific Reports

Poldip2 Knockout Results in Perinatal Lethality, Reduced Cellular Growth and Increased Autophagy of Mouse Embryonic Fibroblasts

(2014) David I. Brown et al.   PLoS One

Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms

(2013) J. M. Shulman et al.   HUMAN MOLECULAR GENETICS

PTL-1 regulates neuronal integrity and lifespan in C. elegans

(2013) Y. L. Chew et al.   JOURNAL OF CELL SCIENCE

Drosophilaas a screening tool to study human neurodegenerative diseases

(2013) Sarah Lenz et al.   JOURNAL OF NEUROCHEMISTRY

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

Tangles, Toxicity, and Tau Secretion in AD – New Approaches to a Vexing Problem

(2013) Kerry L. Gendreau et al.   Frontiers in Neurology

The downward spiral of tau and autolysosomes

(2012) Suren S. Ambegaokar et al.   Autophagy

Drosophila modifier screens to identify novel neuropsychiatric drugs including aminergic agents for the possible treatment of Parkinson’s disease and depression

(2012) H O Lawal et al.   MOLECULAR PSYCHIATRY

Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo

(2012) Brian DuBoff et al.   NEURON

Phospho-dependent ubiquitination and degradation of PAR-1 regulates synaptic morphology and tau-mediated Aβ toxicity in Drosophila

(2012) Seongsoo Lee et al.   Nature Communications

Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease–Related Tau Phosphorylation Via PAR-1

(2012) Kanae Iijima-Ando et al.   PLoS Genetics

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation

(2011) Surendra S. Ambegaokar et al.   HUMAN MOLECULAR GENETICS

A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines

(2011) Wendou Yu et al.   HUMAN MOLECULAR GENETICS

Important neuronal toxicity of microtubule-bound Tau in vivo in Drosophila

(2011) Yasmina Talmat-Amar et al.   HUMAN MOLECULAR GENETICS

The Power and Richness of Modelling Tauopathies in Drosophila

(2011) Katerina Papanikolopoulou et al.   MOLECULAR NEUROBIOLOGY

Filamin-A and Myosin VI colocalize with fibrillary Tau protein in Alzheimer's disease and FTDP-17 brains

(2010) Sébastien Feuillette et al.   BRAIN RESEARCH

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies

(2010) Tomás L. Falzone et al.   HUMAN MOLECULAR GENETICS

Tau Ser262 phosphorylation is critical for A 42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease

(2010) K. Iijima et al.   HUMAN MOLECULAR GENETICS

Paxillin and Hydrogen Peroxide-Inducible Clone 5 Expression and Distribution in Control and Alzheimer Disease Hippocampi

(2010) John Caltagarone et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease

(2010) H.N. Dawson et al.   NEUROSCIENCE

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

(2010) Della C. David et al.   PLOS BIOLOGY

Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo

(2010) Vikram Khurana et al.   PLoS Genetics

Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease

(2010) Oyinkan Sofola et al.   PLoS Genetics

A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation

(2009) Dominik Paquet et al.   JOURNAL OF CLINICAL INVESTIGATION

Axonal Stress Kinase Activation and Tau Misbehavior Induced by Kinesin-1 Transport Defects

(2009) T. L. Falzone et al.   JOURNAL OF NEUROSCIENCE

Axonal Transport Defects in Neurodegenerative Diseases

(2009) G. A. Morfini et al.   JOURNAL OF NEUROSCIENCE

The trip of the tip: understanding the growth cone machinery

(2009) Laura Anne Lowery et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Control of neuronal polarity and plasticity – a renaissance for microtubules?

(2009) Casper C. Hoogenraad et al.   TRENDS IN CELL BIOLOGY

Protein folding diseases and neurodegeneration: Lessons learned from yeast

(2008) Joris Winderickx et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Identification of Novel Genes That Modify Phenotypes Induced by Alzheimer's  -Amyloid Overexpression in Drosophila

(2008) W. Cao et al.   GENETICS

Dissociation of tau toxicity and phosphorylation: role of GSK-3β, MARK and Cdk5 in a Drosophila model

(2008) Shreyasi Chatterjee et al.   HUMAN MOLECULAR GENETICS