Review
Immunology
Guanyu Qu, Shengli Wang, Zhenlong Zhou, Dawei Jiang, Aihua Liao, Jing Luo
Summary: This article summarizes the current knowledge of the γδT cell phenotype in various tissues in mice and humans, describing the similarities and differences of tissue-resident γδT cells in these two species.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
In Kang, Yumin Kim, Heung Kyu Lee
Summary: Gamma delta T cells play important roles in tumor immunity and have potential applications in GBM treatment. However, limitations still exist and further research is needed. This review summarizes the effector functions of gamma delta T cells, current advances and limitations, and suggests future research directions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Yi Wang, Nan Ji, Yang Zhang, Junsheng Chu, Changcun Pan, Peng Zhang, Weiwei Ma, Xueguang Zhang, Jianzhong Jeff Xi, Mingze Chen, Yonghui Zhang, Liwei Zhang, Tao Sun
Summary: The study investigates the therapeutic potential of human V gamma 9V delta 2 T cells in glioblastoma (GBM) treatment. The results show that V gamma 9V delta 2 T cells have a robust anti-tumor effect in some glioma cases, while weaker in others. Elevated expression of BTN2A1 and BTN3A1 correlates with improved response. Weak anti-tumor effect tumors can be sensitized using a BTN3A1 agonistic antibody or bisphosphonates. Genetically engineered V gamma 9V delta 2 T cells, i.e., Car-B7H3, demonstrate promising efficacy. These findings highlight the versatility of V gamma 9V delta 2 T cells for GBM treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Immunology
Guo-Qing Li, Jiliang Xia, Weihong Zeng, Weijia Luo, Logen Liu, Xi Zeng, Deliang Cao
Summary: The intestinal mucosa of mammals, as an effective immune system, contains rare γδT cells that can rapidly produce cytokines and growth factors. These cells play key roles in maintaining epithelial homeostasis, immune surveillance, and even recovery from diseases like ischemic stroke.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ka Sin Lui, Zuodong Ye, Hoi Ching Chan, Yoshimasa Tanaka, Allen Ka Loon Cheung
Summary: The study showed that V delta 2 T cells combined with anti-PD-1 exhibited cytotoxicity against mesothelioma in vivo, especially for high PD-1 expressing cells. This suggests that V delta 2 T cells combined with anti-PD-1 antibody may be developed as a potential combination immunotherapy for mesothelioma.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Gitte Holmen Olofsson, Manja Idorn, Ana Micaela Carnaz Simoes, Pia Aehnlich, Signe Koggersbol Skadborg, Elfriede Noessner, Reno Debets, Bernhard Moser, Ozcan Met, Per Thor Straten
Summary: Human Vγ9Vδ2 T cells expanded in vitro efficiently kill cancer cells, have the ability to cross-present MHC class I-restricted peptides, and support tumor-specific CD8 T cell responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jiechu Deng, Hongna Yin
Summary: Cancer immunotherapy is an important approach in the treatment of cancer, and gamma delta T cells have shown great potential in this field. Gamma delta T cells can recognize a wide range of antigens, exert anti-tumor effects, and can be manipulated for therapeutic interventions. However, research on gamma delta T cells is still in its infancy and faces many challenges and limitations.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Immunology
Wenyi Yan, Louisa S. Chard Dunmall, Nicholas R. Lemoine, Yaohe Wang, Yafeng Wang, Pengju Wang
Summary: This review discusses the heterogeneity of γδ T cells and their importance in cancer immunotherapy. γδ T cells possess unique tumor recognition and anti-tumor functions, and play a role in the tumor microenvironment. Understanding and effectively harnessing these diverse γδ T cell subpopulations is crucial for tumor-specific immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Haeyoun Choi, Tai-Gyu Kim, Sin -Soo Jeun, Stephen Ahn
Summary: This study introduces γδ T cells as a new option for treating glioblastoma, highlighting their unique characteristics and advantages compared to conventional αβ T cells. Several recent preclinical studies using human γδ T cell therapy for glioblastoma are summarized, and future directions for human γδ T cell therapy are suggested.
Article
Medicine, Research & Experimental
Shangyi Wang, Mina Kozai, Hironobu Mita, Zimeng Cai, Md Abdul Masum, Osamu Ichii, Kensuke Takada, Mutsumi Inaba
Summary: Psoriasis is a chronic inflammatory skin disease characterized by epidermal hyperplasia and cellular infiltration. Recent research has highlighted the crucial role of gamma delta T17 cells in psoriasis pathogenesis, revealing their involvement in regulation through REV-ERBs. Synthetic REV-ERB agonists can suppress gamma delta T17 cells both in vitro and in vivo, providing a novel therapeutic approach for psoriasis targeting REV-ERBs in gamma delta T17 cells.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Kohei Nagai, Takenobu Ishii, Tatsukuni Ohno, Yasushi Nishii
Summary: This study investigated the role of gamma delta T cells in the pathology of rheumatoid arthritis (RA) using a mouse model. The study found that mechanical strain on the temporomandibular joint (TMJ) may exacerbate the disease, and gamma delta T cells were suggested to be involved in the etiology of RA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
David A. Rosso, Micaela Rosato, Juan Iturrizaga, Nazareno Gonzalez, Carolina M. Shiromizu, Irene A. Keitelman, Juan Coronel, Fernando D. Gomez, Maria M. Amaral, Alejandra T. Rabadan, Gabriela Salamone, Carolina C. Jancic
Summary: The study showed that HMBPP-activated V gamma 9V delta 2 T cells exhibit a Th1-like immune response when interacting with GBM cells, and GBM patients have better overall survival when expressing high levels of TRGV9 gene. Additionally, there is an association between gamma delta T cell infiltrates and TNF-alpha expression in the tumor microenvironment.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Fisheries
Miaomiao Wu, Qianling Jiang, Ali Nazmi, Jie Yin, Guan Yang
Summary: Pigs are important domestic livestock and studying their immune system is crucial for improving swine vaccine efficacy. Pig models are excellent for immunological studies due to their similarities to humans. Unconventional T cells are a critical component of the porcine immune system and show distinct characteristics compared to conventional T cells.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yanan Wang, Yuan Hu, Yuxia Liu, Chongdeng Shi, Linyan Yu, Nan Lu, Cai Zhang
Summary: Liver-resident CD44(hi)CD27(-) gamma delta T cells have enhanced proliferation capacity and rapidly increase in proportion after infection. These cells can produce both IL-17A and IFN-gamma simultaneously and have a protective role against Listeria monocytogenes infection. Hepatic macrophages promote the migration and accumulation of these cells at infection sites.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Immunology
Li Wang, Jiawei Li, Silin Jiang, Yan Li, Rong Guo, Yuyuan Chen, Yan Chen, Hang Yu, Qingqing Qiao, Mingjie Zhan, Zhinan Yin, Zheng Xiang, Chengfang Xu, Yan Xu
Summary: This study investigated the effects of COVID-19 vaccination on gamma delta-T cells in pregnant women. The results showed that the frequency of CD3(+)gamma delta-T+ cells was lower in vaccinated pregnant women compared to unvaccinated pregnant women. However, there was no significant difference in the frequency of CD3(+)gamma delta-T+ cells between non-pregnant vaccinated women and vaccinated pregnant women. Additionally, there were no significant differences in the frequencies of different subsets of gamma delta-T cells between pregnant women with or without COVID-19 vaccination.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Takayuki Morimoto, Tsutomu Nakazawa, Ryosuke Maeoka, Ichiro Nakagawa, Takahiro Tsujimura, Ryosuke Matsuda
Summary: Glioblastoma (GBM) is an aggressive and malignant brain tumor with poor prognosis. Various treatment strategies have been explored, including immunotherapies. However, current immunotherapies mainly based on T cells have not achieved satisfactory outcomes. This review focuses on the potential of NK cell-based immunotherapy as a novel treatment strategy for GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Ryosuke Matsuda, Ryosuke Maeoka, Noriaki Tokuda, Tsutomu Nakazawa, Takayuki Morimoto, Masashi Kotsugi, Yasuhiro Takeshima, Kentaro Tamura, Shuichi Yamada, Fumihiko Nishimura, Ichiro Nakagawa, Young -Soo Park, Hiroyuki Nakase
Summary: This study evaluated the safety of BCNU wafer implantation after malignant glioma resection, with or without ventricular opening. The results showed similar occurrence of adverse events in both groups, indicating that BCNU wafer implantation is safe and feasible even with ventricular opening.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Takashi Yagi, Masaki Mizuno, Hiroto Kageyama, Kotaro Tatebayashi, Toshiki Endo, Yasuhiro Takeshima, Motoyuki Iwasaki, Ryu Kurokawa, Keisuke Takai, Misao Nishikawa, Kazutoshi Hida
Summary: This study analyzed the clinical characteristics, treatment strategies, and surgical outcomes of subependymoma patients. The results showed that subependymomas have an indolent clinical course and eccentric location. Surgical treatment should prioritize functional preservation, as even subtotal resection has a good prognosis.
Article
Clinical Neurology
Takeshi Hara, Masaki Mizuno, Kazutoshi Hida, Toru Sasamori, Yasuyuki Miyoshi, Hisaaki Uchikado, Hiroki Ohashi, Taku Sugawara, Yasuhiro Takeshima, Yukoh Ohara, Akihide Kondo, Toshiki Endo
Summary: This study reports on the clinical characteristics, imaging findings, and treatment strategies of intramedullary schwannomas. The study analyzed patients who underwent surgical treatment for intramedullary schwannomas at 8 centers between 2009 and 2020. The findings showed that the most common clinical presentation was limb paresthesia and the cervical spine was the most common location for the tumors. The study also discussed the MRI findings of intramedullary schwannomas and suggested treatment strategies based on the extent of tumor resection and symptom improvement.
Article
Multidisciplinary Sciences
Ayako Oi, Hironobu Hayashi, Yasushi Motoyama, Hideaki Kawanishi, Ichiro Nakagawa, Hiroyuki Nakase, Masahiko Kawaguchi
Summary: We report two cases where laser speckle flowgraphy (LSFG) was successfully used to measure ocular blood flow for assessing changes in cerebral perfusion after carotid endarterectomy (CEA). Postoperatively, an increase of 18.7% (case 1) and 47.7% (case 2) in ocular blood flow was measured using LSFG compared to baseline. LSFG may be a useful tool for evaluating cerebral perfusion after CEA.
Article
Neurosciences
Tae-Kyun Kim, Yasuhiro Takeshima, Yukiteru Ouji, Fumihiko Nishimura, Ichiro Nakagawa, Young-Soo Park, Masahide Yoshikawa, Hiroyuki Nakase
Summary: Neurogenesis confirmed in rat models with cerebral arterial ischemia but unclear for cerebral venous ischemia. Using rat models created by two-vein occlusion, neurogenesis was evaluated by immunohistochemistry. The study found significant numbers of newly generated neurons and precursors in the ischemic area, suggesting that the cortex could be the main origin of neurogenesis after cortical venous ischemia.
IBRO NEUROSCIENCE REPORTS
(2023)
Article
Neurosciences
Fumiya Sato, Daisuke Wajima, Yasuhiro Takeshima, Ichiro Nakagawa, Taekyun Kim, Yasushi Motoyama, Young-Soo Park, Hiroyuki Nakase
Summary: This study aimed to investigate the neuroprotective effects of pre-emptive administration of pravastatin sodium against cerebral cortical venous ischemia. The results showed that pravastatin sodium significantly reduced the infarcted area and decreased Bax expression, but had no significant influence on regional cerebral blood flow.
IBRO NEUROSCIENCE REPORTS
(2023)
Article
Oncology
Tsutomu Nakazawa, Takayuki Morimoto, Ryosuke Maeoka, Ryosuke Matsuda, Mitsutoshi Nakamura, Fumihiko Nishimura, Noriko Ouji, Shuichi Yamada, Ichiro Nakagawa, Young Soo Park, Toshihiro Ito, Hiroyuki Nakase, Takahiro Tsujimura
Summary: This study successfully induced CIS-deleted NK cells using CRISPR/Cas9, and found that CIS deletion enhanced the anti-tumor effects of NK cells against glioblastoma. It suggests that CIS deletion could be a promising immunotherapeutic alternative for GBM patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Clinical Neurology
Kentaro Tamura, Ryota Sasaki, Takafumi Sakakibara, Riju Dahal, Yasuhiro Takeshima, Ryosuke Matsuda, Shuichi Yamada, Fumihiko Nishimura, Ichiro Nakagawa, Young-Soo Park, Hidehiro Hirabayashi, Hiroyuki Nakase
Summary: A retrospective study was conducted on 74 patients who underwent VNS implantation, and it was found that high-stimulation settings of VNS therapy are effective for adolescent and adult patients with intractable epilepsy, resulting in a significant reduction in seizures. However, the same high-stimulation settings did not have the same effect on children, even with higher stimulation.
NEUROLOGIA MEDICO-CHIRURGICA
(2023)
Article
Clinical Neurology
Ichiro Nakagawa, Masashi Kotsugi, Shohei Yokoyama, Ryosuke Maeoka, Kentaro Tamura, Yasuhiro Takeshima, Ryosuke Matsuda, Shuichi Yamada, Fumihiko Nishimura, Young-Soo Park, Hiroyuki Nakase
Summary: Chronic subdural hematoma (CSDH), commonly found in the elderly population of Japan, can be treated with either burr-hole irrigation or middle meningeal artery (MMA) embolization. Recent studies have shown the benefits of embolizing both the anterior and posterior branches of the MMA to prevent recurrence. Technical innovations such as the sugar rush technique, which involves injecting soluble glucose during MMA embolization, have also been explored. Radiographically, the spread of embolic materials can be indicated by the bright falx sign and post-embolization enhancement of dural structures and subdural hematoma fluid. This review provides an overview of the current status and future challenges in MMA embolization for CSDH, focusing on technical aspects to improve clinical outcomes.
NEUROLOGIA MEDICO-CHIRURGICA
(2023)
Article
Clinical Neurology
Yasuhiro Takeshima, Hirokazu Takami, Toshiki Endo, Masaki Mizuno, Kazutoshi Hida
Summary: This study investigated the relationship between the extent of resection and recurrence in surgery for intramedullary spinal hemangioblastoma (sHB) and its impact on von Hippel-Lindau (vHL) disease. The study found that postoperative functional improvement can be expected in sporadic sHB, with a favorable long-term functional prognosis. However, this improvement was not significant in the vHL group.
Article
Cell & Tissue Engineering
Tsutomu Nakazawa, Ryosuke Maeoka, Takayuki Morimoto, Ryosuke Matsuda, Mitsutoshi Nakamura, Fumihiko Nishimura, Shuichi Yamada, Ichiro Nakagawa, Young -Soo Park, Toshihiro Ito, Hiroyuki Nakase, Takahiro Tsujimura
Summary: Natural killer cells (NKCs) can attack cancer cells through direct recognition of ligands without prior sensitization. Cord blood-derived NKCs (CBNKCs) have potential for allogeneic NKC-based cancer immunotherapy. Efficient NKC expansion and decreased T cell inclusion are crucial for successful immunotherapy without graft-versus-host reactions. This study evaluated the performance of an NKC expansion system using cord blood and characterized the expanded populations.
REGENERATIVE THERAPY
(2023)