Article
Materials Science, Ceramics
Abdul Wasy Zia, Ioannis Anestopoulos, Mihalis I. Panayiotidis, Martin Birkett
Summary: The biomedical applications of diamond-like carbon (DLC) coatings are increasing due to their superior mechanical properties, low friction coefficient, antiwear characteristics, and biocompatibility. However, the relationship between biocompatibility and the hardness of DLC coatings remains largely unexplored. This study investigates the influence of bias voltage on the atomic structure, physical, mechanical properties, and biocompatibility of DLC coatings. The results show that a softer DLC coating exhibits higher biocompatibility compared to harder coatings.
CERAMICS INTERNATIONAL
(2023)
Article
Chemistry, Physical
Abdul Wasy Zia, Ioannis Anestopoulos, Mihalis I. Panayiotidis, Leon Bowen, Martin Birkett
Summary: Silver enriched diamond-like carbon (Ag/DLC) coatings are gaining popularity in medical applications due to their improved biocompatibility and antimicrobial features. However, higher amounts of silver in the coatings can lead to increased cytotoxic effects. This study investigated the properties of Ag-enriched DLC coatings with different amounts of silver and found that 17% Ag-enriched DLC coatings are a safe candidate for biomedical applications with retained biocompatibility. Additionally, these coatings showed less compromise on mechanical properties compared to coatings with higher silver concentrations.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Review
Physics, Applied
Mohsin Ali, Faizan Ali, Boxiong Yang, Akmal Abbas
Summary: The study focuses on the recent advancements in research on artificial diamond films, particularly CVD diamond coatings, over the past two decades. It highlights the potential biomedical applications of these coatings in fields such as orthopedics, ophthalmology, dentistry, biosensing, neuronal implants, and antibacterial applications. Additionally, the effects of surface termination and functionalization on CVD diamond coatings are analyzed.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2021)
Article
Materials Science, Multidisciplinary
Jia Lou, Zonglong Gao, Jie Zhang, Hao He, Xinming Wang
Summary: The study compared the corrosion resistance of TiN, TiCN, and Ti-DLC films on 316L stainless steel. TiCN and Ti-DLC films showed significantly improved corrosion resistance due to TiC crystals, while TiN had the lowest corrosion resistance. Among them, Ti-DLC film demonstrated the most suitable corrosion protection for 316L SS substrates, especially in electrolytes with high Cl- and H+ concentrations.
Article
Materials Science, Multidisciplinary
Azadeh Valinattaj Omran, Chaimaa Mahi, Romain Vayron, Celine Falentin-Daudre, Fabien Benedic
Summary: This study investigated the characteristics of nanocrystalline diamond films synthesized at low surface temperature on Ti-6Al-4V substrates for biomedical applications. The surface roughness of the substrates was varied by different polishing grits. Regardless of the polishing protocol, nanocrystalline diamond coatings with comparable morphology and purity to those on silicon substrates were achieved. However, the polishing protocol significantly affected the roughness and hardness of the films, with the finest polishing grit leading to increased hardness values.
Review
Chemistry, Multidisciplinary
Mohammad Mamunur Rashid, Petra Forte Tavcer, Brigita Tomsic
Summary: TiO2 nanoparticles have high availability and photocatalytic activity, making them useful in various economic fields. However, the debate surrounding their potential risks and benefits requires careful consideration for ensuring human health and environmental safety.
Article
Chemistry, Physical
Aqeel Abbas, Hui-Yun Hung, Pi-Chen Lin, Kai-Chang Yang, Minn-Chang Chen, Hsin-Chih Lin, Yin-Yi Han
Summary: Using plasma-enhanced atomic layer deposition, TiO2 films were deposited on Ni50Ti50 substrates, showing good bending and corrosion resistance, as well as reduced nickel ion release and improved biocompatibility. This study demonstrates the potential of ALD-TiO2 films in enhancing the performance of NiTi shape memory alloys in biomedical applications.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Review
Biochemistry & Molecular Biology
Shuang Liu, Xingzhu Chen, Mingyue Yu, Jianing Li, Jinyao Liu, Zunxuan Xie, Fengxiang Gao, Yuyan Liu
Summary: Nano-TiO2 has great potential for applications in stomatology due to its excellent biocompatibility and antimicrobial and photocatalytic activities. However, its biosafety is controversial and further research and evaluation are needed.
Article
Chemistry, Physical
Fiona M. Elam, Feng-Chun Hsia, Stefan van Vliet, Roland Bliem, Liuquan Yang, Bart Weber, Steve E. Franklin
Summary: Corrosion affects the nanoscale topography and friction response of a hydrogenated amorphous carbon film (a-C:H), with surface oxidation identified as the main cause of increased friction force and surface adhesion. The highest friction coefficient was observed for the film corroded at 2.5 V, attributed to jagged surface topography promoting an interlocking friction mechanism.
Article
Chemistry, Physical
Alejandra Romero-Moran, Jose L. Sanchez-Salas, Joel Molina-Reyes
Summary: The study established the influence of the crystalline phase and agglomeration degree of TiO2 nanoparticles on photocatalytic hydroxyl radical formation and bacterial inactivation in TiO2/SiO2 composite coatings. A relationship between hydroxyl radicals' formation and charge carrier transfer mechanism between defect levels in SiO2 and TiO2 embedded nanoparticles was established through a simple spectroscopic method. This correlation complements the lack of mechanisms behind the photocatalytic activity in TiO2/SiO2 composites.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2021)
Review
Chemistry, Physical
Yimin Lu, Guojun Huang, Sai Wang, Chaowei Mi, Shangfang Wei, Fangtao Tian, Wei Li, Haiyuan Cao, Yong Cheng
Summary: Pulsed laser deposition is an excellent technology for growing diamond-like carbon films, with high hardness, chemical inertness, low friction, and superior wear resistance. Various parameters and conditions influence the properties of the films, while new techniques like double laser beam deposition and hybrid pulsed laser deposition are under development. Applications in tribology, mechanics, medicine, and optics are driving further research and advancement in this field.
APPLIED SURFACE SCIENCE
(2021)
Article
Engineering, Industrial
M. Cabrini, A. Carrozza, S. Lorenzi, T. Pastore, C. Testa, D. Manfredi, P. Fino, F. Scenini
Summary: Additive manufacturing (AM) technologies are being increasingly used for biomedical applications due to their customization and optimal surface topography. This study evaluated the electrochemical behavior of the laser powder bed fusion (LPBF)-processed Ti-6Al-4V alloy for biomedical implants. The results showed a convergence of ion release rate and good corrosion resistance over a long period of exposure time. A pickling treatment was shown to improve the corrosion performance without compromising the unique surface finishing of the manufacturing technology.
JOURNAL OF MATERIALS PROCESSING TECHNOLOGY
(2022)
Article
Energy & Fuels
S. P. Vinodhini, Joseph Raj Xavier
Summary: This work focuses on synthesizing hybrid nanocomposite electrode materials for supercapacitor applications. The performance of different hybrid electrode materials, such as MoS2/CNTs, TiO2/CNTs, and MoS2/TiO2/CNTs, was enhanced by incorporating carbon nanotubes (CNTs) into MoS2 and TiO2. The synthesized MoS2/TiO2/CNTs exhibited superior electrochemical performance compared to other hybrid electrode materials, with a higher specific capacitance and lower overall impedance. It also displayed good cycling stability and high energy and power densities.
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
(2022)
Review
Engineering, Chemical
Isabel Carvalho, Lisa Rodrigues, Maria Jose Lima, Sandra Carvalho, Sandra M. A. Cruz
Summary: Carbon-based structures have garnered much attention due to their outstanding properties, with diverse applications ranging from coatings in self-lubricating systems to catalysis structures. Biomedical applications, in particular, require careful testing and improvement, with a focus on biocompatibility and antibacterial issues. Sputtered deposition is an environmentally friendly technique that prevents the introduction of hazardous chemical elements in coatings, exhibiting remarkable mechanical properties.
Article
Dentistry, Oral Surgery & Medicine
X. Yu, B. Feng, Y. Lan, J. Li, G. Ye, Q. Li, F. Zhao, Y. Gu, D. You, Y. Zhu, M. Yu, H. Wang, H. Yang
Summary: This study aims to design a personalized two-stage root analog implant (RAI) with a compact structure and uniform roughness to achieve better fracture resistance, initial osseointegration efficiency, and dispersed stress in immediate implantation. RAIs were manufactured using selective laser melting technology, and in vivo experiments showed that they had higher bone-implant contact and bone volume/total volume compared to conventional implants. Customized abutments were also designed for the RAIs, improving the masticatory ability of the beagle dogs.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Renan Matos Moncao, Miguel Rubira Danelon, Larissa Solano de Almeida, Luciana Sgarbi Rossino, Fernanda Roberta Marciano, Thercio Henrique de Carvalho Costa, Michelle Cequeira Feitor, Ruben Maribondo do Nascimento, Romulo Ribeiro Magalhaes de Sousa
Summary: In this study, MoOx coatings were deposited on plasma nitrided surfaces for the first time, and the effect of temperature on their hardness and tribological properties was investigated. The experimental results showed that the deposition of MoOx coatings after plasma nitriding can significantly improve the wear resistance of metallic surfaces.
MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Samson Afewerki, Thiago Domingues Stocco, Andre Diniz Rosa da Silva, Andre Sales Aguiar Furtado, Gustavo Fernandes de Sousa, Guillermo U. Ruiz-Esparza, Thomas J. Webster, Fernanda R. Marciano, Maria Stromme, Yu Shrike Zhang, Anderson Oliveira Lobo
Summary: Precision medicine allows for tailored treatments, improving the efficiency and accuracy of disease prevention, diagnosis, and treatment. The combination of organ-on-a-chip and bioprinting can address precision medicine challenges and be utilized in the current COVID-19 pandemic for efficient diagnostics and treatments. This convergence enables advances in tools and in vitro models for personalized and faster screening of therapeutics.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Review
Microbiology
Paulo Henrique Fonseca do Carmo, Maira Terra Garcia, Livia Mara Alves Figueiredo-Godoi, Anna Carolina Pinheiro Lage, Newton Soares da Silva, Juliana Campos Junqueira
Summary: Candidiasis is a common fungal infection caused by Candida albicans. Current antifungal treatments have limitations such as toxicity and drug resistance, leading to the exploration of nanocarrier systems like metal nanoparticles. This review focuses on the use of silver, gold, and iron nanoparticles as potential antifungal agents against C. albicans, discussing their mechanism of action and potential for reducing drug resistance.
Article
Engineering, Biomedical
Danielle B. B. Andrade, Leticya L. S. Soares, Francisca L. A. Cardoso, Idglan S. S. Lima, Jhaemely G. V. Silva, Maria A. M. Carvalho, Maria G. G. Fonseca, Guilherme de C. Brito, Francisco Eroni P. Santos, Josy A. A. Osajima, Anderson O. O. Lobo, Edson C. C. Silva-Filho
Summary: A nanocomposite hydrogel, synthesized with GelMA and Lap, has potential application in osteogenesis. The hydrogel showed interactions between GelMA and methacrylate anhydride, as evidenced by Fourier-transform infrared spectra. X-ray diffraction patterns confirmed the presence of Lap and GelMA in the hydrogel. The hydrogel exhibited suitable viscosity for injectability, demonstrated low acute toxicity, supported cell viability, and promoted the differentiation of stem cells into osteogenic cells, indicating its potential for osteogenic induction and bone tissue engineering.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Francileia Nogueira Albino Calland, Guilherme de Castro Brito, Gustavo Fernandes de Sousa, Francilio de Carvalho Oliveira, Fernanda Roberta Marciano, Anderson Oliveira Lobo
Summary: New strategies are needed for developing bandages that can improve wound healing in diabetic patients. In this study, we fabricated multifunctional bandages using electrospinning and surface functionalization techniques, and then evaluated their performance in regenerating skin tissue using a diabetes animal model. The bandages showed excellent tissue integration, as indicated by fibroblast adhesion and the formation of mature collagen (type I). These biomaterials developed by our research group have been successfully utilized in various biomedical applications.
Article
Materials Science, Coatings & Films
Luciana Mendes Ribeiro de Sousa, Moises das Virgens Santana, Bruno Pereira da Silva, Thays Oliveira Marques, Ramon Pena-Garcia, Angel Alberto Hidalgo, Maria Leticia Vega, Bartolomeu Cruz Viana, Thiago Domingues Stocco, Luana Marotta Reis de Vasconcellos, William Chiappim, Rodrigo Savio Pessoa, Fernanda Roberta Marciano, Anderson Oliveira Lobo
Summary: By using Atomic Layer Deposition (ALD) and simulated body fluid method, Ti6Al7Nb alloy was modified with Al2O3 and coated with apatite. Various techniques including X-Ray Fluorescence (FRX), Energy Scattering X-Ray Spectroscopy (EDS), Scanning Electron Microscopy (SEM), X-Ray Diffraction Spectroscopy (XRD), Raman Spectroscopy, and Atomic Force Microscopy (AFM) were used to determine the chemical and crystallographic composition of Ti6Al7Nb before and after surface modifications. The results showed that the surface modifications improved the bioactivity of the titanium alloy by promoting the formation of microporosity and influencing the nucleation of apatite at the nanoscale. These nanofilms were found to be non-cytotoxic, making them promising for tissue engineering applications.
SURFACE & COATINGS TECHNOLOGY
(2023)
Correction
Nanoscience & Nanotechnology
Mirian M. Machado-Paula, Marcus A. . F. Corat, Luana M. R. . de Vasconcellos, Juliani C. R. . Araujo, Gujie Mi, Paria Ghannadian, Tatiane V. Toniato, Fernanda R. . Marciano, Thomas J. Webster, Anderson O. Lobo
ACS APPLIED BIO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Pedro Henrique Dias Moura Prazeres, Heloisa Ferreira, Pedro Augusto Carvalho Costa, Walison da Silva, Marco Tullio Alves, Marshall Padilla, Ajay Thatte, Anderson Kenedy Santos, Anderson Oliveira Lobo, Adriano Sabino, Helen Lima Del Puerto, Michael J. Mitchell, Pedro Pires Goulart Guimaraes
Summary: This study demonstrates the use of ionizable lipid nanoparticles (LNPs) to deliver pDNA for the engineering of T cells to express chimeric antigen receptor (CAR). The LNPs efficiently delivered pDNA to T cells with low cytotoxicity and enabled transient expression of CAR. The engineered CAR T cells showed significant specific killing of target cells in vitro.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Geochemistry & Geophysics
Flavio Pessoa Avelino, Roberto Arruda Lima Soares, Ramon Raudel Pena-Garcia, Anderson O. Lobo
Summary: This study developed a formulation for a ceramic coating and investigated the effects of adding eggshell residue on the mechanical properties. The results showed that the addition of eggshell residue significantly decreased the desired physical and mechanical properties.
Article
Geochemistry & Geophysics
Flavio Pessoa Avelino, Wendel Melo Prudencio de Araujo, Roberto Arruda Lima Soares, Ramon Pena-Garcia, Anderson O. Lobo
Summary: This study develops a ceramic coating formulation composed of clay, kaolin, quartz, talc, and feldspar, with the addition of Hap to enhance mechanical characteristics. The incorporation of Hap fills the formulation gaps and reduces the sintering temperature due to high calcium oxide content. X-ray diffraction analysis confirms the presence of mullite, quartz, and anorthite in the sintered samples. Evaluation of physical and mechanical properties reveals a significant improvement, with over 15% increase in mechanical resistance compared to the standard formulation when incorporating 5%, 10%, and 20% Hap.
Article
Materials Science, Multidisciplinary
Ana Claudia Sene, Michely Glenda Pereira da Silva, Paulo Fabricio Macario, Angela Aparecida Vieira, Priscila Maria Sarmeiro Correa Marciano Leite, Newton Soares da Silva, Francisco Das Chagas Marques, Lucia Vieira
Summary: This study investigates the effectiveness of DLC smoothing coatings on stainless steel and titanium alloy to reduce tribocorrosion and improve cell viability. The results show that the DLC coatings have suitable interaction properties, no cytotoxicity or genotoxicity, and demonstrate low friction and high hardness, making them ideal for use on fixed implants.
Article
Engineering, Biomedical
Seania Santos Leal, Gustavo Oliveira de Meira Gusmao, Valdileia Teixeira Uchoa, Jose Figueiredo-Silva, Lucielma Salmito Soares Pinto, Carla R. Tim, Livia Assis, Antonio Luiz Martins Maia-Filho, Rauirys Alencar de Oliveira, Anderson Oliveira Lobo, Adriana Pavinatto
Summary: The study evaluates the effect of Ximenia americana L. extract incorporated into GelMA hydrogel with LED therapy on bone repair. The results show a significant increase in bone formation when using GelMA + X. americana L. compared to control group, and even more significant when using GelMA + X. americana L. + LED.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Correction
Nanoscience & Nanotechnology
Mirian M. Machado-Paula, Marcus A. F. Corat, Luana M. R. de Vasconcellos, Juliani C. R. Araujo, Gujie Mi, Paria Ghannadian, Tatiane Toniato, Fernanda R. Marciano, Thomas J. Webster, Anderson O. Lobo
ACS APPLIED BIO MATERIALS
(2023)
Article
Engineering, Biomedical
Gustavo F. Sousa, Samson Afewerki, Dalton Dittz, Francisco E. P. Santos, Daniele O. Gontijo, Sergio R. A. Scalzo, Ana L. C. Santos, Lays C. Guimaraes, Ester M. Pereira, Luciola S. Barcelos, Semiramis J. H. Do Monte, Pedro P. G. Guimaraes, Fernanda R. Marciano, Anderson O. Lobo
Summary: The use of click chemistry to engineer hydrogels allows for the creation of tailor-made hydrogels with desired mechanical and biocompatible properties. In this study, a versatile and facile catalyst-free click chemistry method was developed to generate a novel hydrogel by combining chondroitin sulfate and polyethylene glycol. The resulting hydrogel showed promising results for wound repair and in situ skin tissue engineering applications.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Mirian M. Machado-Paula, Marcus A. F. Corat, Luana M. R. de Vasconcellos, Juliani C. R. Araujo, Gujie Mi, Paria Ghannadian, Tatiane Toniato, Fernanda R. Marciano, Thomas J. Webster, Anderson O. Lobo
Summary: In this study, a next-generation bone regeneration material was developed by combining polycaprolactone fibers, carbon nanotubes, and hydroxyapatite nanoparticles. Rotary jet spinning fibers showed the best outcomes in repairing rat calvarial defects, and their rough topography allowed for better cellular growth and spreading. Incorporating nanoparticles and bone marrow mesenchymal stem cells enhanced cell performance and resulted in greater bone neoformation.
ACS APPLIED BIO MATERIALS
(2022)
