Review
Cell & Tissue Engineering
Hadi Sadeghzadeh, Hassan Dianat-Moghadam, Azizeh Rahmani Del Bakhshayesh, Daryush Mohammadnejad, Ahmad Mehdipour
Summary: The multidisciplinary research field of regenerative medicine and tissue engineering has effectively resolved numerous issues related to bone tissue disorders caused by aging, diseases, and injuries. Nanotechnology, combined with tissue engineering, has made significant contributions to tissue repair and regeneration. Studies have demonstrated that the incorporation of magnetic nanoparticles (MNPs) into composite scaffolds enhances their healing capabilities for bone defects. Furthermore, the induction of osteogenic differentiation in mesenchymal stem cells (MSCs) has been investigated and verified in the presence of these nanoparticles. This article reviews the different types and unique properties of MNPs, as well as their application in healing damaged bone tissue. It also discusses the molecular effects of MNPs on cell behavior, particularly in osteogenesis. Lastly, the potential applications of MNP-containing nanocomposite scaffolds in the treatment of bone lesions and injuries are outlined. Overall, this review article emphasizes the role of nanocomposite scaffolds containing MNPs as a solution for treating bone defects in tissue engineering and regenerative medicine.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Materials Science, Multidisciplinary
Premkumar Murugaiyan, Amitava Mitra, P. S. M. Jena, B. Mahato, M. Ghosh, Rajat K. Roy, Ashis K. Panda
Summary: The addition of P in FeSiB(P)NbCu nanocomposite alloy leads to grain refinement of alpha-Fe nanocrystals, resulting in reduced coercivity and enhanced soft-magnetic properties. This synergistic grain refinement mechanism is explained by the activation energy of crystallization, selective solute re-distribution, and enhanced stabilization of intergranular amorphous matrix. The optimal soft-magnetic properties are achieved in the 4 at% P alloy.
Article
Chemistry, Multidisciplinary
Anna Poryvai, Michal Smahel, Marie Svecova, Ahlam Nemati, Sasan Shadpour, Pavel Ulbrich, Timothy Ogolla, Jiao Liu, Vladimira Novotna, Miroslav Veverka, Jana Vejpravova, Torsten Hegmann, Michal Kohout
Summary: Combining cobalt ferrite nanocrystals with organic ligands featuring a robust photosensitive unit and a source of chirality, nanoparticles are developed to serve as a multifunctional and multiaddressable dopant to modify the properties of liquid crystalline matrices. These nanoparticles, when dispersed in achiral liquid crystals, form chiral supramolecular structures that can respond to UV-light illumination and possess strong magnetic response.
Review
Biochemistry & Molecular Biology
Lu Fan, Yanru Ren, Steffen Emmert, Ivica Vuckovic, Sanja Stojanovic, Stevo Najman, Reinhard Schnettler, Mike Barbeck, Katja Schenke-Layland, Xin Xiong
Summary: Synthetic bone substitute materials (BSMs) are replacing autologous grafting for bone tissue engineering (BTE). Collagen type I, a main component of bone matrix, has been crucial in the development of synthetic BSMs. However, collagen-based materials have limitations such as poor mechanical properties and fast degradation, hindering efficient bone replacement and clinical translation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Akshith Dasari, Jingyi Xue, Sanjukta Deb
Summary: Tissue engineering approaches offer the possibility to induce new functional bone regeneration by creating a regenerative niche at the site of damage. Magnetic nanoparticles, as a potential tool in bone tissue engineering, leverage the inherent magnetism to enhance the properties of osteoinduction, osteoconduction, and angiogenesis in scaffold design.
Article
Chemistry, Physical
Jiao Ai, Si-Rong Cheng, Yu-Jia Miao, Ping Li, Huan-Xia Zhang
Summary: An innovative approach to fabricate lightweight, highly sensitive 3D conductive nanofiber sponges for pressure sensors was reported. The 3D sponges were prepared by self-assembly of electrospun carbon nanofibers/aminated Fe3O4 and reduced graphene oxide (rGO) nanosheets. The orientation and distribution of the graphene nanosheets were further regulated by an external magnetic field to improve the sponge's performance.
Review
Biochemistry & Molecular Biology
Elaheh Salehi Abar, Somayeh Vandghanooni, Ali Torab, Mehdi Jaymand, Morteza Eskandani
Summary: The creation of a suitable scaffold is crucial in bone tissue engineering, as it affects the fate of cells. Natural polypeptides like gelatin and collagen have been widely used for scaffold preparation. Nanocomposite biomaterials consisting of polymers and nanoparticles have shown potential in addressing challenges in bone tissue engineering. Gelatin combined with various types of nanoparticles is promising for creating scaffolds with superior properties. This review explores the use of nanocomposite biomaterials based on gelatin and nanoparticles in bone tissue engineering applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Materials Science, Composites
Wei Zhao, Zhipeng Huang, Liwu Liu, Wenbo Wang, Jinsong Leng, Yanju Liu
Summary: Bone tissue engineering involves the development of 3D printed porous scaffolds based on shape memory polymer composite (SMPC), which are designed with the addition of magnetic nanoparticles for perfect matching when implanted in the body. The designs are inspired by thorough observation and analysis of lotus root structures, with experiments demonstrating the reliability and biological activity of the scaffolds.
COMPOSITES SCIENCE AND TECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Miriam Filippi, Francesca Garello, Oncay Yasa, Jesil Kasamkattil, Arnaud Scherberich, Robert K. Katzschmann
Summary: The article discusses the applications of magnetic nanoparticles in biomedicine and their combination with polymers to form magnetic nanocomposites. These composites have the potential to modulate various cellular functions and show promise in regenerative medicine and the development of biomedical robots.
Article
Engineering, Multidisciplinary
Ye Li, Min Wang, Meng Sun, Xinxin Wang, Dandan Pei, Bo Lei, Ang Li
Summary: A new hydrogel that encapsulates exosomes derived from stem cells can effectively treat traumatic brain injury (TBI) by reducing neuroinflammation and promoting neuroregeneration through anti-inflammatory and antioxidant effects.
COMPOSITES PART B-ENGINEERING
(2022)
Editorial Material
Chemistry, Physical
Antonio Boccaccio
Summary: The recent advancements in manufacturing technologies and innovative biocompatible materials have enabled the fabrication of high-performing scaffolds for bone tissue engineering. Researchers worldwide are focused on identifying the optimal material, geometry, and surface properties for scaffolds to stimulate bone formation efficiently.
Article
Materials Science, Multidisciplinary
Xiaodi Zhang, Tong Wang, Zhongyang Zhang, Haiqing Liu, Longfei Li, Aochen Wang, Jiang Ouyang, Tian Xie, Liqun Zhang, Jiajia Xue, Wei Tao
Summary: This review provides an overview of the role of endogenous electric field in bone tissue and its interaction with bone-related cells. It then discusses the latest progress in electroactive biomaterials and their contributions to bone healing. The review also explores the implementation of exogenous electrical stimulation and self-powered stimulation systems for bone tissue engineering. Furthermore, it delves into the underlying mechanisms of cellular responses to electrical stimulation and proposes future development directions.
Article
Nanoscience & Nanotechnology
Denisse Jara, Nataly Hoyos Avila, Guillermo Arturo Munoz Medina, Octavio Garate, Pedro Mendoza Zelis, Gabriel Omar Ybarra, Pablo Tancredi
Summary: This study presents the preparation, characterization, and technological performance of smart ferrogels composed of a thermoresponsive polymer and iron oxide nanoparticles. The size of the nanoparticles plays a crucial role in the thermosensitive response of the ferrogel, with 10nm nanoparticles showing the best performance. The ferrogel has potential uses as a remotely activated release device for drug delivery, gel actuators, and other technological applications.
ACS APPLIED NANO MATERIALS
(2023)
Review
Polymer Science
Wenqing Liang, Yongqiang Dong, Hailiang Shen, Ruyi Shao, Xudong Wu, Xiaogang Huang, Bin Sun, Bin Zeng, Songou Zhang, Fangming Xu
Summary: Successful materials design for bone tissue engineering involves understanding the structure and composition of host bone tissue, and selecting appropriate biomimetic natural or synthetic materials. Challenges in biomaterial design drive the development of bio-inspired materials to enhance biofunctionality. Researchers must understand the goals, mechanisms, and requirements of bone tissue regeneration in order to design future research strategies effectively.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Review
Chemistry, Multidisciplinary
Xu Xue, Yan Hu, Yonghui Deng, Jiacan Su
Summary: Hydrogels are promising candidates for bone tissue engineering due to their unique 3D network structure. Injectable hydrogels based on biocompatible materials offer advantages in minimally invasive surgery and drug delivery. Advanced approaches and innovative ideas of bioactive hydrogels are expected to enhance the quality of life for patients with bone injuries.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Environmental
Miroslav Brumovsky, Jana Oborna, Vesna Micic, Ondrej Malina, Josef Kaslik, Daniel Tunega, Miroslav Kolos, Thilo Hofmann, Frantisek Karlicky, Jan Filip
Summary: The article discusses the significant enhancement in reactivity and corrosion resistance of zerovalent iron nanoparticles (nZVI) through nitriding. The study demonstrates the outstanding catalytic performance of iron nitrides (FexN) in various applications and their potential as a tool for trichloroethylene (TCE) dechlorination. The research findings provide valuable insights into the application of nitriding nanoparticles in environmental remediation.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jakub Plasil, Gwladys Steciuk, Juraj Majzlan, Radek Skoda, Jan Filip, Martin Petr, Jan Kolarik, Mariana Klementova, Oliver Baehre, Gert Kloess, Ladislav Lapcak
Summary: The weathering of ore minerals produces initial products that are often poorly characterized but can significantly affect the fate of metals in the system. In this study, 3D electron diffraction techniques were used to characterize nanocrystalline phases in the weathering of uraninite-sulfide. The study identified previously unknown phases and revealed that the abundance of iron controls the formation of different weathering products.
ACS EARTH AND SPACE CHEMISTRY
(2022)
Review
Engineering, Biomedical
Jae Hee Park, Seung Bin Jo, Jung-Hwan Lee, Hae-Hyoung Lee, Jonathan C. Knowles, Hae-Won Kim
Summary: Rigidity of materials and extracellular matrix plays a crucial role in controlling cell behaviors and pathophysiological phenomena. Research on 2D materials has revealed the impact of matrix biophysical cues on cellular events, while recent findings in 3D environments highlight the importance of dynamically changing rigidity in tissue repair and disease progression. These studies provide insights for therapeutic targeting and the design of implantable materials.
BIOACTIVE MATERIALS
(2023)
Article
Materials Science, Ceramics
Ensanya A. Abou Neel, S. Soumya, Sharon R. Oyhanart, Jonathan C. Knowles, Shams A. M. Issa, Ghada Almisned, H. O. Tekin
Summary: The incorporation of Fe2O3 into P2O5-CaO-Na2O glasses enhances their biocompatibility and gamma-ray absorption characteristics, making them suitable for medical and dental applications.
CERAMICS INTERNATIONAL
(2023)
Article
Engineering, Environmental
Yu-Meng Li, Kapil D. Patel, Yoon-Koo Han, Suk-Min Hong, Yu-Xuan Meng, Hae-Hyoung Lee, Jeong Hui Park, Jonathan C. Knowles, Jung Keun Hyun, Jung-Hwan Le, Hae-Won Kim
Summary: Diseased or injured nervous systems have limited self-repair and regenerative capability, leading to lifelong disability and even death. Biomaterial scaffolds with specific properties, such as electroconductivity, can guide the selective differentiation of neural stem/progenitor cells (NSPCs) into neurons and oligodendrocytes. Electroconductive and mechano-competent scaffolds made of shape-memory polyurethane-polycaprolactone (PUCL) nanofibers and carbon nanotubes (CNTs) were prepared and showed promising potential for neural tissue regeneration.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Soo-Jin Chang, Yu-Jin Kim, Huong Thu Vu, Ji-Myung Choi, Jeong-Hui Park, Seong-Jin Shin, Khandmaa Dashnyam, Jonathan C. Knowles, Hae-Hyoung Lee, Soo-Kyung Jun, Mi-Ran Han, Joon-Haeng Lee, Jong-Soo Kim, Ji-Sun Shin, Jong-Bin Kim, Jung-Hwan Lee
Summary: This study investigated the effects of different viscosities of silicone oil on the properties of a sodium iodide paste. Six different paste groups were created and evaluated using various parameters. The D30L group showed superior outcomes compared to the conventional iodoform group, including reduced osteoclast formation. The optimized viscosity of the sodium iodide paste (D30L) may lead to favorable outcomes when used in primary teeth.
Article
Pharmacology & Pharmacy
Yu-Ji Jang, Yu-Jin Kim, Huong Thu Vu, Jeong-Hui Park, Seong-Jin Shin, Khandmaa Dashnyam, Jonathan C. C. Knowles, Hae-Hyoung Lee, Soo-Kyung Jun, Mi-Ran Han, Joon-Haeng Lee, Jong-Soo Kim, Jong-Bin Kim, Jung-Hwan Lee, Ji-Sun Shin
Summary: Calcium silicate-based cement (CSC) is widely used in dentistry due to its excellent biocompatibility, sealing ability, and antibacterial activity. This study compared four commercial CSCs and found that premixed CSCs had improved physical properties, with ECPR exhibiting the highest antibacterial properties. However, there were no significant differences in biological properties at 12.5% dilution. Further investigation is needed for clinical situations.
Review
Pharmacology & Pharmacy
Xiaohan Ma, Jonathan C. Knowles, Alessandro Poma
Summary: Molecular imprinting technology has made significant advancements in the design and production of MIP nanoparticles (MIP NPs) as antibody substitutes. However, its overall sustainability and biodegradability have been questioned. This review aims to examine the production and purification strategies of MIP NPs from a sustainability and waste management perspective.
Article
Biochemistry & Molecular Biology
Mohammad B. Aljaber, Fiona Verisqa, Zalike Keskin-Erdogan, Kapil D. Patel, David Y. S. Chau, Jonathan C. Knowles
Summary: Approximately half of an adult human's body weight is made up of muscles. The source and bloom number of gelatin have been found to have an impact on the mechanical properties and biological activities of GelMA hydrogels.
Article
Chemistry, Multidisciplinary
Ghada Alrabeah, Jonathan C. Knowles, Haralampos Petridis
Summary: The improved peri-implant bone response seen with the platform-switching concept may be due to the reduced release of metal ions from the implant-abutment surfaces. This study investigated the effect of different implant-abutment couplings on osteoblasts' function and found that platform-matched couplings resulted in higher rates of cell apoptosis and upregulation of genes related to bone resorption. These adverse biological responses may be associated with the increased release of metal ions from platform-matched couplings, indicating the potential role of corrosion products in crestal bone loss around dental implants.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Farzad Foroutan, Benjamin A. Kyffin, Athanasios Nikolaou, Jorge Merino-Gutierrez, Isaac Abrahams, Nasima Kanwal, Jonathan C. Knowles, Andrew J. Smith, Glen J. Smales, Daniela Carta
Summary: Mesoporous glasses with high surface area and extended porosity are ideal for controlled release of therapeutic ions and molecules. In this study, mesoporous phosphate-based glasses doped with copper ions were synthesized and their structures were characterized. The copper-doped glasses showed significant antibacterial properties and potential for controlled delivery of antibacterial ions.
Meeting Abstract
Gastroenterology & Hepatology
Elisabetta Caon, Philipp Schwabl, Luca Frenguelli, Hannah Evans, Margarita Papatheodoridi, Zalike Keskin-Erdogan, Nicola Mordan, Jonathan Knowles, Giuseppe Mazza, Massimo Pinzani, Krista Rombouts
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Cell & Tissue Engineering
Fiona Verisqa, Jonathan Knowles, Linh Nguyen, Hae-won Kim
TISSUE ENGINEERING PART A
(2022)
Article
Materials Science, Biomaterials
Yu-Jin Kim, Young-Eun Choe, Seong-Jin Shin, Jeong-Hui Park, Khandmaa Dashnyam, Hye Sung Kim, Soo-Kyung Jun, Jonathan C. Knowles, Hae-Won Kim, Jung-Hwan Lee, Hae-Hyoung Lee
Summary: This study investigates the antimicrobial mechanism of zinc oxide nanoparticles-based acrylic resin under controlled mechanophysical conditions. The results suggest that high intracellular reactive oxygen species (ROS) generation is the main antimicrobial mechanism, and photocatalysis can induce synergistic ROS accumulation, making it a promising application in biomedical materials.
BIOMATERIALS ADVANCES
(2022)
Meeting Abstract
Cell & Tissue Engineering
Taleen Shakouri, Elena Garcia-Gareta, Jonathan C. Knowles
TISSUE ENGINEERING PART A
(2022)
