Review
Biochemistry & Molecular Biology
Dong Keon Yon, Yong Jun Kim, Dong Choon Park, Su Young Jung, Sung Soo Kim, Joon Hyung Yeo, Jeongmin Lee, Jae Min Lee, Seung Geun Yeo
Summary: A literature review on the role of autophagy in peripheral nerve injury and regeneration was conducted. The review identified several factors, such as LC3II/I, PI3K, mTOR, Beclin-1, ATG3, ATG5, ATG7, ATG9, and ATG12, that are involved in the process of nerve degeneration and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Xiang Li, Kuangqi Chen, Zixi Wang, Jiayuan Li, Xiawei Wang, Chen Xie, Jianping Tong, Ye Shen
Summary: Corneal diseases affect millions of people worldwide and current treatments have limitations. Activation of the mTOR signaling pathway is involved in the pathogenesis of various corneal diseases, and inhibition of mTOR with rapamycin has shown promising outcomes, indicating the potential of mTOR as a therapeutic target.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Genetics & Heredity
Lei Zhang, Dingyu Hao, Pengyi Ma, Boyuan Ma, Jia Qin, Guangyuan Tian, Zihao Liu, Xianhu Zhou
Summary: This study revealed significant alterations in m6A methylation pattern in peripheral nervous injury (PNI), with changes in genes related to immune system process, cell activation, and nervous system development. The m6A-modified genes were also found to be involved in regulating cell cycle, B cell receptor signaling pathway, axon guidance pathway, and calcium signaling pathway. Additionally, upregulation of autophagy-related gene (Atg7) m6A methylation and protein expression levels were observed, suggesting a potential role of m6A modification in promoting functional recovery after PNI.
FRONTIERS IN GENETICS
(2021)
Article
Neurosciences
Meng- Zhao, Houting Lv, Na Yang, Guang-Hua Peng
Summary: The study investigated the mechanism of retinal photoreceptor degeneration by establishing a stable retinitis pigmentosa (RP) model. It was found that activation of mTOR may be associated with RP, and the use of mTOR inhibitor rapamycin improved retinal function and photoreceptor thickness and morphology, possibly by activating autophagy to protect retinal photoreceptors.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Takanobu Inada, Hitoshi Sato, Yoshinori Hayashi, Suzuro Hitomi, Akihiko Furukawa, Masatoshi Ando, Eri Oshima, Jo Otsuji, Naoto Taguchi, Ikuko Shibuta, Hiromasa Tsuda, Koichi Iwata, Tatsuo Shirota, Masamichi Shinoda
Summary: This study investigated the therapeutic effects of rapamycin on sensory disturbance caused by inferior alveolar nerve transection in rats. Results showed that rapamycin significantly promoted axon regeneration and increased the number of brain-derived neurotrophic factor positive neurons, making it a promising treatment for sensory disturbance.
Review
Biochemistry & Molecular Biology
Trevor Poitras, Douglas W. Zochodne
Summary: Common mechanisms of peripheral axon regeneration are recruited following diverse forms of damage to peripheral nerve axons. Supporting peripheral axon regrowth could be achieved through direct axon support or manipulation of the inflammatory milieu. Understanding the molecular barriers to regrowth and exploiting the downstream signaling pathways that impact neuron growth are promising approaches for promoting adult peripheral axon regeneration. This review emphasizes intrinsic aspects of adult peripheral axon regeneration and highlights several molecular barriers to regrowth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Lorena R. Lizarraga-Valderrama, Giulia Ronchi, Rinat Nigmatullin, Federica Fregnan, Pooja Basnett, Alexandra Paxinou, Stefano Geuna, Ipsita Roy
Summary: The study demonstrated that PHA-NGCs are highly promising in promoting peripheral nerve regeneration, showing comparable outcomes to autografts in functional evaluation and nerve morphology.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Estefania Contreras, Sara Bolivar, Nuria Nieto-Nicolau, Oscar Farinas, Patricia Lopez-Chicon, Xavier Navarro, Esther Udina
Summary: This study assessed the regenerative potential of decellularized nerve allografts compared to autografts for repairing nerve resections. The results showed that while decellularized allografts sustained regeneration in rats, regeneration was limited with decellularized xenografts.
CELL AND TISSUE RESEARCH
(2022)
Article
Cell Biology
Mariana Borsa, Sandrine Obba, Felix C. Richter, Hanlin Zhang, Thomas Riffelmacher, Joana Carrelha, Ghada Alsaleh, Sten Eirik W. Jacobsen, Anna Katharina Simon
Summary: This study investigates the importance of autophagy in stem cells and finds that autophagy deficiency leads to stem cell loss and bone marrow failure, while inhibition of MTOR can rescue this loss and improve stem cell function.
Article
Pharmacology & Pharmacy
Martina P. Morawe, Fan Liao, Willi Amberg, Jeroen van Bergeijk, Rui Chang, Mary Gulino, Caitlin Hamilton, Carolin Hoft, Casey Lumpkin, Bryan Mastis, Emily McGlame, Judith Nuber, Christian Plaas, Brinda Ravikumar, Kaushambi Roy, Marion Schanzenbaecher, Joseph Tierno, Viktor Lakics, Tammy Dellovade, Matthew Townsend
Summary: In this study, the researchers aimed to reduce tau pathology in Alzheimer's Disease by activating mTOR-dependent autophagy. They found that mTOR inhibitors could effectively reduce tau pathology, with PQR530 showing better results even when treatment was started after the onset of pathology. The researchers concluded that intermittent dosing of mTOR inhibitors can have a disease-modifying effect in AD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Qian Wu, Qianyu Lv, Xiao'an Liu, Xuejiao Ye, Linlin Cao, Manshi Wang, Junjia Li, Yingtian Yang, Lanlan Li, Shihan Wang
Summary: Atherosclerosis (AS) is a chronic inflammatory disease that is a major cause of cardiovascular diseases. The activation of the mechanistic/mammalian target of rapamycin (mTOR) is closely associated with the risk of AS. The mTOR signaling pathway contributes to AS progression through regulating autophagy, cell senescence, immune response, and lipid metabolism. Botanical drugs and their functional compounds have shown anti-AS effects by modulating the activity of the mTOR signaling pathway. This review summarizes the pathogenesis of AS based on the mTOR signaling pathway and recent advances in natural compounds to inhibit the mTOR signaling pathway and delay AS development, providing a new perspective on the mechanisms and precision treatments of AS.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Neslihan Pinar Ozates, Fatma Sogutlu, Ferzan Lerminoglu, Busra Demir, Cumhur Gunduz, Behrouz Shademan, Cigir Biray Avci
Summary: Breast cancer is the most common cancer in women and aberrations in the PI3K/AKT/mTOR pathway present in more than 70% of breast cancer cases have become a therapeutic target. AZD3463, as an anti-cancer agent, induces apoptosis and autophagy in breast cancer cells, reducing cell survival and proliferation. The combination of rapamycin and AZD3463 can increase the expression of certain genes related to apoptosis and decrease genes associated with cell survival, reducing resistance to treatment and leading to cancer cell apoptosis.
Review
Biochemistry & Molecular Biology
Luke Juckett, Tiam Mana Saffari, Benjamin Ormseth, Jenna-Lynn Senger, Amy M. M. Moore
Summary: Peripheral nerve injuries (PNI) often result in lifelong disability with rare complete functional recovery. Intraoperative electrical stimulation (ES) is a promising surgical adjunct that can augment the intrinsic molecular pathways of nerve regeneration. Clinical trials have shown that ES can be an efficacious therapy to improve patient outcomes following PNIs.
Article
Neurosciences
P. Komirishetty, K. Zubkow, A. Areti, H. Ong, D. W. Zochodne
Summary: The study found that local delivery of Rb1 siRNA can promote nerve regeneration at the outset, enhancing reinnervation of epidermal axons. Combining intrinsic Rb1 knockdown with exogenous insulin can significantly improve growth patterns of adult sensory neurons in vitro and enhance regeneration outcomes in vivo. Overall, the findings highlight the responsiveness of regrowing peripheral neurons to both intrinsic and exogenous approaches that improve their recovery, as well as a novel local approach to manipulate gene expression and outcome in regrowing axons.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Cell Biology
Jingxin Zhang, Binjing Zhang, Jinglan Zhang, Weimin Lin, Shiwen Zhang
Summary: Magnesium as a suitable material for promoting peripheral nerve regeneration has both challenges and potentials, but there is currently limited research on this topic, requiring further exploration to address the shortcomings and challenges identified.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Heng-fa Li, Jia-Jun Tang, Jian Chen, Pei Zhang, Ting Wang, Tian-yu Chen, Bo Yan, Bin Huang, Iang Wang, Min-jun Huang, Zhong-min Zhang, Da-di Jin
DRUG DESIGN DEVELOPMENT AND THERAPY
(2015)
Article
Cell Biology
Hua-ji Jiang, Xing-gui Tian, Shou-bin Huang, Guo-rong Chen, Min-jun Huang, Yu-hui Chen, Bin Yan, Sheng-fa Li, Jia-jun Tang, Hui-yu Zhao, Liang Wang, Zhong-min Zhang
CELL AND TISSUE RESEARCH
(2017)
Article
Multidisciplinary Sciences
Bo Yan, Zhongmin Zhang, Dadi Jin, Chen Cai, Chunhong Jia, Wen Liu, Ting Wang, Shengfa Li, Haiyan Zhang, Bin Huang, Pinglin Lai, Hua Wang, Anling Liu, Chun Zeng, Daozhang Cai, Yu Jiang, Xiaochun Bai
NATURE COMMUNICATIONS
(2016)
Article
Clinical Neurology
Jia Liu, Shengfa Li, Ke Huang, Xianzhe Lu, Yu Shi, Kegong Xie, Yujing Tang
EUROPEAN SPINE JOURNAL
(2019)
Article
Medicine, General & Internal
Jian-ping Zheng, Hai-xiong Miao, Shao-wei Zheng, Wei-le Liu, Chu-qun Chen, Hao-bo Zhong, Sheng-fa Li, Yong-ping Fang, Chun-han Sun
Article
Rheumatology
Min-jun Huang, Liang Wang, Da-di Jin, Zhong-min Zhang, Tian-yu Chen, Chun-hong Jia, Yan Wang, Xiao-chen Zhen, Bin Huang, Bo Yan, Yu-hui Chen, Sheng-fa Li, Jin-cheng Yang, Yi-fan Dai, Xiao-chun Bai
ANNALS OF THE RHEUMATIC DISEASES
(2014)
Article
Medical Laboratory Technology
Zou Yucong, Lu Lu, Li Shengfa, Ye Yongliang, Shang Ruguo, Li Yikai
CLINICAL LABORATORY
(2014)
Article
Chemistry, Medicinal
Ting Wang, Chun-han Sun, Hao-bo Zhong, Yan Gong, Zhong-Kai Cui, Jing Xie, Yan-peng Wang, Chuang Liang, He-he Cao, Xiao-rui Chen, Zhi-peng Zou, Sheng-fa Li, Xiao-chun Bai
PHYTOTHERAPY RESEARCH
(2019)
Article
Medicine, General & Internal
Shibo Chen, Guangfeng Ruan, Muhui Zeng, Tianyu Chen, Peihua Cao, Yan Zhang, Jia Li, Xiaoshuai Wang, Shengfa Li, Su'an Tang, Shilong Lu, Tianxiang Fan, Yang Li, Weiyu Han, Jianye Tan, Changhai Ding, Zhaohua Zhu
Summary: The use of metformin is significantly associated with a reduced risk of total knee arthroplasty and a decrease in the severity of knee pain in patients with knee osteoarthritis and diabetes and/or obesity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Yan Zhang, Tianyu Chen, Ping Luo, Shengfa Li, Jianwei Zhu, Song Xue, Peihua Cao, Zhaohua Zhu, Jia Li, Xiaoshuai Wang, Anita E. Wluka, Flavia Cicuttini, Guangfeng Ruan, Changhai Ding
Summary: This study found that higher dietary intake of magnesium and potassium was associated with reduced symptoms, improved quality of life, and milder comorbid conditions in patients with knee OA.
Article
Rheumatology
Ze Gong, Shengfa Li, Peihua Cao, Guangfeng Ruan, Yan Zhang, Qing Zeng, Zijun He, Shilin Li, Rong Chen, Peng Zheng, Tao Fan, Pengcheng Lu, Yijin Zhao, Martin Englund, Henning Madry, Guozhi Huang, Le Li, Jia Li, Changhai Ding
Summary: This study aimed to investigate the association between quadriceps strength and synovitis in knee osteoarthritis (KOA). Data from the Osteoarthritis Initiative (OAI) were analyzed, including participants with or at risk of KOA. Quadriceps strength was measured, and effusion-synovitis and Hoffa-synovitis were assessed using MRI. Generalized estimating equations were used to analyze the associations.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Genetics & Heredity
Guangfeng Ruan, Yi Ying, Shilong Lu, Zhaohua Zhu, Shibo Chen, Muhui Zeng, Ming Lu, Song Xue, Jianwei Zhu, Peihua Cao, Tianyu Chen, Xiaoshuai Wang, Shengfa Li, Jia Li, Yu Liu, Yanqi Liu, Yan Zhang, Changhai Ding
Summary: The causal effect of systemic iron status on knee OA, hip OA, total knee replacement, and total hip replacement was assessed using 2-sample Mendelian randomization (MR) design. The study suggests that high iron status might be a causal factor of hip OA and total hip replacement.
FRONTIERS IN GENETICS
(2023)
Review
Rheumatology
Shengfa Li, Peihua Cao, Tianyu Chen, Changhai Ding
Summary: Osteoarthritis is a prevalent and debilitating disease, and new drugs are needed to alleviate symptoms and prevent disease progression. However, most biologics and other drugs have failed to yield satisfactory results in clinical trials. The clinical heterogeneity of osteoarthritis and the need for different therapeutic approaches based on different phenotypes contribute to these failures.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)