Metals in Alzheimer’s and Parkinson’s Disease: Relevance to Dementia with Lewy Bodies

PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses

(2017) Noel G. Faux et al.   JOURNAL OF ALZHEIMERS DISEASE

Effects of Neonatal Iron Feeding and Chronic Clioquinol Administration on the Parkinsonian Human A53T Transgenic Mouse

(2016) Jessica L. Billings et al.   ACS Chemical Neuroscience

In Vivo MRI Mapping of Brain Iron Deposition across the Adult Lifespan

(2016) J. Acosta-Cabronero et al.   JOURNAL OF NEUROSCIENCE

Alpha-synuclein: relating metals to structure, function and inhibition

(2016) J. S. McDowall et al.   Metallomics

Determinants of iron accumulation in the normal aging brain

(2016) Lukas Pirpamer et al.   NEUROBIOLOGY OF AGING

Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SODG93A mice co-expressing the Copper-Chaperone-for-SOD

(2016) Jared R. Williams et al.   NEUROBIOLOGY OF DISEASE

Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice

(2015) David I. Finkelstein et al.   ACS Chemical Neuroscience

The neurotoxicity of iron, copper and manganese in Parkinson's and Wilson's diseases

(2015) Petr Dusek et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Lewy body dementias

(2015) Zuzana Walker et al.   LANCET

Insights on the interaction of alpha-synuclein and metals in the pathophysiology of Parkinson's disease

(2015) Eleonora Carboni et al.   Metallomics

Is early-life iron exposure critical in neurodegeneration?

(2015) Dominic J. Hare et al.   Nature Reviews Neurology

ZnII(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism

(2015) Erin J. McAllum et al.   NEUROBIOLOGY OF DISEASE

Biological metals and metal-targeting compounds in major neurodegenerative diseases

(2014) Kevin J. Barnham et al.   CHEMICAL SOCIETY REVIEWS

Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies

(2014) Jose Bras et al.   HUMAN MOLECULAR GENETICS

Site-Specific Copper-Catalyzed Oxidation of α-Synuclein: Tightening the Link between Metal Binding and Protein Oxidative Damage in Parkinson’s Disease

(2014) Marco C. Miotto et al.   INORGANIC CHEMISTRY

DJ-1 Is a Copper Chaperone Acting on SOD1 Activation

(2014) Stefania Girotto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oral Treatment with CuII(atsm) Increases Mutant SOD1 In Vivo but Protects Motor Neurons and Improves the Phenotype of a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

(2014) B. R. Roberts et al.   JOURNAL OF NEUROSCIENCE

Divalent metal ions enhance DOPAL-induced oligomerization of alpha-synuclein

(2014) Yunden Jinsmaa et al.   NEUROSCIENCE LETTERS

Nigral Iron Elevation Is an Invariable Feature of Parkinson’s Disease and Is a Sufficient Cause of Neurodegeneration

(2014) Scott Ayton et al.   Biomed Research International

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

Parkinson Disease Protein DJ-1 Binds Metals and Protects against Metal-induced Cytotoxicity

(2013) Benny Björkblom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies

(2013) Stefan Schildknecht et al.   JOURNAL OF NEUROCHEMISTRY

Iron levels in the human brain: A post-mortem study of anatomical region differences and age-related changes

(2013) Patrícia Ramos et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

(2013) David J. Irwin et al.   NATURE REVIEWS NEUROSCIENCE

Copper pathology in vulnerable brain regions in Parkinson's disease

(2013) Katherine M. Davies et al.   NEUROBIOLOGY OF AGING

Mitochondrial dysfunction and oxidative stress in Parkinson's disease

(2013) Sudhakar Raja Subramaniam et al.   PROGRESS IN NEUROBIOLOGY

Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis

(2013) Erin J. McAllum et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Can we clinically diagnose dementia with Lewy bodies yet?

(2013) Yue Huang et al.   Translational Neurodegeneration

Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease

(2012) Scott Ayton et al.   ANNALS OF NEUROLOGY

Copper, zinc and iron in neurodegenerative diseases (Alzheimer's, Parkinson's and prion diseases)

(2012) Henryk Kozlowski et al.   COORDINATION CHEMISTRY REVIEWS

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

(2012) Nicole Exner et al.   EMBO JOURNAL

Metallostasis in Alzheimer's disease

(2012) Scott Ayton et al.   FREE RADICAL BIOLOGY AND MEDICINE

The hypoxia imaging agent Cu II (atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson’s disease

(2012) Lin W. Hung et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mitochondria, oxidative stress and neurodegeneration

(2012) Antonio Federico et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease

(2012) Chuang Guo et al.   NEUROBIOLOGY OF AGING

Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain

(2012) Chuang Guo et al.   NEUROCHEMISTRY INTERNATIONAL

Phosphorylation of α-Synuclein at Y125 and S129 Alters Its Metal Binding Properties: Implications for Understanding the Role of α-Synuclein in the Pathogenesis of Parkinson’s Disease and Related Disorders

(2011) Yu Lu et al.   ACS Chemical Neuroscience

The Alzheimer's therapeutic PBT2 achieves cognitive benefit by combining neuroprotection with neurorestoration: studies in animal models of Alzheimer's disease and Huntington's disease

(2011) Robert Cherny et al.   Alzheimers & Dementia

Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?

(2011) Y. Compta et al.   BRAIN

The Alzheimer’s therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity

(2011) Peter J. Crouch et al.   JOURNAL OF NEUROCHEMISTRY

DLB and PDD: a role for mutations in dementia and Parkinson disease genes?

(2011) Bram Meeus et al.   NEUROBIOLOGY OF AGING

Cyanobacterial metallochaperone inhibits deleterious side reactions of copper

(2011) S. Tottey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Environmental Exposures in Neurodegeneration and Neurodegenerative Diseases

(2011) Jason R. Cannon et al.   TOXICOLOGICAL SCIENCES

The synaptic pathology of α-synuclein aggregation in dementia with Lewy bodies, Parkinson’s disease and Parkinson’s disease dementia

(2010) Walter J. Schulz-Schaeffer   ACTA NEUROPATHOLOGICA

Redox Reactions of the α-Synuclein−Cu2+Complex and Their Effects on Neuronal Cell Viability

(2010) Chengshan Wang et al.   BIOCHEMISTRY

Cellular copper distribution: a mechanistic systems biology approach

(2010) Lucia Banci et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

(2010) I. Irrcher et al.   HUMAN MOLECULAR GENETICS

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

(2010) Kelly Jean Thomas et al.   HUMAN MOLECULAR GENETICS

The Arabidopsis DJ-1a protein confers stress protection through cytosolic SOD activation

(2010) X. M. Xu et al.   JOURNAL OF CELL SCIENCE

Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer's Disease?

(2010) P. A. Adlard et al.   JOURNAL OF NEUROSCIENCE

ZnT3 mRNA levels are reduced in Alzheimer's disease post-mortem brain

(2010) Nancy Beyer et al.   Molecular Neurodegeneration

Affinity gradients drive copper to cellular destinations

(2010) Lucia Banci et al.   NATURE

The structural biochemistry of the superoxide dismutases

(2009) J.J.P. Perry et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Unique copper-induced oligomers mediate alpha-synuclein toxicity

(2009) Josephine A. Wright et al.   FASEB JOURNAL

Identification of the Minimal Copper(II)-Binding α-Synuclein Sequence

(2009) Mark S. Jackson et al.   INORGANIC CHEMISTRY

Physiological and Pathological Role of Alpha-synuclein in Parkinson’s Disease Through Iron Mediated Oxidative Stress; The Role of a Putative Iron-responsive Element

(2009) David Olivares et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Low Micromolar Zinc Accelerates the Fibrillization of Human Tau via Bridging of Cys-291 and Cys-322

(2009) Zhong-Ying Mo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Restored degradation of the Alzheimer’s amyloid-β peptide by targeting amyloid formation

(2009) Peter J. Crouch et al.   JOURNAL OF NEUROCHEMISTRY

Incidental Lewy body disease: Do some cases represent a preclinical stage of dementia with Lewy bodies?

(2009) Roberta Frigerio et al.   NEUROBIOLOGY OF AGING

Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease

(2008) Dennis W. Dickson et al.   ACTA NEUROPATHOLOGICA

Incidental Lewy Body Disease and Preclinical Parkinson Disease

(2008) Anthony DelleDonne et al.   ARCHIVES OF NEUROLOGY

Metals in Alzheimer's and Parkinson's Diseases

(2008) Kevin J Barnham et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Mitochondrial localization of DJ-1 leads to enhanced neuroprotection

(2008) Eunsung Junn et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Site-Specific Interactions of Cu(II) with α and β-Synuclein: Bridging the Molecular Gap between Metal Binding and Aggregation

(2008) Andrés Binolfi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

(2008) Lars Lannfelt et al.   LANCET NEUROLOGY

Environmental-induced oxidative stress in neurodegenerative disorders and aging

(2008) Lucia Migliore et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

CSF Mg and Ca as diagnostic markers for dementia with Lewy bodies

(2008) Fredrik Boström et al.   NEUROBIOLOGY OF AGING

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

(2008) Paul A. Adlard et al.   NEURON

Binding of zinc(II) and copper(II) to the full-length Alzheimer’s amyloid-β peptide

(2007) Vello Tõugu et al.   JOURNAL OF NEUROCHEMISTRY

Occurrence of Copper Proteins through the Three Domains of Life: A Bioinformatic Approach

(2007) Claudia Andreini et al.   JOURNAL OF PROTEOME RESEARCH

Brain iron pathways and their relevance to Parkinson's disease

(2003) D Berg et al.   JOURNAL OF NEUROCHEMISTRY