Multilayered regulations of RIG-I in the anti-viral signaling pathway

HDAC6 regulates cellular viral RNA sensing by deacetylation of RIG-I

(2016) S. J. Choi et al.   EMBO JOURNAL

Cytosolic Low Molecular Weight FGF2 Orchestrates RIG-I–Mediated Innate Immune Response

(2015) Xin Liu et al.   JOURNAL OF IMMUNOLOGY

Cytoplasmic STAT4 Promotes Antiviral Type I IFN Production by Blocking CHIP-Mediated Degradation of RIG-I

(2015) Kai Zhao et al.   JOURNAL OF IMMUNOLOGY

IKKϵ negatively regulates RIG-I via direct phosphorylation

(2015) Xiaoqing Zhang et al.   JOURNAL OF MEDICAL VIROLOGY

Viral Pseudo-Enzymes Activate RIG-I via Deamidation to Evade Cytokine Production

(2015) Shanping He et al.   MOLECULAR CELL

Antiviral Activity of Human OASL Protein Is Mediated by Enhancing Signaling of the RIG-I RNA Sensor

(2014) Jianzhong Zhu et al.   IMMUNITY

USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase

(2014) Yihui Fan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity

(2014) K. Kuniyoshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination

(2014) J. Yan et al.   Journal of Molecular Cell Biology

USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors

(2013) Jun Cui et al.   CELL RESEARCH

ATPase-driven oligomerization of RIG-I on RNA allows optimal activation of type-I interferon

(2013) Jenish R Patel et al.   EMBO REPORTS

Dephosphorylation of the RNA Sensors RIG-I and MDA5 by the Phosphatase PP1 Is Essential for Innate Immune Signaling

(2013) Effi Wies et al.   IMMUNITY

Phosphorylation and Dephosphorylation of the RIG-I-like Receptors: A Safety Latch on a Fateful Pathway

(2013) David Wallach et al.   IMMUNITY

Biphasic RLR-IFN-  Response Controls the Balance between Antiviral Immunity and Cell Damage

(2013) S.-Y. Hwang et al.   JOURNAL OF IMMUNOLOGY

USP4 Positively Regulates RIG-I-Mediated Antiviral Response through Deubiquitination and Stabilization of RIG-I

(2013) L. Wang et al.   JOURNAL OF VIROLOGY

Interferon-Inducible Protein IFI35 Negatively Regulates RIG-I Antiviral Signaling and Supports Vesicular Stomatitis Virus Replication

(2013) A. Das et al.   JOURNAL OF VIROLOGY

Negative Regulation of RIG-I-Mediated Innate Antiviral Signaling by SEC14L1

(2013) M.-T. Li et al.   JOURNAL OF VIROLOGY

A Distinct Role of Riplet-Mediated K63-Linked Polyubiquitination of the RIG-I Repressor Domain in Human Antiviral Innate Immune Responses

(2013) Hiroyuki Oshiumi et al.   PLoS Pathogens

The Mitochondrial Targeting Chaperone 14-3-3ε Regulates a RIG-I Translocon that Mediates Membrane Association and Innate Antiviral Immunity

(2012) Helene Minyi Liu et al.   Cell Host & Microbe

Ankrd17 positively regulates RIG-I-like receptor (RLR)-mediated immune signaling

(2012) Yetao Wang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response

(2012) Xiaomo Jiang et al.   IMMUNITY

Stochastic Expression of the Interferon-β Gene

(2012) Mingwei Zhao et al.   PLOS BIOLOGY

A protein-kinase, IFN-inducible double-stranded RNA dependent inhibitor and repressor of p58 (PRKRIR) enhances type I IFN-mediated antiviral response through the stability control of RIG-I protein

(2011) Hesung Now et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA

(2011) Eva Kowalinski et al.   CELL

The Double-Stranded RNA-Binding Protein PACT Functions as a Cellular Activator of RIG-I to Facilitate Innate Antiviral Response

(2011) Kin-Hang Kok et al.   Cell Host & Microbe

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

ARF-like Protein 16 (ARL16) Inhibits RIG-I by Binding with Its C-terminal Domain in a GTP-dependent Manner

(2011) Yong-Kang Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conventional Protein Kinase C-  (PKC- ) and PKC-  Negatively Regulate RIG-I Antiviral Signal Transduction

(2011) N. P. Maharaj et al.   JOURNAL OF VIROLOGY

DDX60, a DEXD/H Box Helicase, Is a Novel Antiviral Factor Promoting RIG-I-Like Receptor-Mediated Signaling

(2011) M. Miyashita et al.   MOLECULAR AND CELLULAR BIOLOGY

Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction

(2011) Kyung-Soo Inn et al.   MOLECULAR CELL

Structural basis of RNA recognition and activation by innate immune receptor RIG-I

(2011) Fuguo Jiang et al.   NATURE

The Ubiquitin Ligase Riplet Is Essential for RIG-I-Dependent Innate Immune Responses to RNA Virus Infection

(2010) Hiroyuki Oshiumi et al.   Cell Host & Microbe

Negative Role of RIG-I Serine 8 Phosphorylation in the Regulation of Interferon-β Production

(2010) Estanislao Nistal-Villán et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of RIG-I by Casein Kinase II Inhibits Its Antiviral Response

(2010) Z. Sun et al.   JOURNAL OF VIROLOGY

Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I

(2010) Penghua Wang et al.   NATURE IMMUNOLOGY

ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses

(2010) Sumio Hayakawa et al.   NATURE IMMUNOLOGY

SUMOylation of RIG-I positively regulates the type I interferon signaling

(2010) Zhiqiang Mi et al.   Protein & Cell

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Virus Infection Induces NF-κB-Dependent Interchromosomal Associations Mediating Monoallelic IFN-β Gene Expression

(2008) Effie Apostolou et al.   CELL

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response

(2008) Constantin S Friedman et al.   EMBO REPORTS

Riplet/RNF135, a RING Finger Protein, Ubiquitinates RIG-I to Promote Interferon-β Induction during the Early Phase of Viral Infection

(2008) Hiroyuki Oshiumi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY