Review
Biochemistry & Molecular Biology
Adelaide Ohui Fierti, Michael Bright Yakass, Ernest Adjei Okertchiri, Samuel Mawuli Adadey, Osbourne Quaye
Summary: This review summarizes the mechanisms by which Epstein-Barr virus modulates tumor suppressor genes in associated cancers, ultimately promoting malignancies.
Article
Immunology
Yaxian Ma, Peiling Zhang, Yuhan Bao, Hui Luo, Jiachen Wang, Liang Huang, Miao Zheng
Summary: Chronic active Epstein-Barr virus (CAEBV) disease is a high-mortality disease characterized by persistent infectious mononucleosis-like symptoms. This study analyzed the outcomes of PD-1 inhibitors treatment for CAEBV patients and found that the treatment had a high response rate and tolerable toxicity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Francesco Baccianti, Charlene Masson, Susanne Delecluse, Zhe Li, Remy Poirey, Henri-Jacques Delecluse
Summary: EBV efficiently infects and transforms B lymphocytes by activating viral gene expression and manipulating cellular pathways to limit the immune response, according to this study. The viral particle components sequentially activate proinflammatory B lymphocyte signaling pathways, leading to viral gene expression and cytokine release. However, infection also triggers the expression of ZFP36L1, a stress protein that limits the cytokine response. This study highlights the complex interactions between EBV and host cells during infection and transformation.
Article
Multidisciplinary Sciences
Xueyi Zheng, Ruixuan Wang, Xinke Zhang, Yan Sun, Haohuan Zhang, Zihan Zhao, Yuanhang Zheng, Jing Luo, Jiangyu Zhang, Hongmei Wu, Dan Huang, Wenbiao Zhu, Jianning Chen, Qinghua Cao, Hong Zeng, Rongzhen Luo, Peng Li, Lilong Lan, Jingping Yun, Dan Xie, Wei-Shi Zheng, Junhang Luo, Muyan Cai
Summary: This study introduces a deep convolutional neural network called EBVNet and its fusion with pathologists for predicting Epstein-Barr virus-associated gastric cancer (EBVaGC) from histopathology. EBVNet shows high accuracy in discriminating EBVaGC and the human-machine fusion significantly improves diagnostic performance.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Jakob Woerner, Yidi Huang, Stephan Hutter, Carmelo Gurnari, Jesus Maria Hernandez Sanchez, Janet Wang, Yimin Huang, Daniel Schnabel, Michael Aaby, Wanying Xu, Vedant Thorat, Dongxu Jiang, Babal K. Jha, Mehmet Koyuturk, Jaroslaw P. Maciejewski, Torsten Haferlach, Thomas LaFramboise
Summary: This study analyzed deep DNA sequence data from 1870 patients with myeloid malignancies and found evidence of dysbiosis in disease cases, as well as distinct microbial signatures among disease subtypes. It also highlighted the association between microbial content and host gene mutations and myeloblast cell percentages. The study provided evidence that Epstein-Barr virus status refines risk stratification in low-risk myelodysplastic syndrome patients and constructed machine-learning classifiers to discriminate among disease subtypes based solely on bacterial content.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Linlin Zhang, Mengjia Liu, Meng Zhang, Junhong Ai, Jiao Tian, Ran Wang, Zhengde Xie
Summary: Infectious mononucleosis (IM) is an acute syndrome associated with primary Epstein-Barr virus (EBV) infection. The exact pathogenic mechanism of IM remains unclear and there is currently no effective treatment. B cells and NK cells play important roles in IM, while the balance between CD4+ T cells and CD8+ T cells is crucial for lifelong control of the disease. Transcriptome sequencing of different cell populations involved in IM can help understand their functions and pathogenic mechanisms.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Oncology
Wen-Zhuo He, Yu-Hua Huang, Wan-Ming Hu, Fang Wang, Yu-Xia Xu, Jia-Hong Yi, Ju Xue, Yuan-Zhong Yang, Xiao-Ying Chao, Han-Bin Lin, Gui-Fang Guo, Jing-Ping Yun, Liang-Ping Xia
Summary: This study evaluated the efficacy of PD-1 antibody therapy in EBVaICC and found that patients with EBVaICC had significantly longer overall survival when treated with PD-1 antibody.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Yoshimi Enose-Akahata, Limin Wang, Fahad Almsned, Kory R. Johnson, Yair Mina, Joan Ohayon, Xin Wei Wang, Steven Jacobson
Summary: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), and the cause of MS remains unknown. This study investigated the antibody responses against various viruses in the cerebrospinal fluid (CSF) and serum of MS patients, and found significant differences compared to healthy volunteers, as well as a pattern of antibody responses against multiple viruses, including Epstein-Barr virus. These findings indicate that virus-specific antibody signatures might reflect the disease-associated inflammatory milieu in the CSF of patients with neuroinflammatory diseases.
Review
Medicine, General & Internal
John C. Reneau, Polina Shindiapina, Zachary Braunstein, Youssef Youssef, Miguel Ruiz, Saira Farid, Walter Hanel, Jonathan E. Brammer
Summary: Extranodal natural killer/T(NK/T)-cell lymphoma (ENKTL) is a rare subtype of non-Hodgkin lymphoma that usually presents with a nasal mass. Limited disease is treated with chemotherapy and radiation, while advanced stage disease is treated with L-asparaginase containing chemotherapy regimens. Modern radiation therapy techniques and the use of L-asparaginase in chemotherapy have improved outcomes, but relapse and relapse-related deaths remain frequent. Novel therapies have been evaluated for the treatment of this disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Yahong You, Jingshi Wang, Zhao Wang
Summary: We report a case of post-transplant patient with CAEBV treated with salvage programmed death 1 (PD-1) antibody therapy, which eradicated the EBV and achieved full donor chimerism. This case suggests that PD-1 antibody may be a promising option for fighting EBV and mixed DCs.
Article
Oncology
Yang Wang, Shilei Qin, Yuepei Liang, Ling Yan, Min Zheng, Yanwu Zeng, Leilei Lu
Summary: This study conducted genetic sequencing on Chinese lung cancer patients and found that high-grade tumors were more likely to have mutations in the TP53 and PIK3CA genes compared to low-grade tumors. Pathway analysis also revealed that high-grade tumors had more mutations in genes related to bacterial invasion, Epstein-Barr virus infection, and the Wnt signaling pathway. These findings suggest that high-grade lung cancer may be influenced by bacteria and EB virus, and may benefit more from immunotherapy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Masatoshi Ito, Kai Kudo, Hiroshi Higuchi, Hiroko Otsuka, Masayuki Tanaka, Nahoko Fukunishi, Takuma Araki, Masako Takamatsu, Yoko Ino, Yayoi Kimura, Ai Kotani
Summary: The study revealed that EVs derived from EBV-transformed lymphomas contain immunomodulatory proteins and phospholipids associated with TAM formation, which may contribute to the development of lymphomas.
Article
Pathology
Sudipta Samanta, Muthukaruppan Swaminathan, Jianing Hu, Khai Tuck Lee, Ajitha Sundaresan, Chuan Keng Goh, Chor Hiang Siow, Kwok Seng Loh, Soh Ha Chan, Joshua K. Tay, Ian Cheong
Summary: The use of immunofluorescence assay for detecting serum Epstein-Barr virus antibodies is the gold standard screening test for nasopharyngeal cancer in high-risk populations. This study demonstrates that integrating deep learning with automated fuzzy inference can improve the scalability and accuracy of NPC detection.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Microbiology
Makoto Ohashi, Mitchell Hayes, Kyle McChesney, Eric Johannsen
Summary: EBV infection can lead to specific types of lymphoma and some epithelial cancers. In vitro, EBV infection of resting B-lymphocytes drives them to proliferate as lymphoblastoid cell lines, serving as a model for studying EBV lymphomagenesis. This study reveals that interaction between EBNA3C and CtBP results in EBNA3C-mediated upregulation.
Article
Biology
Wesley Soo I. Hoo, Kaylie Higa, Alison A. McCormick
Summary: This study successfully developed a mouse B cell line expressing latent membrane protein 1 and demonstrated that vaccination protected mice against B cell tumors expressing latent membrane protein 1. This research provides a potential for studying vaccine immunotherapy in cancer patients.
Review
Biochemistry & Molecular Biology
Jun Nishikawa, Hisashi Iizasa, Hironori Yoshiyama, Munetaka Nakamura, Mari Saito, Sho Sasaki, Kanami Shimokuri, Masashi Yanagihara, Kouhei Sakai, Yutaka Suehiro, Takahiro Yamasaki, Isao Sakaida
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Oncology
Sho Sasaki, Jun Nishikawa, Kohei Sakai, Hisashi Iizasa, Hironori Yoshiyama, Masashi Yanagihara, Takuya Shuto, Kanami Shimokuri, Teru Kanda, Yutaka Suehiro, Takahiro Yamasaki, Isao Sakaida
Editorial Material
Medicine, General & Internal
Sho Sasaki, Shinichi Hashimoto, Kazuhiro Yamamoto, Isao Sakaida
Editorial Material
Gastroenterology & Hepatology
S. Yada, S. Sasaki, K. Tokuno, Y. Yamashita, I Sakaida
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Sho Sasaki, Jun Nishikawa, Isao Sakaida
CLINICAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Jun Nishikawa, Takuya Shuto, Ayaka Yanagi, Tatsuya Takagi, Ryo Ogawa, Sho Sasaki, Atsushi Goto, Kouichi Hamabe, Shinichi Hashimoto, Takeshi Okamoto, Isao Sakaida
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2020)
