Article
Microbiology
Sarah Preston-Alp, Lisa Beatrice Caruso, Chenhe Su, Kelsey Keith, Samantha S. Soldan, Davide Maestri, Jozef Madzo, Andrew Kossenkov, Giorgia Napoletani, Benjamin Gewurz, Paul M. Lieberman, Italo Tempera
Summary: This study demonstrated that Decitabine treatment can reduce the 5mC levels in the EBV genome and increase the amount of open chromatin in gastric cancer cell lines. It also revealed the presence of heterogeneous epigenetic states within the EBV genome, which are disrupted by Decitabine. These findings emphasize the importance of 5mC in maintaining EBV genomic chromatin structure and latency.
Review
Biotechnology & Applied Microbiology
Linlin Zhang, Ran Wang, Zhengde Xie
Summary: Epstein-Barr virus (EBV) is closely associated with several malignant and lymphoproliferative diseases. Aberrant methylation of viral DNA and the host genome plays a crucial role in EBV-associated diseases. EBV controls gene methylation by hijacking host epigenetic machinery, and its proteins interact with host epigenetic regulatory factors to mediate the methylation of important tumour suppressor gene promoters. Epigenetic modifications, particularly DNA methylation, can be targeted for epigenetic therapy against EBV-associated tumours. The methylation patterns in the host and EBV genomes may also have diagnostic and prognostic value.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Genki Usui, Keisuke Matsusaka, Yasunobu Mano, Masayuki Urabe, Sayaka Funata, Masashi Fukayama, Tetsuo Ushiku, Atsushi Kaneda
Summary: Gastric cancer is a pathologically and molecularly heterogeneous disease with DNA hypermethylation playing an important role. Comprehensive DNA methylation analyses have revealed multiple methylation patterns, allowing gastric cancer to be classified into different molecular subgroups. The frequency and targets of genetic aberrations vary depending on the molecular subgroup.
Review
Immunology
Alison J. Sinclair
Summary: DNA methylation at CpG motifs plays a key role in gene regulation, with hypermethylation generally leading to decreased gene expression. In EBV infection, the viral genome becomes hypermethylated at CpG motifs, impacting viral gene expression. DNA methyl transferase enzymes are crucial in the process of DNA methylation and can be targeted for therapeutic interventions in EBV-associated cancer.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biology
Chunjin Li, Maosheng Cao, Xu Zhou
Summary: Preterm birth worldwide is associated with high morbidity, mortality, and economic cost. The mechanisms underlying preterm birth are still unclear, but epigenetics may play a role in linking social and environmental risk factors.
BIOLOGICAL REVIEWS
(2022)
Article
Gastroenterology & Hepatology
Yan Zhang, Shunxia Hu, Jun Li, Duo Shi, Bing Luo
Summary: This study found that hypermethylation of the TMEM130 gene may affect the migration ability of GC cells and is associated with EBV infection. TMEM130 shows promise as a potential biomarker for the diagnosis of GC.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Oncology
Chloe Borde, Frederique Quignon, Corinne Amiel, Joel Gozlan, Vincent Marechal, Eolia Brissot
Summary: A new molecular assay (methyl-qPCR) was designed to distinguish methylated versus unmethylated Epstein-Barr virus (EBV) genomes. This method showed potential for distinguishing latent and lytic EBV genomes in transplant recipients, aiding in treatment decisions.
CLINICAL EPIGENETICS
(2022)
Article
Virology
Hua Xiao, Jingyang Sun, Weiqing Huang, Wen Liu, Yan Zhang, Haiyu Wang, Bing Luo
Summary: This study revealed that the expression of MAP9 is up-regulated in EBVaGC, and MAP9 plays a role in inhibiting the growth of EBVaGC cells. Additionally, the methylation of MAP9 CpG islands influences this regulation, with MAP9 acting as a tumor suppressor in the development of EBVaGC.
Review
Biochemistry & Molecular Biology
Gadde Shareena, Dileep Kumar
Summary: Epstein Barr virus (EBV) is the first oncogenic virus in humans and is closely associated with various lymphoproliferative and malignant diseases. EBV has a biphasic viral life cycle, consisting of a latent period and lytic replication, with B-cells playing a critical role in latent gene expression and immune recognition evasion. Dysregulation of epigenetic regulation, particularly DNA methylation, in both viral and host genome expression, is closely related to carcinogenesis and long-lasting phenotypes in malignancies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Klaudia Dopytalska, Piotr Ciechanowicz, Kacper Wiszniewski, Elzbieta Szymanska, Irena Walecka
Summary: Psoriasis is a chronic immune-mediated disease with approximately 2% incidence. Genetic and environmental factors play significant roles in its pathogenesis. Epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding RNAs, are highlighted for their role in the etiology and pathogenesis of psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tomohiro Fujii, Jun Nishikawa, Soichiro Fukuda, Naoto Kubota, Junzo Nojima, Koichi Fujisawa, Ryo Ogawa, Atsushi Goto, Koichi Hamabe, Shinichi Hashimoto, Aung Phyo Wai, Hisashi Iizasa, Hironori Yoshiyama, Kohei Sakai, Yutaka Suehiro, Takahiro Yamasaki, Taro Takami
Summary: MC180295 inhibits the growth of EBVaGC cells by suppressing DNA repair and the cell cycle.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Sun Hee Lee, Su Jin Choi, Wonhyeok Choi, Subin Cho, Miyeon Cho, Dong Sun Kim, Byung Woog Kang, Jong Gwang Kim, You Mie Lee, Hyosun Cho, Hyojeung Kang
Summary: Gastric cancer is a common type of cancer, with Epstein-Barr virus-associated gastric carcinoma accounting for a significant proportion. Resistance to platinum drugs in gastric cancer cells can be caused by DNA hypermethylation, but DNA demethylation can enhance the anticancer activity.
Review
Biochemistry & Molecular Biology
Yasmine K. Abd El Fattah, Ahmed I. Abulsoud, Sherihan G. AbdelHamid, Nadia M. Hamdy
Summary: The lncRNA CCDC144NL-AS1 is functionally linked to several human cancers and could serve as a promising prognostic biomarker and therapeutic target.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Cardiac & Cardiovascular Systems
Eric Wang, Shali Chen, Honglin Wang, Tori Chen, Subrata Chakrabarti
Summary: This study confirms the occurrence of EndMT in human hearts during DCM and its correlation with changes in relevant ncRNAs. It further suggests that there may be an interplay between DNA methylation and certain ncRNAs involved in the regulation of EndMT that contribute to the observed changes in ncRNA expression.
CARDIOVASCULAR DIABETOLOGY
(2023)
Review
Cell Biology
Fei Xu, Wenhui Li, Xiao Yang, Lixin Na, Linjun Chen, Guobin Liu
Summary: Osteoporosis is a metabolic disease characterized by decreased bone mineral density and bone microstructure destruction. Epigenetics, including DNA methylation, histone modification, and non-coding RNAs, play an important role in post-transcriptional regulation and are closely related to bone metabolism processes such as osteogenic differentiation and bone remodeling. Abnormal epigenetic regulation can lead to bone metabolism-related diseases like osteoporosis, highlighting the importance of understanding epigenetic mechanisms for potential treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Ken-Ichiro Sakata, Kojiro Maeda, Nozomi Sakurai, Shanshang Liang, Seitaro Nakazawa, Kazuyoshi Yanagihara, Takanori Kubo, Hironori Yoshiyama, Yoshimasa Kitagawa, Jun-Ichi Hamada, Hisashi Iizasa
ANTICANCER RESEARCH
(2020)
Review
Immunology
Hisashi Iizasa, Hyoji Kim, Andy Visi Kartika, Yuichi Kanehiro, Hironori Yoshiyama
FRONTIERS IN IMMUNOLOGY
(2020)
Correction
Immunology
Hisashi Iizasa, Hyoji Kim, Andy Visi Kartika, Yuichi Kanehiro, Hironori Yoshiyama
FRONTIERS IN IMMUNOLOGY
(2020)
Editorial Material
Oncology
Hironori Yoshiyama, Keiji Ueda, Jun Komano, Hisashi Iizasa
JOURNAL OF ONCOLOGY
(2020)
Article
Microbiology
Andy Visi Kartika, Hisashi Iizasa, Dan Ding, Yuichi Kanehiro, Yoshitsugu Tajima, Shunsuke Kaji, Hideo Yanai, Hironori Yoshiyama
Article
Oncology
Fenggang Yu, Yanan Lu, Yingying Li, Yuji Uchio, Utomo Andi Pangnguriseng, Andy Visi Kartika, Hisashi Iizasa, Hironori Yoshiyama, Kwok Seng Loh
Review
Oncology
Timmy Richardo, Pongphol Prattapong, Chawalit Ngernsombat, Nurulfitri Wisetyaningsih, Hisashi Iizasa, Hironori Yoshiyama, Tavan Janvilisri
Editorial Material
Gastroenterology & Hepatology
S. Yada, S. Sasaki, K. Tokuno, Y. Yamashita, I Sakaida
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Sho Sasaki, Jun Nishikawa, Isao Sakaida
CLINICAL ENDOSCOPY
(2022)
Article
Oncology
Chukkris Heawchaiyaphum, Chamsai Pientong, Hironori Yoshiyama, Hisashi Iizasa, Watcharapong Panthong, Tipaya Ekalaksananan
Summary: Nasopharyngeal carcinoma (NPC), Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC), and oral squamous cell carcinoma (OSCC) are epithelial cancers that are associated with EBV infection. In this study, we aimed to identify gene signatures and common signaling pathways of EBV-associated epithelial cancers (EBVaCAs) to predict prognosis. We identified SLC26A9 and TMC8 as gene signatures for EBVaCAs, and IL6/JAK/STAT3 and TNF-alpha/NF-kappa B signaling pathways as common hallmarks. These findings provide new insights into the molecular mechanisms of EBV-driven epithelial cancers.
Article
Biochemistry & Molecular Biology
Hiroko Nishikawa, Priscillia Christiany, Takeru Hayashi, Hisashi Iizasa, Hironori Yoshiyama, Masanori Hatakeyama
Summary: PAR1b is a kinase that regulates cell polarity and cell-cell interactions. It has been found that cytoplasmic DNA/RNA can activate PAR1b and promote the accumulation of BRCA1 in the nucleus, leading to the development of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tomohiro Fujii, Jun Nishikawa, Soichiro Fukuda, Naoto Kubota, Junzo Nojima, Koichi Fujisawa, Ryo Ogawa, Atsushi Goto, Koichi Hamabe, Shinichi Hashimoto, Aung Phyo Wai, Hisashi Iizasa, Hironori Yoshiyama, Kohei Sakai, Yutaka Suehiro, Takahiro Yamasaki, Taro Takami
Summary: MC180295 inhibits the growth of EBVaGC cells by suppressing DNA repair and the cell cycle.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Oncology
Hironori Yoshiyama, Asuka Nanbo, Tomoharu Yasuda
Article
Oncology
Shanshan Liang, Hidehisa Takahashi, Tetsuro Hirose, Yasuhiro Kuramitsu, Shigetsugu Hatakeyama, Hironori Yoshiyama, Ruoyu Wang, Jun-Ichi Hamada, Hisashi Iizasa
CANCER GENOMICS & PROTEOMICS
(2020)
Article
Gastroenterology & Hepatology
Jun Nishikawa, Takuya Shuto, Ayaka Yanagi, Tatsuya Takagi, Ryo Ogawa, Sho Sasaki, Atsushi Goto, Kouichi Hamabe, Shinichi Hashimoto, Takeshi Okamoto, Isao Sakaida
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2020)
