An immunogold single extracellular vesicular RNA and protein ( Au SERP) biochip to predict responses to immunotherapy in non‐small cell lung cancer patients

Contribution of resident and circulating precursors to tumor-infiltrating CD8+ T cell populations in lung cancer

(2021) Paul Gueguen et al.   Science Immunology

Immunomagnetic sequential ultrafiltration (iSUF) platform for enrichment and purification of extracellular vesicles from biofluids

(2021) Jingjing Zhang et al.   Scientific Reports

Quantification of protein cargo loading into engineered extracellular vesicles at single‐vesicle and single‐molecule resolution

(2021) Andreia M. Silva et al.   Journal of Extracellular Vesicles

Reversing T-cell Exhaustion in Cancer: Lessons Learned from PD-1/PD-L1 Immune Checkpoint Blockade

(2021) Natalija Budimir et al.   Cancer Immunology Research

Homogeneous, Low-volume, Efficient, and Sensitive Quantitation of Circulating Exosomal PD-L1 for Cancer Diagnosis and Immunotherapy Response Prediction

(2020) Mengjiao Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Surface engineering within a microchannel for hydrodynamic and self-assembled cell patterning

(2020) Xilal Y. Rima et al.   Biomicrofluidics

From laboratory to clinic: Translation of extracellular vesicle based cancer biomarkers

(2020) Anudeep Yekula et al.   METHODS

Cryo-electron microscopy of extracellular vesicles from cerebrospinal fluid

(2020) Anton Emelyanov et al.   PLoS One

Recent advances in single extracellular vesicle detection methods

(2020) Su Wang et al.   BIOSENSORS & BIOELECTRONICS

PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer

(2020) Brian Diskin et al.   NATURE IMMUNOLOGY

RNA delivery by extracellular vesicles in mammalian cells and its applications

(2020) Killian O’Brien et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Circulating MicroRNAs and Extracellular Vesicle–Containing MicroRNAs as Response Biomarkers of Anti–programmed Cell Death Protein 1 or Programmed Death-Ligand 1 Therapy in NSCLC

(2020) Takehito Shukuya et al.   Journal of Thoracic Oncology

Exosomal PD-L1 and N-cadherin predict pulmonary metastasis progression for osteosarcoma patients

(2020) Jun Wang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Why have microRNA biomarkers not been translated from bench to clinic?

(2019) Kioomars Saliminejad et al.   Future Oncology

Detection of Exosomal PD-L1 RNA in Saliva of Patients With Periodontitis

(2019) Jialiang Yu et al.   Frontiers in Genetics

Comparing and contrasting predictive biomarkers for immunotherapy and targeted therapy of NSCLC

(2019) D. Ross Camidge et al.   Nature Reviews Clinical Oncology

Asymmetric-flow field-flow fractionation technology for exomere and small extracellular vesicle separation and characterization

(2019) Haiying Zhang et al.   Nature Protocols

λ-DNA- and Aptamer-Mediated Sorting and Analysis of Extracellular Vesicles

(2019) Chao Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

Isolation and Analysis of Plasma-Derived Exosomes in Patients With Glioma

(2019) Luz M. Cumba Garcia et al.   Frontiers in Oncology

Circulating microRNAs predict the response to anti-PD-1 therapy in non-small cell lung cancer

(2019) Jinshuo Fan et al.   GENOMICS

Profiling surface proteins on individual exosomes using a proximity barcoding assay

(2019) Di Wu et al.   Nature Communications

Quality and efficiency assessment of six extracellular vesicle isolation methods by nano-flow cytometry

(2019) Ye Tian et al.   Journal of Extracellular Vesicles

Single molecule characterization of individual extracellular vesicles from pancreatic cancer

(2019) Kathleen M. Lennon et al.   Journal of Extracellular Vesicles

Personalized detection of circling exosomal PD-L1 based on Fe3O4@TiO2 isolation and SERS immunoassay

(2019) Yuanfeng Pang et al.   BIOSENSORS & BIOELECTRONICS

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

(2019) Zhaogang Yang et al.   Nature Biomedical Engineering

Multiplexed Profiling of Single Extracellular Vesicles

(2018) Kyungheon Lee et al.   ACS Nano

Nanoparticle Counting by Microscopic Digital Detection: Selective Quantitative Analysis of Exosomes via Surface-Anchored Nucleic Acid Amplification

(2018) Qingchang Tian et al.   ANALYTICAL CHEMISTRY

PD-L1 mRNA expression in plasma-derived exosomes is associated with response to anti-PD-1 antibodies in melanoma and NSCLC

(2018) Marzia Del Re et al.   BRITISH JOURNAL OF CANCER

Single-Exosome-Counting Immunoassays for Cancer Diagnostics

(2018) Chunchen Liu et al.   NANO LETTERS

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

(2018) Daniela S. Thommen et al.   NATURE MEDICINE

Extracellular vesicles in cancer — implications for future improvements in cancer care

(2018) Rong Xu et al.   Nature Reviews Clinical Oncology

Molecular signatures of circulating melanoma cells for monitoring early response to immune checkpoint therapy

(2018) Xin Hong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PD-L1 immunohistochemistry in patients with non-small cell lung cancer

(2018) Takanobu Jotatsu et al.   Journal of Thoracic Disease

Exosomes in Cancer Liquid Biopsy: A Focus on Breast Cancer

(2018) Sina Halvaei et al.   Molecular Therapy-Nucleic Acids

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles

(2018) Franz L. Ricklefs et al.   Science Advances

None of us is the same as all of us: resolving the heterogeneity of extracellular vesicles using single-vesicle, nanoscale characterization with resonance enhanced atomic force microscope infrared spectroscopy (AFM-IR)

(2018) Sally Yunsun Kim et al.   Nanoscale Horizons

Association between PD1 mRNA and response to anti-PD1 monotherapy across multiple cancer-types

(2018) L Paré et al.   ANNALS OF ONCOLOGY

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

A Single Extracellular Vesicle (EV) Flow Cytometry Approach to Reveal EV Heterogeneity

(2018) Wen Shen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells

(2018) Xiangbo Meng et al.   NATURE

Characterization of single microvesicles in plasma from glioblastoma patients

(2018) Kyle Fraser et al.   NEURO-ONCOLOGY

iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics

(2017) Lesley Seymour et al.   LANCET ONCOLOGY

PD-L1 Testing in Guiding Patient Selection for PD-1/PD-L1 Inhibitor Therapy in Lung Cancer

(2017) Katerina Ancevski Hunter et al.   Molecular Diagnosis & Therapy

Coding and noncoding landscape of extracellular RNA released by human glioma stem cells

(2017) Zhiyun Wei et al.   Nature Communications

A signal-amplifiable biochip quantifies extracellular vesicle-associated RNAs for early cancer detection

(2017) Jiaming Hu et al.   Nature Communications

Soluble PD-1 and PD-L1: predictive and prognostic significance in cancer

(2017) Xinxin Zhu et al.   Oncotarget

RNA in extracellular vesicles

(2017) Kyoung Mi Kim et al.   Wiley Interdisciplinary Reviews-RNA

Immunotherapy biomarkers 2016: overcoming the barriers

(2017) James L. Gulley et al.   Journal for ImmunoTherapy of Cancer

Circulating Long RNAs in Serum Extracellular Vesicles: Their Characterization and Potential Application as Biomarkers for Diagnosis of Colorectal Cancer

(2016) L. Dong et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Increase in soluble PD-1 is associated with prolonged survival in patients with advanced EGFR -mutated non-small cell lung cancer treated with erlotinib

(2016) Steffen Filskov Sorensen et al.   LUNG CANCER

Neoantigen landscape dynamics during human melanoma–T cell interactions

(2016) Els M. E. Verdegaal et al.   NATURE

PD-1–PD-L1 immune-checkpoint blockade in B-cell lymphomas

(2016) Aaron Goodman et al.   Nature Reviews Clinical Oncology

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tunable Nanostructured Coating for the Capture and Selective Release of Viable Circulating Tumor Cells

(2015) Eduardo Reátegui et al.   ADVANCED MATERIALS

IFN-γ from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer

(2015) K Abiko et al.   BRITISH JOURNAL OF CANCER

Circulating biomarkers for gliomas

(2015) Manfred Westphal et al.   Nature Reviews Neurology

Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer

(2015) Edward B. Garon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma

(2015) Robert J. Motzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential fates of biomolecules delivered to target cells via extracellular vesicles

(2015) Masamitsu Kanada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptive Immune Resistance: How Cancer Protects from Immune Attack

(2015) A. Ribas   Cancer Discovery

Enhancing Sensitivity of Surface Plasmon Resonance Biosensors by Functionalized Gold Nanoparticles: Size Matters

(2014) Tomáš Špringer et al.   ANALYTICAL CHEMISTRY

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

(2014) Roy S. Herbst et al.   NATURE

Detection of Extracellular RNAs in Cancer and Viral Infection via Tethered Cationic Lipoplex Nanoparticles Containing Molecular Beacons

(2013) Yun Wu et al.   ANALYTICAL CHEMISTRY

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Nivolumab plus Ipilimumab in Advanced Melanoma

(2013) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cancer Biomarker Detection in Serum Samples Using Surface Plasmon Resonance and Quartz Crystal Microbalance Sensors with Nanoparticle Signal Amplification

(2012) Yildiz Uludag et al.   ANALYTICAL CHEMISTRY

Surface Plasmon Resonance Biosensors Incorporating Gold Nanoparticles

(2012) Erin E. Bedford et al.   MACROMOLECULAR BIOSCIENCE

Autocalibrated Scanning-Angle Prism-Type Total Internal Reflection Fluorescence Microscopy for Nanometer-Precision Axial Position Determination

(2010) Wei Sun et al.   ANALYTICAL CHEMISTRY

Receiver Operating Characteristic Curve in Diagnostic Test Assessment

(2010) Jayawant N. Mandrekar   Journal of Thoracic Oncology

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Selective expansion of a subset of exhausted CD8 T cells by  PD-L1 blockade

(2008) S. D. Blackburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA