Understanding and application of Bacillus nitrogen regulation: A synthetic biology perspective

Enhanced production of L-arginine by improving carbamoyl phosphate supply in metabolically engineered Corynebacterium crenatum

(2021) Qing Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Global coordination of metabolic pathways in Escherichia coli by active and passive regulation

(2021) Karl Kochanowski et al.   Molecular Systems Biology

Production of itaconic acid from alkali pretreated lignin by dynamic two stage bioconversion

(2021) Joshua R. Elmore et al.   Nature Communications

Transcription-Factor-based Biosensor Engineering for Applications in Synthetic Biology

(2021) Nana Ding et al.   ACS Synthetic Biology

Metabolic engineering of Bacillus subtilis for enhancing riboflavin production by alleviating dissolved oxygen limitation

(2021) Jiajia You et al.   BIORESOURCE TECHNOLOGY

Production of proteins and commodity chemicals using engineered Bacillus subtilis platform strain

(2021) Quanwei Zhang et al.   Essays in Biochemistry

Exploitation of ammonia-inducible promoters for enzyme overexpression in Bacillus licheniformis

(2021) Peili Shen et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Synergistic improvement of N-acetylglucosamine production by engineering transcription factors and balancing redox cofactors

(2021) Chen Deng et al.   METABOLIC ENGINEERING

Regulatory systems for gene expression control in cyanobacteria

(2020) Petra Till et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Improving phytosterol biotransformation at low nitrogen levels by enhancing the methylcitrate cycle with transcriptional regulators PrpR and GlnR of Mycobacterium neoaurum

(2020) Yang Zhang et al.   Microbial Cell Factories

Construction of a novel sugar alcohol-inducible expression system in Bacillus licheniformis

(2020) Fengxu Xiao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Rational flux-tuning of Halomonas bluephagenesis for co-production of bioplastic PHB and ectoine

(2020) Hong Ma et al.   Nature Communications

Pyruvate-responsive genetic circuits for dynamic control of central metabolism

(2020) Xianhao Xu et al.   Nature Chemical Biology

Programmable cross-ribosome-binding sites to fine-tune the dynamic range of transcription factor-based biosensor

(2020) Nana Ding et al.   NUCLEIC ACIDS RESEARCH

CfrA, a novel carbon flow regulator, adapts carbon metabolism to nitrogen deficiency in cyanobacteria

(2020) M. Isabel Muro-Pastor et al.   PLANT PHYSIOLOGY

Application of biofertilizer containing Bacillus subtilis reduced the nitrogen loss in agricultural soil

(2020) Bo Sun et al.   SOIL BIOLOGY & BIOCHEMISTRY

Fermentative production of Vitamin E tocotrienols in Saccharomyces cerevisiae under cold-shock-triggered temperature control

(2020) Bin Shen et al.   Nature Communications

The nitrogen removal characterization of a cold-adapted bacterium: Bacillus simplex H-b

(2020) Qian Yang et al.   BIORESOURCE TECHNOLOGY

Engineering a New Class of Anti-LacI Transcription Factors with Alternate DNA Recognition

(2019) Ronald E. Rondon et al.   ACS Synthetic Biology

Metabolic Engineering of Main Transcription Factors in Carbon, Nitrogen, and Phosphorus Metabolisms for Enhanced Production of Bacitracin in Bacillus licheniformis

(2019) Dongbo Cai et al.   ACS Synthetic Biology

Introducing substrate limitations to overcome catabolite repression in a protease producing Bacillus licheniformis strain using membrane-based fed-batch shake flasks

(2019) Tobias Habicher et al.   BIOTECHNOLOGY AND BIOENGINEERING

Engineering a Bifunctional Phr60-Rap60-Spo0A Quorum-Sensing Molecular Switch for Dynamic Fine-Tuning of Menaquinone-7 Synthesis in Bacillus subtilis

(2019) Shixiu Cui et al.   ACS Synthetic Biology

Synergetic engineering of central carbon and nitrogen metabolism for the production of N ‐acetylglucosamine in Bacillus subtilis

(2019) Tengfei Niu et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Influence of nitrogen status in wine alcoholic fermentation

(2019) Antoine Gobert et al.   FOOD MICROBIOLOGY

Mixed carbon substrates: a necessary nuisance or a missed opportunity?

(2019) Nian Liu et al.   CURRENT OPINION IN BIOTECHNOLOGY

Changes of DNA topology affect the global transcription landscape and allow rapid growth of a Bacillus subtilis mutant lacking carbon catabolite repression

(2018) Daniel R. Reuß et al.   METABOLIC ENGINEERING

Advances and prospects of Bacillus subtilis cellular factories: From rational design to industrial applications

(2018) Yang Gu et al.   METABOLIC ENGINEERING

Development of an Inducible Secretory Expression System in Bacillus licheniformis Based on an Engineered Xylose Operon

(2018) Youran Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Boosting heterologous protein production yield by adjusting global nitrogen and carbon metabolic regulatory networks in Bacillus subtilis

(2018) Haojie Cao et al.   METABOLIC ENGINEERING

Influence of global gene regulatory networks on single cell heterogeneity of green fluorescent protein production in Bacillus subtilis

(2018) Haojie Cao et al.   Microbial Cell Factories

Synthetic redesign of central carbon and redox metabolism for high yield production of N-acetylglucosamine in Bacillus subtilis

(2018) Yang Gu et al.   METABOLIC ENGINEERING

Mathematical modelling of microbes: metabolism, gene expression and growth

(2017) Hidde de Jong et al.   Journal of the Royal Society Interface

Metabolic Engineering for Expanding the Substrate Range of Yarrowia lipolytica

(2016) Rodrigo Ledesma-Amaro et al.   TRENDS IN BIOTECHNOLOGY

A Two-Layer Gene Circuit for Decoupling Cell Growth from Metabolite Production

(2016) Tat-Ming Lo et al.   Cell Systems

Glucose becomes one of the worst carbon sources for E.coli on poor nitrogen sources due to suboptimal levels of cAMP

(2016) Anat Bren et al.   Scientific Reports

Evidence for synergistic control of glutamate biosynthesis by glutamate dehydrogenases and glutamate inBacillus subtilis

(2015) Lorena Stannek et al.   ENVIRONMENTAL MICROBIOLOGY

Structures of regulatory machinery reveal novel molecular mechanisms controllingB. subtilisnitrogen homeostasis

(2015) Maria A. Schumacher et al.   GENES & DEVELOPMENT

CodY Regulates Expression of the Bacillus subtilis Extracellular Proteases Vpr and Mpr

(2015) Giulia Barbieri et al.   JOURNAL OF BACTERIOLOGY

The Molecular Basis of TnrA Control by Glutamine Synthetase inBacillus subtilis

(2015) Ksenia Hauf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic engineering of Corynebacterium glutamicum for the production of itaconate

(2015) Andreas Otten et al.   METABOLIC ENGINEERING

Molecular modulation of pleiotropic regulator CcpA for glucose and xylose coutilization by solvent-producing Clostridium acetobutylicum

(2015) Yan Wu et al.   METABOLIC ENGINEERING

Genome-wide mapping of TnrA-binding sites provides new insights into the TnrA regulon inBacillus subtilis

(2015) Nicolas Mirouze et al.   MicrobiologyOpen

Coordination of microbial metabolism

(2014) Victor Chubukov et al.   NATURE REVIEWS MICROBIOLOGY

Hierarchical expression of genes controlled by the Bacillus subtilis global regulatory protein CodY

(2014) S. R. Brinsmade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Harnessing Yarrowia lipolytica lipogenesis to create a platform for lipid and biofuel production

(2014) John Blazeck et al.   Nature Communications

Genetic Manipulation of the Fusarium fujikuroi Fusarin Gene Cluster Yields Insight into the Complex Regulation and Fusarin Biosynthetic Pathway

(2013) Eva-Maria Niehaus et al.   CHEMISTRY & BIOLOGY

Disruption of the nitrogen regulatory gene AcareA in Acremonium chrysogenum leads to reduction of cephalosporin production and repression of nitrogen metabolism

(2013) Jinyang Li et al.   FUNGAL GENETICS AND BIOLOGY

Recent advancements in synthetic biology: Current status and challenges

(2013) Vijai Singh   GENE

Biosynthesis of the Urease Metallocenter

(2013) Mark A. Farrugia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of theBacillus subtilisGlutamine Synthetase Dodecamer Reveal Large Intersubunit Catalytic Conformational Changes Linked to a Unique Feedback Inhibition Mechanism

(2013) David S. Murray et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Precise and reliable gene expression via standard transcription and translation initiation elements

(2013) Vivek K Mutalik et al.   NATURE METHODS

Genome-wide identification of Bacillus subtilis CodY-binding sites at single-nucleotide resolution

(2013) B. R. Belitsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of glutamate homeostasis in Bacillus subtilis: a complex interplay between ammonium assimilation, glutamate biosynthesis and degradation

(2012) Katrin Gunka et al.   MOLECULAR MICROBIOLOGY

Bacterial nitrate assimilation: gene distribution and regulation

(2011) Víctor M. Luque-Almagro et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Interaction of the general transcription factor TnrA with the PII-like protein GlnK and glutamine synthetase in Bacillus subtilis

(2011) Airat Kayumov et al.   FEBS Journal

Indirect Repression by Bacillus subtilis CodY via Displacement of the Activator of the Proline Utilization Operon

(2011) Boris R. Belitsky   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structure of Type III Glutamine Synthetase: Surprising Reversal of the Inter-Ring Interface

(2011) Jason M. van Rooyen et al.   STRUCTURE

Time-Resolved Transcriptome Analysis of Bacillus subtilis Responding to Valine, Glutamate, and Glutamine

(2009) Bang-Ce Ye et al.   PLoS One

Deep sequencing analysis of the Methanosarcina mazei Go1 transcriptome in response to nitrogen availability

(2009) D. Jager et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of Nitrogen Regulation in Bacillus subtilis degU Expression

(2008) A. Yasumura et al.   JOURNAL OF BACTERIOLOGY

Bacillus subtilis GlnR contains an autoinhibitory C-terminal domain required for the interaction with glutamine synthetase

(2008) Lewis V. Wray et al.   MOLECULAR MICROBIOLOGY

Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels

(2008) Shota Atsumi et al.   NATURE

Bacillus subtilis glutamine synthetase regulates its own synthesis by acting as a chaperone to stabilize GlnR-DNA complexes

(2008) S. H. Fisher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA