Article
Chemistry, Physical
Yuechao Cao, Tuo Yao, Guimin Zhang, Zongyi Zhou, Lihai Zhai, Songgu Wu
Summary: This study investigates the nucleation behavior of isosorbide 5-mononitrate (5-ISMN) in different solvent systems and finds that the saturation temperature and chemical potential competitively affect the nucleation rate.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Physical
Yuechao Cao, Junli Zhang, Xuxing Wan, Shengzhe Jia, Guimin Zhang, Zongyi Zhou, Songgu Wu
Summary: This study investigated the solubility and dissolution behavior of isosorbide 5-mononitrate (5-SIMN) in organic solvents through experimental and simulation approaches. The results showed that the solubility increased with temperature and was influenced by the properties of the solvents. The findings provide important theoretical and practical insights into the dissolution and mixing properties of this pharmaceutical compound.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biotechnology & Applied Microbiology
Guang Li, Mingjian Ling, Kunyi Yu, Wei Yang, Qiwen Liu, Lijuan He, Xuzi Cai, Min Zhong, Ziyi Mai, Rui Sun, Yuanling Xiao, Zhiqiang Yu, Xuefeng Wang
Summary: This study investigated a reduction-responsive synergetic delivery strategy (PSSP@ ART-ISMN) with co-delivery of artesunate and isosorbide 5-mononitrate for ovarian cancer treatment. The strategy showed various effects on tumor cells and demonstrated excellent antitumor activity with good bio-compatibility in vivo.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Harmony R. Reynolds, Michael H. Picard, John A. Spertus, Jesus Peteiro, Jose Luis Lopez Sendon, Roxy Senior, Mohammad C. El-Hajjar, Jelena Celutkiene, Michael D. Shapiro, Patricia A. Pellikka, Dennis F. Kunichoff, Rebecca Anthopolos, Khaled Alfakih, Khaled Abdul-Nour, Michel Khouri, Leonid Bershtein, Mark De Belder, Kian Keong Poh, John F. Beltrame, James K. Min, Jerome L. Fleg, Yi Li, David J. Maron, Judith S. Hochman
Summary: Improvement in ischemia and angina were common in patients with ischemia with no obstructive coronary artery disease (INOCA), but they were not significantly correlated. The pathophysiology of INOCA is complex and angina is multifactorial in nature.
Article
Medicine, General & Internal
Jei Hak Myung, Bo Ryun Kim, Soo Hoon Yoon, Yeong Kuen Kwon, Sung Soo Park, Sung-Bom Pyun
Summary: This study investigated cardiorespiratory fitness markers in obese patients undergoing sleeve gastrectomy, finding peak aerobic exercise capacity significantly associated with body fat composition and self-reported quality of life. These findings may be useful for developing preoperative and postoperative exercise strategies for morbidly obese patients undergoing laparoscopic sleeve gastrectomy.
Article
Cardiac & Cardiovascular Systems
Christopher L. Schumann, Roshin C. Mathew, John-Henry L. Dean, Yang Yang, Pelbreton C. Balfour, Peter W. Shaw, Austin A. Robinson, Michael Salerno, Christopher M. Kramer, Jamieson M. Bourque
Summary: The study found that patients with INOCA have a significant impact on quality of life, with increased physical limitations, angina frequency, and reduced quality of life. These patients report increased time missed from work and work limitations, indicating a substantial economic impact. CMD is a common cause of INOCA, but it is not associated with increased morbidity.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Katherine C. Michelis, Justin L. Grodin, Lin Zhong, Ambarish Pandey, Kathleen Toto, Colby R. Ayers, Jennifer T. Thibodeau, Mark H. Drazner
Summary: This study found that patient-reported severity of illness often did not match up with objective testing results. Despite common occurrences of symptom minimization and magnification, mortality risk was more closely associated with objective data, emphasizing the importance of using both patient reports and objective data when evaluating heart failure patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Psychiatry
Eun Jung Cha, Yeonsil Moon, Seung-Ho Ryu, Hong Jun Jeon
Summary: This study used network analysis to explore factors related to health-related quality of life (HRQoL) in older adults. The results highlighted the importance of enhancing functional independence and subjective health cognition, increasing routine exercise, and reducing stress for improving HRQoL in older adults.
Article
Cardiac & Cardiovascular Systems
Timothy D. Henry, C. Noel Bairey Merz, Janet Wei, Michel T. Corban, Odayme Quesada, Sandy Joung, Christine L. Kotynski, Jian Wang, Michelle Lewis, Ann M. Schumacher, Ronnda L. Bartel, Hiroshi Takagi, Vishal Shah, Anna Lee, William K. Sietsema, Douglas W. Losordo, Amir Lerman
Summary: This study evaluated the safety and efficacy of intracoronary CD34+ cell therapy in patients with coronary microvascular dysfunction. The results showed that patients receiving CD34+ cell therapy had improved coronary flow reserve, reduced angina symptoms, and improved quality of life after 6 months of treatment. This study supports the potential therapeutic role of CD34+ cells in patients with microvascular angina.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2022)
Review
Multidisciplinary Sciences
Jing Lv, Haining Peng, Tengbo Yu, Xiaohong Huang
Summary: This study aims to explore the causality between mindfulness practices and inflammaging responses through a meta-analysis and systematic review. Data will be collected from relevant observational studies and analyzed using various methods. The effectiveness of mindfulness-based interventions on inflammaging will be evaluated, and a narrative review will provide a deeper understanding of the primary outcomes.
Review
Peripheral Vascular Disease
Vincenzo Sucato, Egle Corrado, Girolamo Manno, Francesco Amata, Gabriella Testa, Giuseppina Novo, Alfredo R. Galassi
Summary: The review summarizes studies investigating blood biomarkers related to coronary microvascular dysfunction (CMD) and microvascular angina (MVA). By analyzing biomarkers into 3 groups based on the main mechanisms of CMD, the review considers mixed mechanisms and biomarkers not included in the 3 major categories. This exploration may lead to easier diagnosis and screening of CMD with reduced risks and costs associated with invasive procedures.
Article
Cardiac & Cardiovascular Systems
Lorenzo Loffredo, Victoria Ivanov, Nicolae Ciobanu, Micaela Ivanov, Paolo Ciacci, Cristina Nocella, Vittoria Cammisotto, Federica Orlando, Aurora Paraninfi, Enrico Maggio, Alessandra D'Amico, Paolo Rosa, Mihail Popovici, Simona Bartimoccia, Francesco Barilla, Elena Deseatnicova, Evgenii Gutu, Francesco Violi, Roberto Carnevale
Summary: This study is the first to show that patients with MVA have high LPS levels, NOX2 activation, and an imbalance between pro-oxidant and antioxidant systems, favoring oxidizing molecules that may be implicated in the endothelial dysfunction and vasoconstriction of the disease.
KARDIOLOGIA POLSKA
(2022)
Article
Cardiac & Cardiovascular Systems
Diana M. Lopez, Sanjay Divakaran, Ankur Gupta, Navkaranbir S. Bajaj, Michael T. Osborne, Wunan Zhou, Jon Hainer, Courtney F. Bibbo, Hicham Skali, Sharmila Dorbala, Viviany R. Taqueti, Ron Blankstein, Marcelo F. Di Carli
Summary: This study aimed to evaluate the sensitivity and specificity of exercise treadmill testing (ETT) in the diagnosis of coronary microvascular disease (CMD) and the prognostic implications of ETT results in CMD patients. The study found that ETT has limited sensitivity in detecting CMD, but a positive ETT with ischemic changes lasting at least 1 minute into recovery and the absence of obstructive coronary artery disease may indicate the presence of CMD.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Gastroenterology & Hepatology
Guillaume Gourcerol, Chloe Melchior, Fabien Wuestenberghs, Charlotte Desprez, Gaetan Prevost, Julien Grosjean, Anne Marie Leroi, Marie Pierre Tavolacci
Summary: This study found that gastroparesis, diagnosed using gastric emptying tests, was associated with increased mortality, independent of age, sex, BMI, or diabetes status.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Obstetrics & Gynecology
Claire Tourny, Amira Zouita, Samira El Kababi, Lea Feuillet, Ayoub Saeidi, Ismail Laher, Katja Weiss, Beat Knechtle, Hassane Zouhal
Summary: This article reviews the effects of physical activity on the management and quality of life in patients with endometriosis. The findings suggest that body awareness practices such as Hatha yoga and progressive muscle relaxation can reduce pain and stress and improve the quality of life associated with endometriosis. However, caution should be taken in considering patients' physical abilities and avoiding intense physical activities. More research is needed to explore nonmedicinal or surgical techniques for different forms of endometriosis and its symptoms.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Endocrinology & Metabolism
Angelo Villano, Erica Mencarelli, Veronica Melita, Alessandro Rizzi, Priscilla Lamendola, Antonio De Vita, Laura Manfredonia, Salvatore Emanuele Ravenna, Dario Pitocco, Gaetano Antonio Lanza, Filippo Crea
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2020)
Review
Cardiac & Cardiovascular Systems
Udo Sechtem, David Brown, Shigeo Godo, Gaetano Antonio Lanza, Hiro Shimokawa, Novalia Sidik
CARDIOVASCULAR RESEARCH
(2020)
Article
Cardiac & Cardiovascular Systems
Gaetano Antonio Lanza, Antonio De Vita, Salvatore Emanuele Ravenna, Alessia D'Aiello, Marcello Covino, Francesco Franceschi, Filippo Crea
Summary: The study demonstrates that standard ECG can be helpful for initial risk stratification of patients admitted for SARS-CoV-2 infectious disease, with ECG variables significantly associated with mortality.
Article
Cardiac & Cardiovascular Systems
Gaetano Antonio Lanza, Vernizia Morgante, Veronica Melita, Erica Mencarelli, Antonio De Vita, Salvatore Emanuele Ravenna, Antonio Bisignani, Angelo Villano, Silvia Baroni, Mirca Antenucci, Filippo Crea
Summary: The study aimed to assess whether the increase in troponin I (TnI) levels after exercise stress test (EST) could help identify patients with obstructive coronary artery disease (CAD) and myocardial ischemia in those suspected of having stable angina. Results showed that TnI levels increased after EST, but this increase was largely independent of the results of coronary angiography and EST, regardless of the presence of obstructive CAD or not, and whether the EST results were positive or negative.
JOURNAL OF CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Rocco A. Montone, Maria Chiara Meucci, Antonio De Vita, Gaetano A. Lanza, Giampaolo Niccoli
Summary: The management of angina and myocardial ischemia has historically focused on obstructive coronary artery disease, but a significant proportion of patients do not have obstructive CAD. Functional mechanisms and coronary vasomotor disorders may be involved in myocardial ischemia, but diagnosing these disorders can be challenging. Coronary provocative tests can provide valuable information on the pathogenic mechanism of myocardial ischemia, but their use in clinical practice is limited and mainly restricted to specialized centers.
Article
Endocrinology & Metabolism
Saverio Tremamunno, Antonio De Vita, Angelo Villano, Veronica Melita, Gessica Ingrasciotta, Eleonora Ruscio, Monica Filice, Antonio Bisignani, Salvatore Emanuele Ravenna, Linda Tartaglione, Gaetano Emanuele Rizzo, Mauro Di Leo, Tamara Felici, Dario Pitocco, Gaetano Antonio Lanza
Summary: This study found that in type 2 diabetes patients, diastolic dysfunction is associated with impairment of endothelium-independent dilatation, but not with endothelium-dependent dilatation; cardiac autonomic dysfunction may be present in patients with more severe diastolic dysfunction. Therefore, further investigation is needed to explore the role of cardiac autonomic dysfunction in diastolic dysfunction in larger populations.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Letter
Cardiac & Cardiovascular Systems
Gaetano Antonio Lanza, Antonio De Vita
Article
Cardiac & Cardiovascular Systems
Gaetano Antonio Lanza, Doralisa Morrone, Carmine Pizzi, Isabella Tritto, Luca Bergamaschi, Antonio De Vita, Angelo Villano, Filippo Crea
Summary: Numerous studies have shown that abnormalities in coronary microcirculation may be the cause of acute and chronic cardiac ischemic syndromes. The microvascular origin of myocardial ischemia and angina is considered in clinical practice when patients have normal or near-normal coronary arteries during angiography. This article reviews the diagnostic approach for patients suspected of having coronary microvascular dysfunction as the cause of ischemic syndromes and proposes a classification for chronic and acute microvascular coronary ischemic syndrome, including myocardial infarction with normal coronary arteries.
TRENDS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Antonio De Vita, Giuseppe De Matteis, Alessia d'Aiello, Salvatore Emanuele Ravenna, Giovanna Liuzzo, Gaetano Antonio Lanza, Massimo Massetti, Filippo Crea, Antonio Gasbarrini, Francesco Franceschi, Marcello Covino
Summary: A retrospective study found that hospitalized COVID-19 patients treated with heparin did not show significant differences in the incidence of thrombotic events and arterial and venous thrombosis compared to AIRD patients with different etiological diagnoses.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Francesco Burzotta, Francesca Graziani, Carlo Trani, Cristina Aurigemma, Piergiorgio Bruno, Antonella Lombardo, Giovanna Liuzzo, Marialisa Nesta, Gaetano Antonio Lanza, Enrico Romagnoli, Gabriella Locorotondo, Antonio Maria Leone, Natalia Pavone, Claudio Spalletta, Gemma Pelargonio, Tommaso Sanna, Nadia Aspromonte, Franco Cavaliere, Filippo Crea, Massimo Massetti
Summary: This study suggests that a multidisciplinary approach using a heart team for the management of complex valvular heart disease patients is feasible and leads to promising early clinical outcomes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Gaetano A. Lanza, Antonio Bisignani, Veronica Melita, Alessandro Telesca, Saverio Tremamunno, Nello Cambise, Antonio De Vita, Oreste Lanza, Roberto Mollo
Summary: This study assessed the long-term prognostic implications of early repolarization (ER)/J wave on electrocardiograms (ECGs) in patients with stable ischemic heart disease (IHD). The results showed that ER/J wave was not associated with increased risk of long-term mortality in clinically stable patients with a documented history of IHD.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Gaetano Antonio Lanza, Hiroaki Shimokawa
Summary: Calcium channel blockers are the first-line treatment for coronary artery spasm. When these medications are ineffective, long-acting nitrates or nicorandil may be added. Other alternative drugs and interventions, such as Rho-kinase inhibitors, anti-adrenergic drugs, neural therapies, and percutaneous coronary interventions, can be considered for refractory cases. Implantation of an ICD or pacemaker should be considered for patients with syncope or cardiac arrest caused by CAS-related arrhythmias, based on the risk of recurrence and efficacy of vasodilator therapy.
EUROPEAN CARDIOLOGY REVIEW
(2023)
Article
Cardiac & Cardiovascular Systems
Saverio Tremamunno, Gaetano Antonio Lanza
Summary: Recent studies have not found a significant increase in arrhythmic risk associated with ER/J wave in athletes, suggesting that it should be considered as benign findings on standard ECG.
CURRENT TREATMENT OPTIONS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Antonio De Vita, Salvatore Emanuele Ravenna, Marcello Covino, Oreste Lanza, Francesco Franceschi, Filippo Crea, Gaetano Antonio Lanza
JOURNAL OF CLINICAL MEDICINE
(2020)
