Tauroursodeoxycholic acid functions as a critical effector mediating insulin sensitization of metformin in obese mice

Mechanism of Endoplasmic Reticulum Stress Pathway in the Osteogenic Phenotypic Transformation of Aortic Valve Interstitial Cells

(2022) Yiming Tao et al.   Frontiers in Endocrinology

Gut Microbiome of Indonesian Adults Associated with Obesity and Type 2 Diabetes: A Cross-Sectional Study in an Asian City, Yogyakarta

(2021) Phatthanaphong Therdtatha et al.   Microorganisms

Metformin treatment for 8 days impacts multiple intestinal parameters in high-fat high-sucrose fed mice

(2021) Amélie Bravard et al.   Scientific Reports

Effects of tauroursodeoxycholic acid on glucose homeostasis: Potential binding of this bile acid with the insulin receptor

(2021) Joel A. da Silva et al.   LIFE SCIENCES

Metformin Exerts Anti-inflammatory and Mucus Barrier Protective Effects by Enriching Akkermansia muciniphila in Mice With Ulcerative Colitis

(2021) Haoran Ke et al.   Frontiers in Pharmacology

The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective

(2020) Loranne Agius et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of action of metformin in type 2 diabetes: Effects on mitochondria and leukocyte-endothelium interactions

(2020) Nadezda Apostolova et al.   Redox Biology

Intestinal microbiota-farnesoid X receptor axis in metabolic diseases

(2020) Bu Zou et al.   CLINICA CHIMICA ACTA

Gut microbiota in human metabolic health and disease

(2020) Yong Fan et al.   NATURE REVIEWS MICROBIOLOGY

Metformin Ameliorates Gestational Diabetes Mellitus-Induced Endothelial Dysfunction via Downregulation of p65 and Upregulation of Nrf2

(2020) Cong Cong Sun et al.   Frontiers in Pharmacology

Metformin diminishes the unfavourable impact of Nrf2 in breast cancer patients with type 2 diabetes

(2019) Elina Urpilainen et al.   TUMOR BIOLOGY

Metformin and gut microbiota: their interactions and their impact on diabetes

(2019) Natalia G. Vallianou et al.   Hormones-International Journal of Endocrinology and Metabolism

NRF2 antioxidant response protects against acidic bile salts-induced oxidative stress and DNA damage in esophageal cells

(2019) Dunfa Peng et al.   CANCER LETTERS

In vivo pharmacodynamic and pharmacokinetic effects of metformin mediated by the gut microbiota in rats

(2019) Bin Wu et al.   LIFE SCIENCES

Mechanism of glucose‐lowering by metformin in type 2 diabetes: Role of bile acids

(2019) Daniel J. Sansome et al.   DIABETES OBESITY & METABOLISM

Tauroursodeoxycholic acid inhibits intestinal inflammation and barrier disruption in mice with non-alcoholic fatty liver disease

(2018) Weijun Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Insulin resistance: Review of the underlying molecular mechanisms

(2018) Habib Yaribeygi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

(2018) Lulu Sun et al.   NATURE MEDICINE

ANNALS EXPRESS: Bile acids and the metabolic syndrome

(2018) Emma Rose McGlone et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease

(2017) Sara Moreira et al.   EXPERIMENTAL NEUROLOGY

Rifampicin-induced injury in HepG2 cells is alleviated by TUDCA via increasing bile acid transporters expression and enhancing the Nrf2-mediated adaptive response

(2017) Weiping Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Bile Acid Alterations Are Associated With Insulin Resistance, but Not With NASH, in Obese Subjects

(2017) Vanessa Legry et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

(2017) Wei Jia et al.   Nature Reviews Gastroenterology & Hepatology

Human gut microbes impact host serum metabolome and insulin sensitivity

(2016) Helle Krogh Pedersen et al.   NATURE

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

Akkermansia muciniphilaand improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology

(2015) Maria Carlota Dao et al.   GUT

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

(2015) Kristoffer Forslund et al.   NATURE

Piper betle induces phase I & II genes through Nrf2/ARE signaling pathway in mouse embryonic fibroblasts derived from wild type and Nrf2 knockout cells

(2014) Wan Nuraini Wan Hasan et al.   BMC Complementary and Alternative Medicine

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

An increase in theAkkermansiaspp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

(2013) Na-Ri Shin et al.   GUT

The Keap1-Nrf2 System Prevents Onset of Diabetes Mellitus

(2013) A. Uruno et al.   MOLECULAR AND CELLULAR BIOLOGY

Potential therapeutic effects of the simultaneous targeting of the Nrf2 and NF-κB pathways in diabetic neuropathy

(2013) Veera Ganesh Yerra et al.   Redox Biology

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women

(2010) Marleen Kars et al.   DIABETES

Metformin and the intestine

(2008) C. J. Bailey et al.   DIABETOLOGIA

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

(2008) Deborah M. Muoio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY