IRE1α overexpression in malignant cells limits tumor progression by inducing an anti-cancer immune response

Radical or Not-So-Radical Prostatectomy: Do Surgical Margins Matter?

(2021) Ioanna Maria Grypari et al.   Cancers

Dietary Approaches to Cancer Therapy

(2020) Mylène Tajan et al.   CANCER CELL

IRE1α-targeting downregulates ABC transporters and overcomes drug resistance of colon cancer cells

(2020) Qiang Gao et al.   CANCER LETTERS

IRE1α disruption in triple-negative breast cancer cooperates with anti-angiogenic therapy by reversing ER stress adaptation and remodeling the tumor microenvironment

(2020) Jonathan M Harnoss et al.   CANCER RESEARCH

Dietary modifications for enhanced cancer therapy

(2020) Naama Kanarek et al.   NATURE

IRE1α Activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8+ T Cell Priming

(2019) Bernardita Medel et al.   Frontiers in Immunology

Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

(2019) Xingzhe Ma et al.   Cell Metabolism

Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics

(2019) Amado Carreras-Sureda et al.   NATURE CELL BIOLOGY

The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc

(2019) Han Dong et al.   NATURE IMMUNOLOGY

Trial watch: dietary interventions for cancer therapy

(2019) Sarah Lévesque et al.   OncoImmunology

Pharmacological targeting of the unfolded protein response for disease intervention

(2019) Claudio Hetz et al.   Nature Chemical Biology

Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance

(2018) Camila Rubio-Patiño et al.   Cell Metabolism

Antigen presentation unfolded: identifying convergence points between the UPR and antigen presentation pathways

(2018) Fabiola Osorio et al.   CURRENT OPINION IN IMMUNOLOGY

Dual IRE1 RNase functions dictate glioblastoma development

(2018) Stéphanie Lhomond et al.   EMBO Molecular Medicine

Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer

(2018) Na Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

IRE1α RNase–dependent lipid homeostasis promotes survival in Myc-transformed cancers

(2018) Hong Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A

(2018) Hery Urra et al.   NATURE CELL BIOLOGY

Reshaping the Immune Tumor Microenvironment Through IRE1 Signaling

(2018) Camila Rubio-Patiño et al.   TRENDS IN MOLECULAR MEDICINE

Integrated Functions of Membrane Property Sensors and a Hidden Side of the Unfolded Protein Response

(2018) Roberto Covino et al.   MOLECULAR CELL

Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy

(2018) Susan E. Logue et al.   Nature Communications

Transcription of the NKG2D ligand MICA is suppressed by the IRE1/XBP1 pathway of the unfolded protein response through the regulation of E2F1

(2018) Akram Obiedat et al.   FASEB JOURNAL

IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity

(2018) Minkyung Song et al.   NATURE

Activation of the Unfolded Protein Response by Lipid Bilayer Stress

(2017) Kristina Halbleib et al.   MOLECULAR CELL

Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer

(2017) Giannicola Genovese et al.   NATURE

Knockdown of IRE1α inhibits colonic tumorigenesis through decreasing β-catenin and IRE1α targeting suppresses colon cancer cells

(2017) X-X Li et al.   ONCOGENE

Mutant KRAS promotes malignant pleural effusion formation

(2017) Theodora Αgalioti et al.   Nature Communications

Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells

(2017) Elodie Villa et al.   Cell Reports

Proline Starvation Induces Unresolved ER Stress and Hinders mTORC1-Dependent Tumorigenesis

(2016) Nisebita Sahu et al.   Cell Metabolism

ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

(2015) Juan R. Cubillos-Ruiz et al.   CELL

Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma

(2014) John C Castle et al.   BMC GENOMICS

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

(2014) Xi Chen et al.   NATURE

The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells

(2014) Fabiola Osorio et al.   NATURE IMMUNOLOGY

Caloric restriction and cancer: molecular mechanisms and clinical implications

(2014) Ophélie Meynet et al.   TRENDS IN MOLECULAR MEDICINE