Non-covalent cyclic peptides simultaneously targeting Mpro and NRP1 are highly effective against Omicron BA.2.75

Application of pseudovirus system in the development of vaccine, antiviral-drugs, and neutralizing antibodies

(2022) Qi Xiang et al.   MICROBIOLOGICAL RESEARCH

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

(2022) Yunlong Cao et al.   NATURE

Non-covalent SARS-CoV-2 Mpro inhibitors developed from in silico screen hits

(2022) Giacomo G. Rossetti et al.   Scientific Reports

Targeting SARS-CoV-2 Proteases for COVID-19 Antiviral Development

(2022) Zongyang Lv et al.   Frontiers in Chemistry

Novel Small-Molecule Inhibitors of the SARS-CoV-2 Spike Protein Binding to Neuropilin 1

(2022) Anja Kolarič et al.   Pharmaceuticals

Highly Potent, Selective, Biostable, and Cell-Permeable Cyclic d-Peptide for Dual-Targeting Therapy of Lung Cancer

(2022) Yunjiang Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural diversity of the SARS-CoV-2 Omicron spike

(2022) Sophie M.-C. Gobeil et al.   MOLECULAR CELL

Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2

(2022) Yao Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Omicron subvariant BA.2: Birth of a new challenge during the COVID-19 pandemic

(2022) Farid Rahimi et al.   International Journal of Surgery

As Omicron rages on, virus’ path remains unpredictable

(2022) Kai Kupferschmidt   SCIENCE

The role of Neuropilin-1 in COVID-19

(2021) Bindu S. Mayi et al.   PLoS Pathogens

SARS-CoV-2 Variants of Concern in the United States—Challenges and Opportunities

(2021) Rochelle P. Walensky et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Establishment of a well-characterized SARS-CoV-2 lentiviral pseudovirus neutralization assay using 293T cells with stable expression of ACE2 and TMPRSS2

(2021) Sabari Nath Neerukonda et al.   PLoS One

Immunity to SARS-CoV-2 variants of concern

(2021) Daniel M. Altmann et al.   SCIENCE

Carvacrol, a Plant Metabolite Targeting Viral Protease (Mpro) and ACE2 in Host Cells Can Be a Possible Candidate for COVID-19

(2021) Hayate Javed et al.   Frontiers in Plant Science

Novel Compounds Targeting Neuropilin Receptor 1 with Potential To Interfere with SARS-CoV-2 Virus Entry

(2021) Samantha Perez-Miller et al.   ACS Chemical Neuroscience

A Cyclic Peptide Inhibitor of the SARS-CoV-2 Main Protease

(2021) Adam G. Kreutzer et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

COVID-19 mRNA vaccines

(2021) Qingrui Huang et al.   Journal of Genetics and Genomics

A Comprehensive Review of the Global Efforts on COVID-19 Vaccine Development

(2021) Yingzhu Li et al.   ACS Central Science

Discovery of chebulagic acid and punicalagin as novel allosteric inhibitors of SARS-CoV-2 3CLpro

(2021) Ruikun Du et al.   ANTIVIRAL RESEARCH

COVID-19 vaccines

(2021) Duduzile Ndwandwe et al.   CURRENT OPINION IN IMMUNOLOGY

Structure-guided design of a perampanel-derived pharmacophore targeting the SARS-CoV-2 main protease

(2021) Maya G. Deshmukh et al.   STRUCTURE

The Role of Neuropilin-1 (NRP-1) in SARS-CoV-2 Infection: Review

(2021) Monika Gudowska-Sawczuk et al.   Journal of Clinical Medicine

Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors

(2021) Sven Ullrich et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Stapled Peptides Targeting SARS-CoV-2 Spike Protein HR1 Inhibit the Fusion of Virus to Its Cell Receptor

(2021) Mengjun Zheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a Dual Tubulin and Poly(ADP-Ribose) Polymerase-1 Inhibitor by Structure-Based Pharmacophore Modeling, Virtual Screening, Molecular Docking, and Biological Evaluation

(2021) Lufeng Zheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Boosting immunity to COVID-19 vaccines

(2021) Jennifer A. Juno et al.   NATURE MEDICINE

Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant

(2021) Jun Zhang et al.   SCIENCE

Developing a direct acting, orally available antiviral agent in a pandemic: the evolution of molnupiravir as a potential treatment for COVID-19

(2021) George R Painter et al.   Current Opinion in Virology

Analysis of the Effectiveness of the Ad26.COV2.S Adenoviral Vector Vaccine for Preventing COVID-19

(2021) Juan Corchado-Garcia et al.   JAMA Network Open

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

The COVID-19 vaccine development landscape

(2020) Tung Thanh Le et al.   NATURE REVIEWS DRUG DISCOVERY

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

(2020) Wenhao Dai et al.   SCIENCE

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

(2020) Linlin Zhang et al.   SCIENCE

The SARS-CoV-2 main protease as drug target

(2020) Sven Ullrich et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19

(2020) Robert L. Hoffman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neuropilin-1 is a host factor for SARS-CoV-2 infection

(2020) James L. Daly et al.   SCIENCE

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

(2020) Ludovico Cantuti-Castelvetri et al.   SCIENCE

Macrocyclic Peptides as Drug Candidates: Recent Progress and Remaining Challenges

(2019) Alexander A. Vinogradov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enhancing the Cell Permeability and Metabolic Stability of Peptidyl Drugs by Reversible Bicyclization

(2016) Ziqing Qian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Overview of Severe Acute Respiratory Syndrome–Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy

(2016) Thanigaimalai Pillaiyar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Novel Polo-Like Kinase 1 Polo-Box Domain Inhibitors to Induce Mitotic Arrest in Tumor Cells

(2016) Tan Qin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modifications of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor To Achieve High Plasma Stability

(2016) Erika J. Olson et al.   ACS Medicinal Chemistry Letters

Molecular mechanism of polyethylene glycol mediated stabilization of protein

(2010) Sanjay Rawat et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modulating Oxytocin Activity and Plasma Stability by Disulfide Bond Engineering

(2010) Markus Muttenthaler et al.   JOURNAL OF MEDICINAL CHEMISTRY

Solving the α-Conotoxin Folding Problem: Efficient Selenium-Directed On-Resin Generation of More Potent and Stable Nicotinic Acetylcholine Receptor Antagonists

(2010) Markus Muttenthaler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Improved side-chain torsion potentials for the Amber ff99SB protein force field

(2010) Kresten Lindorff-Larsen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structure and Activity of (2,8)-Dicarba-(3,12)-cystino α-ImI, an α-Conotoxin Containing a Nonreducible Cystine Analogue†

(2009) Christopher A. MacRaild et al.   JOURNAL OF MEDICINAL CHEMISTRY

C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration

(2009) T. Teesalu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA