Article
Immunology
Wen-Rui Hao, Tsung-Lin Yang, Yu-Hsin Lai, Kuan-Jie Lin, Yu-Ann Fang, Ming-Yao Chen, Min-Huei Hsu, Chun-Chih Chiu, Tsung-Yeh Yang, Chun-Chao Chen, Ju-Chi Liu
Summary: This study retrospectively analyzed the data of 37,117 patients with hypertension and found that influenza vaccination can decrease the risk of developing chronic kidney disease in these patients, and the protective effect is dose-dependent.
Article
Medicine, Research & Experimental
Chun-Hsiang Lin, Oswald Ndi Nfor, Chien-Chang Ho, Shu-Yi Hsu, Disline Manli Tantoh, Yi-Chia Liaw, Mochly-Rosen Daria, Che-Hong Chen, Yung Liaw
Summary: This study found that among Taiwanese adults, the ADH1B rs1229984 TC + CC genotype and alcohol consumption of at least 150 ml/week may increase the risk of developing hemorrhagic stroke. The ALDH2 rs671 genotype was not associated with hemorrhagic or ischemic stroke among alcohol drinkers.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Clinical Neurology
Jacqueline H. Geer, Guido J. Falcone, Kevin N. Vanent, Audrey C. Leasure, Daniel Woo, Jennifer R. Molano, Lauren H. Sansing, Carl D. Langefeld, Margaret A. Pisani, Henry K. Yaggi, Kevin N. Sheth
Summary: The study found that obstructive sleep apnea (OSA) is associated with the risk of intracerebral hemorrhage (ICH). Cases with OSA were more likely to be male and have hypertension, heart disease, hyperlipidemia, and higher body mass index compared to those without OSA. Logistic regression analysis showed that OSA is a risk factor for ICH.
Article
Clinical Neurology
Edith H. Svensson, Martin Soderholm
Summary: Higher baseline FGF23 levels were significantly associated with incident intracerebral hemorrhage (ICH), particularly in lobar and non-lobar ICH. FGF23 was also significantly associated with fatal ICH, ICH with large volume, and ICH with poor functional outcome. Further studies are needed to determine if this association is causal.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Adi-Lukas Kurniawan, Ya-Lan Yang, Mei-Yun Chin, Chien-Yeh Hsu, Rathi Paramastri, Hsiu-An Lee, Po-Yuan Ni, Jane Chao
Summary: The study showed that chronic kidney disease (CKD) patients can benefit from nutrition education (NE) and lifestyle adjustments in improving kidney function and cardiovascular risk factors, particularly for patients who smoke or have inactive physical activity. Nutrition education may play a positive role in enhancing kidney function and improving cardiovascular risk factors.
Article
Cardiac & Cardiovascular Systems
Jianwei Wu, Jiahuan Guo, Anxin Wang, Yijun Zhang, Shouling Wu, Yanfang Liu, Xingquan Zhao
Summary: This study aimed to investigate the association between the severity of nonalcoholic fatty liver disease (NAFLD) steatosis and the risk of future intracerebral hemorrhage (ICH). The results showed that persistent moderate steatosis was significantly associated with an increased risk of future ICH, independent of other conventional risk factors.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Biology
Jin Pyeong Jeon, Sung Woo Han, Tae Yeon Kim, Seung Hyuk Lim, Dong Hyuk Youn, Jong Kook Rhim, Jeong Jin Park, Jun Hyong Ahn, Heung Cheol Kim, Jinseo Yang
Summary: The study found that patients with Hp2-2 phenotype had a higher likelihood of developing perihematomal edema compared to those with Hp1-1. Additionally, higher relative alpha 1 intensities were closely associated with perihematomal edema in patients with Hp2-1.
Article
Medicine, General & Internal
Shih-Han Hung, Sudha Xirasagar, Yen-Fu Cheng, Nai-Wen Kuo, Herng-Ching Lin
Summary: This population-based, case-control study explores the relationship between prior tinnitus and the occurrence of chronic kidney disease (CKD). The study shows that CKD patients are more likely to have previously experienced tinnitus. However, there is no evidence suggesting that tinnitus is a predictor of subsequent CKD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Sophia Keins, Jessica R. Abramson, Akashleena Mallick, Juan Pablo Castello, Axana Rodriguez-Torres, Dominique Popescue, Danielle Hoffman, Christina Kourkoulis, M. Edip Gurol, Steven M. Greenberg, Christopher D. Anderson, Anand Viswanathan, Jonathan Rosand, Alessandro Biffi
Summary: Depressive symptoms after spontaneous intracerebral hemorrhage (ICH) are associated with inadequate blood pressure control. The use of selective serotonin reuptake inhibitors and norepinephrine-serotonin reuptake inhibitors antidepressants is independently associated with higher systolic blood pressure measurements.
Article
Clinical Neurology
Audrey C. Leasure, Lindsey R. Kuohn, Kevin N. Vanent, Matthew B. Bevers, W. Taylor Kimberly, Thorsten Steiner, Stephan A. Mayer, Charles C. Matouk, Lauren H. Sansing, Guido J. Falcone, Kevin N. Sheth
Summary: Higher admission IL-6 levels in patients with spontaneous intracerebral hemorrhage are associated with worse 90-day functional outcome, larger ICH volume, and larger perihematomal edema volume.
Article
Geriatrics & Gerontology
G. Y. Heo, H. J. Kim, D. Kalantar, C. Y. Jung, H. W. Kim, J. T. Park, T. I. Chang, T. H. Yoo, S. W. Kang, C. M. Rhee, K. Kalantar-Zadeh, Seung Hyeok Han
Summary: The study demonstrates that increased fiber intake is associated with a lower risk of chronic kidney disease. In this large cohort study, an increase in fiber intake is linked to a decreased risk of developing CKD.
JOURNAL OF NUTRITION HEALTH & AGING
(2023)
Article
Clinical Neurology
Felix Hess, Christian Foerch, Fee Keil, Alexander Seiler, Sriramya Lapa
Summary: Dysphagia is a common symptom in patients with acute intracerebral hemorrhage, with about 63.6% of patients experiencing swallowing difficulties. Lesions in specific cortical and subcortical areas, such as the right insular cortex and central operculum, are associated with dysphagia development. Factors like intraventricular hemorrhage extension and midline shift do not appear to be related to dysphagia in these patients.
Article
Endocrinology & Metabolism
Chi Wang, Hebin Che, You Zhou, Ruiqing Wang, Di Zhu, Liting Cheng, Chongyou Rao, Qin Zhong, Zongren Li, Yongjie Duan, Jiayu Xu, Wei Dong, Yongyi Bai, Kunlun He
Summary: This retrospective cohort study investigated the joint association of hyperuricemia and chronic kidney disease (CKD) with mortality in patients with chronic heart failure (CHF). The results showed that both hyperuricemia and CKD were independently associated with increased in-hospital and long-term mortality risk in CHF patients. These findings highlight the importance of managing hyperuricemia and CKD together in the management of heart failure.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Aaron M. Gusdon, Carol B. Thompson, Kendel Quirk, Yunis M. Mayasi, Radhika Avadhani, Issam A. Awad, Daniel F. Hanley, Wendy C. Ziai
Summary: The study found that in patients with ICH and IVH, treatment with alteplase compared to saline resulted in significantly enhanced inflammatory response in CSF leukocyte subtypes. Increased serum lymphocytes may be associated with better outcomes, while increased neutrophil-to-lymphocyte ratio (NLR) may be associated with worse outcomes.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Xiangyu Zhu, Qiu Han, Lei Xia, Jin Shang, Xianliang Yan
Summary: This study compared the efficacy of intermittent hemodialysis (IHD) and continuous veno-venous hemofiltration (CVVH) in patients with chronic renal failure complicated by massive intracerebral hemorrhage. The results showed that CVVH was more effective in reducing NIHSS scores and edema volumes compared to IHD, especially in the early postoperative period. CVVH also had lower incidence of adverse events and shorter hospital stay length.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Peripheral Vascular Disease
Ka-Ho Wong, Varsha Muddasani, Cecilia Peterson, Nazanin Sheibani, Cameron Arkin, Irene Cheong, Jennifer J. Majersik, Alessandro Biffi, Nils Petersen, Guido J. Falcone, Lauren H. Sansing, Adam H. de Havenon
Summary: This study found that baseline serum IL-6 is associated with increased subsequent BPV. Further investigation is needed to better understand the relationship between chronic inflammation and BPV.
AMERICAN JOURNAL OF HYPERTENSION
(2023)
Article
Geriatrics & Gerontology
Brienne Miner, Margaret Doyle, Melissa Knauert, Henry Klar Yaggi, Katie L. Stone, Sonia Ancoli-Israel, Jane A. Cauley, Susan Redline, Terri Blackwell, Thomas M. Gill
Summary: ISSD, characterized by insomnia or poor sleep quality with short sleep duration, is common among older adults and is associated with various factors. Future research should focus on determining causal relationships and whether these factors are modifiable risk factors.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Natalia Festa, John Hsu, James K. K. Hammitt, Thomas M. M. Gill
Summary: Although environmental pollution and societal aging are concurrent public health challenges, the relationship between the two is rarely considered. The current approach to valuing public health benefits of environmental policy may not be suitable for aging populations. We describe the limitations of the age-invariant approach used by the US EPA for estimating public health benefits of environmental regulation. We offer an empirical framework that could address these limitations and improve the calibration of environmental regulatory analysis to the changing age distribution of the US population.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Clinical Neurology
Julian N. Acosta, Cameron P. Both, Zachariah S. Demarais, Carolyn J. Conlon, Audrey C. Leasure, Victor M. Torres-Lopez, Adam de Havenon, Nils H. Petersen, Thomas M. Gill, Lauren H. Sansing, Kevin N. Sheth, Guido J. Falcone
Summary: This study examines the relationship between genetic susceptibility to hypertension and blood pressure control in stroke survivors. The results show that stroke survivors with higher genetic susceptibility tend to have worse blood pressure control, with a higher prevalence of uncontrolled and resistant hypertension.
Article
Medicine, General & Internal
Natalia Festa, Kaitlin F. Throgmorton, Nora Heaphy, Maureen Canavan, Thomas M. Gill
Summary: This study examined the preparedness of US nursing homes in coastal areas for hurricane-related inundation and found regional variations in emergency preparedness. Some areas showed deficiencies in emergency preparedness, while there were opportunities to reduce regional heterogeneity and improve nursing home preparedness.
Article
Clinical Neurology
Abdalla A. Ammar, Aladine A. Elsamadicy, Mahmoud A. Ammar, Benjamin C. Reeves, Andrew B. Koo, Guido J. Falcone, David Y. Hwang, Nils Petersen, Jennifer A. Kim, Rachel Beekman, Morgan Prust, Jessica Magid-Bernstein, Julian N. Acosta, Ryan Herbert, Kevin N. Sheth, Charles C. Matouk, Emily J. Gilmore
Summary: This study compared the safety of immediate EVD placement after the bolus administration of a factor Xa-inhibitor reversal agent versus after the infusion of the agent in patients with intracerebral hemorrhage. The results showed no significant differences in the incidence of hemorrhage, mortality, length of hospital stay, and discharge modified Rankin Score between the two groups. Therefore, it may be considered to perform EVD placement immediately after the infusion of the reversal agent to shorten the treatment time.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Review
Clinical Neurology
Shubham Misra, Terence J. Quinn, Guido J. Falcone, Vijay K. Sharma, Adam de Havenon, Yize Zhao, Ece Eldem, Jacqueline A. French, Clarissa Lin Yasuda, Jesse Dawson, David S. Liebeskind, Patrick Kwan, Nishant K. Mishra
Summary: We conducted a systematic review to investigate the association of single-nucleotide polymorphisms (SNPs) with the risk of post-traumatic epilepsy (PTE) and post-stroke epilepsy (PSE). Our findings showed that 11 SNPs were significantly associated with an increased risk of PTE, while 3 SNPs were significantly associated with an increased risk of PSE, and 2 SNPs were associated with a reduced risk. The association between APOE e4 and PTE was not significant.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Julie A. A. Womack, Terrence E. E. Murphy, Linda Leo-Summers, Jonathan Bates, Samah Jarad, Thomas M. M. Gill, Evelyn Hsieh, Maria C. C. Rodriguez-Barradas, Phyllis C. C. Tien, Michael T. T. Yin, Cynthia A. A. Brandt, Amy C. C. Justice
Summary: Among older individuals living with HIV, risk factors commonly associated with serious falls and fragility fractures in the general population also play a significant role.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Review
Geriatrics & Gerontology
Emily J. Smail, Jordan M. Alpert, Mamoun T. Mardini, Christopher N. Kaufmann, Chen Bai, Thomas M. Gill, Roger B. Fillingim, Erta Cenko, Ruben Zapata, Yashaswi Karnati, Michael Marsiske, Sanjay Ranka, Todd M. Manini
Summary: This study introduces a Real-time Online Assessment and Mobility Monitor (ROAMM) smartwatch application that captures daily fluctuations in mobility in ecological settings. The usability and feasibility of ROAMM were assessed using a sample of 31 participants, showing high satisfaction and engagement. Some features of the smartwatch were correlated with traditional measurements, indicating its potential contribution to mobility measurement and risk factors for mobility decline.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Erwin Stolz, Hannes Mayerl, Graciela Muniz-Terrera, Thomas M. Gill
Summary: This study reveals that there is a terminal decline in physical function among older adults, which is comparable to the established terminal decline phenomenon in cognition and may be associated with impending death.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Clinical Neurology
Yuhan Xie, Julian N. Acosta, Yixuan Ye, Zachariah S. Demarais, Carolyn J. Conlon, Ming Chen, Hongyu Zhao, Guido J. Falcone
Summary: This study used whole-exome sequencing data from 152,058 UK Biobank participants and identified a significant association between a rare genetic variant at CYP2R1 and the risk of ischemic stroke (IS). Validation analyses further confirmed this association in other cohorts and neuroimaging traits.
Article
Clinical Neurology
Daniela Renedo, Julian N. Acosta, Andrew B. Koo, Cyprien Rivier, Nanthiya Sujijantarat, Adam de Havenon, Richa Sharma, Thomas M. Gill, Kevin N. Sheth, Guido J. Falcone, Charles C. Matouk
Summary: This study aims to investigate the relationship between the hospital frailty risk score (HFRS) and the risk of stroke, as well as to determine whether there is a significant association between genetically determined frailty and stroke. The results showed that frailty status is positively associated with the risk of stroke, and genetically determined frailty is independently associated with the risk of stroke.
Letter
Clinical Neurology
Guilherme Barros, R. Michael Meyer, David I. Bass, Dominic Nistal, Malia McAvoy, Julian V. Clarke, Kevin N. Vanent, Michael J. Cruz, Michael R. Levitt
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Julian N. Acosta, Stefan P. Haider, Cyprien Rivier, Audrey C. Leasure, Kevin N. Sheth, Guido J. Falcone, Seyedmehdi Payabvash
Summary: In this study, the relationship between higher systolic blood pressure (SBP) and white matter (WM) microstructural/cytostructural disintegrity patterns was investigated. It was found that higher SBP was associated with lower neurite density and higher mean diffusivity (MD). Among various WM tracts, the diffusion metrics of the internal capsule anterior limb, external capsule, superior and posterior corona radiata were most affected by higher SBP. The study also revealed that certain WM tracts mediated the effects of SBP on fluid intelligence.
STROKE AND VASCULAR NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Yixuan Ye, Rommell B. Noche, Natalia Szejko, Cameron P. Both, Julian N. Acosta, Audrey C. Leasure, Stacy C. Brown, Kevin N. Sheth, Thomas M. Gill, Hongyu Zhao, Guido J. Falcone
Summary: Frailty is an aging-related clinical phenotype characterized by increased vulnerability when exposed to stressors. A large-scale GWAS identified 37 novel loci associated with frailty, offering new insights into its genetic architecture and underlying mechanisms.