CRISPR/Cas9 targeted inactivation of the kauniolide synthase in chicory results in accumulation of costunolide and its conjugates in taproots

Inactivation of the germacrene A synthase genes by CRISPR/Cas9 eliminates the biosynthesis of sesquiterpene lactones in Cichorium intybus L.

(2021) Katarina Cankar et al.   PLANT BIOTECHNOLOGY JOURNAL

Sesquiterpene Lactones: Promising Natural Compounds to Fight Inflammation

(2021) Melanie S. Matos et al.   Pharmaceutics

Antitumor activity and mechanism of costunolide and dehydrocostus lactone: Two natural sesquiterpene lactones from the Asteraceae family

(2020) Qijuan Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Efficient Genome Editing Using CRISPR/Cas9 Technology in Chicory

(2019) Guillaume Bernard et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Costunolide—A Bioactive Sesquiterpene Lactone with Diverse Therapeutic Potential

(2019) Dae Yong Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterization of CYP71AX36 from Sunflower (Helianthus annuus L., Asteraceae)

(2019) Maximilian Frey et al.   Scientific Reports

Biosynthesis of Eupatolide—A Metabolic Route for Sesquiterpene Lactone Formation Involving the P450 Enzyme CYP71DD6

(2018) Maximilian Frey et al.   ACS Chemical Biology

Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity

(2018) Qing Liu et al.   Nature Communications

Tissue specific expression and genomic organization of bitter sesquiterpene lactone biosynthesis in Cichorium intybus L. (Asteraceae)

(2018) Milica Bogdanović et al.   INDUSTRIAL CROPS AND PRODUCTS

Discovery of a non-stereoselective cytochrome P450 catalyzing either 8α- or 8β-hydroxylation of germacrene A acid from the Chinese medicinal plant, Inula hupehensis

(2017) Junbo Gou et al.   PLANT JOURNAL

Sesquiterpene Lactones: More Than Protective Plant Compounds With High Toxicity

(2016) Guillermo Federico Padilla-Gonzalez et al.   CRITICAL REVIEWS IN PLANT SCIENCES

A Latex Metabolite Benefits Plant Fitness under Root Herbivore Attack

(2016) Meret Huber et al.   PLOS BIOLOGY

Sesquiterpene Lactone Composition of Wild and Cultivated Sunflowers and Biological Activity against an Insect Pest

(2015) Jarrad R. Prasifka et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Estimation of Costunolide and Dehydrocostus Lactone in Saussurea lappa and its Polyherbal Formulations followed by their Stability Studies Using HPLC-DAD

(2015) KSuresh Babu et al.   Pharmacognosy Magazine

Valencene oxidase CYP706M1 from Alaska cedar (Callitropsis nootkatensis)

(2014) Katarina Cankar et al.   FEBS LETTERS

Elucidation and in planta reconstitution of the parthenolide biosynthetic pathway

(2014) Qing Liu et al.   METABOLIC ENGINEERING

Sesquiterpenoids Lactones: Benefits to Plants and People

(2013) Martin Chadwick et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Low melting point agarose beads as a standard method for plantlet regeneration from protoplasts within the Cichorium genus

(2012) Dieter Deryckere et al.   PLANT CELL REPORTS

Lettuce Costunolide Synthase (CYP71BL2) and Its Homolog (CYP71BL1) from Sunflower Catalyze Distinct Regio- and Stereoselective Hydroxylations in Sesquiterpene Lactone Metabolism

(2011) Nobuhiro Ikezawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Modular Cloning System for Standardized Assembly of Multigene Constructs

(2011) Ernst Weber et al.   PLoS One

Reconstitution of the Costunolide Biosynthetic Pathway in Yeast and Nicotiana benthamiana

(2011) Qing Liu et al.   PLoS One

A chicory cytochrome P450 mono-oxygenase CYP71AV8 for the oxidation of (+)-valencene

(2010) Katarina Cankar et al.   FEBS LETTERS

Biochemical Conservation and Evolution of Germacrene A Oxidase in Asteraceae

(2010) Don Trinh Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY