Cryptococcus escapes host immunity: What do we know?

Macrophage Mediated Immunomodulation During Cryptococcus Pulmonary Infection

(2022) Yan Wang et al.   Frontiers in Cellular and Infection Microbiology

Cryptococcal Immune Reconstitution Inflammatory Syndrome: From Blood and Cerebrospinal Fluid Biomarkers to Treatment Approaches

(2021) Vânia Maria Sabadoto Brienze et al.   Life-Basel

The Transcription Factor Pdr802 Regulates Titan Cell Formation and Pathogenicity of Cryptococcus neoformans

(2021) Julia C. V. Reuwsaat et al.   mBio

Cryptococcus gattii polysaccharide capsule: An insight on fungal‐host interactions and vaccine studies

(2021) Gustavo J. C. Freitas et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Antifungal activity of dendritic cell lysosomal proteins against Cryptococcus neoformans

(2021) Benjamin N. Nelson et al.   Scientific Reports

Cryptococcus extracellular vesicles properties and their use as vaccine platforms

(2021) Juliana Rizzo et al.   Journal of Extracellular Vesicles

Fungal Biofilms as a Valuable Target for the Discovery of Natural Products That Cope with the Resistance of Medically Important Fungi—Latest Findings

(2021) Estefanía Butassi et al.   Antibiotics-Basel

Gene Expression of Diverse Cryptococcus Isolates during Infection of the Human Central Nervous System

(2021) Chen-Hsin Yu et al.   mBio

Innate Lymphoid Cells and Natural Killer Cells in Bacterial Infections: Function, Dysregulation, and Therapeutic Targets

(2021) Noha Mousaad Elemam et al.   Frontiers in Cellular and Infection Microbiology

Human IgM inhibits the formation of Titan-like cells in Cryptococcus neoformans

(2020) Nuria Trevijano-Contador et al.   INFECTION AND IMMUNITY

Pulmonary Macrophage and Dendritic Cell Responses to Cryptococcus neoformans

(2020) Benjamin N. Nelson et al.   Frontiers in Cellular and Infection Microbiology

Group 2 Innate Lymphoid Cells (ILC2) Suppress Beneficial Type 1 Immune Responses During Pulmonary Cryptococcosis

(2020) Markus Kindermann et al.   Frontiers in Immunology

The role of melanins in melanotic fungi for pathogenesis and environmental survival

(2020) Helene C. Eisenman et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Dormancy in Cryptococcus neoformans: 60 years of accumulating evidence

(2020) Alexandre Alanio   JOURNAL OF CLINICAL INVESTIGATION

Intracellular Cryptococcus neoformans disrupts the transcriptome profile of M1- and M2-polarized host macrophages

(2020) Aarthi Subramani et al.   PLoS One

Combination Therapy to Treat Fungal Biofilm-Based Infections

(2020) Jana Tits et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phagosomal F-Actin Retention by Cryptococcus gattii Induces Dendritic Cell Immunoparalysis

(2020) Khusraw Jamil et al.   mBio

A glucuronoxylomannan epitope exhibits serotype-specific accessibility and redistributes towards the capsule surface during Titanisation of the fungal pathogen Cryptococcus neoformans

(2019) Mark Probert et al.   INFECTION AND IMMUNITY

Inflammatory monocytes are detrimental to the host immune response during acute infection with Cryptococcus neoformans

(2019) Lena J. Heung et al.   PLoS Pathogens

Cryptococcus neoformans Glucuronoxylomannan and Sterylglucoside Are Required for Host Protection in an Animal Vaccination Model

(2019) Ana Caroline Colombo et al.   mBio

Identification of Pathogen Genomic Differences That Impact Human Immune Response and Disease during Cryptococcus neoformans Infection

(2019) Aleeza C. Gerstein et al.   mBio

Infectious particle identity determines dissemination and disease outcome for the inhaled human fungal pathogen Cryptococcus

(2019) Naomi M. Walsh et al.   PLoS Pathogens

Pathogenic Fungal Infection in the Lung

(2019) Zhi Li et al.   Frontiers in Immunology

A CCL1/CCR8-dependent feed-forward mechanism drives ILC2 functions in type 2–mediated inflammation

(2019) Lisa Knipfer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Unraveling Melanin Biosynthesis and Signaling Networks in Cryptococcus neoformans

(2019) Dongpil Lee et al.   mBio

Reduced phagocytosis and killing of Cryptococcus neoformans biofilm-derived cells by J774.16 macrophages is associated with fungal capsular production and surface modification

(2019) Hiu Ham Lee et al.   FUNGAL GENETICS AND BIOLOGY

Fungal dissemination is limited by liver macrophage filtration of the blood

(2019) Donglei Sun et al.   Nature Communications

Characterizing the Mechanisms of Nonopsonic Uptake of Cryptococci by Macrophages

(2018) Jenson Lim et al.   JOURNAL OF IMMUNOLOGY

ILC2s in infectious diseases and organ-specific fibrosis

(2018) Markus Kindermann et al.   Seminars in Immunopathology

Identification of T helper (Th)1- and Th2-associated antigens of Cryptococcus neoformans in a murine model of pulmonary infection

(2018) Carolina Firacative et al.   Scientific Reports

The Capsule of Cryptococcus neoformans

(2018) Arturo Casadevall et al.   Virulence

The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis

(2018) Ivy M. Dambuza et al.   PLoS Pathogens

Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators

(2018) Benjamin Hommel et al.   PLoS Pathogens

Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals

(2018) Nuria Trevijano-Contador et al.   PLoS Pathogens

Immunology of Cryptococcal Infections: Developing a Rational Approach to Patient Therapy

(2018) Waleed Elsegeiny et al.   Frontiers in Immunology

A Predicted Mannoprotein Participates in Cryptococcus gattii Capsular Structure

(2018) Julia Catarina Vieira Reuwsaat et al.   mSphere

The group 2 innate lymphoid cell (ILC2) regulatory network and its underlying mechanisms

(2018) Hiroki Kabata et al.   IMMUNOLOGICAL REVIEWS

Cytokine profiles in cerebrospinal fluid of patients with meningitis at a tertiary general hospital in China

(2018) Qianqian Liu et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Capsular specific IgM enhances complement-mediated phagocytosis and killing of Cryptococcus neoformans by methamphetamine-treated J774.16 macrophage-like cells

(2017) Lilit Aslanyan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis

(2017) Radha Rajasingham et al.   LANCET INFECTIOUS DISEASES

CD4 + T Cells Orchestrate Lethal Immune Pathology despite Fungal Clearance during Cryptococcus neoformans Meningoencephalitis

(2017) Lori M. Neal et al.   mBio

Trojan Horse Transit Contributes to Blood-Brain Barrier Crossing of a Eukaryotic Pathogen

(2017) Felipe H. Santiago-Tirado et al.   mBio

IP3-4 kinase Arg1 regulates cell wall homeostasis and surface architecture to promote clearance of Cryptococcus neoformans infection in a mouse model

(2017) Cecilia Li et al.   Virulence

Neutrophil swarming toward Cryptococcus neoformans is mediated by complement and leukotriene B4

(2016) Donglei Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antifungal Activity of Plasmacytoid Dendritic Cells against Cryptococcus neoformansIn VitroRequires Expression of Dectin-3 (CLEC4D) and Reactive Oxygen Species

(2016) Camaron R. Hole et al.   INFECTION AND IMMUNITY

Cryptococcus gattiiCapsule Blocks Surface Recognition Required for Dendritic Cell Maturation Independent of Internalization and Antigen Processing

(2016) Shaunna M. Huston et al.   JOURNAL OF IMMUNOLOGY

A Glucuronoxylomannan-Associated Immune Signature, Characterized by Monocyte Deactivation and an Increased Interleukin 10 Level, Is a Predictor of Death in Cryptococcal Meningitis

(2016) James E. Scriven et al.   JOURNAL OF INFECTIOUS DISEASES

Cryptococcal transmigration across a model brain blood-barrier: evidence of the Trojan horse mechanism and differences between Cryptococcus neoformans var. grubii strain H99 and Cryptococcus gattii strain R265

(2016) Tania C. Sorrell et al.   MICROBES AND INFECTION

Fungal morphogenetic changes inside the mammalian host

(2016) Nuria Trevijano-Contador et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Evasion of Innate Immune Responses by the Highly Virulent Cryptococcus gattii by Altering Capsule Glucuronoxylomannan Structure

(2016) Makoto Urai et al.   Frontiers in Cellular and Infection Microbiology

Therapeutic expansion of CD4+FoxP3+regulatory T cells limits allergic airway inflammation during pulmonary fungal infection

(2016) Bianca Schulze et al.   Pathogens and Disease

Lung epithelium is the major source of IL-33 and is regulated by IL-33-dependent and IL-33-independent mechanisms in pulmonary cryptococcosis

(2016) Laura Heyen et al.   Pathogens and Disease

The formation of titan cells inCryptococcus neoformansdepends on the mouse strain and correlates with induction of Th2-type responses

(2015) Irene García-Barbazán et al.   CELLULAR MICROBIOLOGY

A novel experimental model ofCryptococcus neoformans-related immune reconstitution inflammatory syndrome (IRIS) provides insights into pathogenesis

(2015) Maria Eschke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Host immunity toCryptococcus neoformans

(2015) Soma Rohatgi et al.   Future Microbiology

Role of dendritic cell–pathogen interactions in the immune response to pulmonary cryptococcal infection

(2015) Alison J Eastman et al.   Future Microbiology

Real-Time Imaging of Interactions of Neutrophils with Cryptococcus neoformans Demonstrates a Crucial Role of Complement C5a-C5aR Signaling

(2015) Donglei Sun et al.   INFECTION AND IMMUNITY

Cryptococcal Heat Shock Protein 70 Homolog Ssa1 Contributes to Pulmonary Expansion ofCryptococcus neoformansduring the Afferent Phase of the Immune Response by Promoting Macrophage M2 Polarization

(2015) Alison J. Eastman et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cell Induction and Retention in the Lungs Drives Suppression of Detrimental Type 2 Th Cells During Pulmonary Cryptococcal Infection

(2015) Darin L. Wiesner et al.   JOURNAL OF IMMUNOLOGY

Early ART After Cryptococcal Meningitis Is Associated With Cerebrospinal Fluid Pleocytosis and Macrophage Activation in a Multisite Randomized Trial

(2015) James E. Scriven et al.   JOURNAL OF INFECTIOUS DISEASES

Management of Cryptococcus gattii meningoencephalitis

(2015) Carlos Franco-Paredes et al.   LANCET INFECTIOUS DISEASES

The Role of Cryptococcus in the Immune System of Pulmonary Cryptococcosis Patients

(2015) Jinlin Wang et al.   PLoS One

Capsular polysaccharides from Cryptococcus neoformans modulate production of neutrophil extracellular traps (NETs) by human neutrophils

(2015) Juliana D. B. Rocha et al.   Scientific Reports

Chitin Recognition via Chitotriosidase Promotes Pathologic Type-2 Helper T Cell Responses to Cryptococcal Infection

(2015) Darin L. Wiesner et al.   PLoS Pathogens

Cerebrospinal Fluid Cytokine Profiles Predict Risk of Early Mortality and Immune Reconstitution Inflammatory Syndrome in HIV-Associated Cryptococcal Meningitis

(2015) Joseph N. Jarvis et al.   PLoS Pathogens

Fungal Melanin: What do We Know About Structure?

(2015) Joshua D. Nosanchuk et al.   Frontiers in Microbiology

Cytokine Profiles at Admission Can Be Related to Outcome in AIDS Patients with Cryptococcal Meningitis

(2015) Delio José Mora et al.   PLoS One

Efficient phagocytosis and laccase activity affect the outcome of HIV-associated cryptococcosis

(2014) Wilber Sabiiti et al.   JOURNAL OF CLINICAL INVESTIGATION

Classical versus alternative macrophage activation: the Ying and the Yang in host defense against pulmonary fungal infections

(2014) C M Leopold Wager et al.   Mucosal Immunology

Fungal glycans and the innate immune recognition

(2014) Eliana Barreto-Bergter et al.   Frontiers in Cellular and Infection Microbiology

IL-33 Signaling Regulates Innate and Adaptive Immunity to Cryptococcus neoformans

(2013) A. Flaczyk et al.   JOURNAL OF IMMUNOLOGY

Scavenger Receptor A Modulates the Immune Response to Pulmonary Cryptococcus neoformans Infection

(2013) Y. Qiu et al.   JOURNAL OF IMMUNOLOGY

Macrophage M1/M2 Polarization Dynamically Adapts to Changes in Cytokine Microenvironments in Cryptococcus neoformans Infection

(2013) M. J. Davis et al.   mBio

HYPOXIA SENSING IN CRYPTOCOCCUS NEOFORMANS: BIOFILM-LIKE ADAPTATION FOR DORMANCY?

(2012) Zuzana Moranova et al.   BIOMEDICAL PAPERS-OLOMOUC

The Cryptococcus neoformans Capsule: a Sword and a Shield

(2012) T. R. O'Meara et al.   CLINICAL MICROBIOLOGY REVIEWS

Titan Cell Production Enhances the Virulence of Cryptococcus neoformans

(2012) Juliet N. Crabtree et al.   INFECTION AND IMMUNITY

Molecular Characterization of the Early B Cell Response to Pulmonary Cryptococcus neoformans Infection

(2012) S. Rohatgi et al.   JOURNAL OF IMMUNOLOGY

Regulated expression of cyclic AMP-dependent protein kinase A reveals an influence on cell size and the secretion of virulence factors in Cryptococcus neoformans

(2012) Jaehyuk Choi et al.   MOLECULAR MICROBIOLOGY

Lack of IL-4 receptor expression on T helper cells reduces T helper 2 cell polyfunctionality and confers resistance in allergic bronchopulmonary mycosis

(2012) U Müller et al.   Mucosal Immunology

Cryptococcal Titan Cell Formation Is Regulated by G-Protein Signaling in Response to Multiple Stimuli

(2011) Laura H. Okagaki et al.   EUKARYOTIC CELL

Lung dendritic cells at the innate-adaptive immune interface

(2011) Tracy Voss Condon et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Extracellular Fibrils of Pathogenic Yeast Cryptococcus gattii Are Important for Ecological Niche, Murine Virulence and Human Neutrophil Interactions

(2010) Deborah J. Springer et al.   PLoS One

Cryptococcal Urease Promotes the Accumulation of Immature Dendritic Cells and a Non-Protective T2 Immune Response within the Lung

(2009) John J. Osterholzer et al.   AMERICAN JOURNAL OF PATHOLOGY

Accumulation of CD11b+ Lung Dendritic Cells in Response to Fungal Infection Results from the CCR2-Mediated Recruitment and Differentiation of Ly-6Chigh Monocytes

(2009) J. J. Osterholzer et al.   JOURNAL OF IMMUNOLOGY

Protection by Anti-β-Glucan Antibodies Is Associated with Restricted β-1,3 Glucan Binding Specificity and Inhibition of Fungal Growth and Adherence

(2009) Antonella Torosantucci et al.   PLoS One

Capsular polysaccharides galactoxylomannan and glucuronoxylomannan from Cryptococcus neoformans induce macrophage apoptosis mediated by Fas ligand

(2008) Suellen N. Villena et al.   CELLULAR MICROBIOLOGY

Evidence of a Role for Monocytes in Dissemination and Brain Invasion by Cryptococcus neoformans

(2008) C. Charlier et al.   INFECTION AND IMMUNITY