Single-cell profiling of peripheral neuroblastic tumors identifies an aggressive transitional state that bridges an adrenergic-mesenchymal trajectory

Recent advances in the developmental origin of neuroblastoma: an overview

(2022) Mirco Ponzoni et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype

(2021) Evelyn S. Hanemaaijer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell

(2021) Gerda Kildisiute et al.   Science Advances

Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin

(2021) Polina Kameneva et al.   NATURE GENETICS

Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma

(2021) Selina Jansky et al.   NATURE GENETICS

Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors

(2021) O. C. Bedoya-Reina et al.   Nature Communications

Plasticity in Neuroblastoma Cell Identity Defines a Noradrenergic-to-Mesenchymal Transition (NMT)

(2021) Margot Gautier et al.   Cancers

Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors

(2021) Ellen M. Westerhout et al.   CANCER RESEARCH

A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors

(2020) Michal Slyper et al.   NATURE MEDICINE

Targeting the Tumor Microenvironment in Neuroblastoma: Recent Advances and Future Directions

(2020) Shweta Joshi   Cancers

Single-Cell Characterization of Malignant Phenotypes and Developmental Trajectories of Adrenal Neuroblastoma

(2020) Rui Dong et al.   CANCER CELL

“Re-educating” Tumor Associated Macrophages as a Novel Immunotherapy Strategy for Neuroblastoma

(2020) Kevin X. Liu et al.   Frontiers in Immunology

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma

(2019) Tim van Groningen et al.   Nature Communications

Dynamics of Minimal Residual Disease in Neuroblastoma Patients

(2019) Suguru Uemura et al.   Frontiers in Oncology

Fast, sensitive and accurate integration of single-cell data with Harmony

(2019) Ilya Korsunsky et al.   NATURE METHODS

Cancer Stem Cells and Neuroblastoma: Characteristics and Therapeutic Targeting Options

(2019) Veronica Veschi et al.   Frontiers in Endocrinology

ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry

(2019) Lu Wang et al.   Nature Communications

CONICS integrates scRNA-seq with DNA sequencing to map gene expression to tumor sub-clones

(2018) Sören Müller et al.   BIOINFORMATICS

EnrichedHeatmap: an R/Bioconductor package for comprehensive visualization of genomic signal associations

(2018) Zuguang Gu et al.   BMC GENOMICS

Cancer evolution, mutations, and clonal selection in relapse neuroblastoma

(2018) Marc Schulte et al.   CELL AND TISSUE RESEARCH

Clinically Relevant Cytotoxic Immune Cell Signatures and Clonal Expansion of T Cell Receptors in High-riskMYCN-not-amplified Human Neuroblastoma

(2018) Jun S. Wei et al.   CLINICAL CANCER RESEARCH

High-dimension single-cell analysis applied to cancer

(2018) Lili Wang et al.   MOLECULAR ASPECTS OF MEDICINE

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

EZH2 regulates neuroblastoma cell differentiation via NTRK1 promoter epigenetic modifications

(2018) Zhenghao Li et al.   ONCOGENE

Clustering trees: a visualisation for evaluating clusterings at multiple resolutions

(2018) Luke Zappia et al.   GigaScience

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

(2018) Peng Jiang et al.   NATURE MEDICINE

Microenvironment in neuroblastoma: isolation and characterization of tumor-derived mesenchymal stromal cells

(2018) Gloria Pelizzo et al.   BMC CANCER

A mechanistic classification of clinical phenotypes in neuroblastoma

(2018) Sandra Ackermann et al.   SCIENCE

Neuroblastoma cells undergo transcriptomic alterations upon dissemination into the bone marrow and subsequent tumor progression

(2017) Fikret Rifatbegovic et al.   INTERNATIONAL JOURNAL OF CANCER

CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2

(2017) Liying Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuroblastoma is composed of two super-enhancer-associated differentiation states

(2017) Tim van Groningen et al.   NATURE GENETICS

Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries

(2017) Valentina Boeva et al.   NATURE GENETICS

Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla

(2017) Alessandro Furlan et al.   SCIENCE

MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification

(2017) Mark W. Zimmerman et al.   Cancer Discovery

Dr.seq2: A quality control and analysis pipeline for parallel single cell transcriptome and epigenome data

(2017) Chengchen Zhao et al.   PLoS One

More than the genes, the tumor microenvironment in neuroblastoma

(2016) Lucia Borriello et al.   CANCER LETTERS

CAFs and TAMs: maestros of the tumour microenvironment

(2016) Yoshihiro Komohara et al.   JOURNAL OF PATHOLOGY

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

Enrichment of Targetable Mutations in the Relapsed Neuroblastoma Genome

(2016) Olivia M. Padovan-Merhar et al.   PLoS Genetics

Neuroblastoma

(2016) Katherine K. Matthay et al.   Nature Reviews Disease Primers

Advances in Risk Classification and Treatment Strategies for Neuroblastoma

(2015) Navin R. Pinto et al.   JOURNAL OF CLINICAL ONCOLOGY

Mesenchymal change and drug resistance in neuroblastoma

(2015) Jessica A. Naiditch et al.   JOURNAL OF SURGICAL RESEARCH

Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations

(2015) Thomas F Eleveld et al.   NATURE GENETICS

Mutational dynamics between primary and relapse neuroblastomas

(2015) Alexander Schramm et al.   NATURE GENETICS

Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma

(2015) Daniel R. Carter et al.   Science Translational Medicine

Tumor-infiltrating T lymphocytes improve clinical outcome of therapy-resistant neuroblastoma

(2015) Marco Mina et al.   OncoImmunology

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

The genetic landscape of high-risk neuroblastoma

(2013) Trevor J Pugh et al.   NATURE GENETICS

Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma

(2013) H Kocak et al.   Cell Death & Disease

BEDOPS: high-performance genomic feature operations

(2012) Shane Neph et al.   BIOINFORMATICS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Clinical Significance of Tumor-Associated Inflammatory Cells in Metastatic Neuroblastoma

(2012) Shahab Asgharzadeh et al.   JOURNAL OF CLINICAL ONCOLOGY

Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

(2012) Jan J. Molenaar et al.   NATURE

Oct-4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells

(2011) Annalisa Pezzolo et al.   CELL RESEARCH

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Presence of cancer-associated fibroblasts inversely correlates with Schwannian stroma in neuroblastoma tumors

(2009) Rana Zeine et al.   MODERN PATHOLOGY

Retrospective Study of Childhood Ganglioneuroma

(2008) Bruno De Bernardi et al.   JOURNAL OF CLINICAL ONCOLOGY

Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas

(2008) Frank Westermann et al.   GENOME BIOLOGY