Journal
MOLECULAR ASPECTS OF MEDICINE
Volume 59, Issue -, Pages 70-84Publisher
ELSEVIER
DOI: 10.1016/j.mam.2017.08.005
Keywords
Single-cell analysis; Tumor heterogeneity; Subclone phylogeny; Cell identity; Tumor ecosystem; Correlation analysis
Funding
- National Institutes of Health [NCI P01CA206978-01, R01CA182461-01, U10CA180861-01, R01CA184922-02]
Ask authors/readers for more resources
High-dimension single-cell technology is transforming our ability to study and understand cancer. Numerous studies and reviews have reported advances in technology development. The biological in-sights gleaned from single-cell technology about cancer biology are less reviewed. Here we focus on research studies that illustrate novel aspects of cancer biology that bulk analysis could not achieve, and discuss the fresh insights gained from the application of single-cell technology across basic and clinical cancer studies. (C) 2017 Elsevier Ltd. All rights reserved.
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