Inhibition of the cardiac fibroblast-enriched histone methyltransferase Dot1L prevents cardiac fibrosis and cardiac dysfunction

The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell–monocyte crosstalk and protects against atherosclerosis via the NF-κB pathway

(2022) Floriana Maria Farina et al.   EUROPEAN HEART JOURNAL

Histone methyltransferase DOT1L mediates the TGF-β1/Smad3 signaling pathway through epigenetic modification of SYK in myocardial infarction

(2021) Fei Li et al.   Human Cell

Epigenetic-sensitive pathways in personalized therapy of major cardiovascular diseases

(2020) Concetta Schiano et al.   PHARMACOLOGY & THERAPEUTICS

Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L

(2019) Evan J. Worden et al.   CELL

From chemo-prevention to epigenetic regulation: The role of isothiocyanates in skin cancer prevention

(2018) Melina Mitsiogianni et al.   PHARMACOLOGY & THERAPEUTICS

Epigenetic control of gene regulation during development and disease: A view from the retina

(2018) Ximena Corso-Díaz et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Epigenetic Regulation of Biological Rhythms: An Evolutionary Ancient Molecular Timer

(2018) Tyler J. Stevenson   TRENDS IN GENETICS

The role and clinical implications of diastolic dysfunction in aortic stenosis

(2017) Polydoros N Kampaktsis et al.   HEART

Apelin Is a Negative Regulator of Angiotensin II–Mediated Adverse Myocardial Remodeling and DysfunctionNovelty and Significance

(2017) Zhen-Zhou Zhang et al.   HYPERTENSION

Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis

(2017) Michael J. Bollong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Biological Basis for Cardiac Repair After Myocardial Infarction

(2016) Sumanth D. Prabhu et al.   CIRCULATION RESEARCH

Cardiac Fibrosis

(2016) Joshua G. Travers et al.   CIRCULATION RESEARCH

AF9 YEATS Domain Links Histone Acetylation to DOT1L-Mediated H3K79 Methylation

(2014) Yuanyuan Li et al.   CELL

DOT1L-mediated H3K79me2 modification critically regulates gene expression during cardiomyocyte differentiation

(2014) P Cattaneo et al.   CELL DEATH AND DIFFERENTIATION

Heart Failure With Preserved Ejection Fraction

(2014) Francesco S. Loffredo et al.   CIRCULATION RESEARCH

Association of Fibrosis With Mortality and Sudden Cardiac Death in Patients With Nonischemic Dilated Cardiomyopathy

(2013) Ankur Gulati et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis

(2012) Paul Delgado-Olguín et al.   NATURE GENETICS

Myofibroblast-mediated mechanisms of pathological remodelling of the heart

(2012) Karl T. Weber et al.   Nature Reviews Cardiology

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

(2011) Scott R. Daigle et al.   CANCER CELL

Effects of myocardial fibrosis and ventricular dyssynchrony on response to therapy in new-presentation idiopathic dilated cardiomyopathy: insights from cardiovascular magnetic resonance and echocardiography

(2011) D. P. Leong et al.   EUROPEAN HEART JOURNAL

DOT1L regulates dystrophin expression and is critical for cardiac function

(2011) A. T. Nguyen et al.   GENES & DEVELOPMENT

The FoxO Family in Cardiac Function and Dysfunction

(2010) Sarah M. Ronnebaum et al.   Annual Review of Physiology

Future treatments in systemic sclerosis

(2010) Yoshihide ASANO   JOURNAL OF DERMATOLOGY

Involvement of a Forkhead Transcription Factor, FOXO1a, in UV-Induced Changes of Collagen Metabolism

(2009) Hiroshi Tanaka et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

Myocardial remodeling after infarction: the role of myofibroblasts

(2009) Susanne W. M. van den Borne et al.   Nature Reviews Cardiology

Cell type-specific regulation of CCN2 protein expression by PI3K–AKT–FoxO signaling

(2009) Jana Samarin et al.   Journal of Cell Communication and Signaling

Differential Behaviors of Atrial Versus Ventricular Fibroblasts

(2008) Brett Burstein et al.   CIRCULATION

DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells

(2008) D. J. Steger et al.   MOLECULAR AND CELLULAR BIOLOGY